WASAN MAJEED ABD AL HAMEED

EDUCATION

MBSC IN CHMISTRY

MASTER IN ORGANIC CHMESITRY

ORGANIC CHMISITRY

Synthesis and study the biological activity of new heterocyclic compounds derived from hydrazide derivatives
Wasan Abd-Al Hameed
Indian Journal of Forensic Medicine and Toxicology, 2020
The work involves synthesis of new compounds derived from 2-substituted-3-thio- acetohydrazide1,2,4-triazin. The subsituted hydrazine thiocarbothioamide [IV] was obtained via reaction of hydrazidecompound [III] with ammonium thiocyanate and HCl. The cyclization of compound [IV] in 4% NaOH ledto formation 1,2,4-triazoles [V], which were refluxed with chloro-ethylacetate in ethanol and sodium acetateto give compound [VI]. Condensation of ester-compound [VI] with hydrazine (80%) led to formation newhydrazide compounds [VII]. Ring closure reaction of compound [VII] with 4-aminbenzoic acid in POCl3give 1,3,4-oxadiazoles [VIII]. Compound [VIII] wasreacted with sub. benzaldehyde to form compounds ofSchiff bases [IX]a-d. The synthesized compounds were diagnosed via IR, Mass and 1HNMR spectral data.Many of synthesized compounds were examined against activity of antibacterial: gram (+) (Bacillus subtitis,staphylococcus aureus) and gram (-): (E.coli bacteria) and candida tropicalis fungial. To ensure the safety ofthe synthesis compounds the toxicity was examined.