SHIVAKUMAR H.N

@klepharmblr.org

Vice-Principal & Professor
KLE College of Pharmacy, Bengaluru

SHIVAKUMAR H.N
I have more than 70 Research papers in peer-reviewed journals, six Book Chapters and one patent to my credit. I have been a Principal Investigator in research grants funded by All India Council for Technical Education (AICTE), New Delhi, Biotechnology Industry Research Assistance Council (BIRAC), New Delhi, Board of Research in Nuclear Science, (Department of Atomic Energy) and Vision Group of Science and Technology, Karnataka Science and Technology Promotion Society (KSTP), Department of Science and Technology, Govt of Karnataka. I have been the cofounder of the startup Feplen Health Research Pvt. Ltd. I have been awarded with the Biotechnology Ignition Grant (BIG) & SPARSH (Social Innovation programme for Products: Affordable & Relevant to Societal Health) Grants of BIRAC, Award for Research Paper by KSTP, DST, ‘The Best Teacher Award’ in 2015, STARS Award in 2016 & the Accomplished Alumni Award by American Association of Government College of Pharmacy, Bengaluru.

EDUCATION

I have done my Masters degree on Pharmaceutics from Government college of Phamacy, Bengaluru. I have earned my doctoral degree in Pharmacy from Rajiv Gandhi University of Heath Sciences, Karnataka and my Postdoctoral research fellowship from The University of Mississippi, University, MS, USA.

RESEARCH INTERESTS

Oral lymphatic drug delivery, Transdermal drug delivery, Tranasungual delivery, Pharmaceutical development applying the principles of Quality by Design (QbD), Colon specific drug delivery, oral targeted and sustained drug delivery, Chronotherapeutic Drug Delivery.

FUTURE PROJECTS

Project Title 1

Abstract 1


Applications Invited
Collaborators

Project Title 2

Abstract 2


Applications Invited
Collaborators

Project Title 3

Abstract 3


Applications Invited
Collaborators
107

Scopus Publications

2630

Scholar Citations

28

Scholar h-index

60

Scholar i10-index

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

  • Development and in vivo evaluation of novel bioresponsive nanocubosomal in-situ gelling system for ophthalmic delivery of Amphotericin B
    SP Sanjana, HN Shivakumar, R Shinde, R Kumar, MG Hariprasad
    International Journal of Pharmaceutics, 126990 , 2026
    2026
  • A Review Exploring the Translational Perspective of Artificial Intelligence in Drug Discovery and Formulation Development
    B Agarwal, S Gaware, N More, R Shinde, HN Shivakumar, S Jagdale
    Annales Pharmaceutiques Françaises , 2026
    2026
    Citations: 1
  • Activation-modulated stimuli-responsive systems: an intelligent platform for site-specific gastroretentive delivery of diverse therapeutic agents
    HN Shivakumar, R Shinde, V Somasekhar, MG Hariprasad, NM Mahesh
    International Journal of Pharmaceutics, 126599 , 2026
    2026
  • Formulation and optimization of cilnidipine solid dispersion-based sublingual films using D-optimal mixture design
    HN Shivakumar, M Kamath, A Kumar, S Prakash, R Shinde, A Tekade
    Particulate Science and Technology 44 (1), 111-124 , 2026
    2026
  • Nanoformulations in the management of onychomycosis and other nail disorders
    HN Shivakumar, A Kumar, SN Murthy
    Nanotechnology Applications for the Diagnosis and Therapeutic Treatment of … , 2026
    2026
  • Emerging trends in polymeric mucoadhesive nanocarriers: a promising option for intravaginal HIV preexposure prophylaxis
    A Kumar, D Avlani, SN Murthy, HN Shivakumar, S Jindal
    Journal of Drug Targeting 33 (10), 1718-1742 , 2025
    2025
    Citations: 4
  • Impact of Donor Height in Franz Diffusion Cell on the Performance of Topical Products
    HP Pa, AV Matadh, S HN, RN Murthy, S Rangappa, SN Murthy
    2025
  • Development, in vitro and in vivo evaluation of film forming solutions for transdermal drug delivery of Zaltoprofen
    P Alayadan, A Kumar, SS Prakash, B Bashir, V Bhagya, SN Murthy, ...
    Journal of Biomaterials Science, Polymer Edition 36 (9), 1265-1288 , 2025
    2025
    Citations: 3
  • Topical Formations and Critical Quality Attributes
    A Puri, A Kumar, HN Shivakumar, SN Murthy
    AAPS Introductions in the Pharmaceutical Sciences, 1-25 , 2025
    2025
  • Topical Formulations and Critical Quality Attributes
    HN Shivakumar, A Kumar, A Puri, SN Murthy
    Topical Products and Dermal Drug Delivery, 1-25 , 2025
    2025
    Citations: 1
  • Development of in vitro and in vivo evaluation of mucoadhesive in-situ gel for intranasal delivery of vinpocetine
    SAAA Hard, HN Shivakumar, DA Bafail, MA Moqbel Redhwan
    Journal of Drug Targeting 33 (4), 528-545 , 2025
    2025
    Citations: 14
  • Finite Dose In Vitro Permeation Testing: Significance of Occluding the Donor compartment, a Case study
    PN Murthy, MM Hossain, S Kundu, S Rangappa, S HN
    AAPS PharmSciTech 26 (4), 103 , 2025
    2025
    Citations: 1
  • Time to break and evaporation (TBE): A quality attribute of pharmaceutical topical foams
    B Holla, PN Murthy, AV Matadh, SG Pragathi, L Rakshitha, HP Pa, ...
    Journal of Pharmaceutical Sciences 114 (4), 103699 , 2025
    2025
    Citations: 1
  • Formulation and evaluation of polymeric spherical agglomerates-based porous orodispersible tablets of cilnidipine
    Y Alhamhoom, SS Prakash, A Kumar, SH Nanjappa, M Rahamathulla, ...
    Pharmaceutics 17 (2), 170 , 2025
    2025
    Citations: 6
  • Design and Evaluation of Bisoprolol Fumarate Transdermal Film: A Promising Approach for Cardiovascular Therapy
    HN Shivakumar, A Reddy, D Avlani, P Alayadan, A Kumar
    Journal of the Scientific Society 52 (1), 60-66 , 2025
    2025
  • An AQbD driven stability indicating HPLC method for simultaneous estimation of lamivudine, tenofovir disoproxil fumarate and efavirenz in plasma
    A Kumar, V Somasekhar, S Dhiman, SH Nanjappa, D Avlani
    Analytical Methods 17 (9), 2094-2111 , 2025
    2025
    Citations: 2
  • Biophysical and permeability characterization of lyophilized (freeze-dried) human cadaver skin
    HP Pa, SG Pragathi, K Poornima, SN Murthy, PN Murthy, D Wali, A Kumar, ...
    European Journal of Pharmaceutical Sciences 203, 106870 , 2024
    2024
    Citations: 1
  • Sublingual fast-dissolving thin films of loratadine: Characterization, in vitro and ex vivo evaluation
    Y Alhamhoom, AK Said, A Kumar, SH Nanjappa, D Wali, M Rahamathulla, ...
    Polymers 16 (20), 2919 , 2024
    2024
    Citations: 13
  • Formulation and evaluation of pH-modulated amorphous solid dispersion-based orodispersible tablets of cefdinir
    Y Alhamhoom, T Kumaraswamy, A Kumar, SH Nanjappa, SS Prakash, ...
    Pharmaceutics 16 (7), 866 , 2024
    2024
    Citations: 13
  • Overcoming challenges in dermal and transdermal delivery of herbal therapeutics with polymeric microneedles
    A VM, S Suresh, A Kumar, P K, R NM, S Rangappa, SN Murthy, S HN
    Journal of Biomaterials science, Polymer edition 35 (3), 364-396 , 2024
    2024
    Citations: 9

MOST CITED SCHOLAR PUBLICATIONS

  • Handbook of non-invasive drug delivery systems: non-invasive and minimally-invasive drug delivery systems for pharmaceutical and personal care products
    VS Kulkarni
    William Andrew Pub , 2009
    2009
    Citations: 239
  • Development and evaluation of an oral fast disintegrating anti-allergic film using hot-melt extrusion technology
    MB Pimparade, A Vo, AS Maurya, J Bae, JT Morott, X Feng, DW Kim, ...
    European Journal of Pharmaceutics and Biopharmaceutics 119, 81-90 , 2017
    2017
    Citations: 141
  • Formulation, characterization, and evaluation of matrix-type transdermal patches of a model antihypertensive drug
    VG Jamakandi, JS Mulla, BL Vinay, HN Shivakumar
    Asian Journal of Pharmaceutics (AJP) 3 (1) , 2009
    2009
    Citations: 115
  • Ungual and transungual drug delivery
    HN Shivakumar, A Juluri, BG Desai, SN Murthy
    Drug development and industrial pharmacy 38 (8), 901-911 , 2012
    2012
    Citations: 111
  • Development of taste masked caffeine citrate formulations utilizing hot melt extrusion technology and in vitro–in vivo evaluations
    MB Pimparade, JT Morott, JB Park, VI Kulkarni, S Majumdar, SN Murthy, ...
    International journal of pharmaceutics 487 (1-2), 167-176 , 2015
    2015
    Citations: 106
  • Topical and transdermal drug delivery
    SN Murthy, HN Shivakumar
    Handbook of non-invasive drug delivery systems, 1-36 , 2010
    2010
    Citations: 100
  • Design and optimization of diclofenac sodium controlled release solid dispersions by response surface methodology
    HN Shivakumar, BG Desai, G Deshmukh
    Indian journal of pharmaceutical sciences 70 (1), 22 , 2008
    2008
    Citations: 91
  • Iontophoretic permselective property of human nail
    SN Murthy, DC Waddell, HN Shivakumar, A Balaji, CP Bowers
    Journal of dermatological science 46 (2), 150-152 , 2007
    2007
    Citations: 78
  • Non-dermal applications of microneedle drug delivery systems
    A Panda, VA Matadh, S Suresh, HN Shivakumar, SN Murthy
    Drug Delivery and Translational Research 12 (1), 67-78 , 2022
    2022
    Citations: 75
  • Design and statistical optimization of glipizide loaded lipospheres using response surface methodology
    H Shivakumar, P Patel, B Desai, P Ashok, S Arulmozhi
    Acta pharmaceutica 57 (3), 269 , 2007
    2007
    Citations: 68
  • Formulation and evaluation of gemcitabine-loaded solid lipid nanoparticles
    PT Nandini, RC Doijad, HN Shivakumar, PM Dandagi
    Drug delivery 22 (5), 647-651 , 2015
    2015
    Citations: 67
  • Development and optimization of in-situ gel containing chitosan nanoparticles for possible nose-to-brain delivery of vinpocetine
    SAAA Hard, HN Shivakumar, MAM Redhwan
    International Journal of Biological Macromolecules 253, 127217 , 2023
    2023
    Citations: 62
  • Bilayered nail lacquer of terbinafine hydrochloride for treatment of onychomycosis
    HN Shivakumar, SRK Vaka, NVS Madhav, H Chandra, SN Murthy
    Journal of pharmaceutical sciences 99 (10), 4267-4276 , 2010
    2010
    Citations: 61
  • Delivery of ziconotide to cerebrospinal fluid via intranasal pathway for the treatment of chronic pain
    P Manda, AS Kushwaha, S Kundu, HN Shivakumar, SB Jo, SN Murthy
    Journal of Controlled Release 224, 69-76 , 2016
    2016
    Citations: 58
  • Design and Evaluation of pH Sensitive Multi-Particulate Systems for Chronotherapeutic Delivery of Diltiazem Hydrochloride.
    HN Shivakumar, S Suresh, BG Desai
    Indian journal of pharmaceutical sciences 68 (6) , 2006
    2006
    Citations: 52
  • Rapidly dissolving microneedle patches for transdermal iron replenishment therapy
    A Maurya, SH Nanjappa, S Honnavar, M Salwa, SN Murthy
    Journal of pharmaceutical sciences 107 (6), 1642-1647 , 2018
    2018
    Citations: 48
  • Effect of gamma sterilization on the properties of microneedle array transdermal patch system
    HP Swathi, V Anusha Matadh, J Paul Guin, S Narasimha Murthy, P Kanni, ...
    Drug Development and Industrial Pharmacy 46 (4), 606-620 , 2020
    2020
    Citations: 46
  • Iontophoresis for drug delivery into the nail apparatus: exploring hyponychium as the site of delivery
    A Kushwaha, HN Shivakumar, SN Murthy
    Drug development and industrial pharmacy 42 (10), 1678-1682 , 2016
    2016
    Citations: 42
  • Effect of ß Cyclodextrin Complexation on the Solubility and Dissolution Rate of Carbamazepine from Tablets.
    S Suresh, HN Shivakumar, GK Kumar
    Indian journal of pharmaceutical sciences 68 (3) , 2006
    2006
    Citations: 41
  • Polymer coated polymeric (PCP) microneedles for controlled delivery of drugs (dermal and intravitreal)
    D Jakka, AV Matadh, VK Shankar, HN Shivakumar, SN Murthy
    Journal of pharmaceutical sciences 111 (10), 2867-2878 , 2022
    2022
    Citations: 40

GRANT DETAILS

1. “Development of fast-dissolving tablets for neurological disorders” under Research Project Scheme (Ref: 8023/BOR/RPS-162/2006-07) supported by under of AICTE, New Delhi (Rs. 10.00 Lacs), INDIA.

2. ‘Transdermal delivery of iron’ with a fellowship of $ 30000 per from July 2008 to Oct 2009 by Department of Pharmaceutics, The University of Mississippi, MS-38677, USA.

3. “Formulation of Guinidine HCl gels for treatment of topical scars” funded by The Dept. of Pharmaceutics, University of Mississippi, MS, USA in the year 2013
4. “Formulation and Evaluation of inhalable mucoadhesive microparticles of streptomycin” funded by VGST, DITBST under Science Projects in college education (SPiCE) for the year 2012-13

5.“Design and Evaluation of Ocular Inserts of Dorzolamide Hydrochloride using natural Bioadhesive film formers” funded by VGST, DITBST under SPiCE for the year 2013-14

6.“Transdermal Iron Replenishment Therapy” funded by BIRAC (Rs. 33.20 Lacs) under the Biotechnology Ignition Grant - 2014

7.“Noninvasive electrical device for Transcutaneous Iron replenishment” has been recommended for a funding of Rs. 50 Lacs by BIRAC under SPARSH

8.“Effect Of Gamma Sterilization On The Properties Of Microneedle Array Transdermal Patch System” funded by BRNS, DAE, Govt. of India

9.“Development of Bio-adhesive nanoparticles for vaginal delivery of selected antiretrovirals” dunded by VGST,

10. “Guar gum based Dermal Bio-adhesive for Biomedical Patch Applications” funded by BIRAC.

RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)

Inventor in the Indian patent entitled A METHOD FOR PREPARATION OF CISPLATIN NANOPARTICLE COMPOSITION granted on 12--03-2021

CONSULTANCY

1. International Collaboration
Collaborator with Noninvasive Drug Delivery Laboratory, Department of Pharmaceutics, The University of Mississippi, MS, USA to facilitate Design Experiments (DoE), establish Design Space and Optimize Process/Product in the ongoing projects & undertake Pharmacokinetic testing of prototype formulations
2. Industrial Consultation
a. Formulation Development with DermaPerm Research Inc., Bangalore,
b. Kemwell BioPharma Pvt. Ltd., Bangalore to set up Design Experiments (DoE) &Establish Design Space, Implement
Principle of Quality by Design (QbD) in Pharmaceutical Development.
c. Consultant with SPI Pharma-India branch, Bangalore ( for the below mentioned projects
i. Design of Co-processed excipient systems for enhanced physicochemical and organoleptic properties
ii. Dissolution of powders in USP IV flow through dissolution apparatus
iii. Transport feasibility studies across porcine buccal mucosa
e. Syngene International Ltd, Bangalore ( for the project “Spray drying for enteric coating”
f. Semler Research Inc, Bangalore (
g. Stevia World Agrotech Pvt. Ltd., Bengaluru ( for project “Development and scale up of sugar free tablets of Stevia”
h. Nuwill Research & Innovations Pvt. Ltd. Bangalore

Industry, Institute, or Organisation Collaboration

Department of Pharmaceutics, The University of Mississippi, MS, USA. 1College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA, Department of Pharmacy Practice, College of Clinical Pharmacy, King FaisalUniversity, Al-Ahsa, 31982, Saudi Arabia.

INDUSTRY EXPERIENCE

One year of experience as a Production Executive at Bangalore Pharmaceuticals and Reserach Laboratories, Bangalore and two years of Experience as a Mangager (Formulation Development) at Kemwell Biopharma Pvt. Ltd. Bangalore.

STARTUP

I have been the cofounder of the startup Feplen Health Research Pvt. Ltd., and co-founder of the nonprofit Research Organization Institute for Drug Delivery and Biomedical research, Bengaluru (, a DSIR recognized non-profit research organization that is registered in Darpan portal of Niti Ayog.

SOCIAL, ECONOMIC, or ACADEMIC BENEFITS

Principal Investigator for the project entitled “Noninvasive electrical device for Transcutaneous Iron replenishment” has been recommended for a funding of Rs. 50 Lacs by Biotechnology Industry Research Assistance Council (BIRAC) under Social Innovation programme for Products: Affordable & Relevant to Societal Health (SPARSH)