Doctor of Philosophy
(Organic Chemistry) Indian Institute of Technology Hyderabad, Telangana, India.
Thesis Title: Sustainable approaches for the site-selective C-H functionalization of 2H-Indazoles. 8.2 CPI 2014‒2019
Master of Science
(Chemistry) Madurai Kamaraj University, Madurai, Tamil Nadu, India. 6.5 CPI 2011‒2013
Bachelor of Science
(Chemistry) St. Xavier’s College, Palayamkottai, Tirunelveli,
Tamil Nadu, India. 60.8% 2008‒2011
RESEARCH INTERESTS
Synthesis of heterocycle molecules and nitrogen-enriched molecules
Metal and Photoredox catalyzed selective C-H functionalization
Iodine catalyzed C-H functionalization
Design and synthesis of organic fluorescent dyes
Biological sensing and Imaging applications
Visible-Light-Mediated Photocatalytic Oxidative C-C Bond Cleavage of Geminal Diazides: An Approach to Oxamates Duddu S. Sharada, Narenderreddy Katta, Arumugavel Murugan, Sonika Sharma Synopen, 2021 Photoredox catalysis has received great attention in both academia and industry and remarkable progress has been made over the past decade. Now, it has been shown that a visible-light-mediated oxidative C–C bond cleavage of geminal diazides can be induced by organic dye catalysis for the synthesis of oxamates. A mechanistic study, confirmed by control experiments, indicates that this proceeds through single-electron transfer (SET). This methodology can be applied to convert a wide array of geminal diazides into oxamates.
Regioselective C3-H Trifluoromethylation of 2 H-Indazole under Transition-Metal-Free Photoredox Catalysis Arumugavel Murugan, Venkata Nagarjuna Babu, Ashok Polu, Nagaraj Sabarinathan, Manickam Bakthadoss, Duddu S. Sharada Journal of Organic Chemistry, 2019 Trifluoromethyl-substituted heteroarenes are biologically active compounds and useful building blocks. In this sequence, we have developed a visible-light-promoted regioselective C3-H trifluoromethylation of 2 H-indazole under metal-free conditions, which proceeds via a radical mechanism. The combination of photocatalysis and hypervalent iodine reagent provides a practical approach to a library of trifluoromethylated indazoles in 35-83% yields.
Exocyclic N-Acyliminium Ion (NAI) Cyclization: Access to Fully Substituted Oxazoles and Furocoumarins Venkata Nagarjuna Babu, Arumugavel Murugan, Narenderreddy Katta, Suman Devatha, Duddu S. Sharada Journal of Organic Chemistry, 2019 A concise, one-pot route to oxazoles and furocoumarins has been reported. The key step in this transformation involves in situ generation of N-acyliminium ion (NAI) precursor under catalyst and solvent-free conditions and their further transformations promoted by superacid in the same pot. We have also presented the experimental evidence for the involvement of proto-solvated novel exocyclic N-acyliminium ion. Further, the UV-visible and fluorescence studies revealed that few of the compounds reported here exhibited emission of blue light upon irradiation in EtOH in the region of 404-422 nm.
Iron promoted C3-H nitration of 2H-indazole: direct access to 3-nitro-2H-indazoles Arumugavel Murugan, Koteswar Rao Gorantla, Bhabani S. Mallik, Duddu S. Sharada Organic and Biomolecular Chemistry, 2018 An efficient C3–H functionalization of indazole has been demonstrated. Notably, this method involves chelation-free radical C–H nitration on 2H-indazole. The radical mechanism was confirmed by control experiments and quantum chemical calculations. The synthetic utility has been proven by the synthesis of bio-relevant benzimidazoindazoles via reductive cyclization.
Metal-Free Regioselective Dual C-H Functionalization in a Cascade Fashion: Access to Isocryptolepine Alkaloid Analogues Arumugavel Murugan, Shinde Vidyacharan, Ruma Ghosh, Duddu S. Sharada Chemistryselect, 2017 A metal-free regioselective approach to annulated indazoles is presented via dual C−H functionalization of indazole and benzylamine in a cascade fashion. The salient features of the present protocol are regioselective C3-functionalization, one-pot synthesis of annulated scaffolds, metal-free, peroxide-free, operationally simple and wide substrate scope.
C(sp2)-H Functionalization of 2H-Indazoles at C3-Position via Palladium(II)-Catalyzed Isocyanide Insertion Strategy Leading to Diverse Heterocycles Shinde Vidyacharan, Arumugavel Murugan, Duddu S. Sharada Journal of Organic Chemistry, 2016 Herein, we have reported an efficient Pd-catalyzed C-H functionalization of 2H-indazole at C3-position via an isocyanide insertion strategy for the synthesis of unprecedented benzoxazinoindazoles, indazoloquinaoxalines and benzoxazinoindazolones for the first time. Our new method provides an operationally simple and versatile route for a selective synthesis of 2-(2H-indazol-2-yl)phenols. Furthermore, we developed a sequential one-pot strategy for the synthesis of benzoxazinoindazolone under metal-oxidant-free conditions. We also achieved the isocyanide insertion between C(sp(2))-H and oxygen heteroatom for the first time. The key features of the present protocol are construction of 4 bonds in one-pot, synthesis of new skeletally diverse scaffolds, broad substrate scope, high yields and environmentally benign conditions.
RECENT SCHOLAR PUBLICATIONS
Functional organogel with α-cyanostilbene scaffold: aggregation enhanced emission and picric acid sensing R Dahiwadkar, A Murugan, D Johnson, R Chakraborty, V Thiruvenkatam, ... Journal of Photochemistry and Photobiology A: Chemistry 434, 114227 , 2023 2023.0 Citations: 13
Metal-free, one-pot synthesis of 2-styrylquinolines via Friedländer annulation and sp3 C–H activation using 1,3-dimethylurea and l-tartaric acid (3 : 1) as a deep eutectic solvent DK Neeli Satyanarayana, Kota Sathish, Sakkani Nagaraju, Ravinder Pawar ... New Journal of Chemistry 46, 5162 , 2022 2022.0 Citations: 14
Visible-Light-Mediated Photocatalytic Oxidative C–C Bond Cleavage of Geminal Diazides: An Approach to Oxamates N Katta, A Murugan, S Sharma, DS Sharada SynOpen 5 (02), 152-157 , 2021 2021.0 Citations: 1
Visible light-mediated photocatalytic oxidative cleavage of activated alkynes via hydroamination: a direct approach to oxamates N Katta, M Ojha, A Murugan, S Arepally, DS Sharada RSC advances 10 (21), 12599-12603 , 2020 2020.0 Citations: 14
Regioselective C3–H Trifluoromethylation of 2 H -Indazole under Transition-Metal-Free Photoredox Catalysis A Murugan, VN Babu, A Polu, N Sabarinathan, M Bakthadoss, ... The Journal of Organic Chemistry 84 (12), 7796-7803 , 2019 2019.0 Citations: 82
Exocyclic N -Acyliminium Ion (NAI) Cyclization: Access to Fully Substituted Oxazoles and Furocoumarins VN Babu, A Murugan, N Katta, S Devatha, DS Sharada The Journal of Organic Chemistry 84 (11), 6631-6641 , 2019 2019.0 Citations: 20
Visible-Light-Induced Oxidative Cleavage of CC Triple Bond via Hydroamination: Direct Synthesis of Oxamates from Amines and Activated Alkynes S Duddu. S, S Arepally, A Murugan, N Katta, M Ojha ChemRxiv 2019 (0110) , 2019 2019.0
Rose Bengal-Catalyzed Photoredox CC Triple Bond Oxidative Cleavage via Hydroamination; Direct Synthesis of Oxamates from Amines and Activated Alkynes D SS, S Arepally, A Murugan, M Ojha 2018.0
Iron promoted C3–H nitration of 2 H-indazole: direct access to 3-nitro-2 H-indazoles A Murugan, KR Gorantla, BS Mallik, DS Sharada Organic & Biomolecular Chemistry 16 (28), 5113-5118 , 2018 2018.0 Citations: 57
Metal‐Free Regioselective Dual C‐H Functionalization in a Cascade Fashion: Access to Isocryptolepine Alkaloid Analogues A Murugan, S Vidyacharan, R Ghosh, DS Sharada ChemistrySelect 2 (12), 3511-3515 , 2017 2017.0 Citations: 9
C( sp 2 )–H Functionalization of 2 H -Indazoles at C3-Position via Palladium(II)-Catalyzed Isocyanide Insertion Strategy Leading to Diverse Heterocycles S Vidyacharan, A Murugan, DS Sharada The Journal of Organic Chemistry 81 (7), 2837-2848 , 2016 2016.0 Citations: 88
Visible-Light-Induced Organophotoredox-Catalyzed C-C Triple Bond Oxidative Cleavage; Direct Oxamates Synthesis from Amines and Activated Alkynes S Arepally, A Murugan, M Ojha, DS Sharada
MOST CITED SCHOLAR PUBLICATIONS
C( sp 2 )–H Functionalization of 2 H -Indazoles at C3-Position via Palladium(II)-Catalyzed Isocyanide Insertion Strategy Leading to Diverse Heterocycles S Vidyacharan, A Murugan, DS Sharada The Journal of Organic Chemistry 81 (7), 2837-2848 , 2016 2016.0 Citations: 88
Regioselective C3–H Trifluoromethylation of 2 H -Indazole under Transition-Metal-Free Photoredox Catalysis A Murugan, VN Babu, A Polu, N Sabarinathan, M Bakthadoss, ... The Journal of Organic Chemistry 84 (12), 7796-7803 , 2019 2019.0 Citations: 82
Iron promoted C3–H nitration of 2 H-indazole: direct access to 3-nitro-2 H-indazoles A Murugan, KR Gorantla, BS Mallik, DS Sharada Organic & Biomolecular Chemistry 16 (28), 5113-5118 , 2018 2018.0 Citations: 57
Exocyclic N -Acyliminium Ion (NAI) Cyclization: Access to Fully Substituted Oxazoles and Furocoumarins VN Babu, A Murugan, N Katta, S Devatha, DS Sharada The Journal of Organic Chemistry 84 (11), 6631-6641 , 2019 2019.0 Citations: 20
Metal-free, one-pot synthesis of 2-styrylquinolines via Friedländer annulation and sp3 C–H activation using 1,3-dimethylurea and l-tartaric acid (3 : 1) as a deep eutectic solvent DK Neeli Satyanarayana, Kota Sathish, Sakkani Nagaraju, Ravinder Pawar ... New Journal of Chemistry 46, 5162 , 2022 2022.0 Citations: 14
Visible light-mediated photocatalytic oxidative cleavage of activated alkynes via hydroamination: a direct approach to oxamates N Katta, M Ojha, A Murugan, S Arepally, DS Sharada RSC advances 10 (21), 12599-12603 , 2020 2020.0 Citations: 14
Functional organogel with α-cyanostilbene scaffold: aggregation enhanced emission and picric acid sensing R Dahiwadkar, A Murugan, D Johnson, R Chakraborty, V Thiruvenkatam, ... Journal of Photochemistry and Photobiology A: Chemistry 434, 114227 , 2023 2023.0 Citations: 13
Metal‐Free Regioselective Dual C‐H Functionalization in a Cascade Fashion: Access to Isocryptolepine Alkaloid Analogues A Murugan, S Vidyacharan, R Ghosh, DS Sharada ChemistrySelect 2 (12), 3511-3515 , 2017 2017.0 Citations: 9
Visible-Light-Mediated Photocatalytic Oxidative C–C Bond Cleavage of Geminal Diazides: An Approach to Oxamates N Katta, A Murugan, S Sharma, DS Sharada SynOpen 5 (02), 152-157 , 2021 2021.0 Citations: 1
Visible-Light-Induced Oxidative Cleavage of CC Triple Bond via Hydroamination: Direct Synthesis of Oxamates from Amines and Activated Alkynes S Duddu. S, S Arepally, A Murugan, N Katta, M Ojha ChemRxiv 2019 (0110) , 2019 2019.0
Rose Bengal-Catalyzed Photoredox CC Triple Bond Oxidative Cleavage via Hydroamination; Direct Synthesis of Oxamates from Amines and Activated Alkynes D SS, S Arepally, A Murugan, M Ojha 2018.0
Visible-Light-Induced Organophotoredox-Catalyzed C-C Triple Bond Oxidative Cleavage; Direct Oxamates Synthesis from Amines and Activated Alkynes S Arepally, A Murugan, M Ojha, DS Sharada
