Gabriela Izabela Baltatescu

@spitalulconstanta.ro

Research and Development Centre for The Morphologic and Genetic Study of Malignant Pathology

Gabriela Izabela Baltatescu


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https://researchid.co/gabrielabaltatescu
33

Scopus Publications

243

Scholar Citations

9

Scholar h-index

7

Scholar i10-index

Scopus Publications

  • Dysregulated Cell Signaling Pathways in Prostate Tumoral Plasticity—Checkpoints
    Elena Matei, Ionuț Ciprian Iorga, Mariana Deacu, Georgeta Camelia Cozaru, Gabriela Isabela Băltățescu, et al.
    Oncology Research, 2026
  • Interplay Between Immune Microenvironment CD8+ Tumor-Infiltrating Lymphocytes and PDL-1 Expression as Prognostic Markers in Invasive Cervical Squamous Cell Carcinoma
    Laura-Andra Petrică, Mariana Deacu, Georgeta Camelia Cozaru, Anca Florentina Mitroi, Gabriela Izabela Bălţătescu, et al.
    Medicina Lithuania, 2025
    Background: Cervical cancer remains a major cause of cancer-related morbidity and mortality worldwide, with limited therapeutic options for advanced disease. As we better understand the fine mechanisms involved in the interaction between tumor cells and the tumor microenvironment, new paths and opportunities will emerge. Recent evidence highlights the prognostic and predictive roles of immune checkpoint markers and tumor-infiltrating lymphocytes (TILs), especially CD8+ TILs, in shaping treatment outcomes. Objectives: This study investigated the immunohistochemical expression of PD-L1 and CD8+ TILs in 48 newly diagnosed, treatment-naive cervical cancer cases and analyzed their associations with clinicopathological features and survival outcomes. Results: In our cohort, we observed that PD-L1 positivity was identified in 68.8% of cases, most frequently in advanced FIGO stages and in tumors with lympho-vascular invasion or with a high proliferation rate evaluated by the Ki-67 index. High levels of intra-tumoral CD8+ TILs were observed in 52.1% of cases and correlated positively with stromal TILs, lower proliferation rates, and absence of vascular invasion. A significant inverse relationship was found between PD-L1 expression and the density of CD8+ TILs (p = 0.047). Survival analysis showed that patients exhibiting a “cold” immunophenotype with low levels of CD8+ TILs and PD-L1-positive tumors had worse outcomes, while high levels of CD8+ TILs played a protective role. Conclusions: Our study highlights the importance of the immunohistochemical assessment of PD-L1 and CD8+ TILs biomarkers, which have a complementary inter-relationship and have a significant prognostic impact on cervical squamous cell carcinoma. PD-L1 positivity marks aggressive disease features, while higher intra-tumoral CD8+ TIL density is protective. Their combined evaluation may improve patient stratification and inform immunotherapy strategies.
  • Hydatid Cyst in Pregnancy—A Diagnostic and Therapeutic Dilemma: Study Case Report
    Liliana Steriu, Ionut Eduard Iordache, Antonia Bisinicu, Bianca Andreea Steriu, Gabriela Baltatescu, et al.
    Journal of Clinical Medicine, 2025
    Background: Hydatid disease, caused by the larval form of Echinococcus granulosus, is a rare but potentially life-threatening condition during pregnancy, with an estimated incidence of 1 in 20,000 to 30,000 gestations. Physiological immunosuppression and increased placental steroid levels during pregnancy may promote cyst growth, elevating the risk of rupture, which can result in anaphylactic shock, sepsis, or widespread peritoneal dissemination. Diagnostic imaging, particularly ultrasonography, plays a central role in detection, while treatment decisions are complicated by the lack of standardized guidelines and the need to balance maternal–fetal safety. Methods: This case report describes a 29-year-old pregnant woman at 22 weeks’ gestation who was incidentally diagnosed with two large hepatic hydatid cysts during a routine ultrasound. Results: Given the high rupture risk, she underwent successful laparoscopic surgery in the second trimester, followed by careful monitoring and elective cesarean delivery at term. A third retroperitoneal cyst, initially managed conservatively, was excised postpartum. Conclusions: This case highlights the critical importance of individualized, multidisciplinary management in achieving favorable maternal and neonatal outcomes in complex presentations of hydatid disease during pregnancy.
  • Twisted Troubles: A Rare Case of Intestinal Obstruction Due to Endometriosis and a Review of the Literature
    Ionut Eduard Iordache, Luana Alexandrescu, Alina Doina Nicoara, Razvan Popescu, Nicoleta Leopa, et al.
    Clinics and Practice, 2024
    Background and Objectives: Intestinal endometriosis is an exceptionally rare cause of intestinal obstruction. This case report and literature review aim to highlight the clinical presentation, diagnostic challenges, and surgical management of this condition. Materials and methods: We report the case of a 50-year-old female patient who presented diffuse abdominal pain, nausea, vomiting, a distended abdomen, and an absence of intestinal transit for gas and faeces. Initial symptoms included flatulence and constipation, which gradually worsened for two months prior to the patient’s hospital admission, leading to acute intestinal obstruction. Diagnostic investigations, including blood tests, ultrasound (USG), X-ray, and a contrast-enhanced computer tomography (CT) scan, revealed significant small bowel dilatation and an ileal volvulus. The patient underwent urgent hydro-electrolytic and metabolic rebalancing followed by a median laparotomy surgical procedure. Intraoperative findings included a distended small intestine and an obstructive ileal volvulus, and required an 8 cm segmental enterectomy and terminal ileostomy. Results: Postoperative recovery was slow but favourable, with a gradual digestive tolerance. Histopathological examination of the resected ileum revealed intestinal endometriosis characterized by a fibro-conjunctive reaction and nonspecific chronic active inflammation. Five months later, the patient underwent a successful reversal of the ileostomy with a mechanical lateral anastomosis of the cecum and ileum, resulting in a favourable postoperative course. Conclusions: This case underscores the importance of considering intestinal endometriosis in women presenting with unexplained gastrointestinal symptoms and highlights the need for timely surgical intervention and careful postoperative management. Further research is required to better understand the pathophysiology and optimal treatment strategies for intestinal endometriosis.
  • Cell death and DNA damage via ROS mechanisms after applied antibiotics and antioxidants doses in prostate hyperplasia primary cell cultures
    Elena Matei, Anita Cristina Ionescu, Manuela Enciu, Violeta Popovici, Anca Florentina Mitroi, et al.
    Medicine United States, 2024
    Tumor heterogeneity results in aggressive cancer phenotypes with acquired resistance. However, combining chemical treatment with adjuvant therapies that cause cellular structure and function perturbations may diminish the ability of cancer cells to resist at chemical treatment and lead to a less aggressive cancer phenotype. Applied treatments on prostate hyperplasia primary cell cultures exerted their antitumor activities through mechanisms including cell cycle blockage, oxidative stress, and cell death induction by flow cytometry methods. A 5.37 mM Chloramphenicol dose acts on prostate hyperplasia cells by increasing the pro-oxidant status, inducing apoptosis, autophagy, and DNA damage, but without ROS changes. Adding 6.30 mM vitamin C or 622 µM vitamin E as a supplement to 859.33 µM Chloramphenicol dose in prostate hyperplasia cells determines a significant increase of ROS level for a part of cells. However, other cells remain refractory to initial ROS, with significant changes in apoptosis, autophagy, and cell cycle arrest in G0/G1 or G2/M. When the dose of Chloramphenicol was increased to 5.37 mM for 6.30 mM of vitamin C, prostate hyperplasia cells reacted by ROS level drastically decreased, cell cycle arrest in G2/M, active apoptosis, and autophagy. The pro-oxidant action of 1.51 mM Erythromycin dose in prostate hyperplasia cell cultures induces changes in the apoptosis mechanisms and cell cycle arrest in G0/G1. Addition of 6.30 mM vitamin C to 1.51 mM Erythromycin dose in hyperplasia cell cultures, the pro-oxidant status determines diminished caspase 3/7 mechanism activation, but ROS level presents similar changes as Chloramphenicol dose and cell cycle arrest in G2/M. Flow cytometric analysis of cell death, oxidative stress, and cell cycle are recommended as laboratory techniques in therapeutic and diagnostic fields.
  • Apoptosis–Cell Cycle–Autophagy Molecular Mechanisms Network in Heterogeneous Aggressive Phenotype Prostate Hyperplasia Primary Cell Cultures Have a Prognostic Role
    Elena Matei, Manuela Enciu, Mihai Cătălin Roșu, Felix Voinea, Anca Florentina Mitroi, et al.
    International Journal of Molecular Sciences, 2024
    Our study highlights the apoptosis, cell cycle, DNA ploidy, and autophagy molecular mechanisms network to identify prostate pathogenesis and its prognostic role. Caspase 3/7 expressions, cell cycle, adhesion glycoproteins, autophagy, nuclear shrinkage, and oxidative stress by flow-cytometry analysis are used to study the BPH microenvironment’s heterogeneity. A high late apoptosis expression by caspases 3/7 activity represents an unfavorable prognostic biomarker, a dependent predictor factor for cell adhesion, growth inhibition by arrest in the G2/M phase, and oxidative stress processes network. The heterogeneous aggressive phenotype prostate adenoma primary cell cultures present a high S-phase category (>12%), with an increased risk of death or recurrence due to aneuploid status presence, representing an unfavorable prognostic biomarker, a dependent predictor factor for caspase 3/7 activity (late apoptosis and necrosis), and cell growth inhibition (G2/M arrest)-linked mechanisms. Increased integrin levels in heterogenous BPH cultures suggest epithelial–mesenchymal transition (EMT) that maintains an aggressive phenotype by escaping cell apoptosis, leading to the cell proliferation necessary in prostate cancer (PCa) development. As predictor biomarkers, the biological mechanisms network involved in apoptosis, the cell cycle, and autophagy help to establish patient prognostic survival or target cancer therapy development.
  • CD8-Lymphocytic Phenotype Significance in Primary Multiple and Familial Melanoma with Various CDKN2A Mutational Status
    Luana-Andreea Boşoteanu, Emma Gheorghe, Mariana Aşchie, Georgeta Camelia Cozaru, Mariana Deacu, et al.
    Medicina Lithuania, 2023
    Background and Objectives: In the realm of the rising incidence of cutaneous and mucous melanoma, CDKN2A mutations characterize familial and multiple primary melanoma cases. The involvement of tumor-infiltrating lymphocytes (TILs) is interconnected with survival rates, but may extend even further. The aim of this study is to verify the accuracy of the classical “naked eye” count of CD8-positive T cells comprised within the tumoral population and peritumoral infiltrate versus that obtained via a special software run by the aid of artificial intelligence (AI), used to determine the percentage of CD8-positive TILs. Materials and Methods: The present retrospective cross-sectional study conducted over a period of 5 years (2018–2022) focused on patients diagnosed with mucous and/or cutaneous melanoma, with a positive family history for melanoma, or personal antecedents of primary malignant melanocytic lesions. The 23 selected cases were diagnosed histopathologically, tested for CDKN2A mutations through fluorescent hybridization in situ, and CD8 immunohistochemistry was performed. The included slides were evaluated both manually (naked-eye examination) and automatically (via QuPath platform) for quantifying the CD8-positive TILs. Results: The number of CD8-positive TILs in melanoma samples has been more accurately identified through the use of an AI-mediated software as compared to the human-eye evaluation performed by experimental pathologists. A higher percentage of CD8-positive intratumoral lymphocytes versus stromal lymphocytes was positively associated with more numerous metastatic sites. Conclusions: The CD8 lymphocytic phenotype harbors major significance in the context of familial and multiple primary melanoma and may comprise a cost-effective investigation meant to help in the establishment of melanoma prognosis and response to immunotherapy.
  • The Predictive Role of the Histopathological Scoring System in Adipose Tumors—Lipoma, Atypical Lipomatous Tumor, and Liposarcoma
    Mariana Deacu, Madalina Bosoteanu, Manuela Enciu, Georgeta Camelia Cozaru, Oana Cojocaru, et al.
    Diagnostics, 2023
    Lipomatous tumors are the most frequent soft tissue neoplasms. Sometimes their differential diagnosis is difficult to perform only by microscopic analysis. This study aims to create a histopathological scoring system and highlight the impact of intratumoral microvascular density. This study was conducted over 10 years. We analyzed the main pathogenic pathways (MDM2 and CDK4), as well as the tumor microvascularization (CD31 and CD34) by immunohistochemical tests. We also analyzed the status of the MDM2 gene by CISH. These data, together with the clinical and histopathological information, were statistically analyzed by appropriate tests. We identified 112 eligible cases, with most of the patients being in their sixth decade of life, with a slight predominance of the female sex. We found important associations like tumor location linked to nuclear pleomorphism severity and microvascularization density correlated with atypia severity. Also, we observed that a maximum diameter of a tumor of at least 69 mm is associated with the presence of tumor necrosis. The score designed in this study shows an increased sensitivity and specificity for the diagnosis of lipomas (100%, respectively, 97%), atypical lipomatous tumors (93.8%, respectively, 82.3%), and liposarcomas (100%, respectively, 90.5%). This present study enhances the present data by bringing to attention the histopathological score with a role in differential diagnosis, as well as in the prediction of immunohistochemical and genetic tests. Also, we highlighted the importance of microvascular density, especially in the diagnosis of liposarcomas.
  • CMV and HIV Coinfection in Women from a Region in Eastern Europe
    Stela Halichidis, Mariana Aschie, Georgeta Camelia Cozaru, Mihaela Manea, Nicolae Dobrin, et al.
    Journal of Personalized Medicine, 2023
    (1) Background: Human cytomegalovirus (CMV) infection is one of the most frequent opportunistic infections in immunosuppressed patients. Romania has one of the highest incidences of patients living with human immunodeficiency virus (HIV) which determines an immunosuppressive state. The aim of this study was to establish the prevalence of CMV infection among women living with HIV in Southeastern Romania and also to evaluate and correlate antiretroviral therapy (ART) with CD4 level and CMV disease evolution. (2) Methods: Seventy women living with HIV from Southeastern Romania were screened for CMV infection using antigen quantification. Of these, 50 were included in the study. First, the patients filled out a questionnaire regarding social conditions and other associated diseases. Then, we explored the statistical correlations between the data and HIV status, CD4+ cell counts, viral load, and antiretroviral therapy (ART). (3) Results: Median age of the patients was 33 years. Twenty-nine cases were diagnosed with HIV after sexual life beginning and 21 before. Most of the patients had a CD4 level over 200 cells/µL. ART duration in the CD4 under 200 cells/µL group was a bit longer than that in the CD4 over 200 cells/µL group. Forty-one patients had undetectable viremia. CD4 average value in the lot of patients with undetectable viremia was 704.71 cells/µL and in the lot with detectable viremia was 452.44 cells/µL. Viremia values correlated negatively with CD4 level. A positive correlation between IgG CMV values and ART therapy length was identified. A negative significant correlation between values of IgG CMV and values of CD4 was identified. CD4 value correlated negatively with IgG CMV values and with CMV avidity. (4) Conclusions: IgG CMV values had a weak positive correlation with ART therapy length, and a negative statistically significant correlation with values of CD4. CMV avidity has a negative correlation with CD4 value.
  • Comparison of Ki67 Proliferation Index in Gastrointestinal Non-Hodgkin Large B-Cell Lymphomas: The Conventional Method of Evaluation or AI Evaluation?
    Miruna Cristian, Mariana Așchie, Mariana Deacu, Mădălina Boșoteanu, Gabriela Izabela Bălțătescu, et al.
    Diagnostics, 2023
    The most common NHL subtype in SEEU is DLBCL (39%), and it manifests with a variety of cellular morphologies and a high proliferation index. Also, the GI tract is the most common site of extranodal NHLs, and most NHLs involving the GI tract are of B-cell lineage, of which diffuse large B-cell lymphoma is the most common subtype, irrespective of location. The last few years have seen digital pathology as a vital technology that has a positive impact on diagnostics, but studies on the use of DP for lymphoma identification, however, are still restricted to only determining whether a tumor is present or absent. Using the example of cases of malignant NHL, we aim to investigate the diagnostic utility of DP using QuPath software in evaluating the proliferation index and the prognostic significance and to show that improved visualization and analysis contribute to the convergence of these complementary diagnostic modalities for lymphomas. The average proliferation index (Ki67) was 58.33% with values between 10% and 85%. After the stratification of the cases, an increased proliferation index was observed in the majority of cases (53.33%), and this aspect was associated with the advanced age of the patients (p = 0.045). Visual assessment provides lower Ki67 values than automated digital image analysis. However, the agreement coefficient between the conventional method and the AI method indicates an excellent level of reliability (ICC1–0.970, ICC2–0.990). The multivariate analysis revealed that in the cases where the proliferation index Ki67 is high (˃70%), the IPI score represents an important risk factor predicting mortality (HR = 10.597, p = 0.033).
  • NET G3 vs NEC: p53 and Rb1 Immunolabeling in High-grade Gastrointestinal Neuroendocrine Neoplasms-Is It Enough for the Differential Diagnosis?
    Alexandra Dinu, Mariana Aschie, Georgeta Camelia Cozaru, Anca Florentina Mitroi, Catalin Nicolae Grasa, et al.
    Journal of Gastrointestinal and Liver Diseases, 2023
  • Clinicopathological Outlines of Post-COVID-19 Pulmonary Fibrosis Compared with Idiopathic Pulmonary Fibrosis
    Roxana-Elena Cîrjaliu, Mariana Deacu, Ioana Gherghișan, Angela-Ștefania Marghescu, Manuela Enciu, et al.
    Biomedicines, 2023
  • Morphopathological features induced by SARS-CoV-2 infection-a series of 57 autopsies
    M. Deacu, M. Enciu, A. Nicolau, G. Bălțătescu, L. Neculai-Cândea, et al.
    Histology and Histopathology, 2023
  • Rare paratesticular localization of dedifferentiated liposarcoma: Case report and review of the literature
    Mariana Deacu, Mariana Aschie, Madalina Bosoteanu, Sorin Vamesu, Gabriela-Izabela Baltatescu, et al.
    Medicine United States, 2023
  • PD-L1, CD4+, and CD8+ Tumor-Infiltrating Lymphocytes (TILs) Expression Profiles in Melanoma Tumor Microenvironment Cells
    Bogdan Marian Caraban, Elena Matei, Georgeta Camelia Cozaru, Mariana Aşchie, Mariana Deacu, et al.
    Journal of Personalized Medicine, 2023
  • Umbilical Cord Teratoma–A Short Case Report
    Manuela Enciu, Gabriela Izabela Baltatescu, Oana Cojocaru, Ionut Burlacu, Viorel Constantin Cristurean, et al.
    Fetal and Pediatric Pathology, 2023
  • Implications of Cellular Immaturity in Necrosis and Microvascularization in Glioblastomas IDH-Wild-Type
    Cristian Ionut Orasanu, Mariana Aschie, Mariana Deacu, Madalina Bosoteanu, Sorin Vamesu, et al.
    Clinics and Practice, 2022
  • Characterization of the Tumor Microenvironment and the Biological Processes with a Role in Prostatic Tumorigenesis
    Cristina-Anita Ionescu, Mariana Aschie, Elena Matei, Georgeta Camelia Cozaru, Mariana Deacu, et al.
    Biomedicines, 2022
  • HPV and HIV Coinfection in Women from a Southeast Region of Romania—PICOPIV Study
    Simona Claudia Cambrea, Mariana Aschie, Ghiulendan Resul, Anca Florentina Mitroi, Anca Chisoi, et al.
    Medicina Lithuania, 2022
  • Morphological and Ancillary Features of Uterine Leiomyosarcoma: Case Report
    Mădălina Boșoteanu, Raluca Ioana Vodă, Mariana Așchie, Luana-Andreea Bosoteanu, Gabriela Izabela Bălțătescu
    Clinical Pathology, 2022
  • A Case of Giant Mesenchymal Uterine Tumor: Lipoleiomyoma
    Madalina Bosoteanu, Raluca Ioana Vodă, Cristian Ionut Orasanu, Mariana Aschie, Manuela Enciu, et al.
    American Journal of Case Reports, 2022
  • Assessment of programmed death-ligand 1 receptor immunohistochemical expression and its association with tumor-infiltrating lymphocytes and p53 status in triple-negative breast cancer
    Mariana Deacu, Liliana-Ana Tuţă, Mădălina Boşoteanu, Mariana Aşchie, Anca Florentina Mitroi, et al.
    Romanian Journal of Morphology and Embryology, 2021
  • Syphilis associated with abdominal trauma and splenic rupture in pregnancy
    Liliana Steriu, Roxana-Cleopatra Penciu, Corina Mădălina Nour, Silvia Izvoranu, Iulia-Diana Mocanu, et al.
    Romanian Journal of Morphology and Embryology, 2020
  • Is there a relationship in-between ovarian endometriosis and ovarian cancer? Immunohistochemical profile of four cases with coexisting ovarian endometriosis and cancer
    Roxana-Cleopatra Penciu, Iulia Postolache, Liliana Steriu, Silvia Izvoranu, Andrei-Adrian Tica, et al.
    Romanian Journal of Morphology and Embryology, 2020
  • CD10, CD34 and Ki67 immunohistochemical markers expression in endometriosis and adenomyosis
    Roxana-Cleopatra Penciu, Liliana Steriu, Silvia Izvoranu, Iulia Postolache, Andrei-Adrian Tica, et al.
    Revista De Chimie, 2019

RECENT SCHOLAR PUBLICATIONS

  • Clinical Relevance of Biomarkers in Prostate Cancer: The Role of NKX3. 1, AMACR, and Ki-67 in Risk Stratification-A Comprehensive Clinicopathological Analysis
    MC Roşu, M Enciu, M Aşchie, CA Ionescu, M Pundiche, N Dobrin, ...
    Chirurgia (Bucharest, Romania: 1990) 121 (2), 162-171 , 2026
    2026
  • Dysregulated Cell Signaling Pathways in Prostate Tumoral Plasticity—Checkpoints
    ME Elena Matei, Ionuț Ciprian Iorga, Mariana Deacu, Georgeta Camelia Cozaru ...
    Oncology Research , 2026
    2026
  • Clinical Relevance of Biomarkers in Prostate Cancer: The Role of NKX3. 1, AMACR, and Ki-67 in Risk Stratification
    MC Roæu, M Enciu, M Aæchie, CA Ionescu, M Pundiche, N Dobrin, ...
    Chirurgia 121, 162-171 , 2026
    2026
  • Challenges and Clinical Implications of Prostate Cancer Mimickers. A Study Conducted at a Tertiary Center
    MC Roæu, DL Zob, CA Ionescu, B Cîmpineanu, M Pundiche, GC Cozaru, ...
    Chirurgia (Bucharest, Romania: 1990) 120 (6), 685-695 , 2025
    2025
    Citations: 1
  • Clinically Advanced Warty Invasive Squamous Cell Carcinoma of the Cervix with p16 Overexpression—Case Study and Literature Review
    LA Petrică, M Deacu, GC Cozaru, GI Bălţătescu, M Aşchie
    Reports 8 (4), 243 , 2025
    2025
  • Interplay Between Immune Microenvironment CD8 + Tumor-Infiltrating Lymphocytes and PDL-1 Expression as Prognostic Markers in Invasive Cervical Squamous …
    LA Petrică, M Deacu, GC Cozaru, AF Mitroi, GI Bălţătescu, M Enciu, ...
    Medicina 61 (11), 2007 , 2025
    2025
    Citations: 1
  • Mucinous Tubular and Spindle Cell Carcinoma of the Kidney: A Rare Renal Neoplasm—Case Report and Literature Review
    I Burlacu, M Aşchie, M Boşoteanu, GI Bălţătescu, A Dinu
    Reports 8 (4), 189 , 2025
    2025
    Citations: 1
  • Hydatid Cyst in Pregnancy—A Diagnostic and Therapeutic Dilemma: Study Case Report
    L Steriu, IE Iordache, A Bisinicu, BA Steriu, G Baltatescu, AN Twakor, ...
    Journal of Clinical Medicine 14 (14), 5073 , 2025
    2025
    Citations: 1
  • Cutting edge: A comprehensive guide to colorectal cancer surgery in inflammatory bowel diseases
    IE Iordache, LF Herlo, R Popescu, DO Costea, L Alexandrescu, ...
    Journal of Mind and Medical Sciences 12 (1), 6 , 2025
    2025
    Citations: 2
  • 17p13. 1 Deletion in Small B-cell Lymphocytic Lymphomas: A Prognostic Factor and Diagnostic Approach
    AG STOICA, M CRISTIAN, M ASCHIE, AF MITROI, GC COZARU, ...
    Revista Romana de Hematologie 3 (1) , 2025
    2025
  • Twisted troubles: a rare case of intestinal obstruction due to endometriosis and a review of the literature
    IE Iordache, L Alexandrescu, AD Nicoara, R Popescu, N Leopa, ...
    Clinics and Practice 14 (5), 2027-2043 , 2024
    2024
    Citations: 4
  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN)-a diagnostic challenge
    M Cristian, L Seicaru, R Polimaru, G Baltatescu, E Calin, A Caloian, ...
    VIRCHOWS ARCHIV 485, S309-S309 , 2024
    2024
  • Recto-Sigmoid Synchronous Malignant Tumor with Lack of MLH1 and PMS2 Expression: Case Report and Literature Review
    AC Ghioldis, V Sarbu, M Deacu, M Enciu, A Dinu, GI Baltatescu, R Talpes, ...
    ARS Medica Tomitana 29 (3), 175-183 , 2024
    2024
  • The impact of MYD88 and PIM1 in mature large B-cell non-Hodgkin lymphomas: Defining element of their evolution and prognosis
    M Cristian, M Așchie, AF Mitroi, M Deacu, M Boșoteanu, GI Bălțătescu, ...
    Medicine 103 (6), e36269 , 2024
    2024
  • Clinico-Morphological Features and Immunohistochemical Profile of a Rare Case of Three Synchronous Primary Malignancies in the Female Genital Tract. Reports 2024, 7, 14
    RI Vodă, GI Baltatescu, M Aschie, LA Nurla, CI Orasanu
    2024
  • CD8-Lymphocytic Phenotype Significance in Primary Multiple and Familial Melanoma with Various CDKN2A Mutational Status
    LA Boşoteanu, E Gheorghe, M Aşchie, GC Cozaru, M Deacu, ...
    Medicina 59 (12), 2151 , 2023
    2023
  • The predictive role of the histopathological scoring system in adipose tumors—lipoma, atypical lipomatous tumor, and liposarcoma
    M Deacu, M Bosoteanu, M Enciu, GC Cozaru, O Cojocaru, GI Baltatescu, ...
    Diagnostics 13 (24), 3606 , 2023
    2023
    Citations: 8
  • CMV and HIV Coinfection in Women from a Region in Eastern Europe
    S Halichidis, M Aschie, GC Cozaru, M Manea, N Dobrin, SE Vlad, E Matei, ...
    Journal of Personalized Medicine 13 (11), 1539 , 2023
    2023
    Citations: 4
  • Paratesticular Ectopic Adrenal Rests: Case Report and Ancillary Features
    A Dinu, I Burlacu, M Aschie, M Deacu, I Poinareanu, IC Iorga, R Talpes, ...
    ARS Medica Tomitana 28 (3), 123-126 , 2023
    2023
  • Comparison of Ki67 proliferation index in gastrointestinal non-Hodgkin large B-cell lymphomas: the conventional method of evaluation or AI evaluation?
    M Cristian, M Așchie, M Deacu, M Boșoteanu, GI Bălțătescu, AG Stoica, ...
    Diagnostics 13 (17), 2775 , 2023
    2023
    Citations: 7

MOST CITED SCHOLAR PUBLICATIONS

  • HPV and HIV coinfection in women from a southeast region of Romania—PICOPIV Study
    SC Cambrea, M Aschie, G Resul, AF Mitroi, A Chisoi, AA Nicolau, ...
    Medicina 58 (6), 760 , 2022
    2022
    Citations: 28
  • PD-L1, CD4+, and CD8+ tumor-infiltrating lymphocytes (TILs) expression profiles in melanoma tumor microenvironment cells
    BM Caraban, E Matei, GC Cozaru, M Aşchie, M Deacu, M Enciu, ...
    Journal of personalized medicine 13 (2), 221 , 2023
    2023
    Citations: 21
  • A case of giant mesenchymal uterine tumor: Lipoleiomyoma
    M Bosoteanu, RI Vodă, CI Orasanu, M Aschie, M Enciu, GI Baltatescu
    The American journal of case reports 23, e934913-1 , 2022
    2022
    Citations: 15
  • Characterization of the tumor microenvironment and the biological processes with a role in prostatic tumorigenesis
    CA Ionescu, M Aschie, E Matei, GC Cozaru, M Deacu, AF Mitroi, ...
    Biomedicines 10 (7), 1672 , 2022
    2022
    Citations: 13
  • Morphopathological features induced by SARS-CoV-2 infection—A series of 57 autopsies
    M Deacu, M Enciu, AA Nicolau, GI Bălţătescu, LS Neculai-Cândea, ...
    Histol. Histopathol 38, 513-524 , 2023
    2023
    Citations: 12
  • Laryngeal primary malignant melanoma: a case report
    O Cojocaru, M Aşchie, L Mocanu, GI Baltatescu
    Rom J Morphol Embryol 56 (4), 1513-1516 , 2015
    2015
    Citations: 11
  • Clinico-pathological and molecular subtypes of male breast carcinoma according to immunohistochemistry
    M Aşchie, GI Bălţătescu, A Mitroi
    Rom J Morphol Embryol 54 (3 Suppl), 749-755 , 2013
    2013
    Citations: 10
  • Clinicopathological outlines of post-COVID-19 pulmonary fibrosis compared with idiopathic pulmonary fibrosis
    RE Cîrjaliu, M Deacu, I Gherghișan, AȘ Marghescu, M Enciu, ...
    Biomedicines 11 (6), 1739 , 2023
    2023
    Citations: 9
  • NET G3 vs NEC: p53 and Rb1 Immunolabeling in High-grade Gastrointestinal Neuroendocrine Neoplasms-Is It Enough for the Differential Diagnosis?
    A Dinu, M Aschie, GC Cozaru, AF Mitroi, CN Grasa, IE Iordache, M Deacu, ...
    Journal of Gastrointestinal & Liver Diseases 32 (2) , 2023
    2023
    Citations: 9
  • Implications of cellular immaturity in necrosis and microvascularization in glioblastomas IDH-wild-type
    CI Orasanu, M Aschie, M Deacu, M Bosoteanu, S Vamesu, M Enciu, ...
    Clinics and Practice 12 (6), 1054-1068 , 2022
    2022
    Citations: 9
  • Morphological and ancillary features of uterine leiomyosarcoma: case report
    M Boșoteanu, RI Vodă, M Așchie, LA Bosoteanu, GI Bălțătescu
    Clinical Pathology 15, 2632010X221105224 , 2022
    2022
    Citations: 9
  • Is there a relationship in-between ovarian endometriosis and ovarian cancer? Immunohistochemical profile of four cases with coexisting ovarian endometriosis and cancer
    RC Penciu, I Postolache, L Steriu, S Izvoranu, AA Tica, ID Mocanu, ...
    Romanian journal of morphology and embryology 61 (1), 157 , 2020
    2020
    Citations: 9
  • The predictive role of the histopathological scoring system in adipose tumors—lipoma, atypical lipomatous tumor, and liposarcoma
    M Deacu, M Bosoteanu, M Enciu, GC Cozaru, O Cojocaru, GI Baltatescu, ...
    Diagnostics 13 (24), 3606 , 2023
    2023
    Citations: 8
  • Comparison of Ki67 proliferation index in gastrointestinal non-Hodgkin large B-cell lymphomas: the conventional method of evaluation or AI evaluation?
    M Cristian, M Așchie, M Deacu, M Boșoteanu, GI Bălțătescu, AG Stoica, ...
    Diagnostics 13 (17), 2775 , 2023
    2023
    Citations: 7
  • CD10, CD34 and Ki67 immunohistochemical markers expression in endometriosis and adenomyosis
    RC Penciu, L Steriu, S Izvoranu, I Postolache, AA Tica, D Mocanu, ...
    Rev Chim (Bucharest) 70 (4), 1323-1327 , 2019
    2019
    Citations: 7
  • Synchronous ovarian dysgerminoma and breast carcinoma in a patient with positive immunostain of BRCA1
    GI Baltatescu, M Aschie, V Sârbu
    Chirurgia 108 (2), 259-263 , 2013
    2013
    Citations: 6
  • Rare paratesticular localization of dedifferentiated liposarcoma: Case report and review of the literature
    M Deacu, M Aschie, M Bosoteanu, S Vamesu, GI Baltatescu, GC Cozaru, ...
    Medicine 102 (11), e33265 , 2023
    2023
    Citations: 5
  • Assessment of programmed death-ligand 1 receptor immunohistochemical expression and its association with tumor-infiltrating lymphocytes and p53 status in triple-negative breast …
    M Deacu, LA Tuţă, M Boşoteanu, M Aşchie, AF Mitroi, AA Nicolau, ...
    Romanian Journal of Morphology and Embryology 62 (1), 63 , 2021
    2021
    Citations: 5
  • Overexpression of Survivin-1, TAG-72 and HERC5 in patients diagnosed with hepatocellular carcinoma in the Black Sea coast geographical area
    AI Suceveanu, IS Micu, GI Baltatescu, LC Petcu, N Dobrin, C Brinzan, ...
    Experimental and Therapeutic Medicine 21 (3), 284 , 2021
    2021
    Citations: 5
  • The Role of Artificial Intelligence for Image Analysis in Surgical Pathology.
    GI Baltatescu, M Așchie, M Deacu, LC Petcu, N Dobrin, AA Nicolau, ...
    Annals of the University Dunarea de Jos of Galati: Fascicle: I, Economics … , 2020
    2020
    Citations: 5