I have more than 70 Research papers in peer-reviewed journals, six Book Chapters and one patent to my credit. I have been a Principal Investigator in research grants funded by All India Council for Technical Education (AICTE), New Delhi, Biotechnology Industry Research Assistance Council (BIRAC), New Delhi, Board of Research in Nuclear Science, (Department of Atomic Energy) and Vision Group of Science and Technology, Karnataka Science and Technology Promotion Society (KSTP), Department of Science and Technology, Govt of Karnataka. I have been the cofounder of the startup Feplen Health Research Pvt. Ltd. I have been awarded with the Biotechnology Ignition Grant (BIG) & SPARSH (Social Innovation programme for Products: Affordable & Relevant to Societal Health) Grants of BIRAC, Award for Research Paper by KSTP, DST, ‘The Best Teacher Award’ in 2015, STARS Award in 2016 & the Accomplished Alumni Award by American Association of Government College of Pharmacy, Bengaluru.
EDUCATION
I have done my Masters degree on Pharmaceutics from Government college of Phamacy, Bengaluru. I have earned my doctoral degree in Pharmacy from Rajiv Gandhi University of Heath Sciences, Karnataka and my Postdoctoral research fellowship from The University of Mississippi, University, MS, USA.
RESEARCH INTERESTS
Oral lymphatic drug delivery, Transdermal drug delivery, Tranasungual delivery, Pharmaceutical development applying the principles of Quality by Design (QbD), Colon specific drug delivery, oral targeted and sustained drug delivery, Chronotherapeutic Drug Delivery.
Formulation and evaluation of isosorbide dinitrate-loaded flash-release dispersible sublingual wafers Shivakumar H. Nanjappa, Vanita Somasekhar, Megha Kamath, Sanjana S. Prakash, Avichal Kumar, et al. Rsc Pharmaceutics, 2026 This study aimed to design flash-release dispersible sublingual wafers of isosorbide dinitrate (ISDN) by lyophilisation (LYO) by applying the principles of Quality by Design (QbD).
Cubosomes as Versatile Multifunctional Lipid-Based Nanocarriers for Drug Delivery: A Comprehensive Review Avinash Tekade, Ashutosh Shewale, H. N. Shivakumar, Rushikesh Shinde, Janhavi Nimbalkar Current Pharmaceutical Design, 2026 Cubosomes (QBS) are self-assembled, nanostructured lipid carriers characterized by a bicontinuous cubic liquid crystalline architecture with a three-dimensional honeycomb-like morphology. Their unique internal structure allows simultaneous encapsulation of hydrophilic, lipophilic, and amphiphilic compounds, enabling sustained, site-specific, and targeted drug delivery through various routes, including oral, ocular, nasal, transdermal, and vaginal administration. Composed primarily of amphiphilic lipids such as Glyceryl Monooleate (GMO) and stabilized with surfactants like Pluronic F-127, QBS exhibits superior biocompatibility, structural integrity, and long-term colloidal stability. QBS are typically fabricated using either top-down or bottom-up strategies. Top-down approaches such as high-pressure homogenization, probe sonication, and spray drying fragment bulk cubic phases into nanosized dispersions, ensuring scalability and uniformity. Conversely, bottom-up methods, including the hydrotrope technique, vortex dispersion, and solvent evaporation, enable spontaneous QBS formation under mild conditions ideal for thermolabile actives. Physicochemical properties depend on lipid-to-stabilizer ratios, solvent composition, and processing parameters. Characterization techniques such as Dynamic Light Scattering (DLS), Small-Angle X-ray Scattering (SAXS), Transmission Electron Microscopy (TEM), and Confocal Laser Scanning Microscopy (CLSM) confirm particle size, morphology, and internal nanostructure. Zeta potential and MTT assays evaluate stability and cytocompatibility, while in vitro and ex vivo studies assess drug entrapment, release, and permeation behaviour. QBS represent an advanced class of lyotropic liquid-crystalline nanocarriers with high drug-loading potential, excellent biocompatibility, and controlled-release performance. Their multifunctional versatility underscores their promise as next-generation platforms for targeted and sustained drug delivery applications.
Development and Optimisation of Docetaxel-Loaded Polymeric Nanoparticles for Oral Chemotherapy in Breast Cancer Divya Wali, Shivakumar H. Nanjappa, Avichal Kumar, Rushikesh Shinde Scientia Pharmaceutica, 2025 Docetaxel (DTX)-loaded polymeric nanoparticles composed of Eudragit RL and RS 100 were developed by solvent evaporation using D-α-tocopheryl polyethene glycol 1000 succinate as an emulsifier and optimised by Central Composite Design. The effects of homogenisation and sonication times on entrapment efficiency (%EE) and drug release (%DR) were statistically analysed across nine batches. Particle size (PS) ranged from 302 ± 1.0 to 502 ± 2.0 nm, and zeta potential (ZP) from 25.8 ± 2.5 to 42.9 ± 1.7 mV. %EE and %DR (pH 1.2 for 2 h, then pH 7.4 for 22 h, 40 mL medium at 37 ± 0.5 °C) ranged from 69.32 ± 3.77 to 92.71 ± 0.16% and 19.24 ± 3.03 to 49.17 ± 1.98%, respectively. Optimised DTX nanoparticles (DNPs) showed EE of 78.18 ± 0.56%, DR of 46.21 ± 1.41% at 24 h, PS of 357.9 ± 2.4 nm, and ZP of 42.9 ± 3.7 mV. Scanning electron microscopy revealed ~300 nm cuboidal particles with smooth surfaces. X-Ray Diffraction and Differential Scanning Colorimetry confirmed reduced drug crystallinity in DNPs. In vitro haemolysis assays showed ~11.5-fold lower haemolytic potential (p < 0.0001) versus DTX, confirming improved safety. Fluorescence microscopy indicated enhanced cellular uptake of DNPs in MDA-MB-231 cells, while cytotoxicity assays of DNPs showed a lower IC50 (39.52 µM) compared to DTX (60.81 µM), demonstrating superior anticancer efficacy. Overall, DNPs represent a promising oral chemotherapy platform for breast cancer management.
Development and in vivo evaluation of novel bioresponsive nanocubosomal in-situ gelling system for ophthalmic delivery of Amphotericin B SP Sanjana, HN Shivakumar, R Shinde, R Kumar, MG Hariprasad International Journal of Pharmaceutics, 126990 , 2026 2026
A Review Exploring the Translational Perspective of Artificial Intelligence in Drug Discovery and Formulation Development B Agarwal, S Gaware, N More, R Shinde, HN Shivakumar, S Jagdale Annales Pharmaceutiques Françaises , 2026 2026 Citations: 1
Activation-modulated stimuli-responsive systems: an intelligent platform for site-specific gastroretentive delivery of diverse therapeutic agents HN Shivakumar, R Shinde, V Somasekhar, MG Hariprasad, NM Mahesh International Journal of Pharmaceutics, 126599 , 2026 2026
Formulation and optimization of cilnidipine solid dispersion-based sublingual films using D-optimal mixture design HN Shivakumar, M Kamath, A Kumar, S Prakash, R Shinde, A Tekade Particulate Science and Technology 44 (1), 111-124 , 2026 2026
Nanoformulations in the management of onychomycosis and other nail disorders HN Shivakumar, A Kumar, SN Murthy Nanotechnology Applications for the Diagnosis and Therapeutic Treatment of … , 2026 2026
Emerging trends in polymeric mucoadhesive nanocarriers: a promising option for intravaginal HIV preexposure prophylaxis A Kumar, D Avlani, SN Murthy, HN Shivakumar, S Jindal Journal of Drug Targeting 33 (10), 1718-1742 , 2025 2025 Citations: 4
Impact of Donor Height in Franz Diffusion Cell on the Performance of Topical Products HP Pa, AV Matadh, S HN, RN Murthy, S Rangappa, SN Murthy 2025
Development, in vitro and in vivo evaluation of film forming solutions for transdermal drug delivery of Zaltoprofen P Alayadan, A Kumar, SS Prakash, B Bashir, V Bhagya, SN Murthy, ... Journal of Biomaterials Science, Polymer Edition 36 (9), 1265-1288 , 2025 2025 Citations: 3
Topical Formations and Critical Quality Attributes A Puri, A Kumar, HN Shivakumar, SN Murthy AAPS Introductions in the Pharmaceutical Sciences, 1-25 , 2025 2025
Topical Formulations and Critical Quality Attributes HN Shivakumar, A Kumar, A Puri, SN Murthy Topical Products and Dermal Drug Delivery, 1-25 , 2025 2025 Citations: 1
Development of in vitro and in vivo evaluation of mucoadhesive in-situ gel for intranasal delivery of vinpocetine SAAA Hard, HN Shivakumar, DA Bafail, MA Moqbel Redhwan Journal of Drug Targeting 33 (4), 528-545 , 2025 2025 Citations: 14
Finite Dose In Vitro Permeation Testing: Significance of Occluding the Donor compartment, a Case study PN Murthy, MM Hossain, S Kundu, S Rangappa, S HN AAPS PharmSciTech 26 (4), 103 , 2025 2025 Citations: 1
Time to break and evaporation (TBE): A quality attribute of pharmaceutical topical foams B Holla, PN Murthy, AV Matadh, SG Pragathi, L Rakshitha, HP Pa, ... Journal of Pharmaceutical Sciences 114 (4), 103699 , 2025 2025 Citations: 1
Formulation and evaluation of polymeric spherical agglomerates-based porous orodispersible tablets of cilnidipine Y Alhamhoom, SS Prakash, A Kumar, SH Nanjappa, M Rahamathulla, ... Pharmaceutics 17 (2), 170 , 2025 2025 Citations: 6
Design and Evaluation of Bisoprolol Fumarate Transdermal Film: A Promising Approach for Cardiovascular Therapy HN Shivakumar, A Reddy, D Avlani, P Alayadan, A Kumar Journal of the Scientific Society 52 (1), 60-66 , 2025 2025
An AQbD driven stability indicating HPLC method for simultaneous estimation of lamivudine, tenofovir disoproxil fumarate and efavirenz in plasma A Kumar, V Somasekhar, S Dhiman, SH Nanjappa, D Avlani Analytical Methods 17 (9), 2094-2111 , 2025 2025 Citations: 2
Biophysical and permeability characterization of lyophilized (freeze-dried) human cadaver skin HP Pa, SG Pragathi, K Poornima, SN Murthy, PN Murthy, D Wali, A Kumar, ... European Journal of Pharmaceutical Sciences 203, 106870 , 2024 2024 Citations: 1
Sublingual fast-dissolving thin films of loratadine: Characterization, in vitro and ex vivo evaluation Y Alhamhoom, AK Said, A Kumar, SH Nanjappa, D Wali, M Rahamathulla, ... Polymers 16 (20), 2919 , 2024 2024 Citations: 13
Formulation and evaluation of pH-modulated amorphous solid dispersion-based orodispersible tablets of cefdinir Y Alhamhoom, T Kumaraswamy, A Kumar, SH Nanjappa, SS Prakash, ... Pharmaceutics 16 (7), 866 , 2024 2024 Citations: 13
Overcoming challenges in dermal and transdermal delivery of herbal therapeutics with polymeric microneedles A VM, S Suresh, A Kumar, P K, R NM, S Rangappa, SN Murthy, S HN Journal of Biomaterials science, Polymer edition 35 (3), 364-396 , 2024 2024 Citations: 9
MOST CITED SCHOLAR PUBLICATIONS
Handbook of non-invasive drug delivery systems: non-invasive and minimally-invasive drug delivery systems for pharmaceutical and personal care products VS Kulkarni William Andrew Pub , 2009 2009 Citations: 239
Development and evaluation of an oral fast disintegrating anti-allergic film using hot-melt extrusion technology MB Pimparade, A Vo, AS Maurya, J Bae, JT Morott, X Feng, DW Kim, ... European Journal of Pharmaceutics and Biopharmaceutics 119, 81-90 , 2017 2017 Citations: 141
Formulation, characterization, and evaluation of matrix-type transdermal patches of a model antihypertensive drug VG Jamakandi, JS Mulla, BL Vinay, HN Shivakumar Asian Journal of Pharmaceutics (AJP) 3 (1) , 2009 2009 Citations: 115
Ungual and transungual drug delivery HN Shivakumar, A Juluri, BG Desai, SN Murthy Drug development and industrial pharmacy 38 (8), 901-911 , 2012 2012 Citations: 111
Development of taste masked caffeine citrate formulations utilizing hot melt extrusion technology and in vitro–in vivo evaluations MB Pimparade, JT Morott, JB Park, VI Kulkarni, S Majumdar, SN Murthy, ... International journal of pharmaceutics 487 (1-2), 167-176 , 2015 2015 Citations: 106
Topical and transdermal drug delivery SN Murthy, HN Shivakumar Handbook of non-invasive drug delivery systems, 1-36 , 2010 2010 Citations: 100
Design and optimization of diclofenac sodium controlled release solid dispersions by response surface methodology HN Shivakumar, BG Desai, G Deshmukh Indian journal of pharmaceutical sciences 70 (1), 22 , 2008 2008 Citations: 91
Iontophoretic permselective property of human nail SN Murthy, DC Waddell, HN Shivakumar, A Balaji, CP Bowers Journal of dermatological science 46 (2), 150-152 , 2007 2007 Citations: 78
Non-dermal applications of microneedle drug delivery systems A Panda, VA Matadh, S Suresh, HN Shivakumar, SN Murthy Drug Delivery and Translational Research 12 (1), 67-78 , 2022 2022 Citations: 75
Design and statistical optimization of glipizide loaded lipospheres using response surface methodology H Shivakumar, P Patel, B Desai, P Ashok, S Arulmozhi Acta pharmaceutica 57 (3), 269 , 2007 2007 Citations: 68
Formulation and evaluation of gemcitabine-loaded solid lipid nanoparticles PT Nandini, RC Doijad, HN Shivakumar, PM Dandagi Drug delivery 22 (5), 647-651 , 2015 2015 Citations: 67
Development and optimization of in-situ gel containing chitosan nanoparticles for possible nose-to-brain delivery of vinpocetine SAAA Hard, HN Shivakumar, MAM Redhwan International Journal of Biological Macromolecules 253, 127217 , 2023 2023 Citations: 62
Bilayered nail lacquer of terbinafine hydrochloride for treatment of onychomycosis HN Shivakumar, SRK Vaka, NVS Madhav, H Chandra, SN Murthy Journal of pharmaceutical sciences 99 (10), 4267-4276 , 2010 2010 Citations: 61
Delivery of ziconotide to cerebrospinal fluid via intranasal pathway for the treatment of chronic pain P Manda, AS Kushwaha, S Kundu, HN Shivakumar, SB Jo, SN Murthy Journal of Controlled Release 224, 69-76 , 2016 2016 Citations: 58
Design and Evaluation of pH Sensitive Multi-Particulate Systems for Chronotherapeutic Delivery of Diltiazem Hydrochloride. HN Shivakumar, S Suresh, BG Desai Indian journal of pharmaceutical sciences 68 (6) , 2006 2006 Citations: 52
Rapidly dissolving microneedle patches for transdermal iron replenishment therapy A Maurya, SH Nanjappa, S Honnavar, M Salwa, SN Murthy Journal of pharmaceutical sciences 107 (6), 1642-1647 , 2018 2018 Citations: 48
Effect of gamma sterilization on the properties of microneedle array transdermal patch system HP Swathi, V Anusha Matadh, J Paul Guin, S Narasimha Murthy, P Kanni, ... Drug Development and Industrial Pharmacy 46 (4), 606-620 , 2020 2020 Citations: 46
Iontophoresis for drug delivery into the nail apparatus: exploring hyponychium as the site of delivery A Kushwaha, HN Shivakumar, SN Murthy Drug development and industrial pharmacy 42 (10), 1678-1682 , 2016 2016 Citations: 42
Effect of ß Cyclodextrin Complexation on the Solubility and Dissolution Rate of Carbamazepine from Tablets. S Suresh, HN Shivakumar, GK Kumar Indian journal of pharmaceutical sciences 68 (3) , 2006 2006 Citations: 41
Polymer coated polymeric (PCP) microneedles for controlled delivery of drugs (dermal and intravitreal) D Jakka, AV Matadh, VK Shankar, HN Shivakumar, SN Murthy Journal of pharmaceutical sciences 111 (10), 2867-2878 , 2022 2022 Citations: 40
GRANT DETAILS
1. “Development of fast-dissolving tablets for neurological disorders” under Research Project Scheme (Ref: 8023/BOR/RPS-162/2006-07) supported by under of AICTE, New Delhi (Rs. 10.00 Lacs), INDIA.
2. ‘Transdermal delivery of iron’ with a fellowship of $ 30000 per from July 2008 to Oct 2009 by Department of Pharmaceutics, The University of Mississippi, MS-38677, USA.
3. “Formulation of Guinidine HCl gels for treatment of topical scars” funded by The Dept. of Pharmaceutics, University of Mississippi, MS, USA in the year 2013
4. “Formulation and Evaluation of inhalable mucoadhesive microparticles of streptomycin” funded by VGST, DITBST under Science Projects in college education (SPiCE) for the year 2012-13
5.“Design and Evaluation of Ocular Inserts of Dorzolamide Hydrochloride using natural Bioadhesive film formers” funded by VGST, DITBST under SPiCE for the year 2013-14
6.“Transdermal Iron Replenishment Therapy” funded by BIRAC (Rs. 33.20 Lacs) under the Biotechnology Ignition Grant - 2014
7.“Noninvasive electrical device for Transcutaneous Iron replenishment” has been recommended for a funding of Rs. 50 Lacs by BIRAC under SPARSH
8.“Effect Of Gamma Sterilization On The Properties Of Microneedle Array Transdermal Patch System” funded by BRNS, DAE, Govt. of India
9.“Development of Bio-adhesive nanoparticles for vaginal delivery of selected antiretrovirals” dunded by VGST,
10. “Guar gum based Dermal Bio-adhesive for Biomedical Patch Applications” funded by BIRAC.
RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)
Inventor in the Indian patent entitled A METHOD FOR PREPARATION OF CISPLATIN NANOPARTICLE COMPOSITION granted on 12--03-2021
CONSULTANCY
1. International Collaboration
Collaborator with Noninvasive Drug Delivery Laboratory, Department of Pharmaceutics, The University of Mississippi, MS, USA to facilitate Design Experiments (DoE), establish Design Space and Optimize Process/Product in the ongoing projects & undertake Pharmacokinetic testing of prototype formulations
2. Industrial Consultation
a. Formulation Development with DermaPerm Research Inc., Bangalore,
b. Kemwell BioPharma Pvt. Ltd., Bangalore to set up Design Experiments (DoE) &Establish Design Space, Implement
Principle of Quality by Design (QbD) in Pharmaceutical Development.
c. Consultant with SPI Pharma-India branch, Bangalore ( for the below mentioned projects
i. Design of Co-processed excipient systems for enhanced physicochemical and organoleptic properties
ii. Dissolution of powders in USP IV flow through dissolution apparatus
iii. Transport feasibility studies across porcine buccal mucosa
e. Syngene International Ltd, Bangalore ( for the project “Spray drying for enteric coating”
f. Semler Research Inc, Bangalore (
g. Stevia World Agrotech Pvt. Ltd., Bengaluru ( for project “Development and scale up of sugar free tablets of Stevia”
h. Nuwill Research & Innovations Pvt. Ltd. Bangalore
Industry, Institute, or Organisation Collaboration
Department of Pharmaceutics, The University of Mississippi, MS, USA. 1College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA, Department of Pharmacy Practice, College of Clinical Pharmacy, King FaisalUniversity, Al-Ahsa, 31982, Saudi Arabia.
INDUSTRY EXPERIENCE
One year of experience as a Production Executive at Bangalore Pharmaceuticals and Reserach Laboratories, Bangalore and two years of Experience as a Mangager (Formulation Development) at Kemwell Biopharma Pvt. Ltd. Bangalore.
STARTUP
I have been the cofounder of the startup Feplen Health Research Pvt. Ltd., and co-founder of the nonprofit Research Organization Institute for Drug Delivery and Biomedical research, Bengaluru (, a DSIR recognized non-profit research organization that is registered in Darpan portal of Niti Ayog.
SOCIAL, ECONOMIC, or ACADEMIC BENEFITS
Principal Investigator for the project entitled “Noninvasive electrical device for Transcutaneous Iron replenishment” has been recommended for a funding of Rs. 50 Lacs by Biotechnology Industry Research Assistance Council (BIRAC) under Social Innovation programme for Products: Affordable & Relevant to Societal Health (SPARSH)