ASSOCIATION OF CIGARETTE CONSUMPTION, NICOTINE DERIVATIVES AND CANNABIS WITH PERIODONTAL DISEASE. A REVIEW Olenka Yomira Valenzuela-Torres, Mauricio André Zapata-Sifuentes, Angela Quispe-Salcedo Revista Cientifica Odontologica, 2025 Antecedentes: El tabaquismo es considerado uno de los mayores factores de riesgo de muerte en el mundo. La evidencia científica asegura que fumar está asociado con enfermedades graves y crónicas, como las enfermedades inflamatorias; los cánceres de cabeza, cuello y pulmón; y enfermedades orales, entre las cuales destaca la enfermedad periodontal. El objetivo de esta revisión fue evaluar la asociación entre el consumo de cigarrillos, derivados nicotínicos y cannabis con la enfermedad periodontal. Materiales y métodos: Se realizo una revisión narrativa de estudios pertenecientes a las bases de datos Medline, Scopus y SciELO; incluyéndose aquellos artículos que incorporaban población adulta. Resultados: El screening y síntesis de la información obtenida de los estudios seleccionados fue llevado a cabo por dos revisores que trabajaron de forma independiente. Se tamizó 519 artículos, de los cuales se incluyeron finalmente 39, que consistieron en estudios transversales, ensayos clínicos aleatorios, mendeliano aleatorizado, cohortes, casos-controles, longitudinales e in vitro. Conclusión: El presente estudio concluye que existe asociación entre la enfermedad periodontal y el consumo de cigarrillos, derivados nicotínicos y cannabis, según la evidencia recolectada. Se sugiere a futuras investigaciones poder evaluar y poner más enfoque a la asociación del cannabis con la enfermedad periodontal, ya que la evidencia es poca a diferencia de otras drogas con la enfermedad periodontal.
Stress Distribution in a Mandibular Kennedy Class I with Bilateral Implant-Assisted Removable Partial Denture: A Finite Element Analysis Dagny Ochoa-Escate, Freddy Valdez-Jurado, Romel Watanabe, Martha Pineda-Mejía, Edwin Antonio Córdova Huayanay, et al. Oral, 2025 Objectives: This study evaluated the dental and alveolar bone stress distribution of a mandibular Kennedy Class I restored with a bilateral implant-assisted removable partial denture (IARPD) compared with a conventional removable partial denture (CRPD) through the application of finite element analysis (FEA). Methods: Kennedy Class I plaster models were made, including teeth from the lower left first premolar and lower right canine. The models were scanned, resin-based replicated and digitized. Using Solidworks software, internal hexagonal implants (10 mm × 4 mm) were virtually placed at the level of the first molars. Each model was grouped into a unit, and a load of 200 N was applied, simulating masticatory forces. Von Mises stress distributions were calculated via FEA for the vertical, diagonal and combined forces. Results: In the IARPD, the stress generated in the alveolar bone by the vertical (4.2 Mpa), diagonal (12.2 MPa) and combined forces (12.3 MPa) was lower than that of the CRPD (7 MPa, 26.3 MPa and 32 MPa, respectively). Similarly, at the lower central incisor, the IARPD generated less stress than the CRPD due to the action of the vertical, diagonal and combined forces. Conclusions: Our preliminary data suggest that bilateral implant placement may result in less stress on bone and teeth during rehabilitation with a Kennedy Class I IARPD, with different orientations of the forces applied.
Pulpal Responses to Leukocyte- and Platelet-Rich Plasma Treatment in Mouse Models for Immediate and Intentionally Delayed Tooth Replantation Angela Quispe-Salcedo, Kiyoko Suzuki-Barrera, Mauricio Zapata-Sifuentes, Taisuke Watanabe, Tomoyuki Kawase, et al. Applied Sciences Switzerland, 2024 This study aimed to evaluate the effect of leukocyte and platelet-rich plasma (L-PRP) on the pulpal healing process following immediate and intentionally delayed tooth replantation in mice. After the maxillary first molars of 3-week-old mice were extracted, the teeth were immersed for 1 min [immediate reimplantation (IR)] or 30 min [intentionally delayed reimplantation (IDR)] in phosphate-buffered saline (PBS) solution. The alveolar socket was filled with or without 1.5 μL of L-PRP [experimental or control groups (EG or CG)] followed by tooth replantation. Samples were collected from day 1 to week 4 after the operation, processed for histology, and evaluated by immunohistochemistry for Nestin and Ki-67 expression. Quantitative analysis revealed positive Nestin staining during pulpal healing in the EG at week 1 following IR and week 2 following IDR. Hard tissue deposition was significantly increased in the EG after IR at week 2. Cell proliferation was higher in the EG compared with that in the CG at week 1 and significantly decreased in the coronal pulp of the EG after the IDR at week 2. Our data suggest that treatment with L-PRP may have a positive effect on pulpal healing, even in teeth replanted after an extended extra-oral period.
MOLECULAR BASIS OF AMELOBLASTOMA PATHOGENESIS: A REVIEW Grecia Lourdes Riofrio Chung, Tania Lisseth Santos Tucto, Ángela Quispe-Salcedo Revista Cientifica Odontologica, 2024 RESUMEN El ameloblastoma es un tumor odontogénico benigno muy frecuente y altamente invasivo. Su patogénesis aún no está totalmente esclarecida. Objetivo: Describir los hallazgos moleculares más importantes que fomentan la actividad proliferativa del ameloblastoma y los factores involucrados que promueven la invasión a los tejidos óseos circundantes. Metodología: Se realizó una búsqueda de evidencia científica a través de las bases de datos: ScienceDirect, Medline, Wiley, Web of Science and Google Scholar. Se revisó 32 artículos, cuyos criterios de inclusión fueron que hayan sido publicados en idioma inglés y español; estudios descriptivos y analíticos, revisiones narrativas y sistemáticas publicadas desde enero de 2015 hasta junio de 2021. Se excluyeron las cartas al editor. Resultados: Los hallazgos biológicos moleculares que permiten la invasión de ameloblastoma hacia tejidos circundantes mediante la alteración de vías RANK/RANKL/OPG, factor de crecimiento transformante beta (TGF-β), vía de las Wnt / β-catenina y las metaloproteinasas de matriz, además sus alteraciones en vías de MAPK y SHH las cuales permiten la proliferación y desarrollo tumoral del ameloblastoma. Conclusiones: Estos hallazgos son fundamentales para una mejor comprensión de las vías involucradas en la patogénesis del ameloblastoma.
Effects of Synthetic Toll-Like Receptor 9 Ligand Molecules on Pulpal Immunomodulatory Response and Repair after Injuries Angela Quispe-Salcedo, Tomohiko Yamazaki, Hayato Ohshima Biomolecules, 2024 Synthetic oligodeoxynucleotides (ODNs) containing unmethylated cytosine–phosphate–guanine (CpG) motifs (CpG-ODNs) are ligand molecules for Toll-like receptor 9 (TLR9), which is expressed by odontoblasts in vitro and dental pulp cells. This study determined the effects of CpG-ODNs on pulpal immunomodulatory response and repair following injury. Briefly, the upper right first molars of three-week-old mice were extracted, immersed in Type A (D35) or B (K3) CpG-ODN solutions (0.1 or 0.8 mM) for 30 min, and then replanted. Pulpal healing and immunomodulatory activity were assessed by hematoxylin–eosin and AZAN staining, as well as immunohistochemistry. One week following the operation, inflammatory reactions occurred in all of the experimental groups; however, re-revascularization and newly formed hard tissue deposition were observed in the pulp chamber of all groups at week 2. A positive trend in the expression of immune cell markers was observed toward the CpG-ODN groups at 0.1 mM. Our data suggest that synthetic CpG-ODN solutions at low concentrations may evoke a long-lasting macrophage–TLR9-mediated pro-inflammatory, rather than anti-inflammatory, response in the dental pulp to modulate the repair process and hard tissue formation. Further studies are needed to determine the effects of current immunomodulatory agents in vitro and in vivo and develop treatment strategies for dental tissue regeneration.
Osteopontin deficiency disturbs dentin bridge formation after direct pulp capping with mineral trioxide aggregate R Ohshima, A Quispe-Salcedo, H Ohshima, N Kawashima, T Okiji, ... Journal of Oral Biosciences 68 (1), 100740 , 2026 2026
Stem/progenitor cell dynamics during salivary gland development and regeneration demonstrated by the double pulse-chase paradigm S Ohshima, A Quispe-Salcedo, H Ida-Yonemochi, Y Ueki, A Horii, ... Regenerative Therapy 30, 595-605 , 2025 2025 Citations: 1
Intentionally perforating the pulp chamber floor promotes M2 macrophage polarization in the dental pulp following tooth replantation in mice H Sano, K Nakakura-Ohshima, A Quispe-Salcedo, Y Okada, T Sato, ... Journal of Oral Biosciences 67 (3), 100681 , 2025 2025 Citations: 1
Association of cigarette consumption, nicotine derivatives and cannabis with periodontal disease. A review OY Valenzuela-Torres, MA Zapata-Sifuentes, A Quispe-Salcedo Revista Científica Odontológica 13 (3), e255 , 2025 2025
ASOCIACIÓN DEL CONSUMO DE CIGARRO, DERIVADOS NICOTÍNICOS Y CANNABIS CON ENFERMEDAD PERIODONTAL. UNA REVISIÓN OY Valenzuela-Torres, MA Zapata-Sifuentes, A Quispe-Salcedo Revista Científica Odontológica 13 (3), e255-e255 , 2025 2025
El valor de la mentoría en el fomento del potencial científico entre los estudiantes de odontología de pregrado A Quispe-Salcedo Revista Científica Odontológica 13 (2), e236 , 2025 2025
Stress Distribution in a Mandibular Kennedy Class I with Bilateral Implant-Assisted Removable Partial Denture: A Finite Element Analysis D Ochoa-Escate, F Valdez-Jurado, R Watanabe, M Pineda-Mejía, ... Oral 5 (2), 31 , 2025 2025 Citations: 1
Stress Distribution in a Mandibular Kennedy class I Restored with Bilateral Implant-Assisted Removable Partial Denture: A Finite Element Analysis D Ochoa-Escate, F Valdez-Jurado, R Watanabe, MP Mejía, ... Preprints , 2025 2025
Pulpal Responses to Leukocyte-and Platelet-Rich Plasma Treatment in Mouse Models for Immediate and Intentionally Delayed Tooth Replantation A Quispe-Salcedo, K Suzuki-Barrera, M Zapata-Sifuentes, T Watanabe, ... Applied Sciences 14 (23), 11358 , 2024 2024
Effects on dentin nanomechanical properties, cell viability and dentin wettability of a novel plant-derived biomodification monomer MA Moreira, MM Moreira, D Lomonaco, E Cáceres, L Witek, PG Coelho, ... Dental Materials 40 (10), 1584-1590 , 2024 2024 Citations: 5
Bases moleculares de la patogénesis del ameloblastoma: una revisión GLR Chung, TLS Tucto, A Quispe-Salcedo Revista Científica Odontológica 12 (3), e212-e212 , 2024 2024
Molecular basis of ameloblastoma pathogenesis: A review GLR Chung, TLS Tucto, A Quispe-Salcedo Revista Científica Odontológica 12 (3), e212 , 2024 2024
Effects of synthetic toll-like receptor 9 ligand molecules on pulpal immunomodulatory response and repair after injuries A Quispe-Salcedo, T Yamazaki, H Ohshima Biomolecules 14 (8), 931 , 2024 2024 Citations: 6
Regenerative Therapy M Zapata-Sifuentes, A Quispe-Salcedo, T Watanabe, T Kawase, ... 2024
Effect of leukocyte and platelet-rich plasma on osseointegration after implant placement in mouse maxilla M Zapata-Sifuentes, A Quispe-Salcedo, T Watanabe, T Kawase, ... Regenerative Therapy 26, 741-748 , 2024 2024 Citations: 3
Grupos de investigación: juntos llegamos lejos Research groups: together we reach further A Quispe-Salcedo Revista Cientifica Odontologica (Universidad Cientifica del Sur) 9 (3) , 2024 2024
Las ciencias básicas odontológicas como fundamentos para la práctica clínica Basic dental sciences as the foundations for clinical practice A Quispe-Salcedo Revista Cientifica Odontologica (Universidad Cientifica del Sur) 9 (2) , 2024 2024
Perspectives on peer-review and editorial activities of Peruvian dental researchers A Quispe-Salcedo Revista Científica Odontológica 11 (4), e170 , 2023 2023 Citations: 1
Early revascularization activates quiescent dental pulp stem cells following tooth replantation in mice H Sano, K Nakakura-Ohshima, A Quispe-Salcedo, Y Okada, T Sato, ... Regenerative Therapy 24, 582-591 , 2023 2023 Citations: 2
Importancia de la técnica de perfusión intracardiaca para los estudios in vivo en Odontología MA Zapata-Sifuentes, K Suzuki-Barrera, A Quispe-Salcedo Revista Científica Odontológica 11 (1), e148-e148 , 2023 2023
MOST CITED SCHOLAR PUBLICATIONS
Expression patterns of nestin and dentin sialoprotein during dentinogenesis in mice A Quispe-Salcedo, H Ida-Yonemochi, M Nakatomi, H Ohshima Biomedical research 33 (2), 119-132 , 2012 2012 Citations: 106
Nestin expression is differently regulated between odontoblasts and the subodontoblastic layer in mice M Nakatomi, A Quispe-Salcedo, M Sakaguchi, H Ida-Yonemochi, ... Histochemistry and cell biology 149 (4), 383-391 , 2018 2018 Citations: 45
IGF-1 mediates EphrinB1 activation in regulating tertiary dentin formation S Matsumura, A Quispe-Salcedo, CM Schiller, JS Shin, BM Locke, ... Journal of dental research 96 (10), 1153-1161 , 2017 2017 Citations: 30
Effects of a triple antibiotic solution on pulpal dynamics after intentionally delayed tooth replantation in mice A Quispe-Salcedo, H Ida-Yonemochi, H Ohshima Journal of endodontics 40 (10), 1566-1572 , 2014 2014 Citations: 21
Estudio in vitro del Efecto Antibacteriano de la Oleorresina de Copaifera reticulata y el Aceite Esencial de Origanum majoricum Frente a Streptococcus mutans y Enterococcus … H Moromi-Nakata, D Ramos-Perfecto, J Villavicencio-Gastelumendi, ... International journal of odontostomatology 12 (4), 355-361 , 2018 2018 Citations: 20
The role of dendritic cells during physiological and pathological dentinogenesis A Quispe-Salcedo, H Ohshima Journal of Clinical Medicine 10 (15), 3348 , 2021 2021 Citations: 19
The effects of reducing the root length by apicoectomy on dental pulp revascularization following tooth replantation in mice K Nakakura‐Ohshima, A Quispe‐Salcedo, H Sano, H Hayasaki, ... Dental Traumatology 37 (5), 677-690 , 2021 2021 Citations: 16
The critical role of MMP13 in regulating tooth development and reactionary dentinogenesis repair through the wnt signaling pathway HF Duncan, Y Kobayashi, Y Yamauchi, A Quispe-Salcedo, Z Chao Feng, ... Frontiers in Cell and Developmental Biology 10, 883266 , 2022 2022 Citations: 15
Evaluación del efecto antibacteriano de la combinación de drogas 3 mix en bacterias anaerobias prevalentes en necrosis pulpar A Quispe Salcedo 2007 Citations: 15
Ezh2 knockout in mesenchymal cells causes enamel hyper-mineralization Y Kobayashi, A Quispe-Salcedo, S Bodas, S Matsumura, E Li, R Johnson, ... Biochemical and biophysical research communications 567, 72-78 , 2021 2021 Citations: 12
Responses of oral-microflora-exposed dental pulp to capping with a triple antibiotic paste or calcium hydroxide cement in mouse molars A Quispe-Salcedo, T Sato, J Matsuyama, H Ida-Yonemochi, H Ohshima Regenerative Therapy 15, 216-225 , 2020 2020 Citations: 12
Exploration of the role of the subodontoblastic layer in odontoblast-like cell differentiation after tooth drilling using Nestin-enhanced green fluorescent protein transgenic mice C Imai, H Sano, A Quispe-Salcedo, K Saito, M Nakatomi, ... Journal of Oral Biosciences 64 (1), 77-84 , 2022 2022 Citations: 11
Use of a triple antibiotic solution affects the healing process of intentionally delayed replanted teeth in mice A Quispe-Salcedo, H Ida-Yonemochi, H Ohshima Journal of Oral Biosciences 55 (2), 91-100 , 2013 2013 Citations: 9
Effects of synthetic toll-like receptor 9 ligand molecules on pulpal immunomodulatory response and repair after injuries A Quispe-Salcedo, T Yamazaki, H Ohshima Biomolecules 14 (8), 931 , 2024 2024 Citations: 6
La importancia de las ciencias basicas en la formacion del cirujano dentista. A Quispe-Salcedo Odontología sanmarquina 21 (3), 161-163 , 2018 2018 Citations: 6
The effects of enzymatically synthesized glycogen on the pulpal healing process of extracted teeth following intentionally delayed replantation in mice A Quispe-Salcedo, H Ida-Yonemochi, H Ohshima Journal of Oral Biosciences 57 (2), 124-130 , 2015 2015 Citations: 6
Effects on dentin nanomechanical properties, cell viability and dentin wettability of a novel plant-derived biomodification monomer MA Moreira, MM Moreira, D Lomonaco, E Cáceres, L Witek, PG Coelho, ... Dental Materials 40 (10), 1584-1590 , 2024 2024 Citations: 5
Grupos de investigación: juntos llegamos lejos Á Quispe-Salcedo Revista Científica Odontológica 9 (3), e066-e066 , 2021 2021 Citations: 4
Fibroma odontogénico periférico. Reporte de un caso MS Infantes, AH Huanca, AQ Salcedo Odontología sanmarquina 11 (2), 92-95 , 2008 2008 Citations: 4
Effect of leukocyte and platelet-rich plasma on osseointegration after implant placement in mouse maxilla M Zapata-Sifuentes, A Quispe-Salcedo, T Watanabe, T Kawase, ... Regenerative Therapy 26, 741-748 , 2024 2024 Citations: 3