SUJEET KUMAR

@dr.sujeethkumar@nitte.edu.in

Professor-Pharmaceutical Chemistry/Pharmacy
Nitte College of Pharmaceutical Sciences (A constituent unit of Nitte Education Trust), Bengaluru

Download Compact PDF

https://researchid.co/sujeet

I have been working with KLE College of Pharmacy Bangalore (India) since July 2007 in the Department of Pharmaceutical Chemistry (Associate Professor at present). During my master’s (Pharmaceutical Chemistry) and PhD, I worked on nitrogen, oxygen, and sulfur-containing biologically active small heterocyclic molecules. My Post-doctoral research in the Department of Biomaterials Science at the Pusan National University Republic of Korea gave me in-depth knowledge about the functionalization of biopolymers as a drug delivery tool. Multistep synthesis of heterocyclic molecules, their purification and, structural characterization is the area of my research. I believe in teamwork and collaborative research. In the 15 years of teaching & research, I contributed to 35 research articles. Pharmaceutics, Cell, FEBS, Scientific Reports, EJMC, BMCL, Molecular Carcinogenesis and RSC Advances are few among them

EDUCATION

PhD in Pharmaceutical Sciences (JNTU, Hyderabad)

RESEARCH, TEACHING, or OTHER INTERESTS

Drug Discovery, Pharmaceutical Science, Cancer Research, Organic Chemistry

52

Scopus Publications

1437

Scholar Citations

16

Scholar h-index

27

Scholar i10-index

Scopus Publications

Synthesis, In Vitro Cytotoxicity Evaluation and GSK-3β Binding Study of Some Indole–Triazole-Linked Pyrazolone Derivatives
Ashok Madarakhandi, Sujeet Kumar, Nishith Teraiya, Gokulakrishnan Sakthivel, Basavaraj Metikurki, Veda B. Hacholli, Dominique Schols, Febina Ravindran, Bibha Choudhary, Subhas S. Karki
Chemistry Switzerland, 2026
Glycogen synthase kinase-3 beta (GSK-3β) is a multifunctional serine/threonine kinase mediating multiple cellular functions, such as differentiation, apoptosis, and cell proliferation. Because of their ability to alter carcinogenic pathways, GSK-3β inhibitors are being explored for the development of anticancer molecules. In the present study, we synthesized and evaluated the cytotoxic properties of a series of twenty indole–triazole-linked pyrazolone derivatives, 10Aa–Ed. All derivatives were characterized by FTIR, 1H/13C NMR, and high-resolution mass spectrometry (HRMS) methods. All compounds and standards, sunitinib and 5-Fluorouracil (5-FU), were screened against four adherent cell lines, including pancreatic adenocarcinoma (Capan-1), colorectal carcinoma (HCT-116), glioblastoma(LN229), and lung carcinoma (NCI-4460), and four non-adherent cell lines, including acute myeloid leukemia (HL-60), chronic myeloid leukemia (K562), T lymphoblast (MOLT4), and non-Hodgkin lymphoma (Z138). Among the screened derivatives, molecule 10Aa showed cytotoxicity against MOLT 4, Z138, and HL60 with CC50 values of 14.45 μM, 15.34 μM, and 17.56 μM, respectively. GSK-3β kinase inhibition was evaluated with the 10Aa, which is capable of inhibiting GSK-3β in a dose-dependent manner. Additionally, molecular docking was performed to estimate the correlation between invitro data and GSK-3β binding affinity. The outcomes of the invitro experiments demonstrated strong concordance with the insilico data. The discovery yielded compounds 10Aa and 10Cd, which can be modified to create effective anticancer agents that target GSK-3β.
Assessing the anti-leukemic efficacy of a curcuminoid in cellular and animal models
Vijayalakshmi Sudarshan, P. Shyamjith, Sujeet Kumar, Febina Ravindran, Nishith Teraiya, Bibha Choudhary, Subhas S. Karki
European Journal of Medicinal Chemistry, 2025
Functional Characterization of VS-186B, a Novel HDAC Inhibitor with Anticancer Activity
Laura A. Sanchez-Michael, Vijayalakshmi Sudarshan, Allison Elias, Denisse A. Gutierrez, Jose A. Lopez-Saenz, Jaqueline Pena-Zacarias, Gabriela C. Torres, Armando Varela-Ramirez, Sujeet Kumar, Subhas S. Karki, Renato J. Aguilera
International Journal of Molecular Sciences, 2025
Histone acetylation and deacetylation are key regulators of gene expression and are frequently dysregulated in cancer, contributing to tumorigenesis and drug resistance. Overexpression of histone deacetylases (HDACs) in many cancer types leads to silencing of tumor suppressor genes and uncontrolled proliferation. Tumors often rely on epigenetic mechanisms to escape therapy and develop resistance. This study aimed to identify novel compounds that selectively target cancer cells while minimizing toxicity to non-cancerous cell lines. A series of novel HDAC inhibitors was evaluated using the Differential Nuclear Staining (DNS) assay, flow cytometry, and HDAC inhibition assays. These assays assessed cytotoxicity, selectivity, and mechanisms of cell death. Among seven compounds tested, VS-186B exhibited the highest cytotoxicity and Selective Cytotoxicity Index (SCI), particularly against the human Jurkat T-cell leukemia cell line. Flow cytometry experiments (Annexin V-FITC, ROS, JC-1, and Caspase-3/7 assays) revealed that VS-186B induced apoptosis. VS-186B was more cytotoxic than Curcumin and Vorinostat across most of the cell lines tested and was more specific to hematological cells. Connectivity Map (CMap) analysis showed strong similarity to genes affected by known HDAC inhibitors. Subsequently, HDAC enzymatic assays confirmed that VS-186B inhibits Class I and II HDACs in a dose-dependent manner. VS-186B exhibits promising anticancer potential as a selective HDAC inhibitor since it induces apoptosis in cancer cells without significant cytotoxicity to non-cancerous lines with a similar gene expression profile to known HDAC inhibitors. These findings support further development of VS-186B as an epigenetic treatment for leukemia/lymphoma.
Andrographolide and Mahua Oil-Infused Emulgels: A Comprehensive QbD, In Vitro, and In Silico Strategy for Skin Pigmentation Treatment
N. V. L. Sirisha Mulukuri, Ranjitha Acharya, Sujeet Kumar, Nishith Teraiya, Digambar B. Yevale, Pankaj Kumar
Chemistry and Biodiversity, 2025
Skin pigmentation disorders such as melasma, hyperpigmentation and age spots are primarily associated with excessive melanin production and are a significant dermatological concern. To address this issue, the present study aimed to develop an effective skin‐lightening formulation by synergising the therapeutic benefits of andrographolide with the skin permeation‐enhancing properties of Mahua oil. A two‐factor factorial design was employed to formulate and optimise the emulgel using a quality by design (QbD) approach. The optimised formulation (AG‐6) was subjected to a series of evaluations, including preliminary characterisation, biocompatibility analysis, in vivo skin uptake studies and tyrosinase inhibition assays. Biocompatibility assessment revealed a 92.64% viability of human dermal fibroblast (HDF) cells after 24 h of AG‐6 treatment, indicating low cytotoxicity. Tyrosinase inhibition was observed at 28.94 µg/mL for AG‐6, which is comparable to the reference standard Kojic acid (25.37 µg/mL). Furthermore, molecular docking studies demonstrated that andrographolide exhibited a stronger binding affinity with tyrosinase‐related protein 1 (TYR1, PDB ID: 5M8L), with a binding energy of −7.9 kcal/mol, as compared to kojic acid (−5.6 kcal/mol). These findings suggest that the optimised emulgel AG‐6 holds significant potential for the management of skin pigmentation disorders.
Impact of NaI/KI blending on structural, optical, and impedance properties of sodium carboxymethyl cellulose biopolymer films
S. Nalina, Sujeet Kumar, Tejashree Bhat, V. Prakruthi, N. S. Keerthana, Seema S. Pattanshetty, D. Vinay, Rajeev R. Potadar, Suchitra Putran, A. N. Prabhu, M. S. Murari, Manohar Pillegowda, K. R. Jahnavi, Ganesh Shridhar Hegde
Polymer Bulletin, 2025
Design, synthesis and anticancer evaluation of novel hydrazide-2-oxindole analogues as GSK-3β kinase inhibitors
Ashok Madarakhandi, Sujeet Kumar, Nishith Teraiya, Dominique Schols, Soujanya J. Vastrad, P. Shyamjith, Bibha Choudhary, Arzoo Rai, Subhas S. Karki
Rsc Advances, 2025
GSK-3β plays an essential role in cancer progression, making it a promising target for therapeutic intervention with glycogen synthase kinase (GSK-3β) inhibitors.
Synthesis of novel pyridazine and pyrimidine linked pyrazole derivatives as DNA ligase 1 and IV inhibitors that induce apoptosis
S. Aishwarya, Gabriela C. Torres, Jose A. Lopez-Saenz, Denisse A. Gutierrez, Sujeet Kumar, Ashok Madarakhandi, Basavaraj Metikurki, Nishith Teraiya, Renato J. Aguilera, Subhas S. Karki
Chemico Biological Interactions, 2025
Investigation of Anti-Cancer Properties of Novel Curcuminoids in Leukemic Cells and Dalton Lymphoma Ascites Model
Vijayalakshmi Sudarshan, P. Shyamjith, Sujeet Kumar, Febina Ravindran, Bibha Choudhary, Subhas S. Karki
International Journal of Molecular Sciences, 2025
Leukemia, one of the major causes of cancer death, ranks 11th worldwide among cancer-related deaths. The current treatment of leukemia faces challenges recently due to a high burden of side effects. It is well established that curcumin has anticancer and tumor-suppressing activities in several cancers in addition to leukemia. Accordingly, 15 derivatives were designed and prepared to improve the shortcomings of curcumin, such as poor aqueous solubility, chemical instability, and low bioavailability. All 15 were evaluated for cytotoxicity against the leukemic cell line MOLT-4, which led to the prioritization and further evaluation of compound curcuminoid (2E,5E)-2,5-bis((3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)cyclopentan-1-one 5i. 5i. Compared to curcumin, 5i was significantly more effective in inducing mitochondrial dysfunction in MOLT-4 cells; hence increased ROS production and cytotoxicity. Treatment groups showed change in mitochondrial membrane potential by flow cytometry analysis. Moreover, tumor volume reduction observed with 5i treatment in Dalton’s Lymphoma model was accompanied with low toxicity. Intrinsic pathways of apoptosis was initiated by compound 5i that lowered Bcl-2 expression while augmenting cytochrome c, Bak and Bax levels both in vivo and in vitro. These results showcase the potent antiproliferative as well as cytotoxic effects of 5i at nanomolar doses against leukemia being at least 60 times more effective than curcumin.
Dysfunctional mitochondrial bioenergetics sustains drug resistance in cancer cells
Davide Gnocchi, Dragana Nikolic, Silvia Russo, Maria Laura Matrella, Rosa R. Paparella, Sujeet Kumar, Subhas S. Karki, Carlo Sabbà, Tiziana Cocco, Simona Lobasso, Antonio Mazzocca
American Journal of Physiology Cell Physiology, 2025
Cancer drug resistance (CDR) is increasingly becoming a concerning clinical problem. The mechanisms behind the onset of CDR are still not well defined. In this study, we demonstrated that a treatment mimicking long-term clinical protocols with commonly used chemotherapeutic agents promotes mitochondrial bioenergetic dysfunction, leading to the acquisition of CDR. In a future perspective, interventions aimed at inhibiting fermentation and restoring OXPHOS efficiency may offer tangible opportunities to reduce the clinical burden of CDR.
Synthesis, molecular docking, dynamics study and preliminary cytotoxicity study of some coumarin linked imidazothiadiazoles
Sujeet Kumar, Sravani PV, Gokulakrishnan S, Satyaprakash Khushwah, Basavaraj Metikurki, Dominique Schols, Hakan Alici, Hakan Tahtaci, Satvik Kotha, Swapna B, Shankar G. Alegaon, Subhas S. Karki
Journal of Molecular Structure, 2025
Synthesis, in silico ADME, Molecular Docking and in vitro Cytotoxicity Evaluation of Indolin-2-one linked Stilbene Derivatives
Dimple Pirgal, Subhas S. Karki, Sujeet Kumar, Basavraj Metikurki
Asian Journal of Chemistry, 2025
1,4-Disubstituted-1,2,3-triazole Linked Cyclic Ketones as Cytotoxic Agents
Subhas S. Karki, Basavaraj Metikurki, Arnika Das, Ashok Madarakhandi, Arnav Kumar, Sujeet Kumar, Dominique Schols
Asian Journal of Chemistry, 2025
Discovery of new pyrazole-4-carboxamide analogues as potential anticancer agents targeting dual aurora kinase A and B
Digambar Yevale, Nishith Teraiya, Twinkle Lalwani, Mayur Dalasaniya, Saumya K. Patel, Nandan Dixit, Chetan B. Sangani, Sujeet Kumar, N.V.L. Sirisha Mulukuri, Tao Huang, Yong-Tao Duan, Jie Zhang
European Journal of Medicinal Chemistry, 2024
Statistical modeling, optimization and characterization of andrographolide loaded emulgel for its therapeutic application on skin cancer through enhancing its skin permeability
N. V. L. Sirisha Mulukuri, Sujeet Kumar, Moumita Dhara, Gupta Dheeraj Rajesh, Pankaj Kumar
Saudi Pharmaceutical Journal, 2024
Synthesis, In silico Study and Cytotoxicity Evaluation of Some Newly Synthesized Stilbene Derivatives
Dimple Pirgal, Subhas S. Karki, Sujeet Kumar, Basavraj Metikurki
Asian Journal of Chemistry, 2024
Enhancing the Thermoelectric Power Factor by Lowering the Electrical Resistivity of Bi2Se3/NaI Composites Prepared by Solid-State Reaction
Vivekananda, P. K. Prarthana, M. Archana, R Gowrishree, Tejashree Bhat, V Prakruthi, N. S. Keerthana, P. Sharath, T. Tabassum Sulthana, R. Thulasi, Vaishnavi S. Naidu, V. S. Shilpa, D. Vinay, S. Nalina, Rajeev R. Potadar, Ganesh Shridhar Hegde, A. N. Prabhu, Ashok Rao, U. Deepika Shanubhogue, Suchitra Putran, M. S. Murari, K. R. Jahnavi, Sujeet Kumar
Journal of Electronic Materials, 2023
Synthesis of Novel Pyrazole-Oxindole Conjugates with Cytotoxicity in Human Cancer Cells via Apoptosis
Pravesh M. Jain, Denisse A. Gutierrez, Sujeet Kumar, Renato J. Aguilera, Subhas S. Karki
Chemistry and Biodiversity, 2023
A Coumarin–Imidazothiadiazole Derivative, SP11 Abrogates Tumor Growth by Targeting HSP90 and Its Client Proteins
Snehal Nirgude, Shahana M. V., Febina Ravindran, Sujeet Kumar, Shivangi Sharma, Raghunandan Mahadeva, Anisha Mhatre, Subhas S. Karki, Bibha Choudhary
Molecules, 2023
Synthesis, in vitro cytotoxicity, molecular docking and ADME study of some indolin-2-one linked 1,2,3-triazole derivatives
Arnika Das, Giulia Greco, Sujeet Kumar, Elena Catanzaro, R. Morigi, A. Locatelli, D. Schols, Hakan Alici, Hakan Tahtaci, Febina Ravindran, C. Fimognari, S. Karki
Computational Biology and Chemistry, 2022
Synthesis, characterization, and biological evaluation of some 4-((thiophen-2-yl-methylene)amino)benzenesulfonamide metal complexes
E. Vijaya Sekhar, Subhas S. Karki, Javarappa Rangaswamy, Mahesh Bhat, Sujeet Kumar
Beni Suef University Journal of Basic and Applied Sciences, 2021
Synthesis, molecular docking, and preliminary cytotoxicity study of some novel 2-(naphthalen-1-yl)-methylimidazo[2,1-b][1,3,4]thiadiazoles
Choodamani B, Sujeet Kumar, Alok Kumar Gupta, Dominique Schols, Hakan Tahtaci, Tuncay Karakurt, Satvik Kotha, Swapna B, Ramachandra Setty, Subhas S. Karki
Journal of Molecular Structure, 2021
Qualitative and Quantitative Study of Intermolecular Interactions in Imidazo[2,1-b] [1,3,4] Thiadiazoles
Ammankallu Sowmya, Gudibande N. A. Kumar, Sujeet Kumar, S. Karki
Chemistryselect, 2021
Synthesis, Molecular Docking and Preliminary Antileukemic Activity of 4-Methoxybenzyl Derivatives Bearing Imidazo[2,1-b][1,3,4]thiadiazole
B. Choodamani, Karla G. Cano Hernandez, Sujeet Kumar, Ann Maria Tony, Austre Y. Schiaffino Bustamante, Renato J. Aguilera, Dominique Schols, C. Gopi Mohan, Subhas S. Karki
Chemistry and Biodiversity, 2021
Synthesis, in silico ADME, molecular docking and in vitro cytotoxicity evaluation of stilbene linked 1,2,3-triazoles
Arnika Das, Sujeet Kumar, Leentje Persoons, Dirk Daelemans, Dominique Schols, Hakan Alici, Hakan Tahtaci, Subhas S. Karki
Heliyon, 2021
St09, a novel curcumin derivative, blocks cell migration by inhibiting matrix metalloproteases in breast cancer cells and inhibits tumor progression in eac mouse tumor models
Snehal Nirgude, Raghunandan Mahadeva, Jinsha Koroth, Sujeet Kumar, Kothanahally S. Sharath Kumar, Vidya Gopalakrishnan, Subhas S Karki, Bibha Choudhary
Molecules, 2020
Crystal structure, quantum chemical and theoretical charge density analysis of 5‑bromo-2-(4-methylbenzyl)-6-(4-nitrophenyl)imidazo[2,1-b][1,3,4] thiadiazole
A. Sowmya, G.N. Anil Kumar, Sujeet Kumar, Subhas S. Karki
Chemical Data Collections, 2020
Odorless glutathione microneedle patches for skin whitening
Yechan Lee, Sujeet Kumar, Sou Hyun Kim, Keum-Yong Seong, Hyeseon Lee, Chaerin Kim, Young-Suk Jung, Seung Yun Yang
Pharmaceutics, 2020
Investigation of anti-cancer and migrastatic properties of novel curcumin derivatives on breast and ovarian cancer cell lines
Jinsha Koroth, Snehal Nirgude, Shweta Tiwari, Vidya Gopalakrishnan, Raghunandan Mahadeva, Sujeet Kumar, Subhas S. Karki, Bibha Choudhary
BMC Complementary and Alternative Medicine, 2019
Crystal structure, quantum chemical and Hirshfeld surface analysis of substituted imidazo-thiadiazole-5-carbaldehyde
A. Sowmya, G.N. Anil Kumar, Sujeet Kumar, Subhas S. Karki
Chemical Data Collections, 2018
Utility of thromboelastography versus routine coagulation tests for assessment of hypocoagulable state in patients undergoing cardiac bypass surgery
Seema Sharma, Sujeet Kumar, Prabhat Tewari, Shantanu Pande, Manjula Murari
Annals of Cardiac Anaesthesia, 2018
Identification and characterization of novel ligase I inhibitors
Monica Pandey, Sujeet Kumar, Gunaseelan Goldsmith, Mrinal Srivastava, Santhini Elango, Mohammad Shameem, Dibyendu Bannerjee, Bibha Choudhary, Subhas S. Karki, Sathees C. Raghavan
Molecular Carcinogenesis, 2017
Synthesis and cytotoxic evaluation of some 2-{4-[(2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl] phenoxy}-n-phenylacetamide
Acta Poloniae Pharmaceutica Drug Research, 2017
A novel resveratrol based tubulin inhibitor induces mitotic arrest and activates apoptosis in cancer cells
Elizabeth Thomas, Vidya Gopalakrishnan, Mahesh Hegde, Sujeet Kumar, Subhas S. Karki, Sathees C. Raghavan, Bibha Choudhary
Scientific Reports, 2016
Identification of a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain
Divyaanka Iyer, Supriya V. Vartak, Archita Mishra, Gunaseelan Goldsmith, Sujeet Kumar, Mrinal Srivastava, Mahesh Hegde, Vidya Gopalakrishnan, Mark Glenn, Mahesh Velusamy, Bibha Choudhary, Nagesh Kalakonda, Subhas S. Karki, Avadhesha Surolia, Sathees C. Raghavan
FEBS Journal, 2016
Synthesis of stilbene-based resveratrol analogs as cytotoxic agents
Research Journal of Pharmaceutical Biological and Chemical Sciences, 2016
Synthesis of imidazo[2,1-b][1,3,4]thiadiazole derivatives as possible biologically active agents
Acta Poloniae Pharmaceutica Drug Research, 2016
Synthesis and pharmacological activity of imidazo[2,1-b][1,3,4]thiadiazole derivatives
Acta Poloniae Pharmaceutica Drug Research, 2016
The crystal structure of 6-(4-chlorophenyl)-2-(4-methylbenzyl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde
A. Sowmya, G. N. Anil Kumar, Sujeet Kumar, Subhas S. Karki
Acta Crystallographica Section E Crystallographic Communications, 2016
Synthesis and antiinflammatory activity of some imidazo[2,1-b][1,3,4]thiadiazole derivatives
Acta Poloniae Pharmaceutica Drug Research, 2015
Synthesis and evaluation of the biological activity of N′-[2-oxo-1,2 dihydro-3H-indol-3-ylidene] benzohydrazides as potential anticancer agents
Arpit Katiyar, Mahesh Hegde, Sujeet Kumar, Vidya Gopalakrishnan, Khyati D. Bhatelia, Kavya Ananthaswamy, Sureshbabu A. Ramareddy, Erik De Clercq, Bibha Choudhary, Dominique Schols, Sathees C. Raghavan, Subhas S. Karki
Rsc Advances, 2015
Synthesis and antiproliferative activity of imidazo[2,1-b][1,3,4]thiadiazole derivatives
Sujeet Kumar, Vidya Gopalakrishnan, Mahesh Hegde, Vivek Rana, Sharad S. Dhepe, Sureshbabu A. Ramareddy, Alberto Leoni, Alessandra Locatelli, Rita Morigi, Mirella Rambaldi, Mrinal Srivastava, Sathees C. Raghavan, Subhas S. Karki
Bioorganic and Medicinal Chemistry Letters, 2014
2-(4-Chlorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazoles: Synthesis, cytotoxic activity and mechanism of action
Sujeet Kumar, Mahesh Hegde, Vidya Gopalakrishnan, Vinaya Kumar Renuka, Sureshbabu A. Ramareddy, Erik De Clercq, Dominique Schols, Anil Kumar Gudibabande Narasimhamurthy, Sathees C. Raghavan, Subhas S. Karki
European Journal of Medicinal Chemistry, 2014
Synthesis, cytostatic and antiviral activity of some ruthenium (II) complexes
Turkish Journal of Pharmaceutical Sciences, 2014
Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino) methyl)-2-oxoindolin-3-ylidene)-N-substituted-hydrazinecarbothioamides
Subhas S. Karki, Amol A. Kulkarni, Sujeet Kumar, Suresh Kumar Veliyath, Erik De Clercq, Jan Balzarini
Medicinal Chemistry Research, 2013
An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression
Mrinal Srivastava, Mridula Nambiar, Sheetal Sharma, Subhas S. Karki, G. Goldsmith, Mahesh Hegde, Sujeet Kumar, Monica Pandey, Ram K. Singh, Pritha Ray, Renuka Natarajan, Madhura Kelkar, Abhijit De, Bibha Choudhary, Sathees C. Raghavan
Cell, 2012
Novel Levamisole derivative induces extrinsic pathway of apoptosis in cancer cells and inhibits tumor progression in mice
Mahesh Hegde, Subhas S. Karki, Elizabeth Thomas, Sujeet Kumar, Kuppusamy Panjamurthy, Somasagara R. Ranganatha, Kanchugarakoppal S. Rangappa, Bibha Choudhary, Sathees C. Raghavan
Plos One, 2012
Microwave-assisted synthesis and antimicrobial activity of some imidazo[2,1-b][1,3,4]thiadiazole derivatives
Sharad Dhepe, Sujeet Kumar, R. Vinayakumar, Sureshbabu A. Ramareddy, Subhas S. Karki
Medicinal Chemistry Research, 2012
Design, synthesis and biological evaluation of novel analogs of bortezomib
R. Janaki Rama Rao, A.K.S. Bhujanga Rao, K. Swapna, B. Baby Rani, S. Prasanna Kumar, S. Awantika, Y.L.N. Murthy
Journal of the Korean Chemical Society, 2011
Synthesis and biological evaluation of novel 2-aralkyl-5-substituted-6- (4′-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent anticancer agents
Subhas S. Karki, Kuppusamy Panjamurthy, Sujeet Kumar, Mridula Nambiar, Sureshbabu A. Ramareddy, Kishore K. Chiruvella, Sathees C. Raghavan
European Journal of Medicinal Chemistry, 2011
Synthesis and antimicrobial activity of some 3-substituted-2-oxindole derivatives
Turkish Journal of Pharmaceutical Sciences, 2011
Synthesis, anticancer and cytostatic activity of some 6H-indolo[2,3-b] quinoxalines
Subhas Karki, Rahul Hazare, Sujeet Kumar, Vivek Bhadauria, Jan Balzarini, Erik De Clercq
Acta Pharmaceutica, 2009
1-Arylmethyl-2,3-dioxo-2,3-dihydroindole thiosemicarbazones as leads for developing cytotoxins and anticonvulsants
Subhas S. Karki, Vivek Singh Bahaduria, Vivek Rana, Sujeet Kumar, Prasanna G. Subbaro, Umashankar Das, Jan Balzarini, Erik De Clercq, Jonathan R. Dimmock
Journal of Enzyme Inhibition and Medicinal Chemistry, 2009

RECENT SCHOLAR PUBLICATIONS

Synthesis and Characterization of Piperazine-Linked Eugenol Derivative
MG Yenagunte Narayanaswamy, S Kumar, SR Setty, B Metikurki, ...
Molbank 2026 (3), M2180 , 2026
2026
Synthesis, In Vitro Cytotoxicity Evaluation and GSK-3β Binding Study of Some Indole–Triazole-Linked Pyrazolone Derivatives
Madarakhandi A, Kumar S, Teraiya N, Sakthivel G, Metikurki B, Hacholli VB ...
chemistry (Switzerland) 8 (2), 17 , 2026
2026
Functional Characterization of VS-186B, a Novel HDAC Inhibitor with Anticancer Activity
Laura A. Sanchez-Michael, Vijayalakshmi Sudarshan, Allison Elias, Denisse A ...
International Journal of Molecular Sciences 26, 11354 , 2025
2025
Citations: 2
Assessing the anti-leukemic efficacy of a curcuminoid in cellular and animal models
V Sudarshan, P Shyamjith, S Kumar, F Ravindran, N Teraiya, ...
European Journal of Medicinal Chemistry, 118177 , 2025
2025
Citations: 3
Impact of NaI/KI blending on structural, optical, and impedance properties of sodium carboxymethyl cellulose biopolymer films
S Nalina, S Kumar, T Bhat, V Prakruthi, NS Keerthana, SS Pattanshetty, ...
Polymer Bulletin 82 (12), 6455-6485 , 2025
2025
Design, synthesis and anticancer evaluation of novel hydrazide-2-oxindole analogues asGSK-3-beta kinase inhibitors
Madarakhandi A, Kumar S, Terayia N, Schols D, Vastrad S.J, Shyamjith P ...
RSC Advances 15, 24650 , 2025
2025
Citations: 2
Andrographolide and Mahua Oil-Infused Emulgels: A comprehensive QbD, in vitro, and in silico strategy for skin pigmentation treatment.
Sirisha Mulukuri NVL, Acharya R, Kumar S, Teraiya N, Yevale DB, Kumar P
Chemistry &Biodiversity, e00166. , 2025
2025
Synthesis of novel pyridazine and pyrimidine linked pyrazole derivatives as DNA ligase 1 and IV inhibitors that induce apoptosis
S Aishwarya, GC Torres, JA Lopez-Saenz, DA Gutierrez, S Kumar, ...
Chemico-Biological Interactions 414, 111509 , 2025
2025
Citations: 3
Dysfunctional mitochondrial bioenergetics sustains drug resistance in cancer cells
D Gnocchi, D Nikolic, S Russo, ML Matrella, RR Paparella, S Kumar, ...
American Journal of Physiology-Cell Physiology 328 (4), C1150-C1159 , 2025
2025
Citations: 11
Investigation of anti-cancer properties of novel curcuminoids in leukemic cells and Dalton lymphoma ascites model
V Sudarshan, P Shyamjith, S Kumar, F Ravindran, B Choudhary, SS Karki
International Journal of Molecular Sciences 26 (7), 3186 , 2025
2025
Citations: 2
Synthesis, in silico ADME, Molecular Docking and in vitro Cytotoxicity Evaluation of Indolin-2-one linked Stilbene Derivatives
Dimple Pirgal, Subhas S. Karki, Sujeet Kumar, Basavaraj Metikurki
Asian Journal of Chemistry 37 (3), 737-744 , 2025
2025
Synthesis, molecular docking, dynamics study and preliminary cytotoxicity study of some coumarin linked imidazothiadiazoles
S Kumar, PV Sravani, S Gokulakrishnan, S Khushwah, B Metikurki, ...
Journal of Molecular Structure 1321, 139943 , 2025
2025
Citations: 2
1, 4-Disubstituted-1, 2, 3-triazole Linked Cyclic Ketones Ascytotoxic Agents
A Kumar, S Kumar, A Das, B Metikurki, D Schols, SSS Karki
Asian Journal of Chemistry 37 (8) , 2025
2025
Discovery of new pyrazole-4-carboxamide analogues as potential anticancer agents targeting dual Aurora kinase A and B
Digambar Yevale, Nishith Teraiya, Twinkle Lalwani, Mayur Dalasaniya, Saumya ...
European Journal of Medicinal Chemistry, 116917 , 2024
2024
Citations: 17
Synthesis, In silico Study and Cytotoxicity Evaluation of Some Newly Synthesized Stilbene Derivatives
Dimple Pirgal, Subhas S. Karki, Sujeet Kumar, Basavraj Metikurki
Asian Journal of Chemistry 36 (8), 1882-1888 , 2024
2024
Statistical modeling, optimization and characterization of andrographolide loaded emulgel for its therapeutic application on skin cancer through enhancing its skin permeability
M Sirisha, S Kumar, D Moumita, GD Rajesh, P Kumar
Saudi Pharmaceutical Journal 32 (2024), 102068 , 2024
2024
Citations: 10
Abstract 2396 Novel Ligase 1 and 4 Inhibitor Compounds as Potential Drugs for Cancer Treatment
GT Quesada, L Sanchez-Michael, D Gutierrez, A Varela-Ramirez, P Jain, ...
Journal of Biological Chemistry 300 (3) , 2024
2024
PP053 SP11, a promising coumarin-imidazothiadiazole derivative, targets HSP90 and client proteins to inhibit tumor growth
MV Shahana, S Nirgude, F Ravindran, S Kumar, S Sharma, R Mahadeva, ...
ESMO Open 8 (1) , 2023
2023
Citations: 1
Enhancing the Thermoelectric Power Factor by Lowering the Electrical Resistivity of Bi 2 Se 3 /NaI Composites Prepared by Solid-State Reaction
Vivekananda, PK Prarthana, M Archana, R Gowrishree, T Bhat, ...
Journal of Electronic Materials 52 (12), 8076-8085 , 2023
2023
Synthesis of novel pyrazole-oxindole conjugates with cytotoxicity in human cancer cells via apoptosis
Subhas S Karki, Pravesh J, Gutierrez D A, Kumar S, Aguilera R J
Chemistry & Biodiversity , 2023
2023
Citations: 3

MOST CITED SCHOLAR PUBLICATIONS

An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression
M Srivastava, M Nambiar, S Sharma, SS Karki, G Goldsmith, M Hegde, ...
Cell 151 (7), 1474-87 , 2012
2012
Citations: 469
Synthesis and biological evaluation of novel 2-aralkyl-5-substituted-6-(4′-fluorophenyl)-imidazo [2, 1-b][1, 3, 4] thiadiazole derivatives as potent anticancer agents
SS Karki, K Panjamurthy, S Kumar, M Nambiar, SA Ramareddy, ...
European journal of medicinal chemistry 46 (6), 2109-16 , 2011
2011
Citations: 142
A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells.
E Thomas, V Gopalakrishnan, M Hegde, S Kumar, SS Karki, SC Raghavan, B Choudhary
Scientific Reports 6, 34653 , 2016
2016
Citations: 93
Novel levamisole derivative induces extrinsic pathway of apoptosis in cancer cells and inhibits tumor progression in mice
M Hegde, SS Karki, E Thomas, S Kumar, K Panjamurthy, ...
PloS one 7 (9), e43632 , 2012
2012
Citations: 70
Investigation of anti-cancer and migrastatic properties of novel curcumin derivatives on breast and ovarian cancer cell lines.
Koroth J, Nirgude S, Tiwari S, Gopalakrishnan V, Mahadeva R, Kumar S, Karki ...
BMC Complementary and Alternative Medicine 19 (273), 1-16 , 2019
2019
Citations: 62
Identification of a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain.
NK D Iyer, SV Vartak, A Mishra, G Goldsmith, S Kumar, M Srivastava, M Hegde ...
The FEBS Journal 283, 3408-3437 , 2016
2016
Citations: 53
Odorless glutathione microneedle patches for skin whitening.
SY Lee, Y., Kumar, S., Kim, S.H., Seong, K.Y., Lee, H., Kim, C., Jung, Y.S ...
Pharmaceutics 12 (2), 1-12 , 2020
2020
Citations: 51
Synthesis and antiproliferative activity of imidazo [2, 1-b][1, 3, 4] thiadiazole derivatives
S Kumar, V Gopalakrishnan, M Hegde, V Rana, SS Dhepe, ...
Bioorganic & Medicinal Chemistry Letters 24 (19), 4682-4688 , 2014
2014
Citations: 48
2-(4-Chlorobenzyl)-6-arylimidazo [2, 1-b][1, 3, 4] thiadiazoles: synthesis, cytotoxic activity and mechanism of action
S Kumar, M Hegde, V Gopalakrishnan, VK Renuka, SA Ramareddy, ...
European journal of medicinal chemistry 84, 687-697 , 2014
2014
Citations: 46
Synthesis, anticancer and cytostatic activity of some 6H-indolo [2, 3-b] quinoxalines
S Karki, R Hazare, S Kumar, V Bhadauria, J Balzarini, E De Clercq
Acta Pharmaceutica 59 (4), 431-440 , 2009
2009
Citations: 41
ST09, a novel curcumin derivative, blocks cell migration by inhibiting matrix metalloproteases in breast cancer cells and inhibits tumor progression in EAC mouse tumor models
S Nirgude, R Mahadeva, J Koroth, S Kumar, KSS Kumar, ...
Molecules 25 (19), 4499 , 2020
2020
Citations: 39
Synthesis and evaluation of the biological activity of N'-[2-oxo-1,2 dihydro-3H-indol-3-ylidene] benzohydrazides as potential anticancer agent.
SSK Arpit Katiyar,Mahesh Hegde, Sujeet Kumar, Vidya Gopalakrishnan, Khyati D ...
RSC Advances 5, 45492-501 , 2015
2015
Citations: 28
Microwave-assisted synthesis and antimicrobial activity of some imidazo [2, 1-b][1, 3, 4] thiadiazole derivatives
S Dhepe, S Kumar, R Vinayakumar, SA Ramareddy, SS Karki
Medicinal Chemistry Research 21 (8), 1550-1556 , 2012
2012
Citations: 28
Identification and characterization of novel ligase I inhibitors
M Pandey, S Kumar, G Goldsmith, M Srivastava, S Elango, M Shameem, ...
Molecular carcinogenesis 56 (2), 550-566 , 2017
2017
Citations: 25
1-Arylmethyl-2, 3-dioxo-2, 3-dihydroindole thiosemicarbazones as leads for developing cytotoxins and anticonvulsants
SS Karki, VS Bahaduria, V Rana, S Kumar, PG Subbaro, U Das, ...
Journal of enzyme inhibition and medicinal chemistry 24 (2), 537-544 , 2009
2009
Citations: 23
Discovery of new pyrazole-4-carboxamide analogues as potential anticancer agents targeting dual Aurora kinase A and B
Digambar Yevale, Nishith Teraiya, Twinkle Lalwani, Mayur Dalasaniya, Saumya ...
European Journal of Medicinal Chemistry, 116917 , 2024
2024
Citations: 17
Synthesis, molecular docking, and preliminary cytotoxicity study of some novel 2-(naphthalen-1-yl)-methylimidazo [2, 1-b][1, 3, 4] thiadiazoles
B Choodamani, S Kumar, AK Gupta, D Schols, H Tahtaci, T Karakurt, ...
Journal of Molecular Structure 1234, 130174 , 2021
2021
Citations: 14
Synthesis and antimicrobial activity of some 3-substituted-2-oxindole derivatives
SS Karki, R Hazare, S Kumar, A Saxena, A Katiyar
Turkish Journal of Pharmaceutical Sciences 8, 169-178 , 2011
2011
Citations: 14
Synthesis, characterization, and biological evaluation of some 4-((thiophen-2- yl -methylene)amino)benzenesulfonamide metal complexes
EV Sekhar, SS Karki, J Rangaswamy, M Bhat, S Kumar
Beni-Suef University Journal of Basic and Applied Sciences 10 (1), 28 , 2021
2021
Citations: 13
Synthesis, Molecular Docking and Preliminary Antileukemic Activity of 4‐Methoxybenzyl Derivatives Bearing Imidazo[2,1‐ b ][1,3,4]thiadiazole
B Choodamani, KG Cano Hernandez, S Kumar, AM Tony, ...
Chemistry & biodiversity 18 (2), e2000800 , 2021
2021
Citations: 13

GRANT DETAILS

UGC sponsored project (Diary KABA023/UGCSWRO, dated 28-3-2014 (₹ 1,85,000.00).

AICTE sponsored Research Promotion Scheme, F. No. 8023/BOR/RID/RP S-103/ 2009-10 dated 2211-2010 (₹ 14,30,000.00).

RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)

Indian Patent filed (as co-inventor), Title: Novel inhibitors of anti-apoptotic BCL-2 Proteins.

US Patent filed (as co-inventor), Title: Pyrazole derivatives with anticancer activity.