Somaiah Almubayedh
@uwindsor.ca
University of Windsor
Scopus Publications
Scopus Publications
Somaiah Almubayedh and James R. Green
Royal Society of Chemistry (RSC)
The SnCl4 mediated reactions of cross conjugated aryl enynone-Co2(CO)6 and dienynone-Co2(CO)6 complexes afford benzocycloheptynone complexes or cycloheptenynone complexes in a thermal vinylogous Nazarov process.
Abir S. Abdel-Naby, Sara Nabil, Sarah Aldulaijan, Ibtisam M. Ababutain, Azzah I. Alghamdi, Somaiah Almubayedh, and Khaled D. Khalil
MDPI AG
Chitosan-aluminum oxide nanocomposite was synthesized, characterized, and used as a green heterogeneous catalyst to synthesize novel imidazopyrazolylthione derivatives. Nanocomposite polymeric material was characterized by EDS-SEM and XRD. The powerful catalytic activity, and its base character of the nanocomposite, was used to synthesize imidazopyrazolylthione (1) in a good yield compared to traditional cyclocondensation synthesis. Using the nanocomposite catalyst, substitution of the thiol group (1) afforded the corresponding thiourea (2) and the corresponding ester (3). The efficiency of the nanocomposite over the traditional base organic catalyst, Et3N and NaOH, makes it an effective, economic, and reproducible nontoxic catalyst. Moreover, the heterogeneous nanocomposite polymeric film was easily isolated from the reaction medium, and recycled up to four times, without a significant loss of its catalytic activity. The newly synthesized derivatives were screened as antibacterial agents and showed high potency. Molecular docking was also performed for a more in-depth investigation. The results of the docking studies have demonstrated that the docked compounds have strong interaction energies with both Gram-positive and Gram-negative bacteria.
Somaiah Almubayedh and M'hamed Chahma
Royal Society of Chemistry (RSC)
A stable poly(terthiophene)-bearing-verdazyl radical has been prepared using the electrochemical oxidation of either the parent radical or its precursor.