M SHANKAR
@accp.co.in
Associate Professor, IQAC Director ACU/ Pharmacy
Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University
Dr. M. SHANKAR M. Pharm., Ph. D., MBA. Associate Professor, IQAC Director
Department of Pharmaceutical Chemistry
Sri Adichunchanagiri College of Pharmacy, BG Nagara, Karnataka.
Mobile No: +91-9177636562.
Email: shankarmanichellappa@, shankarm@
In Pharma backed by Ph. D, Master in Pharmacy, MBA & Bachelor of Pharmacy. Currently working as an Associate Professor in the Department of Pharmaceutical Chemistry in Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Karnataka.
EDUCATION
Ph. D
Course : Ph.D
Department : Pharmacy
Year : 2013-2021
University : Himalayan University
Post Graduation
Course : MBA
Department : Health Care and Hospital Management
Duration : 2011-2013
Institution : Belgium University, Europe.
Percentage : 65.01%
Project
Role and importance of Healthcare Industries
Post Graduation
Course : M. Pharm
Department : Pharmaceutical Chemistry
Duration : 2008-2010
Institution : JKKMMRF College of pharmacy
University : The Tamil Nadu Dr. M.G.R. Medical University, Chennai
Percentage : 76.50 %
RESEARCH INTERESTS
1. Pre-Clinical studies
2. Drug Metabolism and Pharmacokinetic studies (In-vitro & In-vivo studies)
3. Bio-analytical Research and development
4. Drug discovery process (Medicinal chemistry)
5. Biological evaluations of medicinal compounds by using in vitro and in vivo models
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Aina Akmal Mohd Noor, Siti Nurul Najiha Othman, Pei Teng Lum, Shankar Mani, Mohd. Farooq Shaikh, and Mahendran Sekar
EManuscript Technologies
Pongamia pinnata (Linn.) belongs to the Fabaceae family which contribute to folklore medicine for such a long time to treat various types of human ailments. This plant is commonly known as Karanja in Hindi, Bengali, and Sanskit. It is known as malapari in Indonesia, mempari in Malaysia and Karum tree in English.1 Karanjin is one of the major phytoconstituent of P. pinnata and categorized under a furanoflavonol group; a type of flavonoid that obtained extensively from the seeds of Karanja tree. Karanjin belongs to the class of Benzofuran flavonoids since they contain fused benzene and furan ring in their molecular structure.2 Phytoconstituents of karanjin are mainly contained flavonoids and in fixed inedible oils. Successful biological activities explored are potentially due to the inherent karanjin content in P. pinnata.3 The versatility of the usage of karanjin can also be seen in agriculture purposes such as in biodiesel.4 Thousands of plants existing in nature are an enormous pool of bioactive molecules that can be established as new derivatives, analogs, chemical entities, and synthetic compounds with natural product derivative pharmacophores or as natural product mimics. The identification of the right chemical entity is the only requirement. This review deals with the chemistry and up-todate information about the biological properties of karanjin. METHODS
Puteri Zarith Sofea Yusri, Nurin Fatini Ghazali, Nurul Azima Mazlan, Pei Teng Lum, Aina Akmal Mohd Noor, Shankar Mani, and Mahendran Sekar
GP Innovations Pvt. Ltd.
Mangiferinis a xanthone glycoside, naturally isolated from Mangiferaindica. Mangiferinhas been reported for a wide range of pharmacological activities and its anticancer potential is very well known. However, the mangiferinanti-cancer potency isinadequate due to its poor water solubility. N,O-Carboxymethyl Chitosan (N,O-CMC) is a smart biopolymer, in which itsbiocompatible, biodegradable and non-toxic making itideal for abundant biological applications include the delivery of lipid soluble drugs. Also useful to improve and replace biological tissues and gene therapy. Hence, this study attempts to synthesize and characterize mangiferin-N,O-CMC nanoparticles and evaluate its antioxidant and cytotoxic properties. The mangiferin-N,O-CMC nanoparticles were prepared by loading mangiferin into N,O-CMC nanoparticles and characterized by FT-IR, DLS, SEM, Zeta potential and XRD measurements. In-vitro antioxidant was carried out by the DPPH method. The cytotoxic effect of mangiferin-N,O-CMC nanoparticles was carried out on Osteosarcoma MG-63 and 3T3 cells by using the MTT assay method. The synthesized mangiferin-N,O-CMC nanoparticles with particle size ranges from 200±10 nm. The charge of N,O-CMC nanoparticles were confirmed by Zeta potential and found to be −45.8 mV. In the DPPH method, mangiferin-N,O-CMC nanoparticles showed IC50 value between 8-16 µg/ml. In MTT assay, mangiferin-N,O-CMC nanoparticles exhibited a significant reduction in the growth of osteosarcoma MG-63 cells and there is no toxic effect against normal 3T3 cells. These findings designated that the synthesized mangiferin-N,O-CMC nanoparticles were very efficient nanocarrier in delivering the mangiferinto cancer cells. In the future, further studies with in-vivo models to be carried out on mangiferin-N,O-CMC nanoparticles to confirm its safety and effectiveness.
Siti Nurul Najiha Othman, Pei Teng Lum, Siew Hua Gan, Shankar Mani, and Mahendran Sekar
EManuscript Technologies
Chemotherapy is the main treatment strategies for cancer patients which may be used alone or in combination with surgery and/or radiotherapy. Chemotherapy is the delivery of cytotoxic agents that have cell-killing activities in order to reduce tumor size or any residuals which creates extensive side effects.1 These side effects include general cell-damaging effects including decreased blood cells, myelosuppression and immunosuppression. More specific side effects are nephrotoxicity, neurotoxicity, testicular dysfunction, cardiotoxicity and hepatotoxicity.2-4 Nevertheless, problems such as myocardial toxicity, ischemia and arrhythmia may arise with the usage of certain anticancer treatment such as anthracyclines and 5-fluorouracil.5 Among all the cardiotoxicity events, cardiac dysfunction and heart failure are reported to be among the most serious cardiovascular disease due to the administration of systemic cancer drugs like anthracyclines and 5-fluorouracil which can be acute or delayed response.5,6
Nurin Fatini Ghazali, Puteri Zarith Sofea Yusri, Nurul Azima Mazlan, Pei Teng Lum, Aina Akmal Mohd Noor, S. Mani and M. Sekar
Embelin is a long alkyl chain substituted hydroxy benzoquinone and naturally isolated from Embelia ribes. Embelin was reported for a widespread range of pharmacological properties that including anticancer activity. However, the potency of embelin as an anticancer molecule is inadequate due to its high lipophilicity. N,O-Carboxymethyl Chitosan (N,O-CMC) are elegance biopolymers which are toxic-free, biodegradable and biocompatible. This is seemly appropriate for numerous biological utilization, such as gene therapy, drug administration and tissue engineering. Hence, in the present study, we aimed to synthesize and characterize embelin loaded N,O-CMC nanoparticles and study its antioxidant and cytotoxic properties. The embelin N,OCMC nanoparticles were prepared by loading embelin into N,O-CMC nanoparticles and characterized by FT-IR, DLS, SEM, Zeta potential and XRD measurements. Antioxidant and cytotoxic studies were conducted for the synthesized embelin loaded N,O-CMC nanoparticles using DPPH and MTT assay methods, respectively. The synthesized embelin loaded N,O-CMC nanoparticles with particle size ranges from 650-850 nm. The charge of embelin loaded N,OCMC nanoparticles were confirmed by Zeta potential measurement and the value was found to be 47.8 mV. In the DPPH method, embelin loaded N,OCMC nanoparticles showed IC50 value between 125-250 g/ml. In MTT assay, embelin loaded N,O-CMC nanoparticles exhibited a significant reduction in the growth of osteosarcoma MG-63 cells. At the same time, it doesn’t produce any toxic effect against 3T3 cells, which are normal cells. These findings demonstrating that the embelin loaded N,O-CMC nanoparticles were efficient nanocarrier for delivering embelin to cancer cells.
Siti Nurul Najiha Othman, Pei Teng Lum, Aina Akmal Mohd Noor, Nurul Azima Mazlan, Puteri Zarith Sofea Yusri, Nurin Fatini Ghazali, Hikmah Mohd Idi, Shazalyana Azman, Masitah Ismail, Shankar Mani,et al.
GP Innovations Pvt. Ltd.
Malaysia is rich in natural and herbal resources which have the potential to be used as traditional medicine as well as cosmetics. These plant sources are used by the folklore to help in enriching their beauty. Leaves, fruits, flowers and roots of medicinal plants in Malaysia are used in cosmetic formulations to get different biological effects. Health issues with particular reference to skin issues, such as acne, dry skin, dull skin and alopecia can be alleviated by using these plants. Since time immemorial, herbal products have been used in maintaining and enhancing physical appearance of humans. Herbal cosmetics have growing demand in the world market and is an invaluable gift of nature. This review is about ten commonly available medicinal plants in Malaysia used in the cosmetic formulations which includes Aloe vera, Curcuma longa, Cocos nucifera, Cucumis sativus, Melaleuca alternifolia, Punica granatum, Garcinia mangostana, Carica papaya, Lawsonia inermis and Hibiscus rosasinensis. These are the ten plants that are commonly used traditionally in treating many skin conditions and hair problems. Different parts of the plant may produce different beneficial effects to the consumers. Using the herbal and natural ingredients in cosmetics alleviates the side effects almost to nil. This is predominantly lower than the side effects caused by synthetic cosmetics.
M. N. L. Aishwarya, M. Shankar, J. Mounika, S. Ashifa, N. Sireesha, P. Mounika, and M. Niranjan Babu
Diva Enterprises Private Limited
M. Shankar, A. Balasubramaniam, N. L. Gowrishankar, and S. Mahendran
Springer Science and Business Media LLC
3-O-benzyl-1,2-O-isopropylidene-xylopentadialdose has emerged as structurally new antibacterial and anti-inflammatory agent. Therefore, various substituted bis-indolyl-(3-O-benzyl-1,2-O-isopropylidene-xylopentadialdose glucofuranose) derivatives were synthesized by addition of substituted xylopentadialdose with various substituted indoles. The structures of the synthesized compounds were characterized by IR, 1H NMR, 13C NMR, and mass spectroscopy techniques. All the synthesised compounds showed maximum zone of inhibition againt both Gram-positive and Gram-negative organisms. In the anti-inflammatory activity test, three compounds (1, 3 and 5) produced significant activity in a dose-dependent manner.
M. Shankar, A. Balasubramaniam, N. L. Gowrishankar, and S. Mahendran
Springer Science and Business Media LLC
3-O-benzyl-1,2-O-isopropylidene-xylopentadialdose has emerged as structurally new antibacterial and anti-inflammatory agent. Therefore, various substituted bis-indolyl-(3-O-benzyl-1,2-O-isopropylidene-xylopentadialdose glucofuranose) derivatives were synthesized by addition of substituted xylopentadialdose with various substituted indoles. The structures of the synthesized compounds were characterized by IR, 1H NMR, 13C NMR, and mass spectroscopy techniques. All the synthesised compounds showed maximum zone of inhibition againt both Gram-positive and Gram-negative organisms. In the anti-inflammatory activity test, three compounds (1, 3 and 5) produced significant activity in a dose-dependent manner.