Thanavathi C
@thanavathi-edu.in
Assistant Professor of History
V.O.C.College of Education, Thoothukudi
Dr.C. Thanavathi is working as an Assistant Professor in History at V.O.C. College of Education, Thoothukudi, Tamilnadu since 2008. She has guided 3 M.Phil. scholars and 10 M.Ed. scholars. She has completed ICSSR, New Delhi major project in 2014 doing a Major Research Project of NCERT-ERIC, New Delhi, and has applied for so many research projects. She has written 27 research articles at state, national, international level peer-reviewed, and impact journals. She has presented 76 papers in the state, national and international seminars, workshops, and conferences. She wrote 3 B.Ed., and 8 M.Ed., subject books. Her chapters were published in 7 different edited books. She has received 4 national and 7 international awards for her outstanding achievements. She is having 13 Life Time Membership, Review Membership and Editorial Board Membership in various research journals. She organized NET/SET and TET Coaching classes. She is working as Statistical Packages of Social Sciences (SPSS) Tutor.
EDUCATION
M.A.(His.), M.Phil. (His.), M.A.(Tamil), B.A. (Eng.), M.Ed., M.Phil. (Edn.)
DGT., DCA, SET (Edn.), CTE, PGDHE, Ph.D. (Edn.), Ph.D. (His.)
RESEARCH INTERESTS
Research Project, Advanced Educational Technology
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Mackenzie Bowman, Lara Casey, Soundarya N. Selvam, Patricia D. A. Lima, Orla Rawley, Megan Hinds, Angie Tuttle, Julie Grabell, Alfonso Iorio, Irwin Walker,et al.
Wiley
BACKGROUND
von Willebrand Factor (VWF) is synthesized by vascular endothelial cells and megakaryocytes. The VWF propeptide is critical for multimerization and acts as an intra-molecular chaperone for mature VWF in sorting to its storage organelles, Weibel-Palade bodies (WPBs). In the Canadian Type 3 VWD study, almost half of the identified variants were in the VWF propeptide and these were associated with an increased bleeding phenotype.
OBJECTIVE
To investigate VWF propeptide variants that cause quantitative von Willebrand disease (VWD) by utilizing patient-derived endothelial colony-forming cells (ECFCs). Patients/Methods ECFCs were isolated from five Type 3 VWD patients from four families with the following variants: 1) homozygous p.Asp75_Gly178del (deletion of exons 4 and 5 deletion; Ex4-5del); 2) homozygous p.Cys633Arg; 3) homozygous p.Arg273Trp, and 4) p.Pro293Glnfs*164 and p.Gln419* inherited in the compound heterozygous state. Additionally, ECFCs were isolated from six family members (two Type 1 VWD, four unaffected).
RESULTS
ECFCs from the Type 3 patient with the compound heterozygous genotype exhibited a true null VWF cellular phenotype, with negligible VWF detected. In contrast, the other three propeptide variants presented a similar expression pattern in homozygous ECFCs where VWF was synthesized but not packaged in WPBs, and variant VWF had an increased association with the endoplasmic reticulum (ER) marker, protein disulfide-isomerase (PDI), indicating an ER-retention phenotype. The biosynthetic phenotype was similar but to a lesser degree in heterozygous ECFCs expressing the non-null variants.
CONCLUSION
This study further elucidates the importance of the VWF propeptide in the VWD phenotype using patient-derived cells.
Soundarya N. Selvam, Mackenzie Bowman, Madeline Inglis, Robert Kloosterman, Julie Grabell, Lara Casey, Amer M. Johri, and Paula James
Wiley
Patients with aortic stenosis (AS) can experience bleeding complications including gastrointestinal bleeding from angiodysplastic lesions due to acquired von Willebrand syndrome. Studies have pointed to a role for von Willebrand factor (VWF) in angiogenesis.
Soundarya N. Selvam, Lara J. Casey, Mackenzie L. Bowman, Lindsey G. Hawke, Avery J. Longmore, Jeffrey Mewburn, Mark L. Ormiston, Stephen L. Archer, Donald H. Maurice, and Paula James
Ovid Technologies (Wolters Kluwer Health)
&NA; Bleeding associated with angiodysplasia is a common, often intractable complication in patients with von Willebrand disease (VWD). von Willebrand factor (VWF), the protein deficient or defective in VWD, is a negative regulator of angiogenesis, which may explain the pathologic blood vessel growth in VWD. This study explores the normal range of angiogenesis in blood outgrowth endothelial cells (BOECs) derived from healthy donors and compares this to angiogenesis in BOECs from VWD patients of all types and subtypes. BOECs were assessed for VWF and angiopoietin-2 (Ang-2) gene expression, secretion, and storage. To explore angiogenic potential, we characterized cellular proliferation, matrix protein adhesion, migration, and tubule formation. We found great angiogenic variability in VWD BOECs with respect to each of the angiogenesis parameters. However, type 1 and 3 VWD BOECs had higher Ang-2 secretion associated with impaired endothelial cell migration velocity and enhanced directionality. Type 2A and 2B BOECs were the most proliferative and multiple VWD BOECs had impaired tubule formation in Matrigel. This study highlights the angiogenic variability in BOECs derived from VWD patients. Abnormal cell proliferation, migration, and increased Ang-2 secretion are common features of VWD BOECs. Despite the many abnormalities of VWD BOECs, significant heterogeneity among individual VWD phenotypes precludes a simple description of relationship between VWD type and in vitro surrogates for angiodysplasia.
Soundarya Selvam and Paula James
Georg Thieme Verlag KG
AbstractSevere and intractable gastrointestinal bleeding caused by angiodysplasia is a debilitating problem for up to 20% of patients with von Willebrand disease (VWD). Currently, the lack of an optimal treatment for this recurrent problem presents an ongoing challenge for many physicians in their management of affected patients. Over the past few years, studies have pointed to a regulatory role for the hemostatic protein, von Willebrand factor (VWF), in angiogenesis, providing a novel target for the modulation of vessel development. This article will review the clinical implications and molecular pathology of angiodysplasia in VWD.
RECENT SCHOLAR PUBLICATIONS
MOST CITED SCHOLAR PUBLICATIONS
Publications
S. No. Title of the book Name of the Publisher & Place I/N* Month and Year of Publication Are you the Main author (or) Co-author? ISBN No.
1. Teacher Education Perumal Publication, Thoothukudi N October, 2012
Yes 978-81-926336-0-2
2. tuyhW fw;gpj;jy; gFjp I Samyukdha Publications, Salem N May, 2016
Yes -
3. tuyhW fw;gpj;jy; Samyukdha Publications, Salem N January, 2017
Yes 978-93-81724-34-7
4. Advanced Techniques of Instruction Samyukdha Publications, Salem N March, 2017
Yes 978-93-81724-38-5
5. Advanced Educational Research and Statistics Samyukdha Publications, Salem N May, 2017
Yes -
6. Curriculum Design and Development Samyukdha Publications, Salem N July, 2017
Yes 978-93-81724-39-2
7. kjpg;Gzh;T kw;Wk; mikjpf; fy;tp Samyukdha Publications, Salem N August, 2017
Yes -
8. Teacher Education in India: Elementary Level Samyukdha Publications, Salem N February, 2018
Yes -
9. Teacher Education in India: Secondary Level Samyukdha Publications, Salem N February, 2018
Yes 978-93-81724-41-5
10. Curriculum, Pedagogy and Assessment at Secondary Level Samyukdha Publications, Salem N September, 2018
Yes 978-93-81724-43-2
11. Kw;Nghf;F fy;tpapay; Muha;r;rp kw;Wk; Gs;spapay; Samyukdha Publications, Salem N March, 2020
Yes -
12. Indian Government and Politics Spectrum Publications I Yes
13. Social Media in Teaching and Learning ESN Publications, Chennai. I July, 2020 Yes 978-93-93188-02-4
14. Digital Media in Teaching and Learning ESN Publications, Chennai. I July, 2020 Yes 9
RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)
Title: An Automated and Integrated Mobile App for Handling Road Accident and Emergency Situation Smartly
S.Deivasigamani, , Raushan Kumar Singh, , , , , Dr. I. D. Soubache, Dr. H. Sudheer, Dr. Capt. K. Sujatha, Er. S. John Pimo. IPI, India Patent No. 202041041120. Arts and Humanities. Completed. Filed Date: 2020-09-23. Published Date: 2020-10-09.