Population-based national incidence of thyroid dysfunction in Spain Silvia Patricia Alonso, Natalia Colomo, Ana Lago-Sampedro, Cristina Maldonado-Araque, Eduardo García-Fuentes, Carolina Gutiérrez-Repiso, María José Tapia-Guerrero, Inmaculada Rueda, Pilar Ocón Sánchez, Wasima Oualla-Bachiri, Alfonso Calle-Pascual, Luis Castaño, Elías Delgado-Álvarez, Edelmiro Menéndez-Torre, Josep Franch-Nadal, Inés Urrutia, Juan Girbés, Felipe Javier Chaves, Eduard Montanya, Gemma Rojo-Martínez, Sergio Valdés Scientific Reports, 2026 Thyroid dysfunction is a common health disorder. However, data on its incidence remain scarce and geographically limited. This study aimed to assess the incidence of thyroid dysfunction in the Spanish adult population and factors associated with its onset. A nationwide observational population‑based cohort study was conducted, including 1,629 euthyroid individuals (not receiving levothyroxine/thionamides, and TSH levels of 0.2-5.0mIU/mL) at baseline (2008-2010), who were re-evaluated in 2016-2017. Multivariable logistic regression analysis assessed the association between incident thyroid dysfunction and potential exposure factors. ROC analysis identified optimal TPOAb and TSH cut-offs for predicting incident hypothyroidism. The age- and sex-adjusted incidence of hypothyroidism was 13.38cases/1,000persons-year (CI95% 10.52-16.25) for TSH ≥ 5mIU/mL, and 6.78cases/1,000persons-year (CI95% 4.73-8.83) for TSH ≥ 10mIU/mL. The incidence of hyperthyroidism was 2.65cases/1,000persons-year (CI95% 1.46-3.83). Female sex, age between 30 and 40 and > 60 years, TPOAb > 20mIU/L and TSH > 2.8mIU/mL were independently associated with new cases of hypothyroidism. The presence of obesity, diabetes or urinary iodine levels were not associated with the incidence of thyroid disease. Baseline TPOAb and TSH cut-offs best predicting hypothyroidism were 9.1mIU/L (AUC 0.654; CI95% 0.583-0.725; p < 0.001), and 2.03mIU/mL (AUC 0.702; CI95% 0.639-0.766; p < 0.001) respectively. This study provides data on incidence rates and risk factors of thyroid dysfunction in the adult Spanish population.
Increased levels of serum surfactant protein D are associated with cardiovascular disease incidence in the Spanish adult population: Di@bet.es study Wasima Oualla‐Bachiri, Ana Lago‐Sampedro, Eva García‐Escobar, Cristina Maldonado‐Araque, Elías Delgado, Felipe J. Chaves, Luis Castaño, Alfonso Calle‐Pascual, Josep Franch‐Nadal, Gabriel Olveira, Gemma Rojo‐Martínez, Viyey Doulatram‐Gamgaram, Sergio Valdés European Journal of Clinical Investigation, 2026 Aims Cardiovascular disease (CVD) remains the leading cause of mortality. New biomarkers are needed to improve CVD risk prediction. Several studies have reported associations between surfactant protein D (SP‐D), an innate immune system component, and CVD; however, general population studies remain scarce. The main aim of this study was to investigate the association between SP‐D and CVD events incidence in the Spanish general adult population. Methods Socio‐demographic, lifestyle (including smoking status) and clinical data from 1707 participants of the di@bet.es cohort without previous CVD events were collected and analysed. CVD events (including both morbidity and mortality) were reported at baseline and after 7.5 years of follow‐up. SP‐D serum levels were measured by ELISA and categorized in quartiles. Results SP‐D categories are associated with CVD events incidence, independently from other strong risk factors such as cardiovascular risk scores (SCORE2 and SCORE2‐OP), BMI, hs‐CRP, or eGFR. Although SP‐D has been linked to smoking, SP‐D categories predicted CVD events incidence even among non‐smokers. The addition of SP‐D to multivariate models improved performance in the assessment, predicting 83% of the events with a specificity of 74% and a sensitivity of 84% in the overall population. Conclusions SP‐D may be considered as a promising biomarker of CVD events in combination with other well established factors in clinical practice.
Extrachromosomal Circular DNA and Transposable Elements in Type 2 Diabetes Celeste Moya-Valera, Alex Fernando Arita, Francisco Lara-Hernández, Ana-Bárbara García-García, Felipe Javier Chaves International Journal of Molecular Sciences, 2025 Type 2 Diabetes (T2D) is a complex disease that arises from interaction between genetic and environmental factors. The activation of transposable elements (TEs) and the production of circular extrachromosomal DNA (eccDNA) may represent genetic mechanisms involved in cellular aging, metabolic alterations, and T2D development through distinct pathways. Although the origin and characteristics of TEs and eccDNA differ substantially, eccDNA can in some cases be derived from TEs. This review summarizes the current understanding of these mechanisms and examines the reported associations between T2D and either TEs or eccDNAs. These findings highlight the significant involvement of these molecules in disease pathogenesis, particularly in relation to aging, and underscore their great potential as biomarkers and targets for T2D prevention.
Surfactant Protein D Mediates the Association Between Smoking and Type 2 Diabetes Mellitus Incidence in the Spanish Adult Population: Di@bet.es Study Wasima Oualla-Bachiri, Ana Lago-Sampedro, Eva García-Escobar, Cristina Maldonado-Araque, Viyey Doulatram-Gamgaram, Marta García-Vivanco, Fernando Martín-Llorente, Juan Luis Garrido, Elías Delgado, Felipe J. Chaves, Luis Castaño, Alfonso Calle-Pascual, Josep Franch-Nadal, Gabriel Olveira, Sergio Valdés, Gemma Rojo-Martínez Journal of Xenobiotics, 2025 It is well known that environmental factors influence the risk of type 2 diabetes mellitus (T2DM). Several studies have linked the xenobiotics present in tobacco or air pollutants to T2DM development, although the underlying mechanisms remain unclear. Surfactant protein D (SP-D), an immune component released into the bloodstream after lung injury, has been associated with metabolic diseases. The aim of this study was to investigate whether SP-D mediates the effects of smoking or air pollution exposure on T2DM risk in the Spanish adult population. Socio-demographic, lifestyle (including smoking status) and clinical data from 2155 participants from the Di@bet.es cohort were analyzed. Annual concentrations of PM10, PM2.5, SO2, CO and NO2 according to participants’ residential address codes were used to study air pollution exposure. T2DM was diagnosed at baseline and after 7.5 years of follow-up. SP-D serum levels were measured by ELISA and categorized as above or below the 25th percentile. Our results revealed a higher percentage of smokers in the high SP-D category; however, no associations were observed between air pollutants (PM10, PM2.5, SO2, CO) and SP-D categories. Both smoking and elevated SP-D levels were found to increase the risk of T2DM independently. Mediation analysis indicated that SP-D mediates 14% of the effect of smoking on T2DM incidence in the Spanish adult population.
A machine learning approach for type 2 diabetes diagnosis and prognosis using tailored heterogeneous feature subsets J. Ramón Navarro-Cerdán, Pedro Pons-Suñer, Laura Arnal, Joaquim Arlandis, Rafael Llobet, Juan-Carlos Perez-Cortes, Francisco Lara-Hernández, Celeste Moya-Valera, Maria Elena Quiroz-Rodriguez, Gemma Rojo-Martinez, Sergio Valdés, Eduard Montanya, Alfonso L. Calle-Pascual, Josep Franch-Nadal, Elias Delgado, Luis Castaño, Ana-Bárbara García-García, Felipe Javier Chaves Medical and Biological Engineering and Computing, 2025 Type 2 diabetes (T2D) is becoming one of the leading health problems in Western societies, diminishing quality of life and consuming a significant share of healthcare resources. This study presents machine learning models for T2D diagnosis and prognosis, developed using heterogeneous data from a Spanish population dataset (Di@bet.es study). The models were trained exclusively on individuals classified as controls and undiagnosed diabetics, ensuring that the results are not influenced by treatment effects or behavioral changes due to disease awareness. Two data domains are considered: environmental (patient lifestyle questionnaires and measurements) and clinical (biochemical and anthropometric measurements). The preprocessing pipeline consists of four key steps: geospatial data extraction, feature engineering, missing data imputation, and quasi-constancy filtering. Two working scenarios (Environmental and Healthcare) are defined based on the features used, and applied to two targets (diagnosis and prognosis), resulting in four distinct models. The feature subsets that best predict the target have been identified based on permutation importance and sequential backward selection, reducing the number of features and, consequently, the cost of predictions. In the Environmental scenario, models achieved an AUROC of 0.86 for diagnosis and 0.82 for prognosis. The Healthcare scenario performed better, with an AUROC of 0.96 for diagnosis and 0.88 for prognosis. A partial dependence analysis of the most relevant features is also presented. An online demo page showcasing the Environmental and Healthcare T2D prognosis models is available upon request. Graphic abstract
Genetic interaction between oxidative stress and body mass index in a Spanish population Francisco Lara-Hernández, Rebeca Melero, María Elena Quiroz-Rodríguez, Celeste Moya-Valera, Mariana de Jesús Gallardo-Espinoza, Luis Álvarez, Ingrid Lizeth Valarezo-Torres, Laisa Briongos-Figuero, Jessica Abadía-Otero, Francisco Javier Mena-Martin, Guillermo Saez, Josep Redon, Juan-Carlos Martín-Escudero, Ana-Bárbara García-García, Guillermo Ayala, Felipe Javier Chaves Redox Biology, 2025 Oxidative stress may act as a contributing factor in the development of an elevated body mass index (BMI). Oxidative stress has the potential to modulate genetic activity at various levels, including gene transcription and protein function regulation. Nevertheless, the interplay between genetic variants and oxidative stress in relation to BMI remains to be elucidated. Based on this premise, we studied the potential association between 723 single-nucleotide polymorphisms (SNPs) located within a set of 212 genes and both BMI and oxidative stress parameters in 1502 adults from the general Spanish population (Hortega Study). Oxidative stress parameters measured included malondialdehyde (MDA) levels, 8-oxo-2'-deoxyguanosine (8-oxo-dG) levels and oxidised/reduced glutathione ratio (GSSG/GSH). We also examined the potential impact of the interaction between these SNPs and oxidative stress levels on BMI. The genes selected regulate several key biological processes, including obesity, blood pressure, inflammation, lipid metabolism and redox homeostasis. Our findings indicate a robust association between specific genes and both BMI and oxidative stress parameters. Significant BMI-related interactions between genes and oxidative stress parameters were identified, which have a multifactorial impact on oxidative stress modulation and on BMI. SNPs identified in genes such as NPPA, CPT1A, DDIT3, NOX and IL6ST were significantly associated with all oxidative stress parameters analysed, indicating a substantial influence on BMI modulation. The results provide compelling evidence of a significant relationship between oxidative stress levels and genetic background. Our data provide new insights into BMI modulation by oxidative stress levels, highlighting a role for TNF as a key player in the interrelation of oxidative stress and BMI.
The Interactive Effects of Fruit Intake Frequency and Serum miR-484 Levels as Biomarkers for Incident Type 2 Diabetes in a Prospective Cohort of the Spanish Adult Population: The Di@bet.es Study Ana Lago-Sampedro, Wasima Oualla-Bachiri, Cristina Maldonado-Araque, Sergio Valdés, Inmaculada González-Molero, Viyey Doulatram-Gamgaram, Elias Delgado, Felipe J. Chaves, Luis Castaño, Alfonso Calle-Pascual, Josep Franch-Nadal, Gemma Rojo-Martínez, Sara García-Serrano, Eva García-Escobar Biomedicines, 2025 Background/Objectives: Although evidence suggests that miR-484 and several fruit components are involved in glucose metabolism and insulin resistance metabolic pathways, the relationship between serum miR-484 levels and fruit consumption in relation to the risk of Type 2 diabetes (T2DM) remains elusive. The aim of this study was to evaluate the possible association between serum miR-484 levels and fruit intake frequency with the risk of T2DM in the Spanish adult population. Methods: 2234 subjects from the Di@bet.es cohort study without T2DM at baseline were studied. Socio-demographic, anthropometric and clinical data were recorded, as well as responses to a questionnaire on habits, including frequency of fruit consumption (daily vs. occasional). T2DM was diagnosed at baseline and after 7.5 years of follow-up. Baseline serum miR-484 levels were measured using real-time qPCR and categorized based on the 25th percentile. Association analyses were performed using logistic regression models adjusted for potential confounders. Interaction effects were evaluated on the multiplicative and additive scales. Results: There was no association between miR-484 levels and fruit intake frequency. Categorized miR-484 levels and fruit consumption were inversely and independently associated with the likelihood of incident T2DM. Analysis of the interaction effect suggests the presence of both positive multiplicative and additive interactions between miR-484 categories and fruit consumption frequency. Conclusions: Our study demonstrates a protective effect of daily fruit intake and high miR-484 levels regarding the risk of T2DM and supports the nutritional recommendations advocating daily fruit consumption. This study also suggests that the combined effect of low miR-484 levels and occasional fruit intake may increase the risk of T2DM beyond their independent effects.
Protective Effect of High Adherence to Mediterranean Diet on the Risk of Incident Type-2 Diabetes in Subjects with MAFLD: The Di@bet.es Study Ana Lago-Sampedro, Wasima Oualla-Bachiri, Sara García-Serrano, Cristina Maldonado-Araque, Sergio Valdés, Viyey Doulatram-Gamgaram, Gabriel Olveira, Elias Delgado, Felipe Javier Chaves, Luis Castaño, Alfonso Calle-Pascual, Josep Franch-Nadal, Gemma Rojo-Martínez, Eva García-Escobar Nutrients, 2024 Background/Objectives: Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) increases the risk of Type-2 Diabetes (T2DM). The Mediterranean diet (MD) has shown advantages in the management of MAFLD and preventing co-morbidities; however, its relationship with T2DM development in MAFLD has been less investigated. We aimed to evaluate the association of MD adherence with the risk of incident T2DM in the Spanish adult population with MAFLD and according to their weight gain at 7.5 years follow-up. Methods: A cohort of 714 participants (without weight increment: 377; with weight increment: 337) from the Di@bet.es cohort study with MAFLD and without T2DM at baseline were investigated. Anthropometric, sociodemographic, clinical data, and a survey on habits were recorded. OGTT and fasting blood biochemistry determinations were made. Baseline adherence to MD was estimated by the adapted 14-point MEDAS questionnaire and categorized as high and low adherence. Results: In total, 98 people developed T2DM at follow-up. The high adherence to MD was inversely associated with the development of T2DM in both the overall population (0.52 [0.31–0.87]) and subjects without weight gain at follow-up (0.35 [0.16–0.78]). Conclusions: Our results suggest the protective effect of high adherence to MD regarding the risk of T2DM in subjects with MAFLD, with this health benefit being more evident in men with the absence of weight gain. These results support the recommendations for MD use in these patients.
Cross-sectional association between severe periodontitis and diabetes mellitus: A nation-wide cohort study Eduardo Montero, Rocío Bujaldón, Eduard Montanya, Alfonso L. Calle‐Pascual, Gemma Rojo‐Martínez, Luis Castaño, Josep Franch‐Nadal, Elías Delgado, Felipe Chaves, Bettina Alonso, Mariano Sanz, David Herrera Journal of Clinical Periodontology, 2024 AimTo evaluate the cross‐sectional association between severe periodontitis and diabetes mellitus (DM), in a representative sample of Spanish population.Materials and MethodsThe di@bet.es epidemiological study is a population‐based cohort study aimed to determine the prevalence and incidence of DM in the adult population of Spain. The at‐risk sample at the final examination (2016–2017) included 1751 subjects who completed an oral health questionnaire. This questionnaire, together with demographic and risk factors, had been previously validated to build an algorithm to predict severe periodontitis in the Spanish population. Logistic regression models were used to evaluate the association between severe periodontitis and DM with adjustment for confounding factors.ResultsIn total, 144 subjects developed DM, which yielded 8.2% cumulative incidence. Severe periodontitis was detected in 59.0%, 54.7% or 68.8% of the subjects depending on three different selected criteria at the 2016–2017 exam. All criteria used to define severe periodontitis were associated with DM in unadjusted analysis, but the magnitude of the association decreased after adjusting for significant confounders. The criteria ‘≥50% of teeth with clinical attachment loss ≥5 mm’ presented an odds ratio of 4.9 (95% confidence interval: 2.2–10.7; p ≤ .001) for DM.ConclusionsSevere periodontitis is associated with DM in the Spanish population.
Association between exposure to air pollution and blood lipids in the general population of Spain Sergio Valdés, Viyey Doulatram‐Gamgaram, Cristina Maldonado‐Araque, Eva García‐Escobar, Sara García‐Serrano, Wasima Oualla‐Bachiri, Marta García‐Vivanco, Juan Luis Garrido, Victoria Gil, Fernando Martín‐Llorente, Alfonso Calle‐Pascual, Luis Castaño, Elías Delgado, Edelmiro Menéndez, Josep Franch‐Nadal, Sonia Gaztambide, Joan Girbés, F. Javier Chaves, José L. Galán‐García, Gabriel Aguilera‐Venegas, Joan Carles Vallvé, Núria Amigó, Montse Guardiola, Josep Ribalta, Gemma Rojo‐Martínez European Journal of Clinical Investigation, 2024
Metabolomic patterns, redox-related genes and metals, and bone fragility endpoints in the Hortega Study Marta Galvez-Fernandez, Zulema Rodriguez-Hernandez, Maria Grau-Perez, F. Javier Chaves, Ana Barbara Garcia-Garcia, Nuria Amigo, Daniel Monleon, Tamara Garcia-Barrera, Jose L. Gomez-Ariza, Laisa S. Briongos-Figuero, Jose L. Perez-Castrillon, Josep Redon, Maria Tellez-Plaza, Juan C. Martin-Escudero Free Radical Biology and Medicine, 2023
Ambient air pollution and thyroid function in Spanish adults. A nationwide population-based study (Di@bet.es study) Sergio Valdés, Viyey Doulatram-Gamgaram, Cristina Maldonado-Araque, Ana Lago-Sampedro, Eva García-Escobar, Sara García-Serrano, Marta García-Vivanco, Luis Garrido Juan, Mark Richard Theobald, Victoria Gil, Fernando Martín-Llorente, Pilar Ocon, Alfonso Calle-Pascual, Luis Castaño, Elías Delgado, Edelmiro Menendez, Josep Franch-Nadal, Sonia Gaztambide, Joan Girbés, F Javier Chaves, José L Galán-García, Gabriel Aguilera-Venegas, Carolina Gutierrez-Repiso, José Carlos Fernández-García, Natalia Colomo, Federico Soriguer, Eduardo García-Fuentes, Gemma Rojo-Martínez Environmental Health A Global Access Science Source, 2022
Thyroid hormone resistance index and mortality in euthyroid subjects: Di@bet.es study Silvia Patricia Alonso, Sergio Valdés, Cristina Maldonado-Araque, Ana Lago, Pilar Ocon, Alfonso Calle, Luis Castaño, Elías Delgado, Edelmiro Menéndez, Josep Franch-Nadal, Sonia Gaztambide, Juan Girbés, Felipe Chaves, Sara Garcia-Serrano, Eva Garcia-Escobar, José Carlos Fernandez-García, Gabriel Olveira, Natalia Colomo, Gemma Rojo-Martínez European Journal of Endocrinology, 2021
Association between long term exposure to particulate matter and incident hypertension in Spain Viyey Doulatram-Gamgaram, Sergio Valdés, Cristina Maldonado-Araque, Ana Lago-Sampedro, Rocío Badía-Guillén, Eva García-Escobar, Sara García-Serrano, Marta García-Vivanco, Juan Luis Garrido, Mark Richard Theobald, Victoria Gil, Fernando Martín-Llorente, Alfonso Calle-Pascual, Elena Bordiu, Luis Castaño, Elías Delgado, Josep Franch-Nadal, F. Javier Chaves, Eduard Montanya, José Luis Galán-García, Gabriel Aguilera-Venegas, Federico Soriguer, Gemma Rojo-Martínez Scientific Reports, 2021
Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study E. García-Escobar, S. Valdés, F. Soriguer, J. Vendrell, I. M. Urrutia-Etxebarria, C. Maldonado-Araque, E. Ortega, P. Ocón, E. Montanya, E. Menéndez, A. Lago-Sampedro, T. González-Frutos, R. Gomis, A. Goday, S. García-Serrano, J. L. Galán-García, C. Castell, E. Bordiú, R. Badía, G. Aguilera-Venegas, J. Girbés, S. Gaztambide, E. Delgado, F. J. Chaves, L. Castaño, A. Calle-Pascual, G. Rojo-Martínez, J. Franch-Nadal Scientific Reports, 2021
Iodine Deficiency and Mortality in Spanish Adults: Di@bet.es Study Cristina Maldonado-Araque, Sergio Valdés, Rocío Badía-Guillén, Ana Lago-Sampedro, Natalia Colomo, Eduardo Garcia-Fuentes, Carolina Gutierrez-Repiso, Albert Goday, Alfonso Calle-Pascual, Luis Castaño, Conxa Castell, Elías Delgado, Edelmiro Menendez, Josep Franch-Nadal, Sonia Gaztambide, Joan Girbés, Francisco Javier Chaves, Federico Soriguer, Gemma Rojo-Martínez Thyroid, 2021
Incidence of diabetes mellitus in Spain as results of the nation-wide cohort di@bet.es study G. Rojo-Martínez, S. Valdés, F. Soriguer, J. Vendrell, I. Urrutia, V. Pérez, E. Ortega, P. Ocón, E. Montanya, E. Menéndez, A. Lago-Sampedro, T. González- Frutos, R. Gomis, A. Goday, S. García-Serrano, E. García-Escobar, J. L. Galán-García, C. Castell, R. Badía-Guillén, G. Aguilera-Venegas, J. Girbés, S. Gaztambide, J. Franch-Nadal, E. Delgado, F. J. Chaves, L. Castaño, A. Calle-Pascual Scientific Reports, 2020
Easy One-Step Amplification and Labeling Procedure for Copy Number Variation Detection Sebastián Blesa, María D Olivares, Andy S Alic, Alicia Serrano, Verónica Lendinez, Verónica González-Albert, Laura Olivares, Sergio Martínez-Hervás, José M Juanes, Pablo Marín, Jose T Real, Blanca Navarro, Ana B García-García, Felipe J Chaves, Carmen Ivorra Clinical Chemistry, 2020
Respiratory chain polymorphisms and obesity in the Spanish population, a cross-sectional study Griselda de Marco, Ana Barbara Garcia-Garcia, Jose Tomas Real, Veronica Gonzalez-Albert, Laisa-Socorro Briongos-Figuero, Marta Cobos-Siles, Ana Lago-Sampedro, Arturo Corbaton, Maria Teresa Martinez-Larrad, Rafael Carmena, Juan Carlos Martin-Escudero, Gemma Rojo-Martínez, Felipe Javier Chaves BMJ Open, 2019
Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study Arce Domingo-Relloso, Maria Grau-Perez, Inmaculada Galan-Chilet, Maria J. Garrido-Martinez, Carmen Tormos, Ana Navas-Acien, Jose L. Gomez-Ariza, Lidia Monzo-Beltran, Guillermo Saez-Tormo, Tamara Garcia-Barrera, Antonio Dueñas Laita, Laisa S. Briongos Figuero, Juan C. Martin-Escudero, F. Javier Chaves, Josep Redon, Maria Tellez-Plaza Environment International, 2019
Dairy product consumption and metabolic diseases in the Di@bet.es study Ana Lago-Sampedro, Eva García-Escobar, Elehazara Rubio-Martín, Nuria Pascual-Aguirre, Sergio Valdés, Federico Soriguer, Albert Goday, Alfonso Calle-Pascual, Conxa Castell, Edelmiro Menéndez, Elías Delgado, Elena Bordiú, Luis Castaño, Josep Franch-Nadal, Juan Girbés, Felipe Chaves, Sonia Gaztambide, Gemma Rojo-Martínez, Gabriel Olveira Nutrients, 2019
Iron deficiency is associated with Hypothyroxinemia and Hypotriiodothyroninemia in the Spanish general adult population: Di@bet.es study Cristina Maldonado-Araque, Sergio Valdés, Ana Lago-Sampedro, Juan Antonio Lillo-Muñoz, Eduardo Garcia-Fuentes, Vidal Perez-Valero, Carolina Gutierrez-Repiso, Albert Goday, Ines Urrutia, Laura Peláez, Alfonso Calle-Pascual, Luis Castaño, Contxa Castell, Elias Delgado, Edelmiro Menendez, Josep Franch-Nadal, Sonia Gaztambide, Joan Girbés, Emilio Ortega, Joan Vendrell, Matilde R. Chacón, Felipe J. Chaves, Federico Soriguer, Gemma Rojo-Martínez Scientific Reports, 2018
Arsenic exposure, diabetes-related genes and diabetes prevalence in a general population from Spain Maria Grau-Perez, Ana Navas-Acien, Inmaculada Galan-Chilet, Laisa S. Briongos-Figuero, David Morchon-Simon, Jose D. Bermudez, Ciprian M. Crainiceanu, Griselda de Marco, Pilar Rentero-Garrido, Tamara Garcia-Barrera, Jose L. Gomez-Ariza, Jose A. Casasnovas, Juan C. Martin-Escudero, Josep Redon, F. Javier Chaves, Maria Tellez-Plaza Environmental Pollution, 2018
Are IL18RAP gene polymorphisms associated with body mass regulation? A cross-sectional study Vanesa Martínez-Barquero, Griselda de Marco, Sergio Martínez-Hervas, Victoria Adam-Felici, Cristina Pérez-Soriano, Verónica Gonzalez-Albert, Gemma Rojo, Juan Francisco Ascaso, José Tomás Real, Ana Barbara Garcia-Garcia, Juan Carlos Martín-Escudero, Raquel Cortes, Felipe Javier Chaves BMJ Open, 2017
Reference values for TSH may be inadequate to define hypothyroidism in persons with morbid obesity: Di@bet.es study Sergio Valdés, Cristina Maldonado‐Araque, Ana Lago‐Sampedro, Juan Antonio Lillo‐Muñoz, Eduardo Garcia‐Fuentes, Vidal Perez‐Valero, Carolina Gutiérrez‐Repiso, Eva Garcia‐Escobar, Albert Goday, Inés Urrutia, Laura Peláez, Alfonso Calle‐Pascual, Elena Bordiú, Luis Castaño, Conxa Castell, Elias Delgado, Edelmiro Menéndez, Josep Franch‐Nadal, Sonia Gaztambide, Joan Girbés, Emilio Ortega, Joan Vendrell, Matilde R. Chacón, F. Javier Chaves, Federico Soriguer, Gemma Rojo‐Martínez Obesity, 2017
Population-Based National Prevalence of Thyroid Dysfunction in Spain and Associated Factors: Study Sergio Valdés, Cristina Maldonado-Araque, Ana Lago-Sampedro, J. Antonio Lillo, Eduardo Garcia-Fuentes, Vidal Perez-Valero, Carolina Gutierrez-Repiso, Pilar Ocon-Sanchez, Albert Goday, Ines Urrutia, Laura Peláez, Alfonso Calle-Pascual, Elena Bordiú, Luis Castaño, Conxa Castell, Elias Delgado, Edelmiro Menendez, Josep Franch, Sonia Gaztambide, Joan Girbés, Emilio Ortega, Alfonso Lopez-Alba, Felipe J. Chaves, Joan Vendrell, Matilde R. Chacón, Federico Soriguer, Gemma Rojo-Martínez Thyroid, 2017
On the use of binary trees for DNA hydroxymethylation analysis César González, Mariano Pérez, Juan M. Orduña, Javier Chaves, Ana-Bárbara García Lecture Notes in Computer Science Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics, 2017
Obesity changes the human gut mycobiome M. Mar Rodríguez, Daniel Pérez, Felipe Javier Chaves, Eduardo Esteve, Pablo Marin-Garcia, Gemma Xifra, Joan Vendrell, Mariona Jové, Reinald Pamplona, Wifredo Ricart, Manuel Portero-Otin, Matilde R. Chacón, José Manuel Fernández Real Scientific Reports, 2015
Do genes modify the association of selenium and lipid levels? Inmaculada Galan-Chilet, Eliseo Guallar, J. Carlos Martin-Escudero, Griselda De Marco, Alejandro Dominguez-Lucas, Isabel Gonzalez-Manzano, Raul Lopez-Izquierdo, Josep Redon, F. Javier Chaves, Maria Tellez-Plaza Antioxidants and Redox Signaling, 2015
Polymorphisms in endothelin system genes, arsenic levels and obesity risk Vanesa Martínez-Barquero, Griselda de Marco, Sergio Martínez-Hervas, Pilar Rentero, Inmaculada Galan-Chilet, Sebastian Blesa, David Morchon, Sonsoles Morcillo, Gemma Rojo, Juan Francisco Ascaso, José Tomás Real, Juan Carlos Martín-Escudero, Felipe Javier Chaves Plos One, 2015
Correlation of zinc with oxidative stress biomarkers María Morales-Suárez-Varela, Agustín Llopis-González, Verónica González-Albert, Raúl López-Izquierdo, Isabel González-Manzano, Javier Cháves, Vicente Huerta-Biosca, Juan Martin-Escudero International Journal of Environmental Research and Public Health, 2015
Hypertension and the Fat-soluble vitamins A, D and E Agustin Llopis-González, Nuria Rubio-López, Monica Pineda-Alonso, Juan Martín-Escudero, Felipe Chaves, Maximino Redondo, Maria Morales-Suarez-Varela International Journal of Environmental Research and Public Health, 2015
Genomic and metabolomic profile associated to microalbuminuria Vannina G. Marrachelli, Daniel Monleon, Pilar Rentero, María L. Mansego, Jose Manuel Morales, Inma Galan, Remedios Segura, Fernando Martinez, Juan Carlos Martin-Escudero, Laisa Briongos, Pablo Marin, Gloria Lliso, Felipe Javier Chaves, Josep Redon Plos One, 2014
Risk factors associated with retinal vein occlusion F. Martínez, E. Furió, M. J. Fabiá, A. V. Pérez, V. González-Albert, G. Rojo-Martínez, M. T. Martínez-Larrad, F. J. Mena-Martín, F. Soriguer, M. Serrano-Ríos, F. J. Chaves, J. C. Martín-Escudero, J. Redón, M. J. García-Fuster International Journal of Clinical Practice, 2014
Impact of obesity-related genes in Spanish population Fernando Martínez-García, María L Mansego, Gemma Rojo-Martínez, Griselda De Marco-Solar, Sonsoles Morcillo, Federico Soriguer, Josep Redón, Monica Pineda Alonso, Juan C Martín-Escudero, Richard S Cooper, Felipe J Chaves BMC Genetics, 2013
Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis Oriol Morales-Ibanez, Marlene Domínguez, Sung H. Ki, Miguel Marcos, Javier F. Chaves, Eric Nguyen-Khac, Hakim Houchi, Silvia Affò, Pau Sancho-Bru, José Altamirano, Javier Michelena, Juan Carlos García-Pagán, Juan G. Abraldes, Vicente Arroyo, Juan Caballería, Francisco-Javier Laso, Bin Gao, Ramón Bataller Hepatology, 2013
Metabolically healthy but obese, a matter of time? Findings from the prospective pizarra study Federico Soriguer, Carolina Gutiérrez-Repiso, Elehazara Rubio-Martín, Eduardo García-Fuentes, María Cruz Almaraz, Natalia Colomo, Isabel Esteva de Antonio, María Soledad Ruiz de Adana, Felipe Javier Chaves, Sonsoles Morcillo, Sergio Valdés, Gemma Rojo-Martínez Journal of Clinical Endocrinology and Metabolism, 2013
C-reactive protein and incidence of type 2 diabetes in the Pizarra study Elehazara Rubio‐Martín, Federico Soriguer, Carolina Gutiérrez‐Repiso, Lourdes Garrido‐Sánchez, Marisol S. Ruíz de Adana, Eduardo García‐Fuentes, Sonsoles Morcillo, Isabel Esteva, Felipe J Chaves, Gemma Rojo‐Martinez European Journal of Clinical Investigation, 2013
Different impacts of cardiovascular risk factors on oxidative stress Maria L. Mansego, Josep Redon, Sergio Martinez-Hervas, Jose T. Real, Fernando Martinez, Sebastian Blesa, Veronica Gonzalez-Albert, Guillermo T. Saez, Rafael Carmena, Felipe J. Chaves International Journal of Molecular Sciences, 2011
Impact of cardiovascular risk factors on oxidative stress and DNA damage in a high risk Mediterranean population Marta Fandos, Dolores Corella, Marisa Guillén, Olga Portolés, Paula Carrasco, Antonio Iradi, Miguel A. Martínez-González, Ramón Estruch, Maria I. Covas, Rosa María Lamuela-Raventós, Maria Teresa Michavilla, Concha Cerdá, Rafael Torregrosa, Josep Redón, Francisco Felipe Chaves, M. Carmen Tormos, Dolores Ocete, Guillermo T. Sáez, for the PREDIMED group Free Radical Research, 2009
Conjunctival mucin MRNA expression in contact lens wear Rosa M. Corrales, David Galarreta, Jose M. Herreras, Victoria Saez, Isabel Arranz, Maria J. González, Agustin Mayo, Margarita Calonge, Felipe J. Chaves Optometry and Vision Science, 2009
A new PCSK9 gene promoter variant affects gene expression and causes autosomal dominant hypercholesterolemia (Journal of Clinical Endocrinology and Metabolism (2008) 93, (3577-3583)) Journal of Clinical Endocrinology and Metabolism, 2009
Analysis of BRCA1 and BRCA2 genes in Spanish breast/ovarian cancer patients: A high proportion of mutations unique to Spain and evidence of founder effects Orland Díez, Ana Osorio, Mercedes Durán, José Ignacio Martinez-Ferrandis, Miguel de la Hoya, Raquel Salazar, Ana Vega, Berta Campos, Raquel Rodríguez-López, Eladio Velasco, Javier Chaves, Eduardo Díaz-Rubio, Juan Jesús Cruz, María Torres, Eva Esteban, Andrés Cervantes, Carmen Alonso, Juan Manuel San Román, Rogelio González-Sarmiento, Cristina Miner, Angel Carracedo, María Eugenia Armengod, Trinidad Caldés, Javier Benítez, Montserrat Baiget Human Mutation, 2003
Plasma Lp (a) values in familial hypercholesterolemia and its relation to coronary heart disease Nutrition Metabolism and Cardiovascular Diseases, 1999
Screening of familial defective apo B-100 in subjects with primary hipercholesterolemia: Identification of the first affected family in Spain Medicina Clinica, 1999
Insertion/deletion polymorphisms of the gene encoding for the conversive enzyme of angiotensin and microalbuminuria in essential arterial hypertension Medicina Clinica, 1999
Familial hypercholesterolemia and plasma Lp(a) levels: 2 cardiovascular risk factors Anales De Medicina Interna Madrid Spain 1984, 1999
Familial hypercholesterolemia: Identification and molecular characterization of the first compound homozygous patient in Spain Medicina Clinica, 1998
