Murugan Arumugavel

@iitgn.ac.in

Research Associate
Indian Institute of Technology Gandhinagar

EDUCATION

Doctor of Philosophy
(Organic Chemistry) Indian Institute of Technology Hyderabad, Telangana, India.
Thesis Title: Sustainable approaches for the site-selective C-H functionalization of 2H-Indazoles. 8.2 CPI 2014‒2019

Master of Science
(Chemistry) Madurai Kamaraj University, Madurai, Tamil Nadu, India. 6.5 CPI 2011‒2013

Bachelor of Science
(Chemistry) St. Xavier’s College, Palayamkottai, Tirunelveli,
Tamil Nadu, India. 60.8% 2008‒2011

RESEARCH INTERESTS

 Synthesis of heterocycle molecules and nitrogen-enriched molecules
 Metal and Photoredox catalyzed selective C-H functionalization
 Iodine catalyzed C-H functionalization
 Design and synthesis of organic fluorescent dyes
 Biological sensing and Imaging applications

Scopus Publications

261

Scholar Citations

Scholar h-index

Scholar i10-index

Scopus Publications

Functional organogel with α-cyanostilbene scaffold: Aggregation enhanced emission and picric acid sensing
Rahul Dahiwadkar, Arumugavel Murugan, Delna Johnson, Rik Chakraborty, Vijay Thiruvenkatam, and Sriram Kanvah
Elsevier BV

Visible-Light-Mediated Photocatalytic Oxidative C-C Bond Cleavage of Geminal Diazides: An Approach to Oxamates
Duddu S. Sharada, Narenderreddy Katta, Arumugavel Murugan, and Sonika Sharma
Georg Thieme Verlag KG
AbstractPhotoredox catalysis has received great attention in both academia and industry and remarkable progress has been made over the past decade. Now, it has been shown that a visible-light-mediated oxidative C–C bond cleavage of geminal diazides can be induced by organic dye catalysis for the synthesis of oxamates. A mechanistic study, confirmed by control experiments, indicates that this proceeds through single-electron transfer (SET). This methodology can be applied to convert a wide array of geminal diazides into oxamates.

Visible light-mediated photocatalytic oxidative cleavage of activated alkynes: Via hydroamination: A direct approach to oxamates
Narenderreddy Katta, Mamata Ojha, Arumugavel Murugan, Sagar Arepally, and Duddu S. Sharada
Royal Society of Chemistry (RSC)
The direct oxidative cleavage of activated alkynes via hydroamination has been described using organic photocatalyst under visible-light irradiation at room temperature.

Regioselective C3-H Trifluoromethylation of 2 H-Indazole under Transition-Metal-Free Photoredox Catalysis
Arumugavel Murugan, Venkata Nagarjuna Babu, Ashok Polu, Nagaraj Sabarinathan, Manickam Bakthadoss, and Duddu S. Sharada
American Chemical Society (ACS)
Trifluoromethyl-substituted heteroarenes are biologically active compounds and useful building blocks. In this sequence, we have developed a visible-light-promoted regioselective C3-H trifluoromethylation of 2 H-indazole under metal-free conditions, which proceeds via a radical mechanism. The combination of photocatalysis and hypervalent iodine reagent provides a practical approach to a library of trifluoromethylated indazoles in 35-83% yields.

Exocyclic N-Acyliminium Ion (NAI) Cyclization: Access to Fully Substituted Oxazoles and Furocoumarins
Venkata Nagarjuna Babu, Arumugavel Murugan, Narenderreddy Katta, Suman Devatha, and Duddu S. Sharada
American Chemical Society (ACS)
A concise, one-pot route to oxazoles and furocoumarins has been reported. The key step in this transformation involves in situ generation of N-acyliminium ion (NAI) precursor under catalyst and solvent-free conditions and their further transformations promoted by superacid in the same pot. We have also presented the experimental evidence for the involvement of proto-solvated novel exocyclic N-acyliminium ion. Further, the UV-visible and fluorescence studies revealed that few of the compounds reported here exhibited emission of blue light upon irradiation in EtOH in the region of 404-422 nm.

Iron promoted C3-H nitration of 2H-indazole: direct access to 3-nitro-2H-indazoles
Arumugavel Murugan, Koteswar Rao Gorantla, Bhabani S. Mallik, and Duddu S. Sharada
Royal Society of Chemistry (RSC)
An efficient C3–H functionalization of indazole has been demonstrated. Notably, this method involves chelation-free radical C–H nitration on 2H-indazole. The radical mechanism was confirmed by control experiments and quantum chemical calculations. The synthetic utility has been proven by the synthesis of bio-relevant benzimidazoindazoles via reductive cyclization.

Metal-Free Regioselective Dual C-H Functionalization in a Cascade Fashion: Access to Isocryptolepine Alkaloid Analogues
Arumugavel Murugan, Shinde Vidyacharan, Ruma Ghosh, and Duddu S. Sharada
Wiley
A metal-free regioselective approach to annulated indazoles is presented via dual C−H functionalization of indazole and benzylamine in a cascade fashion. The salient features of the present protocol are regioselective C3-functionalization, one-pot synthesis of annulated scaffolds, metal-free, peroxide-free, operationally simple and wide substrate scope.

C(sp<sup>2</sup>)-H Functionalization of 2H-Indazoles at C3-Position via Palladium(II)-Catalyzed Isocyanide Insertion Strategy Leading to Diverse Heterocycles
Shinde Vidyacharan, Arumugavel Murugan, and Duddu S. Sharada
American Chemical Society (ACS)
Herein, we have reported an efficient Pd-catalyzed C-H functionalization of 2H-indazole at C3-position via an isocyanide insertion strategy for the synthesis of unprecedented benzoxazinoindazoles, indazoloquinaoxalines and benzoxazinoindazolones for the first time. Our new method provides an operationally simple and versatile route for a selective synthesis of 2-(2H-indazol-2-yl)phenols. Furthermore, we developed a sequential one-pot strategy for the synthesis of benzoxazinoindazolone under metal-oxidant-free conditions. We also achieved the isocyanide insertion between C(sp(2))-H and oxygen heteroatom for the first time. The key features of the present protocol are construction of 4 bonds in one-pot, synthesis of new skeletally diverse scaffolds, broad substrate scope, high yields and environmentally benign conditions.

RECENT SCHOLAR PUBLICATIONS

Functional organogel with α-cyanostilbene scaffold: aggregation enhanced emission and picric acid sensing
R Dahiwadkar, A Murugan, D Johnson, R Chakraborty, V Thiruvenkatam, ...
Journal of Photochemistry and Photobiology A: Chemistry 434, 114227 2023

Metal-free, one-pot synthesis of 2-styrylquinolines via Friedlnder annulation and sp3 C–H activation using 1,3-dimethylurea and l-tartaric acid (3 : 1) as a deep eutectic solvent
DK Neeli Satyanarayana, Kota Sathish, Sakkani Nagaraju, Ravinder Pawar ...
New Journal of Chemistry 46, 5162 2022

Visible-Light-Mediated Photocatalytic Oxidative C–C Bond Cleavage of Geminal Diazides: An Approach to Oxamates
N Katta, A Murugan, S Sharma, DS Sharada
SynOpen 5 (02), 152-157 2021

Visible light-mediated photocatalytic oxidative cleavage of activated alkynes via hydroamination: a direct approach to oxamates
N Katta, M Ojha, A Murugan, S Arepally, DS Sharada
RSC advances 10 (21), 12599-12603 2020

Regioselective C3–H Trifluoromethylation of 2H-Indazole under Transition-Metal-Free Photoredox Catalysis
A Murugan, VN Babu, A Polu, N Sabarinathan, M Bakthadoss, ...
The Journal of Organic Chemistry 84 (12), 7796-7803 2019

Exocyclic N-Acyliminium Ion (NAI) Cyclization: Access to Fully Substituted Oxazoles and Furocoumarins
VN Babu, A Murugan, N Katta, S Devatha, DS Sharada
The Journal of Organic Chemistry 84 (11), 6631-6641 2019

Visible-Light-Induced Oxidative Cleavage of CC Triple Bond via Hydroamination: Direct Synthesis of Oxamates from Amines and Activated Alkynes
S Arepally, A Murugan, N Katta, M Ojha
2019

Visible-Light-Induced Oxidative Cleavage of CC Triple Bond via Hydroamination: Direct Synthesis of Oxamates from Amines and Activated Alkynes
D SS, S Arepally, A Murugan, M Ojha
2018

Rose Bengal-Catalyzed Photoredox CC Triple Bond Oxidative Cleavage via Hydroamination; Direct Synthesis of Oxamates from Amines and Activated Alkynes
S Arepally, A Murugan, M Ojha
2018

Rose Bengal-Catalyzed Photoredox CC Triple Bond Oxidative Cleavage via Hydroamination; Direct Synthesis of Oxamates from Amines and Activated Alkynes
D SS, S Arepally, A Murugan, M Ojha
2018

Iron promoted C3–H nitration of 2 H-indazole: direct access to 3-nitro-2 H-indazoles
A Murugan, KR Gorantla, BS Mallik, DS Sharada
Organic & Biomolecular Chemistry 16 (28), 5113-5118 2018

Metal‐Free Regioselective Dual C‐H Functionalization in a Cascade Fashion: Access to Isocryptolepine Alkaloid Analogues
A Murugan, S Vidyacharan, R Ghosh, DS Sharada
ChemistrySelect 2 (12), 3511-3515 2017

C(sp²)–H Functionalization of 2H-Indazoles at C3-Position via Palladium(II)-Catalyzed Isocyanide Insertion Strategy Leading to Diverse Heterocycles
S Vidyacharan, A Murugan, DS Sharada
The Journal of Organic Chemistry 81 (7), 2837-2848 2016

Visible-Light-Induced Organophotoredox-Catalyzed C-C Triple Bond Oxidative Cleavage; Direct Oxamates Synthesis from Amines and Activated Alkynes
S Arepally, A Murugan, M Ojha, DS Sharada

MOST CITED SCHOLAR PUBLICATIONS

Iron promoted C3–H nitration of 2 H-indazole: direct access to 3-nitro-2 H-indazoles
A Murugan, KR Gorantla, BS Mallik, DS Sharada
Organic & Biomolecular Chemistry 16 (28), 5113-5118 2018
Citations: 50

Visible-Light-Mediated Photocatalytic Oxidative C–C Bond Cleavage of Geminal Diazides: An Approach to Oxamates
N Katta, A Murugan, S Sharma, DS Sharada
SynOpen 5 (02), 152-157 2021
Citations: 1