Chandra Sekhar Bhol

Scopus Publications

Pyrazoline–Imidazopyridine Hybrids as Beclin-1 Mimetics Driving Dual Apoptotic and Autophagy in Breast Cancer
Rashmi Shivakumar, Narasimha M. Beeraka, Riyaz Ali M. Osmani, Bhoomika B. Ravi, Monisha H. S. Yadhav, et al.
Chemical Biology and Drug Design, 2026
Breast cancer is a profound cause of mortality among women globally. Similar to BH3 mimetics, targeting the antiapoptotic Bcl‐xL:Beclin1 protein complex is crucial to inducing apoptosis and autophagy, thereby suppressing tumor progression in breast cancer cells. This study aims to synthesize and evaluate a series of imidazopyridine‐tethered pyrazoline drug prejudice‐scaffold derivatives (5a‐5l) as Beclin‐1 mimetics that induce apoptosis and autophagy and mainly for their potential anticancer activity, focusing on the most potent compound 5c. The primary goal is to assess its ability of compound 5c to inhibit Bcl‐xL:Beclin‐1 interaction, thereby inducing a protective autophagic response subsequently to assess apoptosis to suppress breast cancer cell proliferation. Molecular docking studies were conducted to evaluate the binding affinity of compound 5c with Bcl‐xL, and the interactions were visualized through a three‐dimensional interaction map, highlighting key stabilizing interactions. Cytotoxic effects of compound 5c on MCF‐7 breast cancer cells were assessed using alamarblue assay. To investigate the antiproliferative potential, colony formation, and wound healing assays were performed at varying concentrations. Apoptotic induction was analyzed through Western blotting for key proteins (BAX, Bcl‐xL, Bcl‐2), caspase‐3/7 activation, and AnnexinV/PI assay using flow cytometry. Additionally, autophagy was examined by monitoring LC3B‐I to LC3B‐II conversion, Beclin‐1 upregulation, and lysosomal activity using LysoTrackerRed staining. The involvement of compound 5c in autophagic flux was further confirmed by quantifying LC3‐II accumulation in the presence of an autophagy inhibitor chloroquine (CQ), and then the effect of 5c‐induced cell viability and apoptosis were evaluated and caspase‐3/7 activity, respectively, during autophagy inhibition condition in MCF‐7 cell line. A strong binding interaction of compound 5c with the hydrophobic groove of Bcl‐xL demonstrated its potential as an effective Bcl‐xL inhibitor. Compound 5c significantly reduced MCF‐7 cell viability in a dose‐dependent manner (IC50: 9.7 μM). The inhibitory effect of compound 5c on cancer cell proliferation and migration was observed. Treatment with compound 5c induced dose‐dependent apoptosis in MCF‐7 cells, as confirmed by Annexin V/PI using flow cytometric analysis after 72 h of exposure. A significant decrease in viable cells accompanied by an increase in apoptotic cell populations was observed with increasing concentrations of 5c. Upregulated BAX expression and downregulation in Bcl‐xL and Bcl‐2 expression levels indicated apoptosis induction. Caspase‐3/7 activation further confirmed apoptotic cell death. Autophagy assessment revealed enhanced LC3B‐II accumulation, Beclin‐1 upregulation, and reduced p62 levels, suggesting modulation of autophagy. CQ treatment further increased LC3‐II levels, indicating compound 5c‐mediated autophagic flux induction and a significant reduction in cell viability and increased caspase 3/7 activity, confirming modultion of autophagy‐dependent apoptosis by 5c. Similar to BH3 mimetic, compound 5c emerges as a promising small‐molecule inhibitor targeting the Bcl‐xL:Beclin‐1 complex, which effectively induces apoptosis by modulating protective autophagy in breast cancer cells. Its dual mechanism of action highlights its potential as a novel therapeutic candidate for breast cancer treatment.
Autophagy paradox: Genetic and epigenetic control of autophagy in cancer progression
Chandra Sekhar Bhol, Prakash Kumar Senapati, Rakesh Kumar Kar, Grace Chew, Kewal Kumar Mahapatra, et al.
Cancer Letters, 2025
Molecular regulation of mitophagy signaling in tumor microenvironment and its targeting for cancer therapy
Bishnu Prasad Behera, Soumya Ranjan Mishra, Srimanta Patra, Kewal Kumar Mahapatra, Chandra Sekhar Bhol, et al.
Cytokine and Growth Factor Reviews, 2025
Synthesis and anti-proliferative studies of 2-acyl-4-(het)arylthiazoles on human hepatoma cells
Rajaghatta N. Suresh, Prasanna Doddakunche Shivaramu, Toreshettahally R. Swaroop, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, et al.
Results in Chemistry, 2025
1,2,3-Triazole Tethered Spiro[Indoline-Oxirane] Derivatives Induce Anticancer Effects in Human Hepatoma Cells
Shashikala Mariswamy Rajesh, Prasanna Doddakunche Shivaramu, Chandra Sekhar Bhol, Toreshettahally R. Swaroop, Habbanakuppe D. Preetham, et al.
Chemical Biology and Drug Design, 2025
Epoxides are well‐known compounds as anticancer agents. In this article, we present the synthesis of novel 3′‐phenyl‐1‐((1‐aryl‐1H‐1,2,3‐triazol‐5‐yl)methyl)spiro[indoline‐3,2′‐oxiran]‐2‐one derivatives by the regioselective reaction of sulfur ylides with 1,2,3‐triazole‐tethered isatins and their anticancer effects on hepatocellular carcinoma (HCC) cells HepG2 and HCCLM3. The cell viability assays indicated that RR‐01 and RR‐07 had emerged as the most potent cytotoxic agents on the tested cell lines. Colony formation and migration assay results confirmed the anticancer effects of these compounds by inhibiting the formation of colonies and migration. Further, nuclear fragmentation staining assay showed that the compounds induce apoptosis. Acridine orange staining assays showed that our lead candidates (RR‐01 and RR‐07) induced autophagy in liver cancer cells.
Discovery of Piperazin-2-yl-pyrimidines as Anticancer Agents via Targeting JNK Signaling Pathway in Human MCF-7 Breast Carcinoma
Rashmi Shivakumar, Gautam Sethi, Kurnegala Manikanta, Zhang Xi, Akshay Ravish, et al.
Chemistryselect, 2024
Breast cancer (BC) is the second leading cause of cancer‐related mortality in women, and targeting biological pathways such as the JNK pathway has proven to be a viable therapeutic target for BC therapy. Here, we synthesized piperazin‐2‐yl‐pyrimidines and evaluated them for anticancer activity against MCF‐7 cells. In addition, antioxidant, reactive oxygen species (ROS) inhibition, caspase activity, and toxicity in platelets were studied in the presence and absence of active compound IA‐6 or IA‐7. Our detailed experimental analysis found that the compound IA‐7 showed anticancer activity by either activating p‐JNK or by inducing radical species in cancer and thrombosis model. Evident to in vitro analysis, the structure based molecular interaction studies of binding of IA‐7 to JNK3S exhibited a significant binding energy of −7.56 kcal/mol which was found to be a better binder when compared to previously reported JNK inducer (PC‐12). Overall, we herein report the analytically pure IA‐7 as lead structure that could be used as a template to develop target based anticancer agents where JNK modulation is predominant.
Synthesis of novel triazoles as anticancer agents targeting pJNK in human breast cancer cells
Tejaswini P. Siddappa, Chandra Sekhar Bhol, Akshay Ravish, Zhang Xi, Bhanuprakash C. Narasimhachar, et al.
New Journal of Chemistry, 2024
Breast cancer (BC) is the second-largest cause of cancer-related deaths among women worldwide.
Atg1/ULK1 complex in autophagy process and regulation
Chandra Sekhar Bhol, Sujit Kumar Bhutia
Autophagy Processes and Mechanisms, 2023
PAX9 reactivation by inhibiting DNA methyltransferase triggers antitumor effect in oral squamous cell carcinoma
Chandra Sekhar Bhol, Soumya Ranjan Mishra, Shankargouda Patil, Sunil Kumar Sahu, R Kirtana, et al.
Biochimica Et Biophysica Acta Molecular Basis of Disease, 2022
Inflammasomes in cancer: Effect of epigenetic and autophagic modulations
Soumya Ranjan Mishra, Kewal Kumar Mahapatra, Bishnu Prasad Behera, Chandra Sekhar Bhol, Prakash Priyadarshi Praharaj, et al.
Seminars in Cancer Biology, 2022
Tumour-promoting inflammation is a critical hallmark in cancer development, and inflammasomes are well-known regulators of inflammatory processes within the tumour microenvironment. Different inflammasome components along with the adaptor, apoptosis-associated speck-like protein containing caspase activation and recruitment domain (ASC), and the effector, caspase-1, have a significant influence on tumorigenesis but in a tissue-specific and stage-dependent manner. The downstream products of inflammasome activation, that is the proinflammatory cytokines such as IL-1β and IL-18, regulate tissue homeostasis and induce antitumour immune responses, but in contrast, they can also favour cancer growth and proliferation by directing various oncogenic signalling pathways in cancer cells. Moreover, different epigenetic mechanisms, including DNA methylation, histone modification and noncoding RNAs, control inflammasomes and their components by regulating gene expression during cancer progression. Furthermore, autophagy, a master controller of cellular homeostasis, targets inflammasome-induced carcinogenesis by maintaining cellular homeostasis and removing potential cancer risk factors that promote inflammasome activation in support of tumorigenesis. Here, in this review, we summarize the effect of inflammasome activation in cancers and discuss the role of epigenetic and autophagic regulatory mechanisms in controlling inflammasomes. A proper understanding of the interactions among these key processes will be useful for developing novel therapeutic regimens for targeting inflammasomes in cancer.
Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives
Srimanta Patra, Soumya R. Mishra, Bishnu P. Behera, Kewal K. Mahapatra, Debasna P. Panigrahi, et al.
Seminars in Cancer Biology, 2022
Metabostemness in cancer: Linking metaboloepigenetics and mitophagy in remodeling cancer stem cells
Prajna Paramita Naik, Swagatika Panigrahi, Ratnakar Parida, Prakash Priyadarshi Praharaj, Chandra Sekhar Bhol, et al.
Stem Cell Reviews and Reports, 2022
DSPE-PEG-Coated Uniform Nitrogen-Doped Carbon Capsules for NIR-Mediated Synergistic Chemophototherapy of Skin Cancer
Snigdharani Panda, Chandra S. Bhol, Sujit K. Bhutia, Sasmita Mohapatra
ACS Applied Bio Materials, 2021
The clinical significance and correlative signaling pathways of paired box gene 9 in development and carcinogenesis
Chandra Sekhar Bhol, Shankargouda Patil, Binod Bihari Sahu, Samir Kumar Patra, Sujit Kumar Bhutia
Biochimica Et Biophysica Acta Reviews on Cancer, 2021
Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics
Soumya Ranjan Mishra, Kewal Kumar Mahapatra, Bishnu Prasad Behera, Srimanta Patra, Chandra Sekhar Bhol, et al.
International Journal of Biochemistry and Cell Biology, 2021
PEG-PEI-modified gated N-doped mesoporous carbon nanospheres for pH/NIR light-triggered drug release and cancer phototherapy
Snigdharani Panda, Chandra Sekhar Bhol, Sujit Kumar Bhutia, Sasmita Mohapatra
Journal of Materials Chemistry B, 2021
Intricate role of mitochondrial calcium signalling in mitochondrial quality control for regulation of cancer cell fate
Srimanta Patra, Kewal Kumar Mahapatra, Prakash Priyadarshi Praharaj, Debasna Pritimanjari Panigrahi, Chandra Sekhar Bhol, et al.
Mitochondrion, 2021
Corrigendum to “Abrus agglutinin inhibits oral carcinogenesis through inactivation of NRF2 signaling pathway” [Int J Biol Macromol. 2020; 155:1123–1132.] (International Journal of Biological Macromolecules (2020) 155 (1123–1132), (S0141813019357071), (10.1016/j.ijbiomac.2019.11.079))
Debasna P. Panigrahi, Chandra S. Bhol, R. Nivetha, Siddavaram Nagini, Shankargouda Patil, et al.
International Journal of Biological Macromolecules, 2021
Mitochondrial rewiring through mitophagy and mitochondrial biogenesis in cancer stem cells: A potential target for anti-CSC cancer therapy
Prakash Priyadarshi Praharaj, Debasna Pritimanjari Panigrahi, Chandra Sekhar Bhol, Srimanta Patra, Soumya Ranjan Mishra, et al.
Cancer Letters, 2021
Secretory clusterin promotes oral cancer cell survival via inhibiting apoptosis by activation of autophagy in AMPK/mTOR/ULK1 dependent pathway
Prajna Paramita Naik, Subhadip Mukhopadhyay, Prakash Priyadarshi Praharaj, Chandra Sekhar Bhol, Debasna Pritimanjari Panigrahi, et al.
Life Sciences, 2021
Gamma irradiation promotes chemo-sensitization potential of gallic acid through attenuation of autophagic flux to trigger apoptosis in an NRF2 inactivation signalling pathway
Srimanta Patra, Chandra Sekhar Bhol, Debasna Pritimanjari Panigrahi, Prakash Priyadarshi Praharaj, Biswajita Pradhan, et al.
Free Radical Biology and Medicine, 2020
Epigenetic modifications of autophagy in cancer and cancer therapeutics
Chandra S. Bhol, Debasna P. Panigrahi, Prakash P. Praharaj, Kewal K. Mahapatra, Srimanta Patra, et al.
Seminars in Cancer Biology, 2020
The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics
Debasna P. Panigrahi, Prakash P. Praharaj, Chandra S. Bhol, Kewal K. Mahapatra, Srimanta Patra, et al.
Seminars in Cancer Biology, 2020
Bioactive compounds from marine invertebrates as potent anticancer drugs: the possible pharmacophores modulating cell death pathways
Srimanta Patra, Prakash Priyadarshi Praharaj, Debasna Pritimanjari Panigrahi, Biswajit Panda, Chandra Sekhar Bhol, et al.
Molecular Biology Reports, 2020
Abrus agglutinin inhibits oral carcinogenesis through inactivation of NRF2 signaling pathway
Debasna P. Panigrahi, Chandra S. Bhol, Nivetha R, Siddavaram Nagini, Shankargouda Patil, et al.
International Journal of Biological Macromolecules, 2020

RECENT SCHOLAR PUBLICATIONS

Pyrazoline–Imidazopyridine Hybrids as Beclin‐1 Mimetics Driving Dual Apoptotic and Autophagy in Breast Cancer
R Shivakumar, NM Beeraka, RAM Osmani, BB Ravi, MHS Yadhav, ...
Chemical biology & drug design 107 (4), e70287 , 2026
2026
Synthesis and anti-proliferative studies of 2-acyl-4-(het) arylthiazoles on human hepatoma cells
RN Suresh, PD Shivaramu, TR Swaroop, A Chinnathambi, SA Alharbi, ...
Results in Chemistry, 102599 , 2025
2025
Harnessing Antineoplastic Properties of Artesunate for Prostate Cancer Therapy
CS Bhol, MK Shanmugam, G Chew, GSR Eva, SK Bhutia, G Sethi
Cancer Research 85 (15_Supplement), P47-P47 , 2025
2025
Autophagy paradox: Genetic and epigenetic control of autophagy in cancer progression
CS Bhol, PK Senapati, RK Kar, G Chew, KK Mahapatra, EHC Lee, ...
Cancer letters, 217909 , 2025
2025
Citations: 14
1, 2, 3‐Triazole Tethered Spiro [Indoline‐Oxirane] Derivatives Induce Anticancer Effects in Human Hepatoma Cells
SM Rajesh, P Doddakunche Shivaramu, CS Bhol, TR Swaroop, ...
Chemical Biology & Drug Design 105 (4), e70091 , 2025
2025
Citations: 1
Molecular regulation of mitophagy signaling in tumor microenvironment and its targeting for cancer therapy
BP Behera, SR Mishra, S Patra, KK Mahapatra, CS Bhol, DP Panigrahi, ...
Cytokine & growth factor reviews , 2025
2025
Citations: 18
Discovery of Piperazin‐2‐yl‐pyrimidines as Anticancer Agents via Targeting JNK Signaling Pathway in Human MCF‐7 Breast Carcinoma
R Shivakumar, G Sethi, K Manikanta, Z Xi, A Ravish, PM Uppar, ...
ChemistrySelect 9 (27), e202400307 , 2024
2024
Citations: 2
PAX9 activates cell death via autophagic degradation of EGFR in oral squamous cell carcinoma
CS Bhol, G Sethi, SK Bhutia
Cancer Research 84 (8_Supplement), P50-P50 , 2024
2024
Citations: 1
Synthesis of novel triazoles as anticancer agents targeting pJNK in human breast cancer cells
TP Siddappa, CS Bhol, A Ravish, Z Xi, BC Narasimhachar, AM Kumar, ...
New Journal of Chemistry 48 (26), 11662-11673 , 2024
2024
Citations: 3
Atg1/ULK1 complex in autophagy process and regulation
CS Bhol, SK Bhutia
Autophagy Process. Mech, 35 , 2023
2023
Citations: 2
PAX9 reactivation by inhibiting DNA methyltransferase triggers antitumor effect in oral squamous cell carcinoma
CS Bhol, SR Mishra, S Patil, SK Sahu, R Kirtana, S Manna, ...
Biochimica Et Biophysica Acta (BBA)-Molecular Basis of Disease 1868 (9), 166428 , 2022
2022
Citations: 31
Inflammasomes in cancer: Effect of epigenetic and autophagic modulations
SR Mishra, KK Mahapatra, BP Behera, CS Bhol, PP Praharaj, ...
Seminars in Cancer Biology 83, 399-412 , 2022
2022
Citations: 28
Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives
S Patra, SR Mishra, BP Behera, KK Mahapatra, DP Panigrahi, CS Bhol, ...
Seminars in cancer biology 80, 205-217 , 2022
2022
Citations: 141
Unravelling the Molecular Connection Between Pax9 and Autophagy To Regulate Oral Carcinogenesis
CS Bhol
2022
Metabostemness in cancer: linking metaboloepigenetics and mitophagy in remodeling cancer stem cells
PP Naik, S Panigrahi, R Parida, PP Praharaj, CS Bhol, S Patil, ...
Stem Cell Reviews and Reports 18 (1), 198-213 , 2022
2022
Citations: 17
Dspe-peg-coated uniform nitrogen-doped carbon capsules for nir-mediated synergistic chemophototherapy of skin cancer
S Panda, CS Bhol, SK Bhutia, S Mohapatra
ACS Applied Bio Materials 4 (9), 7059-7069 , 2021
2021
Citations: 6
The clinical significance and correlative signaling pathways of paired box gene 9 in development and carcinogenesis
CS Bhol, S Patil, BB Sahu, SK Patra, SK Bhutia
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1876 (1), 188561 , 2021
2021
Citations: 21
Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics
SR Mishra, KK Mahapatra, BP Behera, S Patra, CS Bhol, DP Panigrahi, ...
The international journal of biochemistry & cell biology 136, 106013 , 2021
2021
Citations: 193
Intricate role of mitochondrial calcium signalling in mitochondrial quality control for regulation of cancer cell fate
S Patra, KK Mahapatra, PP Praharaj, DP Panigrahi, CS Bhol, SR Mishra, ...
Mitochondrion 57, 230-240 , 2021
2021
Citations: 20
Mitochondrial rewiring through mitophagy and mitochondrial biogenesis in cancer stem cells: A potential target for anti-CSC cancer therapy
PP Praharaj, DP Panigrahi, CS Bhol, S Patra, SR Mishra, KK Mahapatra, ...
Cancer letters 498, 217-228 , 2021
2021
Citations: 78

MOST CITED SCHOLAR PUBLICATIONS

The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics
DP Panigrahi, PP Praharaj, CS Bhol, KK Mahapatra, S Patra, BP Behera, ...
Seminars in cancer biology 66, 45-58 , 2020
2020
Citations: 350
Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics
SR Mishra, KK Mahapatra, BP Behera, S Patra, CS Bhol, DP Panigrahi, ...
The international journal of biochemistry & cell biology 136, 106013 , 2021
2021
Citations: 193
Plant lectins in cancer therapeutics: Targeting apoptosis and autophagy-dependent cell death
SK Bhutia, PK Panda, N Sinha, PP Praharaj, CS Bhol, DP Panigrahi, ...
Pharmacological research 144, 8-18 , 2019
2019
Citations: 165
Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives
S Patra, SR Mishra, BP Behera, KK Mahapatra, DP Panigrahi, CS Bhol, ...
Seminars in cancer biology 80, 205-217 , 2022
2022
Citations: 141
Intricate role of mitochondrial lipid in mitophagy and mitochondrial apoptosis: its implication in cancer therapeutics
PP Praharaj, PP Naik, DP Panigrahi, CS Bhol, KK Mahapatra, S Patra, ...
Cellular and Molecular Life Sciences 76 (9), 1641-1652 , 2019
2019
Citations: 111
Antitumor effect of soybean lectin mediated through reactive oxygen species-dependent pathway
PK Panda, S Mukhopadhyay, B Behera, CS Bhol, S Dey, DN Das, ...
Life sciences 111 (1-2), 27-35 , 2014
2014
Citations: 97
N-doped carbon quantum dot (NCQD)-Deposited carbon capsules for synergistic fluorescence imaging and photothermal therapy of oral cancer
RK Das, S Panda, CS Bhol, SK Bhutia, S Mohapatra
Langmuir 35 (47), 15320-15329 , 2019
2019
Citations: 84
Mitochondrial rewiring through mitophagy and mitochondrial biogenesis in cancer stem cells: A potential target for anti-CSC cancer therapy
PP Praharaj, DP Panigrahi, CS Bhol, S Patra, SR Mishra, KK Mahapatra, ...
Cancer letters 498, 217-228 , 2021
2021
Citations: 78
Epigenetic modifications of autophagy in cancer and cancer therapeutics
CS Bhol, DP Panigrahi, PP Praharaj, KK Mahapatra, S Patra, SR Mishra, ...
Seminars in cancer biology 66, 22-33 , 2020
2020
Citations: 75
Terminalia bellirica extract induces anticancer activity through modulation of apoptosis and autophagy in oral squamous cell carcinoma
S Patra, PK Panda, PP Naik, DP Panigrahi, PP Praharaj, CS Bhol, ...
Food and Chemical Toxicology 136, 111073 , 2020
2020
Citations: 73
Dysregulation of histone deacetylases in carcinogenesis and tumor progression: a possible link to apoptosis and autophagy
S Patra, DP Panigrahi, PP Praharaj, CS Bhol, KK Mahapatra, SR Mishra, ...
Cellular and molecular life sciences: CMLS 76 (17), 3263 , 2019
2019
Citations: 63
Rapid assessment of black tea quality using diffuse reflectance spectroscopy
N Panigrahi, CS Bhol, BS Das
Journal of Food Engineering 190, 101-108 , 2016
2016
Citations: 54
Secretory clusterin promotes oral cancer cell survival via inhibiting apoptosis by activation of autophagy in AMPK/mTOR/ULK1 dependent pathway
PP Naik, S Mukhopadhyay, PP Praharaj, CS Bhol, DP Panigrahi, ...
Life Sciences 264, 118722 , 2021
2021
Citations: 52
Bioactive compounds from marine invertebrates as potent anticancer drugs: the possible pharmacophores modulating cell death pathways
S Patra, PP Praharaj, DP Panigrahi, B Panda, CS Bhol, KK Mahapatra, ...
Molecular biology reports 47 (9), 7209-7228 , 2020
2020
Citations: 46
Molecular interplay of autophagy and endocytosis in human health and diseases
KK Mahapatra, DP Panigrahi, PP Praharaj, CS Bhol, S Patra, SR Mishra, ...
Biological Reviews 94 (4), 1576-1590 , 2019
2019
Citations: 45
Monitoring and measuring mammalian autophagy
SK Bhutia, PP Praharaj, CS Bhol, DP Panigrahi, KK Mahapatra, S Patra, ...
Autophagy in Differentiation and Tissue Maintenance: Methods and Protocols … , 2018
2018
Citations: 39
Gamma irradiation promotes chemo-sensitization potential of gallic acid through attenuation of autophagic flux to trigger apoptosis in an NRF2 inactivation signalling pathway
S Patra, CS Bhol, DP Panigrahi, PP Praharaj, B Pradhan, M Jena, ...
Free Radical Biology and Medicine 160, 111-124 , 2020
2020
Citations: 38
PAX9 reactivation by inhibiting DNA methyltransferase triggers antitumor effect in oral squamous cell carcinoma
CS Bhol, SR Mishra, S Patil, SK Sahu, R Kirtana, S Manna, ...
Biochimica Et Biophysica Acta (BBA)-Molecular Basis of Disease 1868 (9), 166428 , 2022
2022
Citations: 31
Inflammasomes in cancer: Effect of epigenetic and autophagic modulations
SR Mishra, KK Mahapatra, BP Behera, CS Bhol, PP Praharaj, ...
Seminars in Cancer Biology 83, 399-412 , 2022
2022
Citations: 28
PEG–PEI-modified gated N-doped mesoporous carbon nanospheres for pH/NIR light-triggered drug release and cancer phototherapy
S Panda, CS Bhol, SK Bhutia, S Mohapatra
Journal of Materials Chemistry B 9 (17), 3666-3676 , 2021
2021
Citations: 23

Chandra Sekhar Bhol

RESEARCH INTERESTS

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS