A novel nanocomposite Lf-DA-MSN-PF127 aided the delivery of dopamine for the treatment of Parkinson's disease in a rat model Ramesha Hanumanthappa, Sumit Ramesh Naik, Sahana Prakash Nayak, Asmatanzeem Bepari, Hanan Nasser Altamimi, et al. Nanoscale Advances, 2025 A multifunctional nanocarrier of lactoferrin-functionalized Pluronic F-127 capped dopamine-loaded mesoporous silica nanocomposite (Lf-DA-MSN-PF127), was designed for targeted drug delivery across the blood–brain barrier (BBB) via intranasal.
Recent advances in therapeutic strategies for Alzheimer's and Parkinson's disease using protein/peptide co-modified polymer nanoparticles Ramesha Hanumanthappa, Aravind Parthasarathy, Geetha B. Heggannavar, Kiran PC, Hemalatha Nanjaiah, et al. Neuroprotection, 2024 The blood‐brain barrier (BBB), which protects the brain from foreign molecules, makes delivery of drugs to the central nervous system is challenging. Nanoparticles (NPs) have been used over the past decade as drug delivery systems for the treatment of many disorders with great results. However, the effectiveness of NPs in delivering drugs to the brain for the treatment of Alzheimer's disease (AD) and Parkinson's disease (PD) is limited by the BBB. A recent breakthrough in nanotechnology delivery systems involves the use of surface‐modified polymer NPs that enhance drug absorption and transport across the BBB; however, the technology still has some limitations. Studies conducted over the past few years have demonstrated that NPs modified with peptides or proteins can effectively cross the BBB via specific receptors, thus enhancing their delivery efficiency. In this review, we explore the use of polymer NPs combined with peptides and proteins for the treatment of AD and PD. This discussion focuses on the pathophysiology of these diseases, the BBB, and the potential of therapeutics based on co‐modifying NPs with peptides and proteins. Additionally, we outline future directions for the use of polymer NPs conjugated with these biomolecules.
Dietary lutein protects against Emamectin benzoate induced neurotoxicity by restoring oxidative and calcium balance in Drosophila melanogaster PC Kiran, P Kumar, KVH Prashanth, KS Devaraju Food Bioscience, 108564 , 2026 2026
Chemotherapy-Induced Cognitive Impairment (CICI): Cisplatin’s Effects on Neurotransmitter Regulation and Oxidative Stress in Drosophila melanogaster RA Aziz, DM Venugopal, AK Kudva, R Hanumanthappa, MS Mustak, ... NeuroToxicology, 103365 , 2025 2025 Citations: 1
Application of TXRF for exploring the concentration levels of multi-trace elements in human diabetes blood: A comparative analysis with a chemometric approach AS Bennal, R Hanumanthappa, KS Devaraju, SS Kulkarni, PB Gai Spectrochimica Acta Part B: Atomic Spectroscopy, 107275 , 2025 2025 Citations: 2
A Levodopa-Encapsulated Poly-ε-Caprolactone Nanocomposite Improves the Motor Symptoms and Neurochemical Changes in a Rotenone-Induced Mouse Model of Parkinson’s Disease R Hanumanthappa, GB Heggannavar, A Banakar, DD Achari, ... ACS omega 10 (19), 19682-19696 , 2025 2025 Citations: 4
Insights into the Age-Dependent Variation in Nutrition-Related Trace Elements in Diabetes Blood Using Total Reflection X-Ray Fluorescence Manjunatha, AS Bennal, R Hanumanthappa, SS Kulkarni, KS Devaraju, ... Biological Trace Element Research 203 (3), 1277-1286 , 2025 2025 Citations: 6
Red emitting SnO2: Eu3+ hierarchical structures for multifunctional applications: Thermal sensing, w-LEDs, latent fingerprint detection and biomedical applications BRR Krushna, IS Pruthviraj, SC Sharma, S Ray, ST Elayakumar, ... Journal of Alloys and Compounds 1013, 178496 , 2025 2025 Citations: 17
A novel nanocomposite Lf-DA-MSN-PF127 aided the delivery of dopamine for the treatment of Parkinson's disease in a rat model R Hanumanthappa, SR Naik, SP Nayak, A Bepari, HN Altamimi, ... Nanoscale Advances 7 (19), 6017-6031 , 2025 2025 Citations: 3
Recent advances in therapeutic strategies for Alzheimer's and Parkinson's disease using protein/peptide co-modified polymer nanoparticles R Hanumanthappa, A Parthasarathy, GB Heggannavar, PC Kiran, ... Neuroprotection 2 (04), 255-275 , 2024 2024 Citations: 12
E5-((3-phenoxyphenyl) diazenyl) quinolin-8-ol (PPDQ): A Novel Promising Anticorrosive for Mild Steel in Acid Media, and a Pharmacologically Potent Antidiabetic, Antioxidant Azo Dye K Pruthviraj, H Ramesh, NK Lokanath, PC Kiran Poral, KS Devaraju, ... Orbital: The Electronic Journal of Chemistry, 198-204 , 2024 2024
Eco-friendly synthesis of CQDs from Pistachio shells: Versatile applications in anti-counterfeiting, flexible films, latent fingerprints and potential anti-cancer activity DH Sandeep, BRR Krushna, SC Sharma, P Ravindran, R Sivayogana, ... Journal of Alloys and Compounds 991, 174311 , 2024 2024 Citations: 30
Ultrasound-driven facile fabrication of Pd doped SnO2 hierarchical superstructures: Structural, growth mechanism, dermatoglyphics, and anti-cancer activity BRR Krushna, K Manjunatha, SY Wu, D Sivaganesh, SC Sharma, ... Biomaterials Advances 160, 213855 , 2024 2024 Citations: 36
Synthesis, Antioxidant, and Electrochemical Behavior Studies of 2-Amino-4 H -Chromene Derivatives Catalyzed by WEOFPA: Green Protocol KB Badiger, K Kamanna, R Hanumanthappa, KS Devaraju, ... Polycyclic Aromatic Compounds 44 (1), 333-360 , 2024 2024 Citations: 12
Phytoconstituents of Cassia auriculata Linn Inhibits the Pro-Inflammatory Cytokines: An In Silico Study to Identify Multi-Target Drug Candidates RH Tejaswini, S Biradar, SJ Shreedevi, KS Devaraju, RL Babu 2024
Polyvinylpyrrolidone-Capped Copper Oxide Nanoparticles-Anchored Pramipexole Attenuates the Rotenone-Induced Phenotypes in a Drosophila Parkinson’s … R Hanumanthappa, DM Venugopal, N PC, A Shaikh, S BM, ... ACS omega 8 (50), 47482-47495 , 2023 2023 Citations: 15
Does Protein Kinases exhibit Binding Affinity with Antipsychotic Drugs? A Molecular Docking Approach DKS Kiran.P.C, Sarojini.R.Bulbule, Ramesha Hanumanthappa, Hemalatha Nanjaiah Journal of Applied Bioinformatics & Computational Biology 12 (3) , 2023 2023
In silico Binding Affinity Studies of Antipsychotic Drugs with Protein Phosphatases by Molecular Docking SRBPA Devaraju KS* J Appl Bioinforma Comput Biol 12 (1), 1-5 , 2023 2023
Corosolic Acid Inhibits Secretory Phospholipase A 2 IIa as an Anti-Inflammatory Function and Exhibits Anti-Tumor Activity in Ehrlich Ascites Carcinoma Bearing Mice S Pundalik, KR Hanumappa, AS Giresha, D Urs, S Rajashekarappa, ... Journal of Inflammation Research, 6905-6921 , 2022 2022 Citations: 14
Binding affinity studies of trifluoperazine with protein kinases. S Bulbule, P Aravind, KS Devaraju Indian Journal of Clinical Biochemistry 33 (S1), S82-S82 , 2022 2022
Large-scale Extraction of DNA by Using Salting-out Principle for Dried Blood Spots to Screen Multiple Mutations in GCDH Gene M Shaik, A Alladi, AB Vedamurthy, KS Devaraju, M Kamate, ... Iranian Journal of Science and Technology, Transactions A: Science 46 (1), 33-40 , 2022 2022 Citations: 1
Pharmacological and therapeutic approaches in the treatment of epilepsy S Ghosh, JK Sinha, T Khan, KS Devaraju, P Singh, K Vaibhav, P Gaur Biomedicines 9 (5), 470 , 2021 2021 Citations: 127
MOST CITED SCHOLAR PUBLICATIONS
Pharmacological and therapeutic approaches in the treatment of epilepsy S Ghosh, JK Sinha, T Khan, KS Devaraju, P Singh, K Vaibhav, P Gaur Biomedicines 9 (5), 470 , 2021 2021 Citations: 127
Molecular docking studies of phytochemicals against trehalose–6–phosphate phosphatases of pathogenic microbes HR Umesh, KV Ramesh, KS Devaraju Beni-Suef University Journal of Basic and Applied Sciences 9 (1), 5 , 2020 2020 Citations: 66
Effect of estrogen and tamoxifen on the expression pattern of AP-1 factors in MCF-7 cells: role of c-Jun, c-Fos, and Fra-1 in cell cycle regulation RL Babu, M Naveen Kumar, RH Patil, KS Devaraju, GT Ramesh, ... Molecular and cellular biochemistry 380 (1), 143-151 , 2013 2013 Citations: 63
Bioimaging of peroxynitrite in MCF-7 cells by a new fluorescent probe rhodamine B phenyl hydrazide G Ambikapathi, SK Kempahanumakkagari, B Ramappa Lamani, ... Journal of fluorescence 23 (4), 705-712 , 2013 2013 Citations: 37
Ultrasound-driven facile fabrication of Pd doped SnO2 hierarchical superstructures: Structural, growth mechanism, dermatoglyphics, and anti-cancer activity BRR Krushna, K Manjunatha, SY Wu, D Sivaganesh, SC Sharma, ... Biomaterials Advances 160, 213855 , 2024 2024 Citations: 36
Eco-friendly synthesis of CQDs from Pistachio shells: Versatile applications in anti-counterfeiting, flexible films, latent fingerprints and potential anti-cancer activity DH Sandeep, BRR Krushna, SC Sharma, P Ravindran, R Sivayogana, ... Journal of Alloys and Compounds 991, 174311 , 2024 2024 Citations: 30
Prediction of kabaddi playing ability from selected anthropometrical and physical variables among college level players K Devaraju, R Kalidasan Asian Journal of Information Technology 11 (4), 131-134 , 2012 2012 Citations: 29
Prediction of playing ability in Kabaddi from Selected anthropometrical, physical, Physiological and psychological variables among college level players K Devaraju, A Needhiraja International Journal of Management 3 (2), 150-157 , 2012 2012 Citations: 25
In silico binding affinity study of calcineurin inhibitors to calcineurin and its close associates BM Harish, KS Devaraju, A Gopi, R Saraswathi, RL Babu, ... Indian Journal of Biotechnology 12, 213-217 , 2013 2013 Citations: 23
Syntheses, characterizations, and antimicrobial activities of binuclear ruthenium (III) complexes containing 2-substituted benzimidazole derivatives B Roopashree, V Gayathri, A Gopi, KS Devaraju Journal of Coordination Chemistry 65 (22), 4023-4040 , 2012 2012 Citations: 23
Red emitting SnO2: Eu3+ hierarchical structures for multifunctional applications: Thermal sensing, w-LEDs, latent fingerprint detection and biomedical applications BRR Krushna, IS Pruthviraj, SC Sharma, S Ray, ST Elayakumar, ... Journal of Alloys and Compounds 1013, 178496 , 2025 2025 Citations: 17
Elevation of gene expression of calcineurin, calmodulin and calsyntenin in oxidative stress induced PC12 cells P Aravind, SR Bulbule, N Hemalatha, RL Babu, KS Devaraju Genes & Diseases 8 (1), 87-93 , 2021 2021 Citations: 16
Biosorption of Chromium(VI) and Lead(II): Role of Spirulina platensis in the Treatment of Industrial Effluent RL Babu, E Vijayalakshmi, MN Kumar, RH Patil, KS Devaraju, SC Sharma Bioremediation journal 17 (4), 231-239 , 2013 2013 Citations: 16
Polyvinylpyrrolidone-Capped Copper Oxide Nanoparticles-Anchored Pramipexole Attenuates the Rotenone-Induced Phenotypes in a Drosophila Parkinson’s … R Hanumanthappa, DM Venugopal, N PC, A Shaikh, S BM, ... ACS omega 8 (50), 47482-47495 , 2023 2023 Citations: 15
Corosolic Acid Inhibits Secretory Phospholipase A 2 IIa as an Anti-Inflammatory Function and Exhibits Anti-Tumor Activity in Ehrlich Ascites Carcinoma Bearing Mice S Pundalik, KR Hanumappa, AS Giresha, D Urs, S Rajashekarappa, ... Journal of Inflammation Research, 6905-6921 , 2022 2022 Citations: 14
Recent advances in therapeutic strategies for Alzheimer's and Parkinson's disease using protein/peptide co-modified polymer nanoparticles R Hanumanthappa, A Parthasarathy, GB Heggannavar, PC Kiran, ... Neuroprotection 2 (04), 255-275 , 2024 2024 Citations: 12
Synthesis, Antioxidant, and Electrochemical Behavior Studies of 2-Amino-4 H -Chromene Derivatives Catalyzed by WEOFPA: Green Protocol KB Badiger, K Kamanna, R Hanumanthappa, KS Devaraju, ... Polycyclic Aromatic Compounds 44 (1), 333-360 , 2024 2024 Citations: 12
Genetic screening of selected disease-causing mutations in glutaryl-CoA dehydrogenase gene among Indian patients with glutaric aciduria type I TP Kruthika-Vinod, S Muntaj, KS Devaraju, M Kamate, AB Vedamurthy Journal of Pediatric Genetics 6 (03), 142-148 , 2017 2017 Citations: 8
Discovery of a latent calcineurin inhibitory peptide from its autoinhibitory domain by docking, dynamic simulation, and in vitro methods BM Harish, R Saraswathi, D Vinod, KS Devaraju Journal of Biomolecular Structure and Dynamics 34 (5), 983-992 , 2016 2016 Citations: 8
Synthesis and biological evaluation of novel pyrazole derivatives as urease inhibitors SB Bole, R Nargund, LVG Nargund, KS Devaraju, AB Vedamurthy, ... Der Pharma. Chemica 3 (5), 73-80 , 2011 2011 Citations: 8