Tem experiência na área de Medicina Veterinária, com ênfase em fisiologia, ginecologia, andrologia e biotécnicas da reprodução animal, atuando principalmente nos seguintes temas: Biotécnicas da reprodução como inseminação artificial, superovulação e transferência de embriões e produção de embriões i
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Scopus Publications
Scopus Publications
Advances in the Use of Recombinant Gonadotropins for Reproductive Biotechnologies in Ruminants: A Review Vitória Leite Di Domenico, Fabiane Pereira de Moraes, Natália Ávila de Castro, Fernando Caetano de Oliveira, Diogo Magnabosco, et al. Reproduction in Domestic Animals, 2026 Recombinant gonadotropins, particularly recombinant follicle‐stimulating hormone (rFSH) and recombinant equine chorionic gonadotropin (reCG), have emerged as viable alternatives to traditional animal‐derived hormones in reproductive biotechnologies. This review aims to provide an updated and comprehensive overview of recombinant gonadotropins, with emphasis on the most recent scientific and technological advances in production and their application. This research integrates studies published following the recent commercial introduction of these molecules and incorporates findings generated by our research group. A total of 12 field studies in ruminants met the inclusion criteria, comprising four evaluating rFSH for superovulation and eight assessing reCG across different reproductive applications. Recent studies demonstrate that rFSH achieves similar superovulatory outcomes to conventional protocols, while reCG effectively promotes follicular growth, ovulation, and fertility in cattle and sheep, with results comparable to purified eCG. Beyond reproductive efficacy, recombinant hormones offer advantages such as reduced animal use, consistent product quality, and simplified management. These findings highlight recombinant gonadotropins as promising, ethical, and efficient tools for advancing assisted reproduction in ruminants.
Is the presence of estradiol benzoate in cow feces environmentally safe? Lucas L. C. Guidoni, Érico Kunde Corrêa, José V. V. Isola, Bernardo G. Gasperin, Arnaldo D. Vieira, et al. Environmental Monitoring and Assessment, 2026 Estradiol benzoate can be used, among other veterinary protocols, to induce lactation in non-pregnant cows with reproductive failures. However, the use of estrogens in livestock is controversial due to concerns about environmental contamination from hormone residues. The objective of this study was to evaluate the ecotoxicity of estradiol benzoate excreted in cow feces using plant and animal bioassays. Onion and celosia seeds, earthworms ( Eisenia fetida ), and microcrustaceans ( Daphnia magna ) were exposed to fecal samples from cows with induced lactation and to aqueous solutions containing estradiol benzoate at 10–100 µg/kg. Exposure to fecal samples did not impair seed germination, earthworm reproduction, or the behavior of either animal bioindicator ( P > 0.05) and was associated with increased adult earthworm weight ( P < 0.05), according to statistical comparisons of means and measures of dispersion. No effects were observed at any tested concentrations of estradiol benzoate on any response ( P > 0.05). These findings indicate that feces from cows treated with estradiol benzoate for lactation induction exerted limited ecotoxicological effects on growth, behavior, and reproduction of plant and animal bioindicators.
Gilts not detected in estrus in a batch farrowing breeding herd: a hormonal strategy to improve gilt utilization Monike Willemin Quirino, Michele Dezordi Franz, Arthur Martelli, Thomaz Lucia Junior, Fabiana Moreira, et al. Animal Reproduction, 2026 This study evaluated reproductive performance of gilts classified as in anestrus in a batch farrowing system. Thirty-three gilts not expressing estrus within 40 days post-arrival were treated with chorionic gonadotropins, with blood collected for progesterone (P4) analysis on the same day. Thirteen gilts expressed estrus within 7 days, and 12 were inseminated (232.8 ± 2.1 days old), with 11 farrowing (91.7%; 14.2 ± 0.83 total piglets). Nineteen gilts had P4 ≤ 2.6 ng/mL at treatment; among the 20 non-responders, 10 had P4 > 2.6 ng/mL. A strong association was observed between P4 levels (≤ 2.6; > 2.6 and < 19; ≥ 19 ng/mL) and the responsiveness of gilts to gonadotropin treatment (P < 0.01; Cramér’s V = 0.63), with greater responsiveness in gilts with P4 levels ≤ 2.6 ng/mL. Non-responsive gilts (n = 20) received Altrenogest for 10 – 11 days, with 17 showing estrus within 10 days and 15 farrowing (88.2%; 14.3 ± 0.84 total piglets). Estrus detection failures and silent heat likely caused misdiagnosis. Gonadotropin, with or without Altrenogest, reduced culling ~8-fold, allowing 41–58% of gilts to reach at least the 3rd farrowing.
Reproductive Performance of Gilts After Different Periods of Altrenogest Treatment in a Batch Farrowing Breeding Herd Michele Dezordi Franz, Monike Willemin Quirino, Arthur Avelino Martelli, Vanessa Peripolli, Fabiana Moreira, et al. Reproduction in Domestic Animals, 2026 Altrenogest is widely used for synchronising gilt breeding groups. On‐farm constraints often require adjusting supplementation duration depending on cycle monitoring and batch intervals; however, the reproductive impact of these shorter regimens remains unclear. This retrospective study evaluated the reproductive performance of gilts treated with Altrenogest for different durations in a batch farrowing breeding herd. Gilts (~166 days old at arrival) that exhibited their first estrus within 40 days post‐arrival were allocated to three treatments: ALT 6–14 ( n = 166), receiving Altrenogest for 6–14 days; ALT 15–21 ( n = 190), receiving Altrenogest for 15–21 days and Control, receiving no treatment ( n = 175). Altrenogest supplementation started on days 11–12 after their last estrus (first or second). Insemination for ALT gilts was performed at the first estrus following treatment (~231 days old). For Control gilts, insemination occurred in the third or fourth estrus (~230 days old). Approximately 98% of the ALT gilts exhibited estrus, whereas 10.3% of the Control gilts did not display estrous signs within the breeding window. The interval from the end of the Altrenogest treatment to estrus expression was slightly longer ( p = 0.05) in ALT 15–21 (6.6 ± 0.2 days) than in ALT 6–14 (6.4 ± 0.2 days). Adjusted farrowing rate and total litter size did not differ among treatments ( p ≥ 0.69). The duration of Altrenogest supplementation did not affect estrous cycle synchronisation efficiency or the reproductive performance of gilts. The strategic use of Altrenogest enables a reduction in labour and costs by allowing progestogen supplementation for fewer than 14 days.
