Abida Raza, a nano-biochemist is among pioneer researchers in the field of Nanomedicine and founder of Nanotheranostic research in Pakistan. She heads NILOP Nanomedicine Research Laboratories (NNRL), National Institute of Lasers & Optronics. Abida does research in Cancer, Virology and Polymer Chemistry. Her current projects are 'Nanomedicine, Nanotheranostic and Virology.
EDUCATION
Post-Doctorate
RESEARCH, TEACHING, or OTHER INTERESTS
Cancer Research, Multidisciplinary, General Pharmacology, Toxicology and Pharmaceutics, Biotechnology
Synthesis, Characterization, Acute Dermal Toxicity, Anti-inflammatory, and Wound Healing Potential of Biogenic Silver Nanoparticles in Balb C Mice Saiqa Andleeb, epub Iqbal, Nazia Gulzar, Abida Raza, Ashfaq Ahmad Current Pharmaceutical Biotechnology, 2024 Aim:The current study aimed to develop an economic plant-based therapeutic agent to improve the treatment strategies for diseases at the nano-scale.Method:In the current research, silver nanoparticles were synthesized using Trillium govanianum aqueous extract. Characterizations were done using UV–visible spectrophotometer, X-ray diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopy. In vivo biological activities such as acute dermal toxicity, wound healing, and anti-inflammatory were done on Balb C mice. Absorbance at 295 nm corresponds to the out-of-plane quadrupole Plasmonresonance while at 350 nm corresponds to in-plane dipole resonance. SEM images showed the morphology of TGAgNPs is not exactly spherical while XRD analysis shows that highly crystalline TGAgNPs with an average size of 27.94 nm. The FTIR spectrum represents sharp peaks of aldehyde, amide I, aromatic rings, and polysaccharides. The microscopic assessment did not find any epidermal and dermal layer abnormalities in Blab C mice when exposed to TGAgNPs during acute dermal toxicity.Result & Discussion:Results revealed that 1000 mg/kg is not a lethal dose. In the wound healing activity, no mortality and no abnormal signs were observed when petroleum jelly, nitrofuranose, TGaqu, and TGAgNPs-based ointments were applied. Enhanced epithelization was recorded in TGaqu and TGAgNPs treated mice (p≤0.001). The wound contraction percentage was higher in nitrofuranose-treated mice (74%) followed by TGAgNPs (71%), and TGaqu (69%) compared to vehicle-treated and open-wounded mice. The paw edema model proved the potential use of TGAgNPs and TGaqu as anti-inflammatory agents.Conclusion:Hence, the results proved that both TGaqu and TGAgNPs are not toxic and possessed strong anti-inflammatory and wound-healing effects due to the presence of phytochemical constituents and could be used in various drug production as a therapeutic agent.
Fungus-mediated synthesis of Se-BiO-CuO multimetallic nanoparticles as a potential alternative antimicrobial against ESBL-producing Escherichia coli of veterinary origin Rida Rasheed, Bushra Uzair, Abida Raza, Reem Binsuwaidan, Nawaf Alshammari Frontiers in Cellular and Infection Microbiology, 2024 Bacterial infections emerge as a significant contributor to mortality and morbidity worldwide. Emerging extended-spectrum β-lactamase (ESBL) Escherichia coli strains provide a greater risk of bacteremia and mortality, are increasingly resistant to antibiotics, and are a major producer of ESBLs. E. coli bacteremia-linked mastitis is one of the most common bacterial diseases in animals, which can affect the quality of the milk and damage organ functions. There is an elevated menace of treatment failure and recurrence of E. coli bacteremia necessitating the adoption of rigorous alternative treatment approaches. In this study, Se-Boil-CuO multimetallic nanoparticles (MMNPs) were synthesized as an alternate treatment from Talaromyces haitouensis extract, and their efficiency in treating ESBL E. coli was confirmed using standard antimicrobial assays. Scanning electron microscopy, UV–visible spectroscopy, and dynamic light scattering were used to validate and characterize the mycosynthesized Se-BiO-CuO MMNPs. UV–visible spectra of Se-BiO-CuO MMNPs showed absorption peak bands at 570, 376, and 290 nm, respectively. The average diameters of the amorphous-shaped Se-BiO-CuO MMNPs synthesized by T. haitouensis extract were approximately 66–80 nm, respectively. Se-BiO-CuO MMNPs (100 μg/mL) showed a maximal inhibition zone of 18.33 ± 0.57 mm against E. coli. Se-BiO-CuO MMNPs also exhibited a deleterious impact on E. coli killing kinetics, biofilm formation, swimming motility, efflux of cellular components, and membrane integrity. The hemolysis assay also confirms the biocompatibility of Se-BiO-CuO MMNPs at the minimum inhibitory concentration (MIC) range. Our findings suggest that Se-BiO-CuO MMNPs may serve as a potential substitute for ESBL E. coli bacteremia.
Acute Toxicity, Anti-diabetic, and Anti-cancerous Potential of Trillium Govanianum-conjugated Silver Nanoparticles in Balb/c Mice Nazia Gulzar, Saiqa Andleeb, Abida Raza, Shaukat Ali, Iram Liaqat, et al. Current Pharmaceutical Biotechnology, 2024 Background: The current study aimed to develop an economic plant-based therapeutic agent to improve the treatment strategies for diseases at the nano-scale because Cancer and Diabetes mellitus are major concerns in developing countries. Therefore, in vitro and in vivo antidiabetic and anti-cancerous activities of Trillium govanianum conjugated silver nanoparticles were assessed. Methods: In the current study synthesis of silver nanoparticles using Trillium govanianum and characterization were done using a scanning electron microscope, UV-visible spectrophotometer, and FTIR analysis. The in vitro and in vivo anti-diabetic and anti-cancerous potential (200 mg/kg and 400 mg/kg) were carried out. Results: It was discovered that Balb/c mice did not show any major alterations during observation of acute oral toxicity when administered orally both TGaqu (1000 mg/kg) and TGAgNPs (1000 mg/kg), and results revealed that 1000 mg/kg is not lethal dose as did not find any abnormalities in epidermal and dermal layers when exposed to TGAgNPs. In vitro studies showed that TGAgNPs could not only inhibit alpha-glucosidase and protein kinases but were also potent against the brine shrimp. Though, a significant reduction in blood glucose levels and significant anti-cancerous effects was recorded when alloxan-treated and CCl4-induced mice were treated with TGAgNPs and TGaqu. Conclusion: Both in vivo and in vitro studies revealed that TGaqu and TGAgNPs are not toxic at 200 mg/kg, 400 mg/kg, and 1000 mg/kg doses and possess strong anti-diabetic and anti-cancerous effects due to the presence of phyto-constituents. Further, suggesting that green synthesized silver nanoparticles could be used in pharmaceutical industries to develop potent therapeutic agents.
A32-10 As-Needed Inhaled Corticosteroid-Short-Acting Beta Agonist Combination Versus Short-Acting Beta Agonist Alone in Asthma: A Systematic Review and Meta-Analysis S Razzaq, A Raza, H Naseer, H Younes, H Haris, A Sorathia, ... American Journal of Respiratory and Critical Care Medicine 212 (Supplement_1 … , 2026 2026
B41-29 Diagnostic Accuracy of Deep Learning Models for Interstitial Lung Disease on Chest CT: A Systematic Review and Meta-Analysis S Razzaq, A Raza, S Suleman, HB Tariq, A Rehman, M Salman, MS Iqbal, ... American Journal of Respiratory and Critical Care Medicine 212 (Supplement_1 … , 2026 2026
Synthesis, structural characterization, and antitumor effect of quercetin-loaded chitosan nanoparticles-stabilized pickering emulsion via suppressing the PI3K/AKT/mTOR … Z Noreen, M Naveed, AR Rao, SM Shah, I Shahid, AR Alzahrani, B Ijaz, ... Journal of King Saud University–Science 38 , 2026 2026
Lipodendriplexes mediated enhanced gene delivery: a cellular to pre-clinical investigation (vol. 10, 21446, 2020) I Tariq, MY Ali, MF Sohail, MU Amin, S Ali, NI Bukhari, A Raza, ... SCIENTIFIC REPORTS 16 (1) , 2026 2026
Correction: Lipodendriplexes mediated enhanced gene delivery: a cellular to pre-clinical investigation I Tariq, MY Ali, MF Sohail, MU Amin, S Ali, NI Bukhari, A Raza, ... Scientific Reports 16 (1), 873 , 2026 2026
COX-2 gene silencing by laser-assisted oligonucleotides release from remote optical Nano-switches (LORONS) in hepatocellular carcinoma cells UA Awan, A Raza, S Ali, M El Sayed Nanomedicine 20 (24), 2947-2959 , 2025 2025 Citations: 2
UHPLC-based phytochemical profiling and network pharmacology insights into mint-derived selenium nanoparticles T Yousaf, I Ahmad, NI Raja, A Raza, D Fernandes, ZUR Mashwani Bioorganic Chemistry, 109119 , 2025 2025
Ultrasound-responsive hybrid liposome-polymer nanoparticles for enhanced stability and cytotoxicity of chemotherapeutic agent S Saeed, U Sarwar, I Tariq, A Amir, A Raza Journal of Microencapsulation 42 (7), 721-735 , 2025 2025
Synthesis and characterization of Gelatin-rGO/TA nanocomposite coatings for controlling Pseudomonas aeruginosa biofilm on hemodialysis catheters S Abbas, B Uzair, A Raza, F Fasim Journal of Drug Delivery Science and Technology 111, 107198 , 2025 2025 Citations: 1
Development of chitosan colistin nano-antibiotics and its in-vitro activity against multidrug resistant Acinetobacter baumannii HU Rahman, J Muhammad, H Ali, A Akbar, A Raza, S Khan, R Ullah, ... 2024
Acute toxicity, anti-diabetic, and anti-cancerous potential of Trillium govanianum-conjugated silver nanoparticles in Balb/c mice N Gulzar, S Andleeb, A Raza, S Ali, I Liaqat, SA Raja, NM Ali, R Khan, ... Current Pharmaceutical Biotechnology 25 (10), 1304-1320 , 2024 2024 Citations: 9
Synthesis, characterization, acute dermal toxicity, anti-inflammatory, and wound healing potential of biogenic silver nanoparticles in balb C mice S Andleeb, Z Iqbal, N Gulzar, A Raza, A Ahmad Current pharmaceutical biotechnology 25 (11), 1452-1465 , 2024 2024 Citations: 6
Fungus Mediated Synthesis of Se-BiO-CuO Multimetallic Nanoparticles as a Potential Alternative Antimicrobial Against ESBL Producing Escherichia coli of Veterinary Origin BM Uzair, R Rasheed, A Raza, M Saeed, N Alshammari Frontiers in Cellular and Infection Microbiology 14, 1301351 , 2024 2024 Citations: 7
Chitosan encapsulation of fluconazole-loaded MgO/CuO nanocomposite for biofilm inhibition of contact lens MBKN Sehrish Abbas, Bushra Uzair, Abida Raza, Shamaila Sajjad Materials Chemistry and Physics 317 (1) , 2024 2024 Citations: 14
AMINI-REVIEW OF MEDICINAL USESAND PHYTOCHEMICALS ISOLATED FROM HIMALAYAN PLANT DELPHINIUM BRUNONIANUM ROYLE H HAANIAISHAQ, K KAINATNISAR, R Riaz, MM SUFYAN, M Shahbaz, ... INTERNATIONAL JOURNAL 6 (10), 507-516 , 2024 2024 Citations: 6
RP-HPLC-UV METHOD VALIDATION FOR RIBAVIRIN USED IN TOPICAL APPLICATIONS M HAMZA, Q KANWAL, A RAZA, K ZEHRA, M YASIR, DEN IQBAL, ... INTERNATIONAL JOURNAL 26 (20) , 2024 2024
Glycol chitosan amphiphile nanotheranostic system for ultrasound-mediated localized release and biodistribution of doxorubicin S Saeed, U Sarwar, M Yasinzai, A Raza Journal of nanoparticle research 25 (9), 194 , 2023 2023 Citations: 9
Enhanced antidepressant activity of nanostructured lipid carriers containing levosulpiride in behavioral despair tests in mice ST Arif, MA Khan, S Zaman, HS Sarwar, A Raza, M Sarfraz, YA Bin Jardan, ... Pharmaceuticals 16 (9), 1220 , 2023 2023 Citations: 4
In vitro anti-cancer effect of polymeric nanoparticles encapsulating Caralluma tuberculata in cancer cells M Fayyaz, U Sarwar, F Nurjis, JS Ali, S Tabassum, A Raza International journal of advanced nano computing and analytics 2 (1), 22-38 , 2023 2023 Citations: 5
A competitive numerical model for virus transmission in a computer network MS Ehsan, M Rafiq, A Raza 2023 4th International Conference on Computing, Mathematics and Engineering … , 2023 2023 Citations: 2
MOST CITED SCHOLAR PUBLICATIONS
Green synthesis of silver nanoparticles via plant extracts: beginning a new era in cancer theranostics M Ovais, AT Khalil, A Raza, MA Khan, I Ahmad, NU Islam, M Saravanan, ... Nanomedicine 11 (23), 3157-3177 , 2016 2016 Citations: 429
Designing stimuli‐responsive upconversion nanoparticles that exploit the tumor microenvironment M Ovais, S Mukherjee, A Pramanik, D Das, A Mukherjee, A Raza, C Chen Advanced Materials 32 (22), 2000055 , 2020 2020 Citations: 220
Wound healing applications of biogenic colloidal silver and gold nanoparticles: recent trends and future prospects M Ovais, I Ahmad, AT Khalil, S Mukherjee, R Javed, M Ayaz, A Raza, ... Applied microbiology and biotechnology 102 (10), 4305-4318 , 2018 2018 Citations: 216
Selected hepatoprotective herbal medicines: Evidence from ethnomedicinal applications, animal models, and possible mechanism of actions M Ali, T Khan, K Fatima, QUA Ali, M Ovais, AT Khalil, I Ullah, A Raza, ... Phytotherapy research 32 (2), 199-215 , 2018 2018 Citations: 198
Current state and prospects of the phytosynthesized colloidal gold nanoparticles and their applications in cancer theranostics M Ovais, A Raza, S Naz, NU Islam, AT Khalil, S Ali, MA Khan, ZK Shinwari Applied microbiology and biotechnology 101 (9), 3551-3565 , 2017 2017 Citations: 175
Advances in nano-delivery systems for doxorubicin: an updated insight U Kanwal, N Irfan Bukhari, M Ovais, N Abass, K Hussain, A Raza Journal of drug targeting 26 (4), 296-310 , 2018 2018 Citations: 174
Phyto-therapeutic and nanomedicinal approaches to cure Alzheimer’s disease: present status and future opportunities M Ovais, N Zia, I Ahmad, AT Khalil, A Raza, M Ayaz, A Sadiq, F Ullah, ... Frontiers in aging neuroscience 10, 284 , 2018 2018 Citations: 165
Exogenous application of glycinebetaine and potassium for improving water relations and grain yield of wheat under drought MAS Raza, MF Saleem, GM Shah, IH Khan, A Raza Journal of soil science and plant nutrition 14 (2), 348-364 , 2014 2014 Citations: 165
Multifunctional theranostic applications of biocompatible green-synthesized colloidal nanoparticles M Ovais, AT Khalil, A Raza, NU Islam, M Ayaz, M Saravanan, M Ali, ... Applied microbiology and biotechnology 102 (10), 4393-4408 , 2018 2018 Citations: 160
Design and characterization of paclitaxel-loaded polymeric nanoparticles decorated with trastuzumab for the effective treatment of breast cancer M Sakhi, A Khan, Z Iqbal, I Khan, A Raza, A Ullah, F Nasir, SA Khan Frontiers in pharmacology 13, 855294 , 2022 2022 Citations: 100
Development of mannose-anchored thiolated amphotericin B nanocarriers for treatment of visceral leishmaniasis G Shahnaz, BJ Edagwa, JE McMillan, S Akhtar, A Raza, NA Qureshi, ... Nanomedicine 12 (2), 99-115 , 2017 2017 Citations: 100
HPLC-DAD finger printing, antioxidant, cholinesterase, and α-glucosidase inhibitory potentials of a novel plant Olax nana M Ovais, M Ayaz, AT Khalil, SA Shah, MS Jan, A Raza, M Shahid, ... BMC complementary and alternative medicine 18 (1), 1 , 2018 2018 Citations: 96
PEG capped methotrexate silver nanoparticles for efficient anticancer activity and biocompatibility Z Muhammad, A Raza, S Ghafoor, A Naeem, SS Naz, S Riaz, W Ahmed, ... European Journal of Pharmaceutical Sciences 91, 251-255 , 2016 2016 Citations: 91
Docetaxel‐loaded solid lipid nanoparticles: a novel drug delivery system Sumera, A Anwar, M Ovais, A Khan, A Raza IET Nanobiotechnology 11 (6), 621-629 , 2017 2017 Citations: 79
Biosynthesized colloidal silver and gold nanoparticles as emerging leishmanicidal agents: an insight M Ovais, A Nadhman, AT Khalil, A Raza, F Khuda, MF Sohail, Zakiullah, ... Nanomedicine 12 (24), 2807-2819 , 2017 2017 Citations: 72
Doxorubicin-loaded quaternary ammonium palmitoyl glycol chitosan polymeric nanoformulation: uptake by cells and organs AR Ummarah Kanwal, Nadeem Irfan Bukhari, Nosheen Fatima Rana, Mehreen Rehman ... International Journal of Nanomedicine, 1-15 , 2019 2019 Citations: 60
Utility of PCR in diagnosis of problematic cases of typhoid A Haque, N Ahmed, A Peerzada, A Raza, S Bashir, G Abbas Japanese journal of infectious diseases 54 (6), 237-239 , 2002 2002 Citations: 60
Annihilation of Leishmania by daylight responsive ZnO nanoparticles: a temporal relationship of reactive oxygen species-induced lipid and protein oxidation A Nadhman, MI Khan, S Nazir, M Khan, G Shahnaz, A Raza, DF Shams, ... International Journal of Nanomedicine, 2451-2461 , 2016 2016 Citations: 52
Molecular epidemiology of hepatitis C virus genotypes in different geographical regions of Punjab Province in Pakistan and a phylogenetic analysis H Aziz, A Raza, S Murtaza, Y Waheed, A Khalid, J Irfan, Z Samra, ... International Journal of Infectious Diseases 17 (4), e247-e253 , 2013 2013 Citations: 50
Synthesis and characterization of pre-activated thiolated chitosan nanoparticles for oral delivery of octreotide S Maria, HS Sarwar, MF Sohail, M Imran, OS Qureshi, A Raza, NM Ahmad, ... Journal of Drug Delivery Science and Technology 58, 101807 , 2020 2020 Citations: 44
