Dr. TAMILARASAN RAMALINGAM
@ritchennai.org
Assistant Professor, Department of chemistry
Rajalakshmi Institute of Technology
RESEARCH, TEACHING, or OTHER INTERESTS
Organic Chemistry, Catalysis, Chemical Engineering
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
A. S. Stella Shalini, L. Shahanaz, P. Rajeswaran, R. Tamilarasan, S. Kumaran, and P. Siva Karthik
Springer Science and Business Media LLC
Ramalingam Tamilarasan, Annadurai Subramani, G. Sasikumar, Pandurangan Ganapathi, S. Karthikeyan, Sasikumar Ponnusamy, Salim Albukhaty, Mustafa K. A. Mohammed, Zaidon T. Al-aqbi, Faris A. J. Al-Doghachi,et al.
Springer Science and Business Media LLC
AbstractUnder conventional and silica-supported Muffle furnace methods, water-soluble substituted trimeric triaryl pyridinium cations with various inorganic counter anions are synthesized. The solvent-free synthesis method is superior to the conventional method in terms of non-toxicity, quicker reaction times, ease of workup, and higher yields. Trimeric substituted pyridinium salts acted as excellent catalytic responses for the preparation of Gem-bisamide derivatives compared with available literature. To evaluate the molecular docking, benzyl/4-nitrobenzyl substituted triaryl pyridinium salt compounds with VEGFR-2 kinase were used with H-bonds, π–π stacking, salt bridges, and hydrophobic contacts. The results showed that the VEGFR-2 kinase protein had the most potent inhibitory activity. Intriguingly, the compound [NBTAPy]PF6- had a strongly binds to VEGFR-2 kinase and controlled its activity in cancer treatment and prevention.
Gopalakrishnan Sasikumar, Annadurai Subramani, Ramalingam Tamilarasan, Punniyamurthy Rajesh, Ponnusamy Sasikumar, Salim Albukhaty, Mustafa K. A. Mohammed, Subramani Karthikeyan, Zaidon T. Al-aqbi, Faris A. J. Al-Doghachi,et al.
MDPI AG
A new series of ternary metal complexes, including Co(II), Ni(II), Cu(II), and Zn(II), were synthesized and characterized by elemental analysis and diverse spectroscopic methods. The complexes were synthesized from respective metal salts with Schiff’s-base-containing amino acids, salicylaldehyde derivatives, and heterocyclic bases. The amino acids containing Schiff bases showed promising pharmacological properties upon complexation. Based on satisfactory elemental analyses and various spectroscopic techniques, these complexes revealed a distorted, square pyramidal geometry around metal ions. The molecular structures of the complexes were optimized by DFT calculations. Quantum calculations were performed with the density functional method for which the LACVP++ basis set was used to find the optimized molecular structure of the complexes. The metal complexes were subjected to an electrochemical investigation to determine the redox behavior and oxidation state of the metal ions. Furthermore, all complexes were utilized for catalytic assets of a multi-component Mannich reaction for the preparation of -amino carbonyl derivatives. The synthesized complexes were tested to determine their antibacterial activity against E. coli, K. pneumoniae, and S. aureus bacteria. To evaluate the cytotoxic effects of the Cu(II) complexes, lung cancer (A549), cervical cancer (HeLa), and breast cancer (MCF-7) cells compared to normal cells, cell lines such as human dermal fibroblasts (HDF) were used. Further, the docking study parameters were supported, for which it was observed that the metal complexes could be effective in anticancer applications.
A. Ashma, Showket Yahya, A. Subramani, R. Tamilarasan, G. Sasikumar, S.J. Askar Ali, Hamad A. Al-Lohedan, and Muthusamy Karnan
Elsevier BV
Ramalingam Tamilarasan, Kilivelu Ganesan, Annadurai Subramani, Liyakath Benazir Ali, Mohammed Mujahid Alam, and Amanullah Mohammed
American Chemical Society (ACS)
Substituted pyridinium bromides are prepared by conventional and solvent-free greener methods. The solvent-free solid-phase (greener) method is superior to the conventional method because of its nontoxic nature, simple reaction setup procedure, and twenty times less time consumption. Column chromatography and toxic organic solvents are avoided. Substituted pyridinium salts 1–2(a–c) show excellent catalytic response in the preparation of β-amino carbonyl derivatives using the conventional approach. Pharmacokinetics is very important in target validation and in shifting a lead compound into a drug. The physicochemical properties discussed here can be used effectively in the drug designing candidate, which is a cumbersome process in clinical research. In addition, molecular simulations are demonstrated, and compounds 1–2(a–c) possess the most potent VEGFR-2 kinase protein inhibitory activities, and most interestingly, compound 2a strongly binds and regulates the VEGFR-2 kinase activity in therapeutic approaches and cancer prevention.
Ramalingam Tamilarasan, Sadaiyan Govindaraj, and Kilivelu Ganesan
Informa UK Limited
Abstract Synthesis of dimeric substituted ester derivative of pyridinium salt with flexible linker units under conventional/silica supported approach. Solid-phase approach is much superior to the conventional method due to nontoxic, solvent free, easy work up procedure, and lesser reaction period. Synthesized dimeric ester derivative of pyridinium salts is showed excellent catalytic response for the preparation of oxizinone derivatives under conventional/approach. Graphical Abstract
K Prabaakaran, Sri Krishnakumar, R Srividhya, R Ganesh Raw, R Gotham, and R Tamilarasan
IOP Publishing
Abstract To enhance the power quality issue in grid system a new strategy with modification in algorithm is presented as reinforcement learning. A new technique will mitigate issues like reactive power, harmonics, voltage sag, voltage swell. A system as a current controller to enhance the current issue and the voltage controller to enhance the power quality issues in voltage. Due to an issue of unbalanced load in the grid the weak AC supply can be compensated by using the modified reinforcement learning algorithm. During the occurrence of the power quality issue in the grid modified reinforcement learning algorithm is proposed due to quick response.
R. Tamilarasan and A. Sreekanth
CEMADES
The inhibition efficiency of the piperazine dithiosemicarbazone derivatives on the corrosion of high carbon steel in HCL medium were studied by electrochemical impedance spectroscopy (EIS), polarization (Tafel), X-ray Photoelectron Spectroscopy (XPS) and UV-Visible spectroscopy. Electrochemical studies show that piperazine based dithiosemicarbazone derivatives acts as mixed type of inhibitors on high carbon steel. XPS data revealed that the inhibitors are adsorbed on the high carbon steel surface. It’s also obeying the Langmuir’s adsorption isotherm. Received 27Jan 2017, Revised 04 Aug 2017, Accepted 10 Aug 2017
Ramalingam Tamilarasan and Anandaram Sreekanth
Royal Society of Chemistry (RSC)
The effect of tris(5-methyl-2-thioxo-1,3,4-thiadiazole)borate (HB(mtdaMe)3) on the corrosion of high carbon steel (HCS) and aluminium (Al) in HCl media has been examined by Electrochemical Impedance Spectroscopy (EIS), polarization (Tafel), Scanning Electron Microscopy (SEM), X-ray Photoelectron Spectroscopy (XPS), Electronic spectroscopy and adsorption kinetics methods. The polarization studies show that HB(mtdaMe)3 acts as a cathodic inhibitor for HCS, while it is a mixed type inhibitor of predominantly the cathodic reaction in Al. The inhibition efficiency of the compound is very high and the SEM and XPS results have revealed that HB(mtdaMe)3 is adsorbed on the HCS and Al surface. The adsorption of HB(mtdaMe)3 on the HCS and Al surface obeys the Langmuir adsorption isotherm. DFT calculations were used to gain insight into the structural and electronic properties in relation to the inhibition efficiency.
Saravana Loganathan Ashok Kumar, Ramalingam Tamilarasan, Moorthy Saravana Kumar, and Anandram Sreekanth
American Chemical Society (ACS)
Bisthiocarbohydrazone derivatives of two heterocyclic ketones were designed and synthesized to selectively sense fluoride ion from a biologically competing solvent dimethylsulfoxide (DMSO). The selective recognition of fluoride is clearly visible to the naked eye with a distinct color change. The recognition mechanism has been investigated by UV–visible, fluorescence spectroscopy, and 1H NMR titration experiments. From the Benesi–Hidebrand equation and Job's plot, it was inferred that both compounds bind to fluoride with a 1:1 stoichiometry. 1H NMR titration data indicates deprotonation of the NH protons by fluoride as a prominent step in the recognition.
M. Saravana Kumar, R. Tamilarasan, and A. Sreekanth
Elsevier BV