Khurshid Ahmad

Scopus Publications

Integrated virtual screening, ADMET profiling, and molecular dynamics simulations of novel natural HDAC6 inhibitors with the potential to ameliorate skeletal muscle degeneration
Khurshid Ahmad, Syed Sayeed Ahmad, Inho Choi
Scientific Reports, 2026
Emerging therapeutic strategies in muscular dystrophy: an updated review on pathogenesis and treatment advances
Shahid Parwez, Khurshid Ahmad, Eun Ju Lee, Inho Choi
Molecular Biology Reports, 2026
Updated trends in the global prevalence and burden of mental disorders, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
Damian F Santomauro, Paul Anthony Miller, Jamileh Shadid, Sarah Wulf Hanson, Anh Vo, et al.
Lancet, 2026
Global, regional, and national burden of meningitis, its risk factors, and aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
Sarah Brooke Sirota, Rose Grace Bender, Regina-Mae Villanueva Dominguez, Avina Vongpradith, Amanda Movo, et al.
Lancet Neurology, 2026
Global burden of lower respiratory infections and aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
Sarah Brooke Sirota, Rose Grace Bender, Regina-Mae Villanueva Dominguez, Amanda Movo, Lucien R Swetschinski, et al.
Lancet Infectious Diseases, 2026
Plant secondary metabolites as potential myostatin inhibitors: Computational insights for skeletal muscle atrophy
Norah Alhasson, Khurshid Ahmad
Journal of King Saud University Science, 2026
Myostatin (MSTN), a TGF-β superfamily member, inhibits skeletal muscle (SM) growth and differentiation. Dysregulated MSTN signaling is strongly associated with muscle-wasting conditions such as sarcopenia, cachexia, and muscular dystrophies. Inhibiting MSTN, therefore, represents a promising therapeutic strategy to restore muscle mass and function. In the present study, a library of 2,853 plant secondary metabolites (PSMs) from the PSC-db database was systematically screened using a structure-based virtual screening approach to identify potential MSTN inhibitors. Several PSMs displayed stronger predicted binding than the positive control, curcumin (−6.8 kcal·mol⁻ 1 ), with PSCdb02834 (−7.5 kcal·mol⁻ 1 ), PSCdb02056 (−7.3 kcal·mol⁻ 1 ), and PSCdb02107 (−7.3 kcal·mol⁻ 1 ) emerging as the most promising candidates. To evaluate interaction stability, we performed 200-ns all-atom molecular dynamics simulations (MDS) for each MSTN-ligand complex. The complexes retained bound conformations with low-amplitude backbone (Cα) root mean square deviation (RMSD) and persistent ligand–protein hydrogen bonds, indicating equilibrated binding. Post-MD analyses (solvent-accessible surface area (SASA), water–ligand radial distribution functions (RDF), and water-bridge occupancy) supported a solvent-assisted, stable recognition at the pocket. Consistently, MM/PBSA estimates ranked the leads more favorably than the control, with PSCdb02834 showing the most negative ΔG (relative ranking), reinforcing its prioritization for experimental validation. In silico ADMET (absorption, distribution, metabolism, excretion, toxicity) predictions indicated that all three compounds possessed favorable pharmacokinetic properties, low predicted toxicity, and drug-likeness. These findings highlight the potential of PSMs as MSTN inhibitors and provide a robust computational framework for guiding future experimental validation.
Global, regional, and national burden of breast cancer among females, 1990–2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023
Kayleigh Bhangdia, Miranda L May, Jonathan M Kocarnik, Natalie Pritchett, Andrew Crist, et al.
Lancet Oncology, 2026
Exploring Genetic and Epigenetic Interplay: Novel Therapeutic Targets for Disability Management
Qazi Mohammad Sajid Jamal, Ali H Alharbi, Varish Ahmad, Khurshid Ahmad
Current Neuropharmacology, 2026
Disabilities result from a complex interaction of genetic, epigenetic, and environmental factors, each contributing in unique and often overlapping ways to health outcomes. Despite significant advances in genetic research that have clarified the roles of both clearly pathogenic and clinically uncertain variants in disease causes, consistent application of these findings in clinical practice remains a significant challenge. Modifiable factors such as diet, lifestyle, and exposure to toxic environmental agents can either exacerbate underlying genetic vulnerabilities or help mitigate overall risk. This highlights the importance of adopting a truly integrative and holistic approach to understanding and addressing disability and related disorders. This review examines how genetic variants interact with epigenetic mechanisms, including DNA methylation, histone modifications, and various non-coding RNAs, to influence the onset, severity, and progression of disabilities. It also explores emerging and innovative therapeutic strategies targeting epigenetic regulators, evaluating their potential not only to alter the biological course of disease but also to improve long-term functional outcomes. Our comprehensive perspective emphasizes the dynamic and reciprocal interactions among genes, epigenetic modifications, and environmental influences, offering a unified framework for researchers and clinicians. We propose that utilizing this integrated knowledge is essential for formulating precise interventions that target underlying pathology and improve the quality of life for individuals with disabilities.
BF3.OEt2-Catalyzed Regioselective One-Pot Multicomponent Synthesis of Arylated 1H-Indenes With EGFR Inhibitory Potential: A Combined Synthetic and Biocomputational Study
Sabera Sultana, Khurshid Ahmad, Yong Rok Lee, Anil K. Saikia
Asian Journal of Organic Chemistry, 2026
We developed a regioselective one‐pot strategy for synthesizing highly substituted arylated 1 H ‐indenes bearing heterocycles using BF 3 ·OEt 2 ‐catalyzed multicomponent reactions. The proposed reaction mechanism includes BF 3 complex formation, tautomerization, nucleophilic aryl addition to arylalkyne, cyclization via a 4π‐Nazarov‐type intermediate, and deprotonation. The anticancer potential of the resulting compounds was evaluated using molecular docking studies that targeted the epidermal growth factor receptor (EGFR). All synthesized indene derivatives had high binding affinities, surpassing those of the reference drug erlotinib, indicating their potential as EGFR inhibitors. These findings suggest that, with further biological validation, the newly synthesized arylated indenes could serve as effective leads for the development of anticancer drugs.
Isobavachalcone reduces blood glucose and promotes muscle development via dipeptidyl peptidase-4 inhibition
Eun Ju Lee, Sibhghatulla Shaikh, Khurshid Ahmad, Si Han Lee, Jae-Moon Choi, et al.
International Journal of Biological Macromolecules, 2026
Global, Regional, and National Burden of Cardiovascular Diseases and Risk Factors in 204 Countries and Territories, 1990-2023
Benjamin A. Stark, Nicole K. DeCleene, Emily C. Desai, Johnathan M. Hsu, Catherine O. Johnson, et al.
Journal of the American College of Cardiology, 2025
Hydrogel-integrated biomimetic hydroxyapatite scaffolds with tunable porosity for enhanced curcumin delivery
Kamrun Nahar Fatema, Longlong Li, Khurshid Ahmad, Jongyun Kim, Dong-Weon Lee
Journal of Drug Delivery Science and Technology, 2025
Structure-Based Computational Discovery of Natural Inhibitors from Piper longum Against Monkeypox Virus E12 Protein
Khurshid Ahmad, Ali H. Alharbi, Mohammad Azam Ansari, Qazi Mohammad Sajid Jamal
Chemistryselect, 2025
Catharanthus roseus Phytochemicals as Multi-Target Modulators of Disability-Linked Neurodegeneration: Bio-Computational Insights
Qazi Mohammad Sajid Jamal, Ali H. Alharbi, Varish Ahmad, Khurshid Ahmad
Pharmaceuticals, 2025
Global age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950–2023: a demographic analysis for the Global Burden of Disease Study 2023
Austin E Schumacher, Peng Zheng, Ryan M Barber, Bhoomadevi A, Mohammad Amin Aalipour, et al.
Lancet, 2025
Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
Mohsen Naghavi, Hmwe Hmwe Kyu, Bhoomadevi A, Mohammad Amin Aalipour, Hasan Aalruz, et al.
Lancet, 2025
Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
Simon I Hay, Kanyin Liane Ong, Damian F Santomauro, Bhoomadevi A, Mohammad Amin Aalipour, et al.
Lancet, 2025
The global, regional, and national burden of cancer, 1990–2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023
Lisa M Force, Jonathan M Kocarnik, Miranda L May, Kayleigh Bhangdia, Andrew Crist, et al.
Lancet, 2025
Explainable Artificial Intelligence: A Perspective on Drug Discovery
Yazdan Ahmad Qadri, Sibhghatulla Shaikh, Khurshid Ahmad, Inho Choi, Sung Won Kim, et al.
Pharmaceutics, 2025
Skeletal Muscle Aging: Enhancing Skeletal Muscle Integrity and Function as a Potential Pharmacological Approach
Sibhghatulla Shaikh, Khurshid Ahmad, Jeong Ho Lim, Syed Sayeed Ahmad, Eun Ju Lee, et al.
Pharmaceuticals, 2025
The current scenario in cultured meat production and the challenges for industrialization
Syed Sayeed Ahmad, Kaiser Younis, Ga Eul Lee, Ananda Baral, Sibhghatulla Shaikh, et al.
Food Bioscience, 2025
Global, regional, and national trends in routine childhood vaccination coverage from 1980 to 2023 with forecasts to 2030: a systematic analysis for the Global Burden of Disease Study 2023
Emily Haeuser, Sam Byrne, Jason Nguyen, Catalina Raggi, Susan A McLaughlin, et al.
Lancet, 2025
Integrated in silico identification of cholinesterase inhibitors from Nyctanthes arbor-tristis
Qazi Mohammad Sajid Jamal, Ali H. Alharbi, Varish Ahmad, Khurshid Ahmad
Plos One, 2025
Deciphering the Anti-Autism Potential of Withania somnifera Phytochemicals Targeting SLC6A4 Through Computational Approaches
Qazi Mohammad Sajid Jamal, Ali H. Alharbi, Varish Ahmad, Khurshid Ahmad
Journal of Disability Research, 2025
Machine Learning-Driven Consensus Modeling for Activity Ranking and Chemical Landscape Analysis of HIV-1 Inhibitors
Danishuddin, Md Azizul Haque, Geet Madhukar, Qazi Mohammad Sajid Jamal, Jong-Joo Kim, et al.
Pharmaceuticals, 2025

RECENT SCHOLAR PUBLICATIONS

Emerging therapeutic strategies in muscular dystrophy: an updated review on pathogenesis and treatment advances
S Parwez, K Ahmad, EJ Lee, I Choi
Molecular Biology Reports 53 (1), 278 , 2026
2026
Citations: 1
Global burden of lower respiratory infections and aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
SB Sirota, RG Bender, RMV Dominguez, A Movo, LR Swetschinski, ...
The Lancet infectious diseases 26 (4), 343-361 , 2026
2026
Citations: 26
Global, regional, and national burden of meningitis, its risk factors, and aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
AR Collaborators
2026
Plant secondary metabolites as potential myostatin inhibitors: Computational insights for skeletal muscle atrophy
N Alhasson, K Ahmad
Journal of King Saud University–Science 38 , 2026
2026
Global, regional, and national burden of breast cancer among females, 1990–2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023
K Bhangdia, ML May, JM Kocarnik, N Pritchett, A Crist, L Penberthy, ...
The Lancet Oncology 27 (3), 302-326 , 2026
2026
Citations: 11
Integrated virtual screening, ADMET profiling, and molecular dynamics simulations of novel natural HDAC6 inhibitors with the potential to ameliorate skeletal muscle degeneration
K Ahmad, SS Ahmad, I Choi
Scientific Reports , 2026
2026
BF 3 .OEt 2 ‐Catalyzed Regioselective One‐Pot Multicomponent Synthesis of Arylated 1 H ‐Indenes With EGFR Inhibitory Potential: A Combined Synthetic and …
S Sultana, K Ahmad, YR Lee, AK Saikia
Asian Journal of Organic Chemistry 15 (1), e70264 , 2026
2026
Isobavachalcone reduces blood glucose and promotes muscle development via dipeptidyl peptidase-4 inhibition
EJ Lee, S Shaikh, K Ahmad, SH Lee, JM Choi, YH Lee, I Choi
International Journal of Biological Macromolecules, 149858 , 2025
2025
Citations: 1
Global, regional, and national burden of cardiovascular diseases and risk factors in 204 countries and territories, 1990-2023
Global Burden of Cardiovascular Diseases and Risks 2023 Collaborators
Journal of the American College of Cardiology 86 (22), 2167-2243 , 2025
2025
Citations: 272
Catharanthus roseus Phytochemicals as Multi-Target Modulators of Disability-Linked Neurodegeneration: Bio-Computational Insights
QMS Jamal, AH Alharbi, V Ahmad, K Ahmad
Pharmaceuticals 18 (11), 1734 , 2025
2025
Structure‐Based Computational Discovery of Natural Inhibitors from Piper longum Against Monkeypox Virus E12 Protein
K Ahmad, AH Alharbi, MA Ansari, QMS Jamal
ChemistrySelect 10 (43), e02694 , 2025
2025
Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
M Naghavi, HH Kyu, MA Aalipour, H Aalruz, HS Ababneh, BJ Abafita, ...
The Lancet 406 (10513), 1811-1872 , 2025
2025
Citations: 314
Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational …
SI Hay, KL Ong, DF Santomauro, MA Aalipour, H Aalruz, HS Ababneh, ...
The Lancet 406 (10513), 1873-1922 , 2025
2025
Citations: 283
Global age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950–2023: a demographic analysis for …
AE Schumacher, P Zheng, RM Barber, MA Aalipour, H Aalruz, ...
The Lancet 406 (10513), 1731-1810 , 2025
2025
Citations: 112
The global, regional, and national burden of cancer, 1990–2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023
LM Force, JM Kocarnik, ML May, K Bhangdia, A Crist, L Penberthy, ...
The Lancet 406 (10512), 1565-1586 , 2025
2025
Citations: 268
Hydrogel-Integrated Biomimetic Hydroxyapatite Scaffolds with Tunable Porosity for Enhanced Curcumin Delivery
KN Fatema, L Li, K Ahmad, J Kim, DW Lee
Journal of Drug Delivery Science and Technology, 107572 , 2025
2025
Citations: 2
Nafion-stabilized silver nanoparticles modified glassy carbon electrode for ultrasensitive detection of alpha-1-acid glycoprotein
G Rabbani, A Mohammad, ME Khan, W Zakri, MV Khan, K Ahamd, W Ali, ...
Bioelectrochemistry, 109112 , 2025
2025
Citations: 4
Skeletal Muscle Aging: Enhancing Skeletal Muscle Integrity and Function as a Potential Pharmacological Approach
S Shaikh, K Ahmad, JH Lim, SS Ahmad, EJ Lee, I Choi
Pharmaceuticals 18 (9), 1407 , 2025
2025
Citations: 4
Network-based clustering and statistical evaluation to elucidate structure-activity relationships of EZH2 inhibitors
Danishuddin, MA Haque, G Madhukar, S Khan, QMS Jamal, S Srivastava, ...
SAR and QSAR in Environmental Research 36 (9), 827-851 , 2025
2025
Explainable artificial intelligence: a perspective on drug discovery
YA Qadri, S Shaikh, K Ahmad, I Choi, SW Kim, AV Vasilakos
Pharmaceutics 17 (9), 1119 , 2025
2025
Citations: 38

MOST CITED SCHOLAR PUBLICATIONS

Mechanistic insights into the antimicrobial actions of metallic nanoparticles and their implications for multidrug resistance
S Shaikh, N Nazam, SMD Rizvi, K Ahmad, MH Baig, EJ Lee, I Choi
International journal of molecular sciences 20 (10), 2468 , 2019
2019
Citations: 597
Computer aided drug design: success and limitations
M Hassan Baig, K Ahmad, S Roy, J Mohammad Ashraf, M Adil, ...
Current pharmaceutical design 22 (5), 572-581 , 2016
2016
Citations: 522
Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
M Naghavi, HH Kyu, MA Aalipour, H Aalruz, HS Ababneh, BJ Abafita, ...
The Lancet 406 (10513), 1811-1872 , 2025
2025
Citations: 314
Binding of tolperisone hydrochloride with human serum albumin: effects on the conformation, thermodynamics, and activity of HSA
G Rabbani, EJ Lee, K Ahmad, MH Baig, I Choi
Molecular pharmaceutics 15 (4), 1445-1456 , 2018
2018
Citations: 284
Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational …
SI Hay, KL Ong, DF Santomauro, MA Aalipour, H Aalruz, HS Ababneh, ...
The Lancet 406 (10513), 1873-1922 , 2025
2025
Citations: 283
Global, regional, and national burden of cardiovascular diseases and risk factors in 204 countries and territories, 1990-2023
Global Burden of Cardiovascular Diseases and Risks 2023 Collaborators
Journal of the American College of Cardiology 86 (22), 2167-2243 , 2025
2025
Citations: 272
The global, regional, and national burden of cancer, 1990–2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023
LM Force, JM Kocarnik, ML May, K Bhangdia, A Crist, L Penberthy, ...
The Lancet 406 (10512), 1565-1586 , 2025
2025
Citations: 268
Implications of insulin-like growth factor-1 in skeletal muscle and various diseases
SS Ahmad, K Ahmad, EJ Lee, YH Lee, I Choi
Cells 9 (8), 1773 , 2020
2020
Citations: 239
Computer aided drug design and its application to the development of potential drugs for neurodegenerative disorders
MH Baig, K Ahmad, G Rabbani, M Danishuddin, I Choi
Current neuropharmacology 16 (6), 740-748 , 2018
2018
Citations: 207
Peptide based therapeutics and their use for the treatment of neurodegenerative and other diseases
MH Baig, K Ahmad, M Saeed, AM Alharbi, GE Barreto, GM Ashraf, I Choi
Biomedicine & Pharmacotherapy 103, 574-581 , 2018
2018
Citations: 175
Global, regional, and national trends in routine childhood vaccination coverage from 1980 to 2023 with forecasts to 2030: a systematic analysis for the Global Burden of Disease …
E Haeuser, S Byrne, J Nguyen, C Raggi, SA McLaughlin, C Bisignano, ...
The Lancet 406 (10500), 235-260 , 2025
2025
Citations: 132
Enzyme targeting strategies for prevention and treatment of cancer: Implications for cancer therapy
MH Baig, M Adil, R Khan, S Dhadi, K Ahmad, G Rabbani, T Bashir, ...
Seminars in cancer biology 56, 1-11 , 2019
2019
Citations: 127
Myostatin and its regulation: a comprehensive review of myostatin inhibiting strategies
MH Baig, K Ahmad, JS Moon, SY Park, J Ho Lim, HJ Chun, AF Qadri, ...
Frontiers in Physiology 13, 876078 , 2022
2022
Citations: 125
Halotolerant microbial consortia for sustainable mitigation of salinity stress, growth promotion, and mineral uptake in tomato plants and soil nutrient enrichment
C Kapadia, RZ Sayyed, HA El Enshasy, H Vaidya, D Sharma, N Patel, ...
Sustainability 13 (15), 8369 , 2021
2021
Citations: 114
Global age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950–2023: a demographic analysis for …
AE Schumacher, P Zheng, RM Barber, MA Aalipour, H Aalruz, ...
The Lancet 406 (10513), 1731-1810 , 2025
2025
Citations: 112
Implication of caspase‐3 as a common therapeutic target for multineurodegenerative disorders and its inhibition using nonpeptidyl natural compounds
S Khan, K Ahmad, EMA Alshammari, M Adnan, MH Baig, M Lohani, ...
BioMed research international 2015 (1), 379817 , 2015
2015
Citations: 104
Protein-protein interactions and their role in various diseases and their prediction techniques
G Rabbani, MH Baig, K Ahmad, I Choi
Current Protein and Peptide Science 19 (10), 948-957 , 2018
2018
Citations: 88
Extracellular matrix: the critical contributor to skeletal muscle regeneration—a comprehensive review
K Ahmad, S Shaikh, HJ Chun, S Ali, JH Lim, SS Ahmad, EJ Lee, I Choi
Inflammation and Regeneration 43 (1), 58 , 2023
2023
Citations: 79
Cell types used for cultured meat production and the importance of myokines
S Shaikh, E Lee, K Ahmad, SS Ahmad, H Chun, J Lim, Y Lee, I Choi
Foods 10 (10), 2318 , 2021
2021
Citations: 76
Use of peptides for the management of Alzheimer’s disease: diagnosis and inhibition
MH Baig, K Ahmad, G Rabbani, I Choi
Frontiers in aging neuroscience 10, 21 , 2018
2018
Citations: 76

Khurshid Ahmad

EDUCATION

RESEARCH, TEACHING, or OTHER INTERESTS

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS