P L Sujatha

@tanuvas.ac.in

University Deputy Librarian
Tamil Nadu Veterinary and Animal Sciences University

P L Sujatha


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https://researchid.co/sujathaloganathan

RESEARCH INTERESTS

Bioinformatics, Information Technology, Information Science
5

Scopus Publications

60

Scholar Citations

4

Scholar h-index

1

Scholar i10-index

Scopus Publications

  • A Systematic Way to Understand the Anti-obese Potentials of Cissus quadrangularis (Pirandai): A Nutraceutical Approach
    N. Gokul Kannaa, P.L. Sujatha, V. Appa Rao, I. Manikkavasagan, K. Vijayarani, et al.
    Asian Journal of Dairy and Food Research, 2024
    Background: The development of obesity involves hormones and neurotransmitters. The prevalence of obesity is measured by body mass index (BMI) raised to unacceptable levels in both men and women worldwide. Thyroid hormones are involved in multiple physiological processes, regulate basal metabolic rate, promote the adrenergic nervous system to generate heat in response to cold exposure and stimulate gluconeogenesis and lipolysis and lipogenesis. The increase in the production of thyroid hormone will increase the basal metabolic rate in the body. Thus, the increase in BMR reduces the breakdown of LDL-cholesterol, total cholesterol, and triglycer ides, which causes fat storage. The reduction in the fat level will eventually lead to a lower risk of obesity. Methods: Cissus quadrangularis has been reported to reduce obesity in humans, but no scientific evidence is available to support its use. The computational approach is used to study its biological properties such as molecular docking and functional analysis was performed using BIOVIA Discovery Studio software. Result: The molecular docking, pharmacodynamic and pharmacokinetic studies conducted on the active principles of Cissus quadrangularis showed good interaction with selected target proteins involved in obesity. Almost all the active principles possess anti-obesity properties. Amoyrone and ascorbic acid of Cissus quadrangularis has shown excellent interaction, drug likeliness, pharmacokinetic properties. This finding might help in developing an alternate, cost-effective, safe, eco-friendly anti-obese drug. However the results could be validated with in vivo and in vitro studies.
  • Phytochemical Analysis of Tinospora Cordifolia by Gc-Ms and Evaluation of its Antiurolithiatic Potential by In Siilico
    Sowmya. M, Ramesh. S, Ganne Venkata Sudhakar Rao, Ramesh. S, Jalantha. P, et al.
    Indian Veterinary Journal, 2024
    Urolithiasis is the third most common urinary tract disorder affecting both men and women with an estimated global frequency of approximately 14%. Ethylene glycol is a lithiatic agent which is a potent component for experimental induction of urolithiasis. The enzymes like glycolate oxidase, oxalate oxidase are employed in oxalate metabolism which involve in caliculi formation. CD44 is a receptor of the stone modulating protein, Osteopontin (OPN). Tinospora cordifo-lia is a medicinal plant distributed throughout the Indian subcontinent, and contains many phytochemicals used for various ailments. GC-MS and ADME analysis were done and active principles (
  • Screening of bioactive compounds from natural remedies for photoaging, to target Ap-1; An in silico approach
    E. Felix Anto Ophelia, P.L. Sujatha, P. Kumarasamy
    Proceeding of IEEE 2nd International Conference on Advances in Electrical Electronics Information Communication and Bio Informatics IEEE Aeeicb 2016, 2016
    Although skin aging due to UV exposure (photoaging) and chronological skin aging have been thought to be distinct, photoaging has a considerable effect on chronological aging. UV irradiation of skin leads to oxidative stress and increases reactive oxygen species (ROS) and also reduces antioxidant enzyme. As a consequence, several cell surface cytokines and growth factor receptors are activated which results in recruitment of several adaptor proteins to regulate downstream signaling. AP-1 is a transcription factor which up-regulates matrix-metalloproteinases and down-regulates type 1 procollagen. Thus AP-1 can be an effective target for photoaging. In this study, the effect of 56 active ingredients from several natural and easily available traditional remedies for skin aging has been studied by means of in silico approach and the potential active ingredients have been identified.
  • Identification of therapeutic inhibitors for the treatment of oral cancer using herbal bio-active principles by means of computational approach
    P L. Sujatha, Ravi Reddy, Jaideep Mahendra, K. Kumanan, P. Kumarasamy, et al.
    Proceeding of IEEE 2nd International Conference on Advances in Electrical Electronics Information Communication and Bio Informatics IEEE Aeeicb 2016, 2016
    Oral cancer is a type of cancer which targets mouth and surrounding tissues. It includes, lips, cheeks, tongue, sinuses, throat. Oral cancer could be life threatening, if not diagnosed in early stages. American Cancer Society says that men are at more risk than women. Oral cancer can be treated like any other cancers. But still the efficacy of the drugs is questionable. Hence, an attempt was tried to find the suitable inhibitors for the treatment of oral cancer using bioactive principles of Cissus quadrangularis, targeting SIRT3, P21 and P53. The Resveratol in Cissus quadrangularis has showed very good interaction with two target proteins involved in oral cancer viz., SIRT3 and P21. Resveratol also has very good pharmacodynamic and pharmacokinetic properties. This study concludes that Resveratol in Cissus quadrangularis has the potential to serve as an anticancerous drug. However, the results might be validated through in-vivo and in-vitro studies to prove the efficacy of the active compounds and to protect the mankind from oral cancer.
  • A computational approach to use the active principles in Custard apple (Annona squamosa), as an ectoparasiticide by using potential target Acetylcholinesterase of Rhipicephalus sanguineus (Brown dog tick)
    S. Pavithra, S.P. Preetha, P.L. Sujatha, M.R Srinivasan, A. Karthikeyan, et al.
    Proceeding of IEEE 2nd International Conference on Advances in Electrical Electronics Information Communication and Bio Informatics IEEE Aeeicb 2016, 2016
    Rhipicephalus sanguineus is a brown dog tick that transmits rickettsial infection between dogs and man. It can be prevented by using ectoparasiticides generally acting through acetylcholinesterase inhibiting mechanism which is responsible for the catalysis of acetylcholine neurotransmitter. To overcome the toxic effects produced by synthetic ectoparasticides, new in silico approaches were carried out using the active principles from the custard apple. Custard apple is a small tree cultivated throughout India with various medicinal properties. A novel docking study was performed using the active ingredients present in the leaves of the custard apple. The dock scores were analysed and the best active ingredient-target interactions were identified. The active principle Norcorydine gives good docking scores with Acetylcholinesterase. Hence the present study projects the positive role of custard apple in the synthesis of bio-insecticides for the control of ectoparasites.

RECENT SCHOLAR PUBLICATIONS

  • APPLICATION OF COMPUTATIONAL METHODS IN DRUG DISCOVERY
    PL Sujatha, KA Kumar, P Devendran, SP Preetha, M Ilangopathy
    2025
  • A systematic way to understand the anti-obese potentials of Cissus quadrangularis (Pirandai): a nutraceutical approach
    NG Kannaa, PL Sujatha, VA Rao, I Manikkavasagan, K Vijayarani, ...
    Asian J Dairy Food Res 43, 275-281 , 2024
    2024
    Citations: 3
  • An in silico evaluation of anti-diabetic potential of vasicine, a quinazoline alkaloid of justicia adhatoda linnaeus
    KSS Ravali, G Sarathchandra, SU Kumary, PL Sujatha, TA Kannan, ...
    Indian Journal of Animal Research 1 (4) , 2024
    2024
    Citations: 3
  • IN SILICO INTERACTION STUDIES OF RESVERATROL AND SILIBININ WITH DIFFERENT PROTEIN TARGETS USING MOLECULAR DOCKING
    JV Yadav, GVS Rao, N Pazhanivel, PL Sujatha
    2024
  • Validation of guloochiyadi kashayam and chundai vatral choornam for the treatment of canine parvo viral enteritis in dogs
    DP Priya K, Senthil Kumar P, Chithra S, Sakthikarthikeyan S, Chellapandian M ...
    Global Ayurveda Festival, Kerala, 1563 , 2023
    2023
  • Gemcitabine (A Chemotherapy Medication) Vs. Phytochemicals Against Non-Small Cell Lung Cancer – A Computational Approach
    SS Sujatha P L, S P Preetha, Manikkavasagan I, P Devendran, Anbukumar K
    International Journal of Membrane Science and Technology, 10 (3), 2827-2837 , 2023
    2023
  • In silico Prediction of Antiviral Activity of Andrographis paniculata Against NDV2K35 strain of Newcastle Disease Virus
    PLS S. Nagajothi, P. Mekala, A. Raja, M. J. Raja, P. Senthil Kumar
    Agricultural Mechanization in Asia 54 (5), 13099-130114 , 2023
    2023
  • Application of IoT in Beverage Industry
    ARM Arivazhagan A, Sujatha P L
    International Conference on “Innovations in Food and Beverage Technology for … , 2023
    2023
  • Design and Development of Si-FAV (South Indian Anit-Cancerous fruits and vegetables): An android APP
    IMVAR S Sowmiya, P L Sujatha
    International Conference on “Innovations in Food and Beverage Technology for … , 2023
    2023
  • A comprehensive analysis of circulating porcine circovirus 2 (PCV2) genotypes from 2008 to 2023 in India
    KA Kumar, PL Sujatha, P Devendran
    Pharma Innov. J 12, 990-996 , 2023
    2023
    Citations: 4
  • Keloids: A review of the diseases, causes, and current treatments
    J Anirudh, T Gomathi, PL Sujatha, P Devendran, KA Kumar
    Journal of Pharmaceutical Research International 34 (53A), 1-15 , 2022
    2022
    Citations: 1
  • Chapter-6 Bioinformatics Approaches in Food Industry
    PL Sujatha, I Manikkavasagan, P Kumarasamy, T Arvindprabhu
    in Food Technology and Nutrition, 83 , 2022
    2022
  • A Systematic Way to Understand the Anti-obese Potentials of Cissus quadrangularis (Pirandai): A Nutraceutical Approach
    P.L. Sujatha, V. Appa Rao, I. Manikkavasagan, K. Vijayarani, T. Arvind ...
    Asian Journal of Dairy and Food Research, DOI: 10.18805/ajdfr.DR-1702 , 2022
    2022
  • Bioinformatics Approaches in Food Industry
    PLS , V Appa Rao, I Manikkavasagan, K Vijayarani
    Research Trends in Food Technology and Nutrition 20 , 2022
    2022
  • A Preliminary In-silico Analysis and Molecular Docking of Active Compounds in Coriandrum sativum as Potential Drug Targets Against SARS-COV-2 Infection
    HK T. Arvind Prabhu , N.M Hariharan, K.E Premalatha, P. L. Sujatha
    Journal of Applied Life Sciences International 25 (2), 15-25 , 2022
    2022
    Citations: 5
  • Databases used for Genomic and Proteomic Data
    MIARV Sujatha PL, Vijayarani K
    Recent Trends in Multidisciplinary Research 23, 75-93 , 2021
    2021
  • SMARTPHONE APPLICATIONS IN THE FIELD OF FOOD SCIENCE AND TECHNOLOGY: AN EVALUATIVE REVIEW
    SS Gokul Kannaa, Sujatha P L, Appa Rao V
    International Journal of Electronics and Communication Engineering (IJECE … , 2021
    2021
  • A Systematic Review on The Commonly Available Plants With Anti-Obesity Potential
    MI N GOKUL KANNAA, P L SUJATHA, V APPA RAO, S SOWMYA, K VIJAYARANI
    IOSR Journal Of Pharmacy 11 (6), 33-36 , 2021
    2021
  • Identification of the lead compounds for the treatment of breast cancer using phytochemicals: A bioinformatics approach
    Sujatha PL, Appa Rao V, Vijayarani K and Manikkavasagan Ilangopathy
    The Pharma Innovation Journal 9 (8), 48-51 , 2020
    2020
  • Identification of the lead compounds for the treatment of breast cancer using phytochemicals: A bioinformatics approach
    PL Sujatha, V Appa Rao, K Vijayarani
    2020

MOST CITED SCHOLAR PUBLICATIONS

  • Vetinformatics: A New Paradigm for Quality Veterinary Services
    PL Sujatha, P Kumarasamy, SP Preetha, P Balachandran
    Research & Reviews: Journal of Veterinary Science and Technology 5 (2), 16-19 , 2018
    2018
    Citations: 13
  • ANALYSIS OF THE MECHANISM OF ACTION BY MOLECULAR DOCKING STUDIES OF ONE ETHNO VETERINARY HERBAL PREPARATION USED IN BOVINE MASTITIS
    PSP PUNNIAMURTHY N , SUJATHA P L
    International Journal of Applied and Natural Sciences 6 (5), 23-28 , 2017
    2017
    Citations: 8
  • Molecular docking studies of Bacoside-A, an active component of Bacopa monniera with DJ1 for Anti-Parkinson's drug design
    S Chandrasekar, S Thangarajan, S Loganathan, S Sundaram
    Biomirror 4 (9) , 2013
    2013
    Citations: 7
  • A Preliminary In-silico Analysis and Molecular Docking of Active Compounds in Coriandrum sativum as Potential Drug Targets Against SARS-COV-2 Infection
    HK T. Arvind Prabhu , N.M Hariharan, K.E Premalatha, P. L. Sujatha
    Journal of Applied Life Sciences International 25 (2), 15-25 , 2022
    2022
    Citations: 5
  • A comprehensive analysis of circulating porcine circovirus 2 (PCV2) genotypes from 2008 to 2023 in India
    KA Kumar, PL Sujatha, P Devendran
    Pharma Innov. J 12, 990-996 , 2023
    2023
    Citations: 4
  • A computer aided approach to develop herbal acaricide using Leucas aspera and Cassia alata against the cattle tick Rhipicephalus (Boophilus) microplus
    PSCY M Nithya Priyadarshini, SP Preetha, PL Sujatha, M Thangapandiyan, G ...
    The Pharma Innovation 8 (11), 79-87 , 2019
    2019
    Citations: 4
  • A systematic way to understand the anti-obese potentials of Cissus quadrangularis (Pirandai): a nutraceutical approach
    NG Kannaa, PL Sujatha, VA Rao, I Manikkavasagan, K Vijayarani, ...
    Asian J Dairy Food Res 43, 275-281 , 2024
    2024
    Citations: 3
  • An in silico evaluation of anti-diabetic potential of vasicine, a quinazoline alkaloid of justicia adhatoda linnaeus
    KSS Ravali, G Sarathchandra, SU Kumary, PL Sujatha, TA Kannan, ...
    Indian Journal of Animal Research 1 (4) , 2024
    2024
    Citations: 3
  • A computational approach to use the active principles in Custard apple (Annona squamosa), as an ectoparasiticide by using potential target Acetylcholinesterase of Rhipicephalus …
    S Pavithra, SP Preetha, PL Sujatha, MR Srinivasan, A Karthikeyan, ...
    2016 2nd International Conference on Advances in Electrical, Electronics … , 2016
    2016
    Citations: 2
  • Screening of bioactive compounds from natural remedies for photoaging, to target Ap-1; an in silico approach
    EFA Ophelia, PL Sujatha, P Kumarasamy
    2016 2nd International Conference on Advances in Electrical, Electronics … , 2016
    2016
    Citations: 2
  • Computer-Aided Approach to Study the Anti- Tumour Potentials of Seaweed against Canine Breast Cancer
    PL Sujatha
    International Journal of Basic and Applied Biology 3 (3), 206-209 , 2016
    2016
    Citations: 2
  • Rapid Vaccine Identification In Microbial Genomes–An In Silico Approach With Special Reference To Chikungunya Virus
    PL Sujatha, P Kumarasamy, SP Preetha
    Int J of Sci Res and Engineer Stu 2 (8), 35-46 , 2015
    2015
    Citations: 2
  • Keloids: A review of the diseases, causes, and current treatments
    J Anirudh, T Gomathi, PL Sujatha, P Devendran, KA Kumar
    Journal of Pharmaceutical Research International 34 (53A), 1-15 , 2022
    2022
    Citations: 1
  • An Evaluation of the Anti-Cancerous Effects of Tinospora cordifolia and Aristolochia bracteolate Using CADD (Computer Aided Drug Discovery) Tools
    CBNP Cecilia Joseph, S. Preetha, P.L. Sujatha
    International Journal of Current Microbiology and Applied Sciences 7 (6 … , 2018
    2018
    Citations: 1
  • Identification of therapeutic inhibitors for the treatment of oral cancer using herbal bio-active principles by means of computational approach
    PL Sujatha, R Reddy, J Mahendra, K Kumanan, P Kumarasamy, ...
    Advances in Electrical, Electronics, Information, Communication and Bio … , 2016
    2016
    Citations: 1
  • A Computational Approach to use the Active Compounds in Rosemary (Rosmarinusofficinalis), Responsible for its Anti-Inflammatory Properties, as Potential Ligands in Non …
    A Hari, P Kumarasamy, PL Sujatha, S Sureshkannan, P Sankar
    Biomirror 5 (6) , 2014
    2014
    Citations: 1
  • Computational Prediction and In Silico Analysis of Gyrase Gene QRDR Region Coding Drug Resistance among Mycobacterium Tuberculosis Isolates of India
    A Sasikalaveni, AW Aruni
    International Journal of Computational Bioinformatics and In Silico Modeling … , 2014
    2014
    Citations: 1
  • A Computational Approach to use the Active Compounds in Rosemary (Rosmarinusofficinalis), Responsible for its Anti-Inflammatory Properties, as Potential Ligands in Non …
    PS Archana Hari, Kumarasamy P, Sujatha P L, Sureshkannan S
    B I O M I R R O R 5, 53-58 , 2014
    2014
    Citations: 1
  • APPLICATION OF COMPUTATIONAL METHODS IN DRUG DISCOVERY
    PL Sujatha, KA Kumar, P Devendran, SP Preetha, M Ilangopathy
    2025
  • IN SILICO INTERACTION STUDIES OF RESVERATROL AND SILIBININ WITH DIFFERENT PROTEIN TARGETS USING MOLECULAR DOCKING
    JV Yadav, GVS Rao, N Pazhanivel, PL Sujatha
    2024