Robert Paul Coppes

@rug.nl

University Medical Center Groningen, Departments of Biomedical Sciences of Cells & System and Radiation Oncology
University Medical Center Groningen

Robert Paul Coppes


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https://researchid.co/coppesrp
2019-present Editorial Board Member of Cancers
2018-present Member of Scientific Advisory Board of the Helmholtz-Zentrum Dresden-Rossendorf Germany
2018-present Member of the UMCG Appointment Advisory Committee for academic promotions
2016-present Editorial Board Member Stem Cells
2016-present Member of the Scientific Council of the European Society of Radiotherapy and Oncology (ESTRO)
2015-2021 Chair of the Radiobiology Committee of ESTRO.
2015-present Editor Biology of Radiotherapy and Oncology, Journal of ESTRO.
2015-2021 Associate senior editor of the International Journal of Radiation Oncology*Biology*Physics.
2014-present Faculty at ESTRO Basic Clinical Radiobiology course
2014-present Chair of the Animal Welfare Body of the University of Groningen, Centre of Life Sciences
2013-present Programme leader of Cancer Research Center Groningen (CRCG) research ; Damage and Repair in Cancer Development and Cancer Treatment (DARE)
2012-present Full Professor of Radiotherapy

EDUCATION

1993-1998 Post-doctoral training in clinical radiation biology. Dept Radiobiology, University of Groningen, The Netherlands
1993 PhD in Molecular Pharmacology, Faculty of Mathematics and Natural Sciences, University of Groningen, The Netherlands
1988 MSc in Biology, University of Groningen

RESEARCH INTERESTS

Radiotherapy is involved in 75% of all cancer treatments. The dose that can be delivered to the tumor however is limited to the tolerance of the surrounding normal tissues. Therefore, the Coppes lab focuses on the effects of radiation on normal tissues in vivo and in vitro organoid models.
177

Scopus Publications

16083

Scholar Citations

61

Scholar h-index

133

Scholar i10-index

Scopus Publications

  • Radiation-induced interferon-I response impairs thyroid organoid function
    Rufina Maturi, Davide Cinat, Anne L Jellema-de Bruin, Gabriella De Vita, Schelto Kruijff, et al.
    Radiotherapy and Oncology, 2026
  • Brain irradiation drives remote liver changes via senescence-independent mechanisms
    Yuting Jiang, Daniëlle C. Voshart, Alessandro Gustinelli, Ayla C. Scholma, Eline Hageman, et al.
    Radiotherapy and Oncology, 2026
  • Differential synaptic signaling responses in human cortical organoids after photon and proton irradiation
    Yuting Jiang, Danieli Born Guerra, Daniëlle C. Voshart, Eline Hageman, Luiza Reali Nazario, et al.
    Stem Cell Reports, 2026
  • Notch signaling is a driver of glandular stem cell activity and regenerative migration after damage
    Davide Cinat, Rufina Maturi, Jeremy P Gunawan, Anne L Jellema-de Bruin, Laura Kracht, et al.
    EMBO Journal, 2026
    Organoid models have significantly enhanced our understanding of adult stem cell function, however, uncovering regulatory mechanisms governing rare and often quiescent stem cells in glandular organs remains challenging. Here, we employ an integrative multi-omics approach, combining single-cell RNA sequencing, bulk ATAC and RNA sequencing, to profile the cellular populations and signaling pathways characterizing a mouse salivary gland organoid model across different temporal stages and after radiation-induced damage. Our findings identify Sox9- and Itgb1/Cd44- expressing cells as primitive adult stem/progenitor populations with a critical migratory role in tissue repair. Notch signaling is a key driver of self-renewal and migration in response to irradiation. Additionally, scRNA-seq analysis of irradiated salivary gland tissue confirms these findings in an in vivo setting. Extending these findings to murine and patient-derived salivary, mammary and thyroid gland organoids, we reveal the conserved role of Notch signaling in coordinating stem/progenitor cell-mediated regeneration across glandular tissues. These insights position Notch signaling as a central regulator of glandular stem cell-like populations and as a promising therapeutic target for enhancing glandular tissue regeneration following cancer therapies.
  • lncRNAs: a new generation of targets and biomarkers in thyroid cancer
    Rufina Maturi, Matteo Esposito, Rob P Coppes, Gabriella De Vita
    European Thyroid Journal, 2026
    Long non-coding RNAs (lncRNAs) are untranslated RNA molecules that regulate gene expression through diverse mechanisms, acting as scaffolds, guides, decoys, or signals. In thyroid cancer, the most prevalent endocrine malignancy, lncRNAs are increasingly recognized as key contributors to tumor development and progression. Elucidating these molecular mechanisms is essential for advancing diagnostic, prognostic, and therapeutic strategies. This review highlights major lncRNAs implicated in thyroid cancer, categorizing them as upregulated/oncogenes or downregulated/tumor suppressors and describing their mechanisms of action and interactions. lncRNAs are typically expressed at low levels and tightly regulated to preserve normal cell behavior. In thyroid cancer, they serve as crucial regulators of oncogenesis, frequently acting as competing endogenous RNAs that influence key signaling pathways. While most studies focus on miRNA sponging, other mechanisms are underexplored. Circulating lncRNAs offer potential for non-invasive diagnostics, and several lncRNAs show promise as therapeutic targets. Thus, continued research into the diverse functions of lncRNAs is vital to fully harness their clinical potential in thyroid cancer.
  • Hyaluronic Acid-silk Fibroin Hydrogel for Salivary Gland Tissue Engineering
    Maryam Hajiabbas, Cibele Pelissari, Dorian Parisis, Tobias Putz, Claudia D'Agostino, et al.
    Advanced Healthcare Materials, 2026
    Cell‐material‐based therapies have emerged as a promising avenue within tissue engineering strategies for salivary gland (SG) regeneration. However, replicating the complex architecture and functional properties of SG tissue remains a challenge. In this study, we used an engineered in situ cross‐linked hydrogel designed to recapitulate the biochemical and rheological characteristics of SG, providing a platform for investigating SG cell behavior and organoid differentiation. Among hydrogel formulations, derived from enzymatically cross‐linked blends of tyramine‐conjugated hyaluronic acid (HA‐Tyr) and silk fibroin (SF), a blend of 2.5% HA‐Tyr and 4% SF4 (HA‐Tyr‐SF4) showed rheological properties partially comparable to native submandibular glands (SMG), achieving high cell viability. Comparative analyses of cell‐scaffold interactions in 2D and 3D cultures revealed that cell encapsulation within HA‐Tyr‐SF4 hydrogel enhanced cell‐cell spatial organization. Encapsulated NS‐SV‐AC cells and human SG organoids (hSGOs) exhibited morphogenesis, supported by transcriptomic data indicating upregulation of genes associated with SG development, extracellular matrix remodeling, and epithelial phenotype stabilization. Furthermore, hSGOs grown in HA‐Tyr‐SF4 or matrix (MA) of basement membrane extract (BME) displayed similar transcriptomic profiles. This study establishes HA‐Tyr‐SF4 as a reproducible, biologically active scaffold with substantial potential for SG tissue engineering and regenerative medicine applications.
  • Development of a National Indication Protocol for Proton Therapy in Patients With Seminoma Testis to Reduce the Risk on Subsequent Primary Cancers
    Nienke Kuijsters, Peter Sinnige, Pauline A. Bakker, Shafak Al Uwini, Charlotte L. Brouwer, et al.
    International Journal of Radiation Oncology Biology Physics, 2026
  • Establishment of salivary tissue-organoid biorepository: characterizing salivary gland stem/progenitor cells and novel differentiation marker PSMA/FOLH1
    Syed Mohammed Musheer Aalam, Ana Rita Varela, Aalim Khaderi, Ronsard J. Mondesir, Dong-Gi Mun, et al.
    Npj Regenerative Medicine, 2025
  • IFN-I signaling enhances salivary gland stem and progenitor cell activity after irradiation
    Davide Cinat, Ryan van der Wal, Mirjam Baanstra, Abel Soto-Gamez, Rufina Maturi, et al.
    Science Signaling, 2025
    The goal of radiotherapy in cancer treatment is to maximize DNA damage in tumors while minimizing harm to surrounding healthy tissues, especially to stem and progenitor cells essential for tissue regeneration and organ function. Here, we investigated the molecular responses to photon and proton irradiation, two key modalities in head and neck cancer treatment. Multiomics and in vitro analyses revealed that both photon and proton irradiation of mouse salivary gland organoids induced similar early responses, including DNA damage, micronuclei formation, increased amounts of the cytosolic DNA sensor cGAS, and type I interferon (IFN-I) signaling. In addition, both types of radiation induced comparable increases in the release of mitochondrial DNA (mtDNA) into the cytoplasm and stimulated the production of ZBP1, a cytosolic nucleic acid sensor involved in mtDNA recognition. However, proton irradiation resulted in a more pronounced loss of heterochromatin regulators and derepression of transposable elements at later times after irradiation, which was accompanied by increased accumulation of intracellular double-stranded RNA (dsRNA) and an enhanced RIG-I–mediated IFN-I response. Genetic and pharmacological modulation demonstrated its critical role for IFN-I signaling in enhancing salivary gland stem and progenitor cell activity after irradiation in vitro and in vivo. Our findings reveal more pronounced molecular changes after proton irradiation as compared with photon irradiation and uncover a proregenerative role of IFN-I signaling in the salivary gland, suggesting this pathway as a promising therapeutic target to mitigate radiation-induced side effects.
  • Patient-derived medullary thyroid cancer organoids: a potential model for mechanistic studies on diagnostics and therapy
    Eline C Jager, Luc H J Sondorp, Rufina Maturi, Inês F Antunes, Bettien M van Hemel, et al.
    European Thyroid Journal, 2025
    Objective Medullary thyroid carcinoma (MTC) is a rare neuroendocrine thyroid tumor, with only 30 new patients annually in the Netherlands. PET imaging provides information on distant metastases, after which tyrosine kinase inhibitors (TKIs) may be initiated. The rarity of the disease impedes large controlled trials, and therefore the challenge of selecting the best TKI and PET tracer for individual patients persists. To explore whether an in vitro model could be developed to guide the selection of appropriate PET tracers or TKI therapies in the future, we aimed to establish an MTC organoid model for the first time. Methods Dispersed cells from MTC biopsies were suspended in Matrigel, allowing organoid formation. The self-renewal potential was tested by dissociation and re-plating cells and determining organoid-forming efficiency. MTC-specific gene and protein expression were characterized by qPCR and immunofluorescent staining. Moreover, MTC-organoids (MTOs) were exposed to TKIs and PET tracers in proof-of-principle experiments. Results Ten MTC biopsies were processed and successfully cultured as MTOs. MTC-derived cells showed self-renewal potency for several passages, indicating the presence of putative stem cells. Gene and protein expression of MTC-specific markers in tissue and MTOs, and function measurements showed the production of calcitonin and CEA. Interpretation of the preliminary experiments with TKIs and PET tracers was limited by sample size but demonstrates their future potential. Conclusion We were able to culture MTC organoids that resemble the original tissue in gene expression, protein expression, and functionality. However, international, multi-center studies are required to meet the standards for future clinical applications.
  • Selection of patients for proton therapy to reduce risk of second primary lung and breast cancer
    Radiotherapy and Oncology, 2025
  • Development and validation of cost-effective multi-sample hypoxia chambers for proton ultra-high dose rate organoid irradiations
    Rutger Jan Cornelis de Koster, Jeremy Putra Gunawan, Hans Peters, Johan Bussink, Lara Barazzuol, et al.
    Clinical and Translational Radiation Oncology, 2025
  • Sustainable radiation oncology in a world with grand environmental and societal challenges: Society Matters – A new section in the Green Journal
    Kari Tanderup, Birgitte V. Offersen, Dietmar Georg, Rob P. Coppes, Pierre Blanchard
    Radiotherapy and Oncology, 2025
  • Clinical applications of human organoids
    Monique M. A. Verstegen, Rob P. Coppes, Anne Beghin, Paolo De Coppi, Mattia F. M. Gerli, et al.
    Nature Medicine, 2025
  • BIOLOGICAL MODIFIERS OF NORMAL TISSUE EFFECTS
    Robert P. Coppes, Wolfgang Dörr
    Basic Clinical Radiobiology Sixth Edition, 2025
  • VOLUME EFFECTS, REGIONAL RESPONSES AND RISK MODELS
    Peter van Luijk, Robert P. Coppes, Wolfgang Dörr, Albert J. van der Kogel
    Basic Clinical Radiobiology Sixth Edition, 2025
  • EARLY EFFECTS IN EPITHELIAL TISSUES: The role of stem cells and time factors
    Robert P. Coppes, Wolfgang Dörr, Peter van Luijk, Lara Barazzuol
    Basic Clinical Radiobiology Sixth Edition, 2025
  • Driving innovation in radiation oncology in a changing world: The Green Journal's roadmap for the next decade
    Pierre Blanchard, Dietmar Georg, Rob P. Coppes, Birgitte Vrou Offersen
    Radiotherapy and Oncology, 2025
  • CANCER STEM CELLS IN RADIOTHERAPY
    Robert P. Coppes, Michael Baumann, Mechthild Krause, Richard P. Hill
    Basic Clinical Radiobiology Sixth Edition, 2025
  • PATHOGENESIS OF LATE NORMAL TISSUE EFFECTS
    Lara Barazzuol, Peter van Luijk, Robert P. Coppes, Albert J. van der Kogel, Wolfgang Dörr
    Basic Clinical Radiobiology Sixth Edition, 2025
  • Sparing of the Heart Facilitates Recovery From Cardiopulmonary Side Effects After Thoracic Irradiation
    Julia Wiedemann, Sai K. Paruchuru, Lisette E. den Boef, Uilke Brouwer, Herman H.W. Silljé, et al.
    International Journal of Radiation Oncology Biology Physics, 2025
  • Resistance of HNSCC cell models to pan-FGFR inhibition depends on the EMT phenotype associating with clinical outcome
    Felix Broghammer, Irina Korovina, Mahesh Gouda, Martina Celotti, Johan van Es, et al.
    Molecular Cancer, 2024
  • Radiation-induced DNA double-strand breaks in cortisol exposed fibroblasts as quantified with the novel foci-integrated damage complexity score (FIDCS)
    Wilhelmina E. Radstake, Alessio Parisi, Silvana Miranda, Kiran Gautam, Randy Vermeesen, et al.
    Scientific Reports, 2024
  • Radiation-induced Xerostomia is Related to Stem Cell Dose-dependent Reduction of Saliva Production
    Maria I. van Rijn-Dekker, Sacha la Bastide-van Gemert, Monique A. Stokman, Arjan Vissink, Robert P. Coppes, et al.
    International Journal of Radiation Oncology Biology Physics, 2024
  • Future of Team-based Basic and Translational Science in Radiation Oncology
    Seminars in Radiation Oncology, 2024

RECENT SCHOLAR PUBLICATIONS

  • Hyaluronic Acid‐silk Fibroin Hydrogel for Salivary Gland Tissue Engineering
    M Hajiabbas, C Pelissari, D Parisis, T Putz, C D'Agostino, M Baanstra, ...
    Advanced Healthcare Materials, e71225 , 2026
    2026
  • Radiation-induced interferon-I response impairs thyroid organoid function
    R Maturi, D Cinat, AL Jellema-de Bruin, G De Vita, S Kruijff, RP Coppes, ...
    Radiotherapy and Oncology, 111453 , 2026
    2026
  • Development of a national indication protocol for proton therapy in patients with seminoma testis to reduce the risk on subsequent primary cancers
    N Kuijsters, P Sinnige, PA Bakker, S Al Uwini, CL Brouwer, T Budiharto, ...
    International Journal of Radiation Oncology* Biology* Physics , 2026
    2026
  • lncRNAs: a new generation of targets and biomarkers in thyroid cancer
    R Maturi, M Esposito, RP Coppes, G De Vita
    European Thyroid Journal 15 (1) , 2026
    2026
  • Brain irradiation drives remote liver changes via senescence-independent mechanisms
    Y Jiang, DC Voshart, A Gustinelli, AC Scholma, E Hageman, LR Nazario, ...
    Radiotherapy and Oncology, 111373 , 2026
    2026
  • Differential synaptic signaling responses in human cortical organoids after photon and proton irradiation
    Y Jiang, DB Guerra, DC Voshart, E Hageman, LR Nazario, ...
    Stem Cell Reports , 2026
    2026
    Citations: 1
  • A MONTE CARLO FRAMEWORK FOR ROBUST PROTON CONFORMAL FLASH IRRADIATION OF ECTOPIC MAMMARY TUMORS IN MICE
    R De Koster, J Gunawan, L Barazzuol, MJ Van Goethem, R Coppes, ...
    International Journal of Particle Therapy 17, 101048 , 2025
    2025
  • IFN-I signaling enhances salivary gland stem and progenitor cell activity after irradiation
    D Cinat, R Van Der Wal, M Baanstra, A Soto-Gamez, R Maturi, ...
    Science signaling 18 (913), eady0398 , 2025
    2025
    Citations: 6
  • Notch signaling is a driver of glandular stem cell activity and regenerative migration after damage
    D Cinat, R Maturi, JP Gunawan, AL Jellema-de Bruin, L Kracht, ...
    The EMBO Journal 45 (2), 374 , 2025
    2025
    Citations: 3
  • Patient-derived medullary thyroid cancer organoids: a potential model for mechanistic studies on diagnostics and therapy
    EC Jager, LHJ Sondorp, R Maturi, IF Antunes, BM van Hemel, U Brouwer, ...
    European Thyroid Journal 14 (5) , 2025
    2025
    Citations: 3
  • Role of Klhl14 in senescence and epithelial-to-mesenchymal transition via TGF-β modulation
    R Maturi, A Soto-Gamez, AL Jellema-de Bruin, M Esposito, S Kruijff, ...
    bioRxiv, 2025.09. 12.675818 , 2025
    2025
  • Selection of patients for proton therapy to reduce risk of second primary lung and breast cancer
    LJ Boersma, A Hessels, S Roberti, E Seravalli, N Bijker, RP Coppes, ...
    Radiotherapy and Oncology 210, 110998 , 2025
    2025
    Citations: 3
  • Radiation-induced lung disease
    P van Luijk, J Wiedemann
    ERS Handbook of Respiratory Medicine, 646-648 , 2025
    2025
  • Radiation-induced lung disease
    RP Coppes, P van Luijk
    ERS Handbook of Respiratory Medicine (out of print), 369-370 , 2025
    2025
  • Development and validation of cost-effective multi-sample hypoxia chambers for proton ultra-high dose rate organoid irradiations
    RJC de Koster, JP Gunawan, H Peters, J Bussink, L Barazzuol, ...
    Clinical and Translational Radiation Oncology 53, 100970 , 2025
    2025
    Citations: 1
  • ABS0128 GENERATION OF PLURIPOTENT STEM CELL-DERIVED SALIVARY GLAND PROGENITOR CELLS FOR TRANSPLANTATION IN SJÖGREN'S DISEASE
    A Soto-Gamez, JH Terpstra, C Tesa, H Bootsma, FGM Kroese, R Coppes, ...
    Annals of the Rheumatic Diseases 84, 2073 , 2025
    2025
  • Sustainable radiation oncology in a world with grand environmental and societal challenges: Society Matters–A new section in the Green Journal
    K Tanderup, BV Offersen, D Georg, RP Coppes, P Blanchard
    Radiotherapy and Oncology 207, 110876 , 2025
    2025
    Citations: 5
  • Establishment of salivary tissue-organoid biorepository: characterizing salivary gland stem/progenitor cells and novel differentiation marker PSMA/FOLH1
    SMM Aalam, AR Varela, A Khaderi, RJ Mondesir, DG Mun, A Ding, ...
    npj Regenerative Medicine 10 (1), 23 , 2025
    2025
    Citations: 8
  • 3329 Combination of Captopril, Ambrisentan and Sildenafil mitigates long-term side effects of combined heart and lung irradiation
    J Wiedemann, U Brouwer, HHW Silljé, MG Dickinson, RP Coppes, ...
    Radiotherapy and Oncology 206, S3942-S3943 , 2025
    2025
  • Clinical applications of human organoids
    MMA Verstegen, RP Coppes, A Beghin, P De Coppi, MFM Gerli, ...
    Nature medicine 31 (2), 409-421 , 2025
    2025
    Citations: 169

MOST CITED SCHOLAR PUBLICATIONS

  • Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
    M Mauthe, I Orhon, C Rocchi, X Zhou, M Luhr, KJ Hijlkema, RP Coppes, ...
    Autophagy 14 (8), 1435-1455 , 2018
    2018
    Citations: 2406
  • Oral sequelae of head and neck radiotherapy
    A Vissink, J Jansma, FKL Spijkervet, FR Burlage, RP Coppes
    Critical Reviews in Oral Biology & Medicine 14 (3), 199-212 , 2003
    2003
    Citations: 1380
  • Rescue of salivary gland function after stem cell transplantation in irradiated glands
    IMA Lombaert, JF Brunsting, PK Wierenga, H Faber, MA Stokman, T Kok, ...
    PloS one 3 (4), e2063 , 2008
    2008
    Citations: 608
  • Prevention and treatment of the consequences of head and neck radiotherapy
    A Vissink, FR Burlage, FKL Spijkervet, J Jansma, RP Coppes
    Critical Reviews in Oral Biology & Medicine 14 (3), 213-225 , 2003
    2003
    Citations: 604
  • Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers
    A Vissink, JB Mitchell, BJ Baum, KH Limesand, SB Jensen, PC Fox, ...
    International Journal of Radiation Oncology* Biology* Physics 78 (4), 983-991 , 2010
    2010
    Citations: 491
  • On the mechanism of salivary gland radiosensitivity
    AWT Konings, RP Coppes, A Vissink
    International Journal of Radiation Oncology* Biology* Physics 62 (4), 1187-1194 , 2005
    2005
    Citations: 454
  • Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer
    P Van Luijk, S Pringle, JO Deasy, VV Moiseenko, H Faber, A Hovan, ...
    Science translational medicine 7 (305), 305ra147-305ra147 , 2015
    2015
    Citations: 324
  • Long-term in vitro expansion of salivary gland stem cells driven by Wnt signals
    M Maimets, C Rocchi, R Bron, S Pringle, J Kuipers, BNG Giepmans, ...
    Stem cell reports 6 (1), 150-162 , 2016
    2016
    Citations: 311
  • Human salivary gland stem cells functionally restore radiation damaged salivary glands
    S Pringle, M Maimets, M van der Zwaag, MA Stokman, D van Gosliga, ...
    Stem cells 34 (3), 640-652 , 2016
    2016
    Citations: 295
  • Prevention and treatment of radiotherapy‐induced side effects
    L Barazzuol, RP Coppes, P van Luijk
    Molecular oncology 14 (7), 1538-1554 , 2020
    2020
    Citations: 294
  • Parotid and submandibular/sublingual salivary flow during high dose radiotherapy
    FR Burlage, RP Coppes, H Meertens, MA Stokman, A Vissink
    Radiotherapy and Oncology 61 (3), 271-274 , 2001
    2001
    Citations: 276
  • Regeneration of irradiated salivary glands with stem cell marker expressing cells
    LSY Nanduri, M Maimets, SA Pringle, M van der Zwaag, RP van Os, ...
    Radiotherapy and oncology 99 (3), 367-372 , 2011
    2011
    Citations: 257
  • Purification and ex vivo expansion of fully functional salivary gland stem cells
    LSY Nanduri, M Baanstra, H Faber, C Rocchi, E Zwart, G de Haan, ...
    Stem cell reports 3 (6), 957-964 , 2014
    2014
    Citations: 236
  • Isolation and characterization of human salivary gland cells for stem cell transplantation to reduce radiation-induced hyposalivation
    J Feng, M van der Zwaag, MA Stokman, R van Os, RP Coppes
    Radiotherapy and oncology 92 (3), 466-471 , 2009
    2009
    Citations: 229
  • Concise review: Adult salivary gland stem cells and a potential therapy for xerostomia
    S Pringle, R Van Os, RP Coppes
    Stem cells 31 (4), 613-619 , 2013
    2013
    Citations: 223
  • Patient-derived tumor organoids for prediction of cancer treatment response
    PW Nagle, JTM Plukker, CT Muijs, P van Luijk, RP Coppes
    Seminars in cancer biology 53, 258-264 , 2018
    2018
    Citations: 209
  • Salisphere derived c-Kit+ cell transplantation restores tissue homeostasis in irradiated salivary gland
    LSY Nanduri, IMA Lombaert, M van der Zwaag, H Faber, JF Brunsting, ...
    Radiotherapy and oncology 108 (3), 458-463 , 2013
    2013
    Citations: 206
  • Mobilization of bone marrow stem cells by granulocyte colony-stimulating factor ameliorates radiation-induced damage to salivary glands
    IMA Lombaert, PK Wierenga, T Kok, HH Kampinga, G dehaan, ...
    Clinical Cancer Research 12 (6), 1804-1812 , 2006
    2006
    Citations: 206
  • Early to late sparing of radiation damage to the parotid gland by adrenergic and muscarinic receptor agonists
    RP Coppes, LJW Zeilstra, HH Kampinga, AWT Konings
    British journal of cancer 85 (7), 1055-1063 , 2001
    2001
    Citations: 200
  • Keratinocyte growth factor prevents radiation damage to salivary glands by expansion of the stem/progenitor pool
    IMA Lombaert, JF Brunsting, PK Wierenga, HH Kampinga, G De Haan, ...
    Stem cells 26 (10), 2595-2601 , 2008
    2008
    Citations: 198