Synthesis and Characterization of Novel pH-Responsive Aminated Alginate Derivatives Hydrogels for Tissue Engineering and Drug Delivery Shokouh Khodayar, Mohammad Reza Shushizadeh, Elham Tahanpesar, Behzad Sharif Makhmalzadeh, Haleh Sanaeishoar Current Organic Synthesis, 2025 Aims: The aims of this study are to synthesize new derivatives of sodium alginate that improve the inherent properties, such as hydrogel strengthening, and create environmental sensitivity, such as pH sensitivity, for use in drug delivery Introduction: Today, hydrogels, due to outstanding properties such as biodegradability, biocompatibility, me-chanical properties, and response to stimuli properties, are widely used as harmless biomaterials in various fields in drug delivery, wound dressing, and tissue engineering. Stimulus-sensitive polymers significantly respond to slight changes in their environment. Different types of stimuli are used to influence the properties of polymers, the most important of which are temperature and pH because these are two vital factors in the human body; hence, temperature-sensitive and pH-sensitive hydrogels have been extensively studied. The ability to absorb water and swell the hydrogel is due to hydrophilic chains in the hydrogel network, and water absorption by hydrogel can be controlled by response to the stimuli. Since hydrogels mimic human tissue, the ability to retain water in them is essential. As a result, it is considered in many biomedical drug delivery systems. Stimulus-responsive swelling can control diffusion out of and into the hydrogel network, which allows temporal and spatial control of drug release. When a drug is loaded onto a biodegradable and stimuli-sensitive hydrogel, the drug delivery system has the added advantage of sustained release of the drug, which reduces side effects. Methods: In this study, two different hydrocarbons, [1,3-diaminopropane (DAP)] as a short-chain hydrocarbon, and [1,7-diaminoheptane (DAH)] as a long-chain hydrocarbon were grafted onto three types of sodium alginate (SA), through amide bond linkages. The hydrogel copolymer matrices were compared with sodium alginate (SA) beads. The graft copolymers were characterized using FTIR, 1HNMR, XRD spectroscopy, elemental analysis (CHNS) and thermal analysis (TGA, DTA and DSC). An environmental scanning electron microscope (ESEM) was used to investigate the surface morphology of hydrogels. Results: Effects of variables such as the length of hydrocarbon chains cross-linked to alginate, temperature, pH, and cross-linkers on the properties of hydrogels investigated in the temperature range of 2-70˚C and two different pH values (4.4 and 7.4). The results showed that when the hydrocarbon chain length of diamines decreases, the extent of cross-linking and strength of the hydrogels are increased. Other results suggest that the hydrogels ob-tained from high-viscosity alginate derivatives had positive pH sensitivity. Hydrogels prepared in this study demonstrated good mechanical and swelling ratios that are necessary for wound dressing. Conclusion: DAP-g-SA and DAH-g-SA pH-sensitive hydrogels were successfully synthesized through amide bond linkages. The new synthesis derivatives showed lower swelling levels at low pH (4.4). In contrast, their swelling levels at higher pH (7.4) were significantly enhanced. Higher swelling degree could be obtained at high pH. pH-responsive hydrogels are especially useful for various biological applications due to their unique feature of controlled swelling, biodegradability, biocompatibility, and fluid retention in their network structures. pH-responsive hydrogels, as intelligent systems, can be used in controlled-release drug delivery systems such as insulin delivery.
Application of a novel surface modified mesoporous silica nanoparticles as chemical demulsifiers for breaking water-in-crude oil emulsion Forough Mohammadi, Haleh Sanaeishoar, Elham Tahanpesar Petroleum Science and Technology, 2024 Produced crude oil is frequently in the form of W/O emulsion. Chemical demulsification is a commonly method to separate water in crude oil emulsion. However, there is a need to enhance this technique to become environmental friendly and economically competitive. Therefore, in this research, using nanotechnology led to reducing the amount of conventional demulsifier consumption in the demulsification process and unexpectedly greatly improving the demulsification efficiency of conventional demulsifier. Thus, mesoporous silica nanoparticles (MSNs) were functionalized with different organic moieties of APTES (aminopropyl triethoxysilan) and PhTES (phenyltriethoxysilane) using a post-grafting method to improve the performance of conventional chemical demulsifier. The prepared mesoporous silica nanoparticles were characterized by TEM, XRD, FT-IR, DLS and BET. Furthermore, the demulsification performance of nanodemulsifiers was evaluated by bottle test. Moreover, the effect of nanodemulsifier dosages, salt and temperature on DE (demulsification efficiency) was studied. The results demonstrate all parameters have an impact on the stability of W/O emulsion and MSN-APTES has the DE to a value of 90% in optimum concentration in the present of a commercial demulsifier. Simultaneous use of APTES functionalized MSNs and a conventional demulsifier reduces the IFT at the water-crude oil interface.
Sb(III)-Impregnated Magnetic Carbon Nitride Nanosheets: Preparation, Characterization, and Evaluation of Its Catalytic Activity for Synthesis of Imidazo-Pyridines Asieh Azhdari, Najmedin Azizi, Haleh Sanaeishoar, Elham Tahanpesar Polycyclic Aromatic Compounds, 2023 The magnetic nanoparticle (Fe3O4) and catalytic antimony trichloride (SbCl3) were co-immobilized in the graphitic carbon nitride nanosheets (SbCl3@Fe3O4/g-C3N4) using a straightforward solvent evaporation process. The designed catalysts showed excellent catalytic activity for the Groebke–Blackburn–Bienaymé multi-component reaction to prepare substituted imidazo[1,2-a]pyridines at room temperature. The convergent synthetic protocol enabled molecular diversity synthesis under appealingly mild conditions with a selective, time, and cost-effective operational simplicity. X-ray diffraction (XRD), infrared spectroscopies (FTIR), thermogravimetry (TG), scanning electron microscopy (SEM) indicate the structural integrity of all components. Combining environmentally benign reaction conditions and effortless composite recyclability offers magnetic carbon nitride economically viable for industrial processes.
Novel Persian Gulf Aminated Alginate Derivatives from Sargassum Bovaneum: Synthesis and Characterization Shokouh Khodayar, Mohammad Reza Shushizadeh, Elham Tahanpesar, Behzad Sharif Makhmalzadeh, Haleh Sanaeishoar Letters in Organic Chemistry, 2023 Aims: The aim of the study was to extract and characterize alginate from a new source, conduct synthesis and characterization of novel aminated alginate derivatives, make a comparison of physicochemical properties of extracted sodium alginate with its aminated derivatives, and investigate the effect of diamines chain length on physicochemical properties of newly synthesized derivatives. Background: Alginate is a natural biopolymer found in marine brown seaweeds. Alginate is widely used in the industry due to its features, such as gelling ability, biocompatibility, biodegradability, hydrophilicity, and non-toxicity. Alginate has two types of functional groups, free hydroxyl and carboxyl groups, which can be modified. Methods: In this study, sodium alginate was extracted from sargassum boveanum in basic media and characterized by physical and spectral properties. In order to prepare alginate precursors with clickable groups for hydrogel cross-linking application, extracted sodium alginate was further treated with two different diamines, diaminoheptane (DAH) and diaminopropane (DAP), in the presence of 1-ethyl-3- (3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) to form amide linkages on the alginate backbone and synthesise aminated derivatives. The products were characterized by techniques, such as FTIR, 1HNMR, TGA, XRD, and elemental analysis. Results: The average molar weight and the intrinsic viscosity of alginate from Sargassum bovaneum with a yield of 24.38% were 41.53 kDa and 0.9 dL/g 105 cps (2.5% C). Results showed that as the alginate concentration increased, the flow rate decreased with a mild slope. Conclusion: Elemental analysis (CHNS) of alginate derivatives indicated the percent of amine groups to be increased after amination reaction in comparison to corresponding alginates. The thermal analysis results indicate that the thermal stability of the sodium alginate is better than graft copolymers. Synthetic derivatives showed no particular sensitivity to environmental stimuli, such as temperature and pH changes.
Ionic Liquid-Assisted Preparation of Co3O4 Nanosheets as a New and Efficient Catalyst for Green Synthesis of Various 1,5-Benothiazepine Derivatives in Water M. Darband, E. Tahanpesar, H. Sanaeishoar, R. Badri Russian Journal of Applied Chemistry, 2021 A novel and green method for the preparation of cobalt oxide nanosheets using pyridinium-based ionic liquid by simple reflux method is described in the present work. Pyridinium-based ionic liquid, N-butyl pyridinium bromide [BuPy]Br plays an important role as reaction media and morphology template to control Co3O4 nanostructures. This catalyst is characterized by XRD, FE-SEM, FT-IR, VSM and UV-Visible spectroscopy. Further, this nanocatalyst is used to catalyzes the condensation reaction of o-amino thiophenol with α,β-unsaturated ketones for preparation of 1,5-benzothiazepine derivatives in excellent yields. This efficient catalyst could be recovered and reused several times without any significant loss of activity.
Green Synthesis of Cobalt Oxide Nanostructures: Morphology, Optical and Magnetic Characterization M. Darband, E. Tahanpesar, R. Badri, H. Sanaeishoar Russian Journal of Inorganic Chemistry, 2021 Synthesis of Co3O4 nanostructures with morphologies of nanoparticles and nanosheets were successfully achieved by reflux method in the presence of pyridinium based ionic liquids, N-butylpyridinium bromide [BuPy]Br and N-octylpyridinium bromide [OPy]Br. The ionic liquid plays an important role as reaction media and morphology template to control Co3O4 nanostructures. Different morphologies of Co3O4 nanostructures were obtained by changing the ratio of the NaOH to Co(NO3)2·6H2O. The structure, morphology, and properties of prepared Co3O4 nanostructures were characterized by Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), field-emission scanning electron microscope (FE-SEM), vibrating sample magnetometer (VSM) and UV-visible spectroscopy. SEM and X-ray powder diffraction results showed that the Co3O4 nanostructures were obtained with smaller crystallite sizes by using butyl pyridinium ionic liquid with a shorter alkyl side chain. The results of optical measurements illustrate the blue shift of the bandgap using ILs. Furthermore, the ferromagnetic behavior of Co3O4 nanostructures was confirmed in magnetic measurement by the presence of a hysteresis loop.
Dual Copper (II) Complex Supported on Diatomite as a Novel and Green Catalyst for the Synthesis of Dihydropyrano[3;2-b]Chromenediones and Aminopyranopyrans Elham Davoodi, Elham Tahanpesar, Ahmad Reza Massah Chemistryselect, 2021 Abstract Immobilized copper (II) complex, namely, 2,2′‐((1E,1′E)‐((6‐(l2‐azaneyl)‐1,3,5‐triazine‐2,4‐diyl)bis(azaneylylidene))bis(methaneylylidene))diphenol, supported on diatomite (Diatomite‐Si‐Pr‐TAT‐Bis‐(AZY‐MY)(Cu)Phenol) was introduced as a robust and heterogeneous catalyst for the synthesis of dihydropyrano[3;2‐b]chromenediones and aminopyranopyrans. The Diatomite‐Si‐Pr‐TAT‐Bis‐(AZY‐MY)(Cu)Phenol catalyst was synthesized by complexation of copper (II) acetate with TAT‐Bis‐(AZY‐MY)Phenol as a ligand with oxygen and nitrogen ligation sites that were anchored on diatomite through 3‐chloropropyltrimethoxysilane. The prepared catalyst was characterized using different microscopic and spectroscopic techniques including SEM, TEM, EDX, XRD, FT‐IR, TGA and ICP. The diatomite is available and cheap support with a high specific surface area and a large amount of hydroxyl group on the surface. A large amount of dual copper (II) complexes were supported on diatomite through covalent bonds. The Diatomite‐Si‐Pr‐TAT‐Bis‐(AZY‐MY)(Cu)Phenol showed good catalytic activity for the synthesis of dihydropyrano[3;2‐b]chromenediones and aminopyranopyrans using aromatic aldehyde, kojic acid, dimedone, or malononitrile. In addition, this catalyst system was reusable for five consecutive catalytic cycles without loss of their catalytic activity.
Synthesis and characterization of novel pH-responsive aminated alginate derivatives hydrogels for tissue engineering and drug delivery S Khodayar, MR Shushizadeh, E Tahanpesar, BS Makhmalzadeh, ... Current Organic Synthesis 22 (1), 90-100 , 2025 2025 Citations: 9
Application of a novel surface modified mesoporous silica nanoparticles as chemical demulsifiers for breaking water-in-crude oil emulsion F Mohammadi, H Sanaeishoar, E Tahanpesar Petroleum Science and Technology 42 (2), 269-286 , 2024 2024 Citations: 7
Synthesis and Physicochemical Characterization of New Amidic Derivative of Sodium Alginate S Khodayar, MR Shushizadeh, E Tahanpesar, B Sharif Makhmalzadeh, ... Journal of Chemical Reactivity and Synthesis 5 (4), 286 , 2023 2023
Melamine-terephthalaldehyde covalent organic framework-copper-tetrabenzenecarboxylic acid metal organic framework (COF–MOF): an efficient heterogeneous acidic catalyst for the … Z Baymaninezhad, H Tavakkoli, SJ Saghanezhad, E Tahanpesar Research on Chemical Intermediates 49 (11), 5101-5119 , 2023 2023 Citations: 12
Melamine-terephthalaldehyde supported Copper tetrabenzenecarboxylic acid As An Efficient Heterogeneous Acidic Catalyst (COF-MOF) for the One-pot Preparation of 1, 8 … Z Baymaninezhad, H Tavakkoli, SJ Saghanezhad, E Tahanpesar Journal of Chemical Reactivity and Synthesis 13 (3), 232-239 , 2023 2023
Biosynthesis of NiO-NPs using mucilage of Cordia myxa fruit and their potential application as an efficient catalyst for the synthesis of chromenes F Mirsalari, E Tahanpesar, H Sanaeishoar Research on Chemical Intermediates 49 (9), 4127-4148 , 2023 2023 Citations: 16
Synergistic effect of disordered mesoporous silica and nonionic surfactant on demulsification efficiency of water-in-crude oil emulsions F Mohammadi, H Sanaeishoar, E Tahanpesar Journal of Chemical Reactivity and Synthesis 13 (1), 51-65 , 2023 2023
Sb (III)-Impregnated Magnetic Carbon Nitride Nanosheets: Preparation, Characterization, and Evaluation of Its Catalytic Activity for Synthesis of Imidazo-Pyridines A Azhdari, N Azizi, H Sanaeishoar, E Tahanpesar Polycyclic Aromatic Compounds 43 (2), 1833-1844 , 2023 2023 Citations: 2
Novel Persian Gulf Aminated Alginate Derivatives from Sargassum Bovaneum: Synthesis and Characterization S Khodayar, MR Shushizadeh, E Tahanpesar, BS Makhmalzadeh, ... Letters in Organic Chemistry 20 (2), 175-184 , 2023 2023 Citations: 1
Synthesis and drug delivery evaluation of graphene oxide supported 5-fluorouracil Z Javidi, N Goudarzian, MK Mohammadi, PE Tahan Iranian Journal of Chemistry and Chemical Engineering 42 (4), 1134-1146 , 2023 2023 Citations: 10
Synthesis of 1,8‐dioxo-octahydroxanthenes utilizing nanodiatomite@melamine-SO 3 H as a novel heterogeneous catalyst under solvent-free conditions E Davoodi, E Tahanpesar, AR Massah Journal of Chemical Sciences 134 (3), 72 , 2022 2022 Citations: 5
Study of adsorption and release of 5-fluorouracil on Graphene oxide as anticancer drug delivery system Z Javidi, MK Mohammadi, N Goodarzian, E Tahanpesar Int. J. Bio-Inorg. Hybr. Nanomater 11 (3), 137-145 , 2022 2022
سنتز و مشخصه یابی نانوذرات مغناطیسی و بررسی اثرهم افزایی آن بر تالو آمین اتوکسیله در فرایند تعلیق زدایی از نفت خامFe3O4 فروغ محمدی، هاله ثنایی شعار، الهام طحان پسر مجله بلورشناسی و کانی شناسی ایران 30 (4), 743-750 , 2022 2022
اثر غلظت سود بر نانو ذرات اکسید کبالت تهیه شده به روش هم رسوبی با مایع یونی بر پایه پیریدینیوم میترا دربند، الهام طحان پسر، رشید بدری، هاله ثنایی شعار مجله بلورشناسی و کانی شناسی ایران 30 (2), 327-336 , 2022 2022
اثر دما بر سنتز سبز نانو ذرات اکسید کبالت به روش سل- ژل و بررسی خواص ساختاری و نوری آن سیده فاطمه میرسالاری، الهام طحان پسر ، هاله ثنایی شعار مجله بلورشناسی و کانی شناسی ایران 30 (3), 535-542 , 2022 2022
Ionic Liquid-Assisted Preparation of Co3O4 Nanosheets as a New and Efficient Catalyst for Green Synthesis of Various 1, 5-Benothiazepine Derivatives in Water M Darband, E Tahanpesar, H Sanaeishoar, R Badri Russian Journal of Applied Chemistry 94 (12), 1624-1634 , 2021 2021 Citations: 5
Green Synthesis of Cobalt Oxide Nanostructures: Morphology, Optical and Magnetic Characterization M Darband, E Tahanpesar, R Badri, H Sanaeishoar Russian Journal of Inorganic Chemistry 66 (14), 2068-2076 , 2021 2021 Citations: 1
Dual copper (II) complex supported on diatomite as a novel and green catalyst for the synthesis of dihydropyrano [3; 2‐b] chromenediones and aminopyranopyrans E Davoodi, E Tahanpesar, AR Massah ChemistrySelect 6 (37), 9833-9846 , 2021 2021 Citations: 16
Immobilization of Mn(II) on Fe 3 O 4 @Schiff base as an efficient and recoverable magnetic nanocatalyst for the synthesis of hydroquinolines and Hantzsch reaction F Lashkari, R Badri, E Tahanpesar Reaction Kinetics, Mechanisms and Catalysis 134 (1), 361-383 , 2021 2021 Citations: 4
Green synthesis of nickel oxide nanoparticles using Eucalyptus leaf extract: Optical and Morphology Characterization F Mirsalari, E Tahanpesar Journal of Chemical Reactivity and Synthesis 4 (3), 118 , 2021 2021 Citations: 1
MOST CITED SCHOLAR PUBLICATIONS
Ni-guanidine@MCM-41 NPs: a new catalyst for the synthesis of 4,4ʹ-(arylmethylene)-bis-(3-methyl-1-phenyl-1 H -pyrazol-5-ols) and symmetric di-aryl sulfides H Filian, A Ghorbani-Choghamarani, E Tahanpesar Journal of the Iranian Chemical Society 16 (12), 2673-2681 , 2019 2019 Citations: 35
Highly sensitive detection of Ceftriaxone in water, food, pharmaceutical and biological samples based on gold nanoparticles in aqueous and micellar media F Shahrouei, S Elhami, E Tahanpesar Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 203, 287-293 , 2018 2018 Citations: 32
Amidosulfonic acid supported on graphitic carbon nitride: novel and straightforward catalyst for Paal–Knorr pyrrole reaction under mild conditions A Azhdari, N Azizi, H Sanaeishoar, E Tahanpesar Monatshefte für Chemie-Chemical Monthly 152 (6), 625-634 , 2021 2021 Citations: 25
Electro-organic synthesis of tetrahydroimidazo[1,2- a ]pyridin-5(1 H )-one via a multicomponent reaction MR Asghariganjeh, AA Mohammadi, E Tahanpesar, A Rayatzadeh, ... Molecular Diversity 25 (1), 509-516 , 2021 2021 Citations: 25
Pd (0)-guanidine@ MCM-41 as efficient and reusable heterogeneous catalyst for C–C coupling reactions H Filian, A Ghorbani-Choghamarani, E Tahanpesar Journal of Porous Materials 26 (4), 1091-1101 , 2019 2019 Citations: 25
Solvent-mediated highly efficient synthesis of [1, 2, 4] triazolo/benzimidazoloquinazolinone derivatives F Malamiri, S Khaksar, R Badri, E Tahanpesar Current Organic Synthesis 16 (8), 1185-1190 , 2019 2019 Citations: 21
Facile Sol-Gel Synthesis of Co 3 O 4 Nanoparticles — An Efficient and Recyclable Catalyst for the Synthesis of 1,2-Disubstituted Benzimidazoles Under Solvent … E Tahanpesar, H Tavakkoli, S Hadikhani Russian Journal of Organic Chemistry 55 (8), 1217-1222 , 2019 2019 Citations: 20
Alignment-independent 3D-QSAR and molecular docking studies of tacrine− 4-oxo-4H-Chromene hybrids as anti-Alzheimer's agents E Manouchehrizadeh, A Mostoufi, E Tahanpesar, M Fereidoonnezhad Computational Biology and Chemistry 80, 463-471 , 2019 2019 Citations: 20
Synthesis and characterization of MCM-41@ XA@ Ni (II) as versatile and heterogeneous catalyst for efficient oxidation of sulfides and acetylation of alcohols under solvent-free … S Nazarzadeh, A Ghorbani-Choghamarani, E Tahanpesar Journal of the Iranian Chemical Society 15 (3), 649-659 , 2018 2018 Citations: 18
A highly efficient protocol for the synthesis of new 3-(α-aroylamido)-4-hydroxycoumarin derivatives using SnCl 2 –SiO 2 nanoparticles under solvent-free conditions M Arfavi-Safari, H Anaraki-Ardakani, R Badri, E Tahanpesar Journal of Chemical Research 41 (6), 321-324 , 2017 2017 Citations: 18
Synthesis of substituted coumarins catalyzed by sawdust-SO 3 H. An efficient and environmentally benign solid acid catalyst under solvent-free conditions E Tahanpesar, L Sarami Russian Journal of General Chemistry 85 (9), 2135-2140 , 2015 2015 Citations: 18
Biosynthesis of NiO-NPs using mucilage of Cordia myxa fruit and their potential application as an efficient catalyst for the synthesis of chromenes F Mirsalari, E Tahanpesar, H Sanaeishoar Research on Chemical Intermediates 49 (9), 4127-4148 , 2023 2023 Citations: 16
Dual copper (II) complex supported on diatomite as a novel and green catalyst for the synthesis of dihydropyrano [3; 2‐b] chromenediones and aminopyranopyrans E Davoodi, E Tahanpesar, AR Massah ChemistrySelect 6 (37), 9833-9846 , 2021 2021 Citations: 16
Melamine-terephthalaldehyde covalent organic framework-copper-tetrabenzenecarboxylic acid metal organic framework (COF–MOF): an efficient heterogeneous acidic catalyst for the … Z Baymaninezhad, H Tavakkoli, SJ Saghanezhad, E Tahanpesar Research on Chemical Intermediates 49 (11), 5101-5119 , 2023 2023 Citations: 12
Synthesis and drug delivery evaluation of graphene oxide supported 5-fluorouracil Z Javidi, N Goudarzian, MK Mohammadi, PE Tahan Iranian Journal of Chemistry and Chemical Engineering 42 (4), 1134-1146 , 2023 2023 Citations: 10
Synthesis and characterization of novel pH-responsive aminated alginate derivatives hydrogels for tissue engineering and drug delivery S Khodayar, MR Shushizadeh, E Tahanpesar, BS Makhmalzadeh, ... Current Organic Synthesis 22 (1), 90-100 , 2025 2025 Citations: 9
Application of a novel surface modified mesoporous silica nanoparticles as chemical demulsifiers for breaking water-in-crude oil emulsion F Mohammadi, H Sanaeishoar, E Tahanpesar Petroleum Science and Technology 42 (2), 269-286 , 2024 2024 Citations: 7
Synthesis of 1,8‐dioxo-octahydroxanthenes utilizing nanodiatomite@melamine-SO 3 H as a novel heterogeneous catalyst under solvent-free conditions E Davoodi, E Tahanpesar, AR Massah Journal of Chemical Sciences 134 (3), 72 , 2022 2022 Citations: 5
Ionic Liquid-Assisted Preparation of Co3O4 Nanosheets as a New and Efficient Catalyst for Green Synthesis of Various 1, 5-Benothiazepine Derivatives in Water M Darband, E Tahanpesar, H Sanaeishoar, R Badri Russian Journal of Applied Chemistry 94 (12), 1624-1634 , 2021 2021 Citations: 5
Immobilization of Mn(II) on Fe 3 O 4 @Schiff base as an efficient and recoverable magnetic nanocatalyst for the synthesis of hydroquinolines and Hantzsch reaction F Lashkari, R Badri, E Tahanpesar Reaction Kinetics, Mechanisms and Catalysis 134 (1), 361-383 , 2021 2021 Citations: 4
