Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song Advanced Healthcare Materials, 2025 Tendon injuries pose significant clinical challenges due to complex structure and limited healing capacity. Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review summarizes the role of Extracellular Matrix (ECM), ongoing trends in the decellularization methods, as well as their integration with emerging technologies such as 3D printing, hybrid composite scaffold and hydrogels. Preclinical results and translational challenges are discussed. Overall, the review on the dECM‐based scaffold strategies offer a compelling overview in understanding the tendon tissue engineering and their potential for clinical translation.
The Impact of Particle Size and Surface Treatment of Zirconia Suspension for Photocuring Additive Manufacturing Mee-Jin Jun, Jin-Ho Kang, Kumaresan Sakthiabirami, Seyed Aliakbar Hosseini Toopghara, Ye-Seul Kim, et al. Materials, 2023 To prepare a photocurable ceramic suspension for use in commercialized additive manufacturing equipment, the effects of the rheological properties of zirconia particles added to a binder, and the presence or absence of a silane coupling agent on the particles was evaluated. To this end, three experimental groups (ZSs, ZMs, ZLs) and three control groups (ZS, ZM, ZL) were designed depending on the size of the underlying zirconia particles. The test-group zirconia suspensions were prepared through silanization, which was not applied to the control-group suspensions. Depending on the particle size, viscosity differences between the test and control groups were 16,842, 18,623, and 12,303 mPa·s, respectively. Compared to the other groups, the viscosity of the ZLs group suspension decreased by 70.98–88.04%. This confirmed that the viscosity of the suspensions was affected by the particle size and the presence of silane coating. The dispersion stability of the zirconia suspensions was evaluated over 20 days. A sedimentation test confirmed that the sedimentation rate of the ZLs group was slower than those of the other groups. This study aimed to optimize the suspension manufacturing method to effectively be utilized in further commercializing zirconia three-dimensional (3D) printing and could also help to develop various medical applications.
Closer to nature Pooja Jain, Kumaresan Sakthiabirami, Himanshu Kathuria, Gopu Sriram, Nileshkumar Dubey Multiscale Cell Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine, 2023
Effects of UV Absorber on Zirconia Fabricated with Digital Light Processing Additive Manufacturing Jin-Ho Kang, Kumaresan Sakthiabirami, Hyun-Ah Kim, Seyed Aliakbar Hosseini Toopghara, Mee-Jin Jun, et al. Materials, 2022 This study evaluated the effect of UV absorbers on the dimensional accuracy of zirconia specimens fabricated by additive manufacturing using a digital light process. Zirconia suspension for additive manufacturing was prepared by setting the volume fractions (0, 0.005, 0.05, and 0.1%) of various UV absorbers. The effect of UV absorber content was evaluated through curing thickness, geometric overgrowth model design, linear deviation, and microstructure evaluation before and after sintering. Statistical analysis was performed by Kruskal–Wallis H and post-tested by the Bonferroni correction method. There was no significant difference in the cure depth according to the presence or absence of the UV absorber, the difference in geometric overgrowth was from 2.1 to 12.5%, and the overgrowth significantly decreased as the amount of added UV absorber increased. This result may contribute to improved precision of 3D multilayer ceramic products.
Aqueous Rechargeable Zn/ZnO Battery Based on Deposition/Dissolution Chemistry Vaiyapuri Soundharrajan, Jun Lee, Seokhun Kim, Dimas Yunianto Putro, Seulgi Lee, et al. Molecules, 2022 Recently, a novel electrochemical regulation associated with a deposition/dissolution reaction on an electrode surface has been proven to show superiority in large-scale energy storage systems (ESSs). Hence, in the search for high-performance electrodes showcasing these novel regulations, we utilized a low-cost ZnO microsphere electrode to construct aqueous rechargeable batteries (ARBs) that supplied a harvestable and storable charge through electrochemical deposition/dissolution via a reversible manganese oxidation reaction (MOR)/manganese reduction reaction (MRR), respectively, induced by the inherent formation/dissolution of zinc basic sulfate in a mild aqueous electrolyte solution containing 2 M ZnSO4 and 0.2 M MnSO4.
Evaluation of Physical Properties of Zirconia Suspension with Added Silane Coupling Agent for Additive Manufacturing Processes Jae-Gon Jang, Jin-Ho Kang, Kwang-Bum Joe, Kumaresan Sakthiabirami, Kyoung-Jun Jang, et al. Materials, 2022 In this study, we have analysed the effects of a silane coupling agent on the volume fraction of zirconia for digital light processing (DLP)-based additive manufacturing processes. Zirconia suspension was prepared by the incorporation of silane-modified zirconia particles (experimental group) or untreated zirconia particles (control group). Furthermore, the control and experimental group were subdivided into three groups based on the volume fraction (52, 54, and 56 vol%) of zirconia particles. The disk-shaped zirconia samples were 3D (three-dimensional) printed using the DLP technique and their physical and mechanical properties were evaluated. The addition of a silane coupling agent to the zirconia samples was found to have influence of about 6% on the hardness and biaxial flexural strength. Moreover, the decrease in minute air gaps inside the zirconia layers significantly increased the material density (visualized from the microstructure analysis). Thus, from this study, it was established that the silane-modified zirconia particles had a positive effect on the physical properties of the zirconia parts.
Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review K Sakthiabirami, Y Park, S Kyeong Jo, M Hee Kim, J Hwang Song Advanced Healthcare Materials, e03676 , 2025 2025 Citations: 1
Bioabsorbable PLA/PHA composite pins for orthopedic applications: In vitro and in vivo study EJ Sim, K Sakthiabirami, TG Jung, SK Jo, SJ Lee, P Xu, HK Sung, EH Lee, ... Journal of Industrial and Engineering Chemistry 146, 861-870 , 2025 2025 Citations: 11
Biomimetic dual-structured zirconia scaffolds for bone tissue engineering K Sakthiabirami, E Lee, J Kang, P Zhang, SAH Toopghara, K Yun, H Lim, ... Journal of Industrial and Engineering Chemistry 140, 277-284 , 2024 2024 Citations: 5
Closer to nature: Recreating extracellular matrix microenvironment with 3D printing P Jain, K Sakthiabirami, H Kathuria, G Sriram, N Dubey Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering … , 2024 2024 Citations: 1
Manganese ion batteries: LiV3O8 nanorods as a robust and long-life cathode module V Soundharrajan, S Nithiananth, J Lee, K Sakthiabirami, DT Pham, ... Journal of Power Sources 558, 232542 , 2023 2023 Citations: 28
The impact of particle size and surface treatment of zirconia suspension for photocuring additive manufacturing MJ Jun, JH Kang, K Sakthiabirami, SA Hosseini Toopghara, YS Kim, ... Materials 16 (4), 1670 , 2023 2023 Citations: 12
Effects of UV absorber on zirconia fabricated with digital light processing additive manufacturing JH Kang, K Sakthiabirami, HA Kim, SA Hosseini Toopghara, MJ Jun, ... Materials 15 (24), 8726 , 2022 2022 Citations: 14
Aqueous rechargeable Zn/ZnO battery based on deposition/dissolution chemistry V Soundharrajan, J Lee, S Kim, DY Putro, S Lee, B Sambandam, ... Molecules 27 (24), 8664 , 2022 2022 Citations: 9
Evaluation of Physical properties of Zirconia suspension with added silane Coupling Agent for Additive Manufacturing processes JG Jang, JH Kang, KB Joe, K Sakthiabirami, KJ Jang, MJ Jun, GJ Oh, ... Materials 15 (4), 1337 , 2022 2022 Citations: 29
Mechanical and biological evaluation of lattice structured hydroxyapatite scaffolds produced via stereolithography additive manufacturing JH Kang, K Sakthiabirami, KJ Jang, JG Jang, GJ Oh, C Park, JG Fisher, ... Materials & Design 214, 110372 , 2022 2022 Citations: 65
Perspective chapter: Additive manufactured zirconia-based bio-ceramics for biomedical applications S Kumaresan, S Vaiyapuri, JH Kang, N Dubey, G Manivasagam, KD Yun, ... Advanced Additive Manufacturing , 2022 2022 Citations: 7
The advent of manganese-substituted sodium vanadium phosphate-based cathodes for sodium-ion batteries and their current progress: a focused review V Soundharrajan, S Nithiananth, K Sakthiabirami, JH Kim, CY Su, ... Journal of Materials Chemistry A 10 (3), 1022-1046 , 2022 2022 Citations: 71
Three-dimensional zirconia-based scaffolds for load-bearing bone-regeneration applications: Prospects and challenges K Sakthiabirami, V Soundharrajan, JH Kang, YP Yang, SW Park Materials 14 (12), 3207 , 2021 2021 Citations: 36
Hybrid porous zirconia scaffolds fabricated using additive manufacturing for bone tissue engineering applications K Sakthiabirami, JH Kang, JG Jang, V Soundharrajan, HP Lim, KD Yun, ... Materials Science and Engineering: C 123, 111950 , 2021 2021 Citations: 66
Vivo Degradation of ẞ-TCP/PCL of Different Composite Ratios for Bone Tissue Engineering JH Kang, J Kaneda, JG Jang, K Sakthiabirami, E Lui, C Kim, A Wang, ... 3D Printing for Tissue Engineering and Regenerative Medicine, 5 , 2020 2020
Wear behavior of the human enamel antagonist to different glazed zirconia SK Ryu, GJ Oh, JH Kang, JG Jang, K Sakthiabirami, BK Moon, KK Lee, ... Journal of Nanoscience and Nanotechnology 20 (9), 5676-5679 , 2020 2020 Citations: 2
Fabrication and characterization of 45S5 bioactive glass/thermoplastic composite scaffold by ceramic injection printer JH Kang, KJ Jang, K Sakthiabirami, GJ Oh, JG Jang, C Park, HP Lim, ... Journal of Nanoscience and Nanotechnology 20 (9), 5520-5524 , 2020 2020 Citations: 7
Two-step sintering of partially stabilized zirconia for applications in ceramic crowns BA Darmawan, JG Fisher, DT Trung, K Sakthiabirami, SW Park Materials 13 (8), 1857 , 2020 2020 Citations: 24
The influence of electron beam sterilization on in vivo degradation of β-TCP/PCL of different composite ratios for bone tissue engineering JH Kang, J Kaneda, JG Jang, K Sakthiabirami, E Lui, C Kim, A Wang, ... Micromachines 11 (3), 273 , 2020 2020 Citations: 27
Mechanical properties and optical evaluation of scaffolds produced from 45S5 bioactive glass suspensions via stereolithography JH Kang, KJ Jang, K Sakthiabirami, GJ Oh, JG Jang, C Park, HP Lim, ... Ceramics International 46 (2), 2481-2488 , 2020 2020 Citations: 39
MOST CITED SCHOLAR PUBLICATIONS
The advent of manganese-substituted sodium vanadium phosphate-based cathodes for sodium-ion batteries and their current progress: a focused review V Soundharrajan, S Nithiananth, K Sakthiabirami, JH Kim, CY Su, ... Journal of Materials Chemistry A 10 (3), 1022-1046 , 2022 2022 Citations: 71
Hybrid porous zirconia scaffolds fabricated using additive manufacturing for bone tissue engineering applications K Sakthiabirami, JH Kang, JG Jang, V Soundharrajan, HP Lim, KD Yun, ... Materials Science and Engineering: C 123, 111950 , 2021 2021 Citations: 66
Mechanical and biological evaluation of lattice structured hydroxyapatite scaffolds produced via stereolithography additive manufacturing JH Kang, K Sakthiabirami, KJ Jang, JG Jang, GJ Oh, C Park, JG Fisher, ... Materials & Design 214, 110372 , 2022 2022 Citations: 65
Mechanical properties and optical evaluation of scaffolds produced from 45S5 bioactive glass suspensions via stereolithography JH Kang, KJ Jang, K Sakthiabirami, GJ Oh, JG Jang, C Park, HP Lim, ... Ceramics International 46 (2), 2481-2488 , 2020 2020 Citations: 39
Three-dimensional zirconia-based scaffolds for load-bearing bone-regeneration applications: Prospects and challenges K Sakthiabirami, V Soundharrajan, JH Kang, YP Yang, SW Park Materials 14 (12), 3207 , 2021 2021 Citations: 36
Evaluation of Physical properties of Zirconia suspension with added silane Coupling Agent for Additive Manufacturing processes JG Jang, JH Kang, KB Joe, K Sakthiabirami, KJ Jang, MJ Jun, GJ Oh, ... Materials 15 (4), 1337 , 2022 2022 Citations: 29
Manganese ion batteries: LiV3O8 nanorods as a robust and long-life cathode module V Soundharrajan, S Nithiananth, J Lee, K Sakthiabirami, DT Pham, ... Journal of Power Sources 558, 232542 , 2023 2023 Citations: 28
The influence of electron beam sterilization on in vivo degradation of β-TCP/PCL of different composite ratios for bone tissue engineering JH Kang, J Kaneda, JG Jang, K Sakthiabirami, E Lui, C Kim, A Wang, ... Micromachines 11 (3), 273 , 2020 2020 Citations: 27
Two-step sintering of partially stabilized zirconia for applications in ceramic crowns BA Darmawan, JG Fisher, DT Trung, K Sakthiabirami, SW Park Materials 13 (8), 1857 , 2020 2020 Citations: 24
Evaluation of cure depth and geometrical overgrowth depending on zirconia volume fraction using digital light processing KJ Jang, JH Kang, K Sakthiabirami, HP Lim, KD Yun, EK Yim, GJ Oh, ... Journal of Nanoscience and Nanotechnology 19 (4), 2154-2157 , 2019 2019 Citations: 22
Effects of UV absorber on zirconia fabricated with digital light processing additive manufacturing JH Kang, K Sakthiabirami, HA Kim, SA Hosseini Toopghara, MJ Jun, ... Materials 15 (24), 8726 , 2022 2022 Citations: 14
Tailoring interfacial interaction through glass fusion in glass/zinc-hydroxyapatite composite coatings on glass-infiltrated zirconia K Sakthiabirami, JW Kim, JH Kang, KJ Jang, GJ Oh, JG Fisher, KD Yun, ... Ceramics International 44 (14), 16181-16190 , 2018 2018 Citations: 14
The impact of particle size and surface treatment of zirconia suspension for photocuring additive manufacturing MJ Jun, JH Kang, K Sakthiabirami, SA Hosseini Toopghara, YS Kim, ... Materials 16 (4), 1670 , 2023 2023 Citations: 12
Bioabsorbable PLA/PHA composite pins for orthopedic applications: In vitro and in vivo study EJ Sim, K Sakthiabirami, TG Jung, SK Jo, SJ Lee, P Xu, HK Sung, EH Lee, ... Journal of Industrial and Engineering Chemistry 146, 861-870 , 2025 2025 Citations: 11
Aqueous rechargeable Zn/ZnO battery based on deposition/dissolution chemistry V Soundharrajan, J Lee, S Kim, DY Putro, S Lee, B Sambandam, ... Molecules 27 (24), 8664 , 2022 2022 Citations: 9
Perspective chapter: Additive manufactured zirconia-based bio-ceramics for biomedical applications S Kumaresan, S Vaiyapuri, JH Kang, N Dubey, G Manivasagam, KD Yun, ... Advanced Additive Manufacturing , 2022 2022 Citations: 7
Fabrication and characterization of 45S5 bioactive glass/thermoplastic composite scaffold by ceramic injection printer JH Kang, KJ Jang, K Sakthiabirami, GJ Oh, JG Jang, C Park, HP Lim, ... Journal of Nanoscience and Nanotechnology 20 (9), 5520-5524 , 2020 2020 Citations: 7
Biomimetic dual-structured zirconia scaffolds for bone tissue engineering K Sakthiabirami, E Lee, J Kang, P Zhang, SAH Toopghara, K Yun, H Lim, ... Journal of Industrial and Engineering Chemistry 140, 277-284 , 2024 2024 Citations: 5
Effect of argon plasma treatment on surface-treated titanium K Sakthiabirami, JH Kang, JG Jang, HP Lim, KD Yun, C Park, EK Yim, ... Advances in Dentistry & Oral Health 11 (5), 158-164 , 2019 2019 Citations: 3
Wear behavior of the human enamel antagonist to different glazed zirconia SK Ryu, GJ Oh, JH Kang, JG Jang, K Sakthiabirami, BK Moon, KK Lee, ... Journal of Nanoscience and Nanotechnology 20 (9), 5676-5679 , 2020 2020 Citations: 2