LUIS NIETO

Extensive experience in Plastic Surgery and Aesthetic Surgery, specializations in High Complexity Reconstructive Microsurgery, Brachial Plexus Injuries in adults and children, Congenital or acquired Facial Palsy, Peripheral Nerve Surgery and Hand Surgery. Research in Healing and Nervous Regeneration

EDUCATION

Plastic Surgeon, Microsurgery, Hand Surgeon, Master Degree Neurosciences

RESEARCH INTERESTS

Peripheral Nerve Regeneration
Nerve Injuries
Microsurgery
Hand surgery

Scopus Publications

Adjustable conduits for guided peripheral nerve regeneration prepared from bi-zonal unidirectional and multidirectional laminar scaffold of type I collagen
Diana Millán, Ronald A. Jiménez, Luis E. Nieto, Ivan Y. Poveda, Maria A. Torres, et al.
Materials Science and Engineering C, 2021
Shortness of donor nerves has led to the development of nerve conduits that connect sectioned peripheral nerve stumps and help to prevent the formation of neuromas. Often, the standard diameters of these devices cannot be adapted at the time of surgery to the diameter of the nerve injured. In this work, scaffolds were developed to form filled nerve conduits with an inner matrix with unidirectional channels covered by a multidirectional pore zone. Collagen type I dispersions (5 mg/g and 8 mg/g) were sequentially frozen using different methods to obtain six laminar scaffolds (P1 to P5) formed by a unidirectional (U) pore/channel zone adjacent to a multidirectional (M) pore zone. The physicochemical and microstructural properties of the scaffolds were determined and compared, as well as their biodegradability, residual glutaraldehyde and cytocompatibility. Also, the Young's modulus of the conduits made by rolling up the bizonal scaffolds from the unidirectional to the multidirectional zone was determined. Based on these comparisons, the proliferation and differentiation of hASC were assessed only in the P3 scaffolds. The cells adhered, aligned in the same direction as the unidirectional porous fibers, proliferated, and differentiated into Schwann-like cells. Adjustable conduits made with the P3 scaffold were implanted in rats 10 mm sciatic nerve lesions to compare their performance with that of autologous sciatic nerve grafted lesions. The in vivo results demonstrated that the tested conduit can be adapted to the diameter of the nerve stumps to guide their growth and promote their regeneration.
Microsurgical tongue reconstruction
Luis Eduardo Nieto Ramírez, Clara Italia Pedraza Borrero
Revista Chilena De Cirugia, 2016
Los tumores malignos de lengua son una patologia frecuente con alto grado de morbilidad y mortalidad. Su tratamiento requiere manejo quirurgico y sistemico oncologico, con la respectiva reconstruccion, para lograr asi una adecuada calidad de vida, debido a la funcion primordial de la lengua durante la alimentacion, la comunicacion, la interaccion social y laboral. Es por esto que la eleccion de los tejidos donantes para ello depende en gran medida de sus caracteristicas y del tipo de defecto, aspecto fundamental para obtener resultados favorables en los pacientes. Se realiza una revision de la clasificacion de los defectos resultantes despues de la reseccion de tumores de lengua, un algoritmo de manejo y los colgajos libres microvasculares mas utilizados en este tipo de reconstruccion.
Preclinical evaluation of collagen type I scaffolds, including gelatin-collagen microparticles and loaded with a hydroglycolic Calendula officinalis extract in a lagomorph model of full-thickness skin wound
D. Millán, R. A. Jiménez, L. E. Nieto, I. Linero, M. Laverde, et al.
Drug Delivery and Translational Research, 2016
Previously, we have developed collagen type I scaffolds including microparticles of gelatin-collagen type I (SGC) that are able to control the release of a hydroglycolic extract of the Calendula officinalis flower. The main goal of the present work was to carry out the preclinical evaluation of SGC alone or loaded with the C. officinalis extract (SGC-E) in a lagomorph model of full-thickness skin wound. A total of 39 rabbits were distributed in three groups, of 13 animals each. The first group was used to compare wound healing by secondary intention (control) with wound healing observed when wounds were grafted with SGC alone. Comparison of control wounds with wounds grafted with SGC-E was performed in the second group, and comparison of wounds grafted with SGC with wounds grafted with SGC-E was performed in the third group. Clinical follow-ups were carried in all animals after surgery, and histological and histomorphometric analyses were performed on tissues taken from the healed area and healthy surrounding tissue. Histological and histomorphometric results indicate that grafting of SGC alone favors wound healing and brings a better clinical outcome than grafting SGC-E. In vitro collagenase digestion data suggested that the association of the C. officinalis extract to SGC increased the SGC-E cross-linking, making it difficult to degrade and affecting its biocompatibility.
Personal experience in metacarpal hand
Cirugia Plastica Ibero Latinoamericana, 2016
Palatoplasty as the technique of choice for prevention of obstructive sleep apnea secondary to surgery for velopharyngeal insufficiency
Jose Rolando Prada Madrid, Luis Eduardo Nieto, Viviana Gomez, Pilar Echeverry, Maria Cristina Tavera, et al.
Cleft Palate Craniofacial Journal, 2011
Objective The aim of this study is to compare patients treated with pharyngoplasty and those treated with palatoplasty for velopharyngeal insufficiency to establish what surgical procedure poses the highest risk for developing sleep apnea. The hypothesis tested in this study is that the incidence of obstructive sleep apnea syndrome associated with pharyngoplasty is greater than that associated with palatoplasty for velopharyngeal insufficiency. Subjects Twenty patients were taken from the Institution FISULAB. Design Observational cohort analytic study. Main Outcome Measures An overnight polysomnographic study was used to determine the incidence and severity of obstructive sleep apnea syndrome. Results The incidence of obstructive sleep apnea syndrome following pharyngoplasty was shown to be significantly higher than after palatoplasty. The apnea-hypopnea index, also called the respiratory disturbance index, was 12.7 in the pharyngoplasty group and 1.35 in the palatoplasty group (p < .001). When obstructive sleep apnea syndrome was stratified into different levels of severity according to the values of respiratory disturbance index, there were noticeable differences between these two groups. In the palatoplasty group, one patient had mild obstructive sleep apnea syndrome. In the pharyngoplasty group, two patients had mild obstructive sleep apnea syndrome, one patient had moderate obstructive sleep apnea syndrome, and two patients had severe obstructive sleep apnea syndrome. Conclusions When comparing the apnea-hypopnea index (i.e., respiratory disturbance index) of patients treated for velopharyngeal insufficiency with palatoplasty versus pharyngoplasty, we observed an important difference between the groups, with the highest indices in the pharyngoplasty group.
Masseteric-Facial Nerve Anastomosis: Case Report
Luis Bermudez, Luis Nieto
Journal of Reconstructive Microsurgery, 2004
When a viable proximal facial nerve is not accessible, facial nerve paralysis has been managed with hypoglossal facial anastomosis, which results in varying degrees of hemiglossal atrophy and its sequelae. These authors have used the masseteric nerve to neurotize the facial nerve in one patient.

RECENT SCHOLAR PUBLICATIONS

Facial reconstruction in muco
L Nieto
Am J Med 1 , 2023
2023
LESION CELULAR POR SINDROME ISQUEMIA-REPERFUSION EN CIRUGÍA
TG Gonzalez, LE Nieto, D Cardona
Universitas Medica 64 (1) , 2023
2023
Síndrome de isquemia-reperfusión en microcirugía
TG Gonzalez, LE Nieto, D Cardona
Universitas Medica 64 (1) , 2023
2023
Síndrome de isquemia-reperfusión en microcirugía
D Cardona, L Nieto, T Guerra
Universitas Medica 64 (1), 1-35 , 2023
2023
Reconstruction sequence and microsurgery in ectrodactyly-ectodermal dysplasia-cleft lip/palate syndrome: a case report
J Gaviria-Pinzon, J Gutierrez, L Bermudez, L Nieto
International Surgery Journal 9 (2), 467-470 , 2022
2022
Citations: 1
Manifestaciones clínicas del Síndrome de Möbius: scoping review
LE Nieto, SM Jaramillo, TVC Vásquez, C Téllez
Universitas Medica 63 (2), 5 , 2022
2022
Transosteal radial free flap in palate reconstruction
L Nieto, OD León, R Smit, Z Paéz, C Cháves
Int J Oral Craniofac Sci 8 (2), 032-035 , 2022
2022
Manifestaciones clínicas del síndrome de Möbius: revisión exploratoria
TC Nieto LE, Mejía Jaramillo S, CamayoVásquezT
Universitas Medica 63 (2), 1-13 , 2022
2022
Microvascular free flap in a pregnant patient after resection of a high-grade neuroendocrine carcinoma
T Luna-Pisciotti, M Izquierdo, MP Echeverri, A Sanín, LE Nieto
Science & Art Plastic Surgery Journal , 2021
2021
Citations: 1
Neurotización: concepto clave en reparación nerviosa
NL Barreto Ana
Universitas Medica 62 (3) , 2021
2021
Citations: 3
Adjustable conduits for guided peripheral nerve regeneration prepared from bi-zonal unidirectional and multidirectional laminar scaffold of type I collagen
D Millán, RA Jiménez, LE Nieto, IY Poveda, MA Torres, AS Silva, ...
Materials Science and Engineering: C 121, 111838 , 2021
2021
Citations: 16
Regeneración del nervio periférico con células madre y plasma rico en plaquetas
L NIETO, LUZM ÁVILA, J ÁVILA, P PÉREZ, E SANTAMARÍA
Revista Colombiana de Cirugía Plástica y Reconstructiva 26 (2) , 2020
2020
Citations: 1
Lipoma gigante en mano. Reporte de caso
LE NIETO, C ORTIZ
Revista Colombiana de Cirugía Plástica y Reconstructiva 26 (1) , 2020
2020
Citations: 1
Transferencias nerviosas y aplicación en lesiones de nervio periférico del miembro inferior
LR Nieto, ZE Páez, R Smit, JA Medina, JA Rueda
Rev Colombiana Cir Plást Reconstr 24 (2) , 2018
2018
Citations: 4
Comparison of regenerative changes in peripheral nerve injuries using regenerative tube with human mesenquimal cells and platelet-rich plasma versus autologous nerve graft
LE Nieto, P Perez, E Santamaria, J Avila, LM Avila
Cytotherapy 20 (5), S28 , 2018
2018
Citations: 2
Célula de Büngner
L Nieto, SCT Arciniegas, ECR Rosado, IAT Jiménez, SDC Casas
Universitas Médica 58 (1) , 2017
2017
Bungner Cell
L Nieto, SC Torres Arciniegas, EC Rios Rosado, IA Torres Jimenez, ...
UNIVERSITAS MEDICA 58 (1) , 2017
2017
Reconstrucción de ala nasal con colgajo libre de helix-Alar reconstruction with helix free flap
L NIETO, LEB RODRÍGUEZ, AFD PINILLA
Revista Colombiana de Cirugía Plástica y Reconstructiva 22 (2) , 2016
2016
Citations: 1
Evaluación mecánica del material de osteosíntesis bioabsorbible para cirugía de mano-Mechanics assessment resorbable osteosynthesis material hand surgery
AFD PINILLA, L NIETO, DMC BERNAL, OFA SÁNCHEZ
Revista Colombiana de Cirugía Plástica y Reconstructiva 22 (2) , 2016
2016
Reconstrucción microquirúrgica de lengua
L Nieto, CI Pedraza Borrero
Revista chilena de cirugía 68 (2), 180-185 , 2016
2016
Citations: 2

MOST CITED SCHOLAR PUBLICATIONS

Masseteric-facial nerve anastomosis: case report
LE Bermudez, LE Nieto
Journal of reconstructive microsurgery 21 (01), 25-30 , 2004
2004.0
Citations: 41
Palatoplasty as the technique of choice for prevention of obstructive sleep apnea secondary to surgery for velopharyngeal insufficiency
JR Prada Madrid, LE Nieto, V Gomez, P Echeverry, MC Tavera, ...
The Cleft palate-craniofacial journal 48 (2), 145-149 , 2011
2011.0
Citations: 26
Preclinical evaluation of collagen type I scaffolds, including gelatin-collagen microparticles and loaded with a hydroglycolic Calendula officinalis extract in a …
D Millán, RA Jiménez, LE Nieto, I Linero, M Laverde, MR Fontanilla
Drug delivery and translational research 6 (1), 57-66 , 2016
2016.0
Citations: 21
Adjustable conduits for guided peripheral nerve regeneration prepared from bi-zonal unidirectional and multidirectional laminar scaffold of type I collagen
D Millán, RA Jiménez, LE Nieto, IY Poveda, MA Torres, AS Silva, ...
Materials Science and Engineering: C 121, 111838 , 2021
2021.0
Citations: 16
Colgajos de perforantes principios básicos y aplicaciones clínicas
D CORREA BERNAL, H Garcìa, C LORDUY MÁRQUEZ, JP Rodriguez, ...
Revista Med 20 (1), 42-51 , 2012
2012.0
Citations: 15
Antibiotic prophilaxis in burn lesions
LE Nieto, LMA Acosta, MA Bedoya, V Tapias
Pontificia Universidad Javeriana , 0
Citations: 9
Transferencias nerviosas y aplicación en lesiones de nervio periférico del miembro inferior
LR Nieto, ZE Páez, R Smit, JA Medina, JA Rueda
Rev Colombiana Cir Plást Reconstr 24 (2) , 2018
2018.0
Citations: 4
INERVACION TENAR DUAL ANASTOMOSIS DE RICHIE CANNIEU
L NIETO
2013.0
Citations: 4
Microcirugía de la Guerra, Parte I
LE Bermúdez, LE Nieto
Rev Colom Cir Plast y Recons 3, 146-67 , 2003
2003.0
Citations: 4
Neurotización: concepto clave en reparación nerviosa
NL Barreto Ana
Universitas Medica 62 (3) , 2021
2021.0
Citations: 3
Proyección topográfica de las anastomosis entre nervios mediano y cubital en antebrazo y mano
L Rojas, LE Nieto, C Sepúlveda
Cirugía Plástica 24 (2), 82-87 , 2014
2014.0
Citations: 3
Masseteric-facial nerve anastomosis
LE Bermudez, LE Nieto
Case report 2004, 20 , 0
Citations: 3
Comparison of regenerative changes in peripheral nerve injuries using regenerative tube with human mesenquimal cells and platelet-rich plasma versus autologous nerve graft
LE Nieto, P Perez, E Santamaria, J Avila, LM Avila
Cytotherapy 20 (5), S28 , 2018
2018.0
Citations: 2
Reconstrucción microquirúrgica de lengua
L Nieto, CI Pedraza Borrero
Revista chilena de cirugía 68 (2), 180-185 , 2016
2016.0
Citations: 2
Experiencia personal en mano metacarpiana
L Nieto, LM Rodríguez, F Carvajal
Cirugía Plástica Ibero-Latinoamericana 42 (1), 57-63 , 2016
2016.0
Citations: 2
Lesiones Nerviosas de la Mano
LE Nieto
Cirugía Plástica, Reconstructiva y Estética, 3ra Edición, Editorial Amolca, 2008 , 2008
2008.0
Citations: 2
Colgajo libre osteomuscular para la reconstrucción del pie
L Nieto, C Lemus Torres
Rev. colomb. ortop. traumatol , 2008
2008.0
Citations: 2
Reconstruction sequence and microsurgery in ectrodactyly-ectodermal dysplasia-cleft lip/palate syndrome: a case report
J Gaviria-Pinzon, J Gutierrez, L Bermudez, L Nieto
International Surgery Journal 9 (2), 467-470 , 2022
2022.0
Citations: 1
Microvascular free flap in a pregnant patient after resection of a high-grade neuroendocrine carcinoma
T Luna-Pisciotti, M Izquierdo, MP Echeverri, A Sanín, LE Nieto
Science & Art Plastic Surgery Journal , 2021
2021.0
Citations: 1
Regeneración del nervio periférico con células madre y plasma rico en plaquetas
L NIETO, LUZM ÁVILA, J ÁVILA, P PÉREZ, E SANTAMARÍA
Revista Colombiana de Cirugía Plástica y Reconstructiva 26 (2) , 2020
2020.0
Citations: 1