Metal Complexes of Curcumin: A Comprehensive Approach to Design, Synthesis, Characterization and Assessment of Anti-tubercular Activity Paramita Das, Yamuna HM, Harshashree M, Raman Dang Indian Journal of Pharmaceutical Education and Research, 2024 Background: The primary challenge facing Tuberculosis (TB) is the growing prevalence of drug resistance and the hepatotoxicity secondary effects of first and second-line anti-TB treatments have reignited interest in exploring new metal drug complexes as possible sources of anti-TB medications. Aim: To perform in silico studies for Curcumin-metal complexes, synthesis and evaluate their antitubercular activity and cytotoxicity. Materials and Methods: Designed metal complexes were docked against 2NSD and performed ADMET studies. Based on binding affinity, a series of Curcumin-metal complexes were synthesized, characterized by IR, NMR, MASS, P-XRD and the antitubercular activity was evaluated by MABA and MTT assay for cytotoxicity investigations. Results and Discussion: The binding energies ranged from -8.0 to -10.1 ‘ kcal/mol ’ . At -10.1 ‘ kcal/ mol ’ , the Curcumin-Cu complex (C1) exhibited the best binding. The synthesized compounds was evaluated against Mycobacterium tuberculosis (H37Rv) using the MABA assay. Curcumin-Cu complex (C1) showed the highest activity and was the most sensitive at 0.8 µg/mL and showed less toxicity with an IC 50 of 10.0 and a selectivity index of 4.0. Cytotoxicity was evaluated by the ATCC CCL-81 cell line. Conclusion: Therefore, we can conclude that the molecular hit will be a good lead to develop novel therapies for tuberculosis treatment.
Quality by design based development of etravirine self micro emulsifying drug delivery system KAVITHA A. N., JANAKIRAMAN K., RAMAN DANG International Journal of Applied Pharmaceutics, 2021 Objective: The main objective of the present research work was to develop systematically the Self Micro Emulsifying Drug Delivery system of BCS Class IV drug in a Quality by Design framework.
 Methods: The quality by design-based formulation development proceeds with defining the Quality Target Product Profile and Critical Quality Attributes of dosage form with appropriate justification for the same. The statistical Mixture design was used for the development of the formulation. The independent variables selected for the design were Oleic acid, Labrasol and PEG 6000, whereas droplet size (nm), emulsification time (sec), % drug loading and % drug release at 15 min were considered as the potential quality attributes of the Self Micro Emulsifying System. The eight different batches of Etravirine-Self Micro Emulsifying systems (ETV-SMEDDS) were prepared and checked for the Critical Quality Attributes. The simultaneous optimization of the formulation was done by the global desirability approach.
 Results: The characterization report obtained for all the different batches of formulation was analyzed statistically by fitting into regression models. The statistically significant models determined for droplet size (nm) (R2= 0.96 and p-0.1022), emulsification time (sec) (R2= 0.99 and p-0.0267), % drug loading (R2= 0.93 and p-0.1667) and % drug release at 15 min (R2= 0.96 and p-0.0911) and were statistically significant. The maximal global desirability value obtained was 0.9415 and the value indicates, the selected factors and responses have a good correlation and are significant enough for optimization and prediction of best formulation.
 Conclusion: The QbD approach utilized during the development of ETV-SMEEDS facilitated the identification of Critical Material Attributes and their significant impact on the Critical Quality Attributes of SMEDDS. The concept of building quality into product through the QbD application was utilized successfully in the formulation development.
Dynamic method for liaison of community pharmacists with national programme for tuberculosis control: Efforts to harness untapped opportunities Rajeswari Ramasamy, Guru Prasad Mohanta, Shobha Rani R Hiremath, Chandramouli Ramnarayanan, Raman Dang, et al. Indian Journal of Pharmaceutical Education and Research, 2020 Context: Revised National Tuberculosis Control Program (RNTCP) Directly Observed Treatment-Short course (DOTS) strategy to involve Community Pharmacist (CPs), was conceived and implemented in India, with the objective of improving accessibility of Tuberculosis free medicines. Though the RNTCP personnel in the study area had tried to create liaison with CPs; and to train them in DOTS provision roles, it was not successful as CPs were not forthcoming to be a part RNTCP DOTS paradigm. Hence this study was ideated and executed to develop a liaison model between CP and RNTCP personnel, to support the delivery of DOTS treatment under RNTCP programme. This article discusses the liaison method followed by the researchers to integrate the CPs with RNTCP’S TB centres in Bangalore City. Aim: To establish liaison between community pharmacists and RNTCP personnel to strengthen Public Private Mix (PPM) Partnership for providing TB care role in Bengaluru City, India. Methodology: An educational interventional study involving CPs in Bengaluru City was conducted with the regulatory support from Drugs Control department, Karnataka.Awareness and Training was given on the basis of the RNTCP training module for Community Pharmacist. The change in the level of awareness on existence of PPM RNTCP strategy among community pharmacist; and the percentage of pharmacists showing interest for TB care role after the program was measured. Results and Discussion: Out of 125 CPs representations, 93 CPs enrolled them as Private DOTS providers immediately after programme. The change in the Level of Awareness on the existence of TB-DOTS provider role was found to be 100% in this study. This result clearly points to the fact that CPs needs to be sensitized. Conclusion: The policy level changes in the ease of enrolling CPs to be a DOTS provider under the aegis of drugs control department, needs to be revisited and rethought in RNTCP’s national strategy for pharmacists.
Model predictive control based closed loop drug infusion device in critical care setups using computational therapeutics – A modelling and simulation study International Journal of Pharmaceutical Research, 2019
Evaluation of potency of sweetness of a natural plant based drug, Stevia rebaudiana with human subjects from cultivated field of Shimoga, Karnataka Journal of the Indian Chemical Society, 2018
Infusions of potent vasoactive drugs using computational therapeutic models in critical care setups - A modeling and simulation study Asian Journal of Pharmaceutics, 2018
Acute oral toxicity studies of antipsoriatic herbal mixture comprising of aqueous extracts of Calendula officinalis, Momordica charantia, Cassia tora and Azadirachta indica seed oil Thai Journal of Pharmaceutical Sciences, 2009
Influence of bio-fertilizers on the availability of nutrients (N, P and K) in soil in relation to growth and yield of Stevia rebaudiana grown in South India International Journal of Applied Research in Natural Products, 2008
