Mubarak Muhammad Dahiru
@adamawastatepoly.edu.ng
Department of Pharmaceutical Technology
Adamawa State Polytechnic
RESEARCH, TEACHING, or OTHER INTERESTS
Biochemistry, Pharmacology, Drug Discovery, Pharmaceutical Science
Scopus Publications
Scholar Citations
Scholar h-index
Scopus Publications
Muhammad Mubarak DAHIRU, Enoch Buba BADGAL, and Neksumi MUSA
Ankara Universitesi Eczacilik Fakultesi Dergisi
Objective: The present study aimed to investigate the phytochemical and heavy metals components of A. leiocarpus considering its applications in ethnomedicine.
 Material and Method: The phytochemical components were determined qualitatively and quantitatively gravimetrically, while component identification was done using (Gas spectrometer-mass spectrometer (GC-MS) technique. Heavy metals were quantified by atomic absorption spectrophotometer.
 Result and Discussion: Saponins and flavonoids were detected in the aqueous extracts in concentrations of 10.22% ±0.48, and 38.67% ±0.17 respectively, and concentrations of 17.37% ±0.65 and 19.63% ±0.60 respectively in the ethanol extract.. GC-MS analysis identified 16 and 26 compounds in the aqueous and ethanol extracts respectively. In the aqueous extract, 5-Hydroxymethylfurfural, 1,2,4-Benzenetriol, and cis-Vaccenic acid had the highest peak areas of 46.24, 17.12, and 15.13% respectively, while in the ethanol extract 5-Hydroxymethylfurfural (14.40%),1,2,3-Benzenetriol (12.29%) and -methoxybenzene-1,4-diol (7.54%) were the highest. Chromium (0.548 ppm ±0.030) was detected only in the aqueous concentration, while Cadmium had a concentration of 0.002 ±0.001 and 0.006 ppm ±0.002 in the aqueous and ethanol extract respectively. Lead was present with aqueous and ethanol extracts concentrations of 0.096 ±0.020 and 0.096 ppm ±0.040 respectively. Conclusively, the present study agrees with the claims for the traditional application of the plant in folkloric medicine to manage different ailments.
Naziru Halliru, Murtala M. Badamasi, Ibrahim Y. Tudunwada, Titus B. Dajel, Saidu B. Abubakar, Auwalu S. Hamza, Sandra B. Oluwashola, Nasiru K. Nalado, Muhammad Dahiru, Ibrahim Na’abdu,et al.
Informa UK Limited
Abstract The role of epidemiologic and spatiotemporal factors affecting access to care among snakebite patients in Nigeria are determined. In 2021 a total of 2,942 snakebite patients were prospectively studied at four designated Health Facilities for Managing Snakebites (HFMS). The patients came from 94 Local Government Areas (LGAs) in 12 states in northern Nigeria. It was found that 435 (14.8%) patients actually accessed care within ≤2 hours of bite although 38.0% could have reached the HFMS within the time by car. In certain areas 92% of patients would have been able to reach a secondary or tertiary facility within ≤2 hours. Similarly, 437 (14.9%) patients traveled distances of ≤20 Km to reach a designated HFMS although 86% of patients resided within 5 Km of a road network. There was longer median delay to access care (15 hours), more patients (365) and higher proportion not treated with antivenom (22%) in August the wettest month of the year. Furthermore the patients who died (47) took a median time of 48 hours compared to 11 hours among known survivors (2,649) to access care. Expanding antivenom access to other secondary and tertiary HF in high burden areas especially during peak seasons will potentially improve the outcome among patients.
Mubarak Muhammad Dahiru and Nadro Margret Samuel
Universitas Gadjah Mada
Hyperlipidemia is characterized by elevated levels of Triglycerides, Cholesterol, LDL, and decreased levels of HDL are challenges in the management of Diabetes mellitus which might lead to death. This study aimed to determine the hypolipidemic potential of ethyl acetate extract of Hyphaene thebaica fruit in streptozotocin-induced diabetic rats. The hypolipidemic potential of H. thebaica fruit in streptozotocin-induced diabetic rats was determined. Rats were divided into six groups. Treatment groups were administered the extract at doses of 400 and 200 mg/kg body weight. Oral administration of the extract at 400 mg/kg body weight for four weeks significantly (p < 0.05) decreased the levels of total cholesterol (151.7 mg/dl ±2.40), Triglyceride (84.0 mg/dl ±1.15), LDL (75.2 mg/dl ±1.20) and increased HDL (39.3 mg/dl ±1.88) level. However no significant (p < 0.05) difference was observed between the 400 and 200 mg/kg body weight dose. Conclusively, H. thebaica can be used as a medicinal plant due to its protective action against dyslipidemic complications of diabetes mellitus.