Nadeem Rais
@bhagwantuniversity.ac.in
Pharmacology Academician & Researcher
Bhagwant University, Ajmer
Pharmacology | Diabetology | Antioxidants
EDUCATION
Ph.D., M. Pharm (Pharmacology)
RESEARCH INTERESTS
Pharmacology | Diabetology
Scopus Publications
Scopus Publications
Ashok K. Das, Sanjay Kalra, Shashank Joshi, Ambrish Mithal, Prasanna Kumar K. M., Ambika G. Unnikrishnan, Hemant Thacker, Bipin Sethi, Subhankar Chowdhury, Amarnath Sugumaran,et al.
Wiley
There are limited data on the real‐world management of diabetes in the Indian population. In this 2‐year analysis of the LANDMARC study, the management of type 2 diabetes mellitus (T2DM) and related complications were assessed.
Manoj Kumar, Baohong Zhang, Jayashree Potkule, Kanika Sharma, Radha, Christophe Hano, Vijay Sheri, Deepak Chandran, Sangram Dhumal, Abhijit Dey,et al.
Springer Science and Business Media LLC
Nadeem Rais, Akash Ved, Mohd. Shadab, Rizwan Ahmad, and Mohammad Shahid
Emerald
PurposeTaurine (2-aminoethane sulfonic acid; C2H7NO3S) is a nonprotein sulfur-containing β-amino acid present in nearly all mammalian tissues and the most ubiquitous free endogenous biomolecule in human cells. Taurine is commonly known as a conditionally essential amino acid because taurine is one of the few amino acids that are not incorporated in protein synthesis. The purpose of this study is to review the existing articles related to taurine and to give an account how useful is taurine to the different body systems. In this thorough overview, taurine is covered in terms of its essentiality, sources, advantages for neonates and the elderly, the effects of taurine deficiency, and the safety and toxicity of taurine supplements.Design/methodology/approachThis is a narrative review into the subject matter. Published articles were searched on different portals like PubMed, EMBASE, Scopus, Google Scholar, PubChem etc. The authors also evaluated the availability of taurine in commercially available energy drinks.FindingsThis comprehensive review, presents the potential clinical benefits and functional properties of taurine as a conditionally essential amino acid. Energy drinks containing taurine (and their concentration) are also reported in this review.Originality/valueThis is the first data that the authors are aware of that shows taurine content in a variety of energy drinks on the market.
Nadeem Rais, Akash Ved, Rizwan Ahmad, Kehkashan Parveen, and Mohd. Shadab
Emerald
PurposeRenal failure is an end-stage consequence after persistent hyperglycemia during diabetic nephropathy (DN), and the etiology of DN has been linked to oxidative stress. The purpose of this research was to determine the beneficial synergistic effects of S-Allyl Cysteine (SAC) and Taurine (TAU) on oxidative damage in the kidneys of type 2 diabetic rats induced by hyperglycemia.Design/methodology/approachExperimental diabetes was developed by administering intraperitoneal single dose of streptozotocin (STZ; 65 mg/kg) with nicotinamide (NA; 230 mg/kg) in adult rats. Diabetic and control rats were treated with SAC (150 mg/kg), TAU (200 mg/kg) or SAC and TAU combination (75 + 100 mg/kg) for four weeks. The estimation of body weight, fasting blood glucose (FBG), oral glucose tolerance test (OGTT), oxidative stress markers along with kidney histopathology was done to investigate the antidiabetic potential of SAC/TAU in the NA/STZ diabetic group.FindingsThe following results were obtained for the therapeutic efficacy of SAC/TAU: decrease in blood glucose level, decreased level of thiobarbituric acid reactive substances (TBARS) and increased levels of GSH, glutathione-s-transferase (GST) and catalase (CAT). SAC/TAU significantly modulated diabetes-induced histological changes in the kidney of rats.Originality/valueSAC/TAU combination therapy modulated the oxidative stress markers in the kidney in diabetic rat model and also prevented oxidative damage as observed through histopathological findings.
Nadeem Rais, Rizwan Ahmad, Akash Ved, Kehkashan Parveen, Darakhshan Gazala Bari, and Om Prakash
Bentham Science Publishers Ltd.
Introduction: Diabetes mellitus (DM) and steroid medication, coincided with coronavirus disease 2019 (COVID-19), results in a weakened immune system, allowing some commonly found pathogens to become more harmful. Mucormycosis (black fungus) is a type of opportunistic infection caused by fungi belonging to the Mucorales family. DM is the most prominent risk factor for mucormycosis. Excessive blood sugar and decreased insulin levels lead to diabetic ketoacidosis (DKA), a devastating complication of DM that can be fatal if left untreated. Methods: Diabetic ketoacidosis is more common in type 1 diabetic patients, although it can also be fall in type 2 diabetic patients. DKA occurs when the body lacks enough insulin to allow blood sugar to enter the cells and is used for energy. Instead, the liver breaks down fat for fuel-producing chemicals known as ketones. Results: When too many ketones are created too quickly, they can reach dangerously high levels in the body. Mucormycosis is a rare but serious infectious disease that requires medication or surgical removal. Conclusion: The confluence of diabetes and COVID-19 makes managing mucormycosis a serious and dead issue. Although the effectiveness of prophylactic antifungal therapy has yet to be demonstrated, hyperglycemia control appears to be the most important step in managing mucormycosis in DKA patients.
Manoj Kumar, Mrunal D. Barbhai, Tuba Esatbeyoglu, Baohong Zhang, Vijay Sheri, Sangram Dhumal, Nadeem Rais, Radha, Eman Mohammad Said Al Masry, Deepak Chandran,et al.
Elsevier BV
Manoj Kumar, Muzaffar Hasan, Jose M. Lorenzo, Sangram Dhumal, Jyoti Nishad, Nadeem Rais, Aman Verma, Sushil Changan, Mrunal Deepak Barbhai, Radha,et al.
Elsevier BV
Radha, Suraj Prakash, Niharika Sharma, Amit Kumar, Neeraj Kumari, Sunil Puri, Ashok Pundir, Vijay Kumar, Abhishek Kumar Sharma, Nadeem Rais,et al.
Elsevier BV
Neeraj Kumari, Suraj Prakash, Manoj Kumar, Radha, Baohong Zhang, Vijay Sheri, Nadeem Rais, Deepak Chandran, Abhijit Dey, Tanmay Sarkar,et al.
MDPI AG
Annona squamosa L. (custard apple or sugar apple), belonging to the Annonaceae family, is a small tree or shrub that grows natively in subtropical and tropical regions. Seeds of the custard apple have been employed in folk medicines because of the presence of bioactive chemicals/compounds such as alkaloids, flavonoids and phenolic compounds and acetogenins and cyclopeptides that are responsible for various biological activities. The seeds also show the presence of tannins, vitamin C, vitamin E and a higher content of amino acids. From investigations, it has been shown that the seeds of A. squamosa have considerable potential to be used as an antibacterial, hepatoprotective, antioxidant and antitumor/anticancer agent. Cyclosquamosin B, extracted from the custard apple seed, possesses vasorelaxant properties. Tocopherols and fatty acids, notably oleic acid and linoleic acid, are also found in the seed oil. A. squamosa seeds contain a high amount of annonaceous acetogenins compounds, which are potent mitochondrial complex I inhibitors and have high cytotoxicity. A survey primarily based on the nutritional, phytochemical and biological properties showed that A. squamosa seeds can be used for the discovery of novel products, including pharmaceutical drugs. Although there are sufficient in vitro and in vivo experimental investigations supporting the benefits of seeds, clinical investigations/trials are still needed to determine the health contributing benefits of A. squamosa seeds.
Manoj Kumar, Mrunal D Barbhai, Muzaffar Hasan, Sangram Dhumal, Surinder Singh, Ravi Pandiselvam, Nadeem Rais, Suman Natta, Marisennayya Senapathy, Neha Sinha,et al.
Wiley
Functional food development is rapidly increasing as a result of consumer consciousness concerning healthy and nutritious foods. In turn, research exploring novel ingredients for formulating functional foods has been accelerated. Onion peel or skin is a byproduct obtained from onion processing that contains abundant phytochemicals, contributing to its antioxidant potential. The main focus of this review is to highlight different extraction techniques (both conventional and nonconventional) that can be implemented to extract the bioactive compounds from onion peel and assess their antioxidant activity. Furthermore, this review highlights the major areas for the application of onion peel and its extract as prospective functional ingredients, thus aiding in the preparation of designer foods with additional health benefits. The use of onion peel could also assist in redesigning popularly consumed processed foods, such as baked products, noodles or pasta, as packaging material, meat quality improvers, colorants, and juice clarifiers. This review serves as a preliminary document that can assist in exploring different ways of incorporating bioactive onion peels or skin into the functional food industry and concludes that future research can assist in the effective and efficient utilization of this resource.
Akash Ved, Nadeem Rais, Rizwan Ahmad, Kehkashan Parveen, Girendra Kumar Gautam, Darakhshan Gazala Bari, Karuna S. Shukla, Ravi Gaur, and Akhand Pratap Singh
Bentham Science Publishers Ltd.
: The aim of the present study was to review the streptozotocin-nicotinamide (STZ-NA) diabetes model. Type 2 diabetes is more prevalent (90-95%) in adults than type 1. Experimentally- induced diabetes models may be established by chemicals, viral agents, insulin antibodies, surgery, etc. The most advisable and prompt method to induce diabetes is using chemicals, and STZ and alloxan are widely used chemicals. STZ has proven to be a better diabetogenic agent than alloxan because alloxan has many drawbacks, as it induces only type 1 diabetes, has a high mortality rate in rats, and causes ketosis in animals. Moreover, it has lesser selectivity towards β-cells, and the diabetes-induced is reversible. STZ can be used to induce both type 1 and type 2 diabetes. It is noted that the genotoxic behavior of STZ in animals is accomplished through a reduction of nicotinamide adenine dinucleotide (NAD+) in pancreatic β-cells via the GLUT2 (Glucose transporter 2), which can cause cellular damage by DNA (Deoxyribonucleic acid) strand breaks that lead to cell death. NA is a biochemical precursor of NAD+, and it is a poly-ADP-ribose-polymerase-1 (PARP- 1) inhibitor. NAD+ is an important redox reaction co-enzyme for the production of adenosine triphosphate (ATP) and many other metabolic pathways. Extreme DNA damage contributes to the over-activation of PARP-1, loss of cellular resources, and necrotic cells death. Some studies have expressed that NA can protect pancreatic β-cells against the severe cytotoxicity of STZ. The review concluded that the STZ-NA model is dependent on the competency of NA to attain partial protection against the β-cytotoxic essence of STZ to induce type-2 diabetes.
Anami Ahuja, P. Tyagi, M. Kumar, N. Sharma, S. Prakash, Radha, Deepak Chandran, SANGRAM SAHEBRAO DHUMAL, N. Rais, Surinder Singh,et al.
Stem cells are a well-known autologous pluripotent cell source, having excellent potential to develop into specialized cells, such as brain, skin, and bone marrow cells. The oral cavity is reported to be a rich source of multiple types of oral stem cells, including the dental pulp, mucosal soft tissues, periodontal ligament, and apical papilla. Oral stem cells were useful for both the regeneration of soft tissue components in the dental pulp and mineralized structure regeneration, such as bone or dentin, and can be a viable substitute for traditionally used bone marrow stem cells. In recent years, several studies have reported that plant extracts or compounds promoted the proliferation, differentiation, and survival of different oral stem cells. This review is carried out by following the PRISMA guidelines and focusing mainly on the effects of bioactive compounds on oral stem cell-mediated dental, bone, and neural regeneration. It is observed that in recent years studies were mainly focused on the utilization of oral stem cell-mediated regeneration of bone or dental mesenchymal cells, however, the utility of bioactive compounds on oral stem cell-mediated regeneration requires additional assessment beyond in vitro and in vivo studies, and requires more randomized clinical trials and case studies.
Manoj Kumar, Swati Kapoor, Sangram Dhumal, Joanna Tkaczewska, Sushil Changan, Vivek Saurabh, Mohamed Mekhemar, Radha, Nadeem Rais, Varsha Satankar,et al.
Elsevier BV
Nadeem Rais, Akash Ved, Rizwan Ahmad, Kehkashan Parveen, Om Prakash, Darakhshan Gazala Bari, Khursheed Ahmad, Muhammad Farman, and Naze Alam
Bentham Science Publishers Ltd.
Background: Coronavirus disease 2019 (Covid-19) is caused by a novel coronavirus (SARS-CoV-2) infection, while influenza viruses cause the flu. SARS-CoV-2 and influenza virus co-infection seems to be a real and serious concern. Objective: This study aims to evaluate the clinical features, laboratory investigations, computed tomography scans, and interventions of Covid-19 patients during seasonal influenza. Methods: This was a multi-center prospective cohort study that collected data from hospitals, clinics, and laboratories on measurements, treatments, and outcomes from Covid-19 patients admitted to temporary Covid-19 care centers. Results: A total of 480 individuals (female, 231 [48.12%]; male, 249 [51.88%]) were recruited from March 31st to May 14th, 2021 at five hospitals/clinics in Uttar Pradesh, North India. The patients were divided into six groups based on their age (65+ years [25.41% of cases] being the most affected age) and five groups based on their conditions (asymptomatic 65 [13.54%], mild 94 [19.58%], moderate 206 [42.91%], severe 84 [17.50%] and critical 31 [6.45%]). Patients’ outcomes were documented as death (19 [3.95%]), recovery (421 [87.71%]) and undertreatment (40 [8.34%]). Conclusions: The most common clinical symptoms reported were fever, sore throat, and dyspnea. The severity was linked to hypoxemia, lymphocytopenia, thrombocytopenia, elevated erythrocyte sedimentation rate (ESR), and high blood urea nitrogen (BUN). The vast majority of patients were given symptomatic treatment. Any onset of fever should be suspected and examined for the viral strain to distinguish between Covid-19 and the seasonal flu.
Neeraj Kumari, Radha, Manoj Kumar, Mohamed Mekhemar, José M. Lorenzo, Ashok Pundir, Kumari Baveja Devi, Suraj Prakash, Sunil Puri, Mamta Thakur,et al.
Elsevier BV
K. Sharma, Manoj Kumar, Roji B. Waghmare, R. Suhag, O. Gupta, J. Lorenzo, S. Prakash, Radha, N. Rais, Vellaikumar Sampathrajan,et al.
International Journal of Biological Macromolecules
Manoj Kumar, Suraj Prakash, Radha, José M. Lorenzo, Deepak Chandran, Sangram Dhumal, Abhijit Dey, Marisennayya Senapathy, Nadeem Rais, Surinder Singh,et al.
MDPI AG
Periodontal diseases are caused mainly by inflammation of the gums and bones surrounding the teeth or by dysbiosis of the oral microbiome, and the Global Burden of Disease study (2019) reported that periodontal disease affects 20–50% of the global population. In recent years, more preference has been given to natural therapies compared to synthetic drugs in the treatment of periodontal disease, and several oral care products, such as toothpaste, mouthwash, and dentifrices, have been developed comprising honeybee products, such as propolis, honey, royal jelly, and purified bee venom. In this study, we systematically reviewed the literature on the treatment of periodontitis using honeybee products. A literature search was performed using various databases, including PubMed, Web of Science, ScienceDirect, Scopus, clinicaltrials.gov, and Google Scholar. A total of 31 studies were reviewed using eligibility criteria published between January 2016 and December 2021. In vitro, in vivo, and clinical studies (randomized clinical trials) were included. Based on the results of these studies, honeybee products, such as propolis and purified bee venom, were concluded to be effective and safe for use in the treatment of periodontitis mainly due to their antimicrobial and anti-inflammatory activities. However, to obtain reliable results from randomized clinical trials assessing the effectiveness of honeybee products in periodontal treatment with long-term follow-up, a broader sample size and assessment of various clinical parameters are needed.
Akash Ved, Nadeem Rais, Rizwan Ahmad, Kehkashan Parveen, Tauheed Ishrat, Om Prakash, Mohd Shadab, Darakhshan Gazala Bari, and Nasir Ali Siddiqui
Bentham Science Publishers Ltd.
Background: Diabetes mellitus (DM) is among the most frequently reported comorbidities in patients tainted with the pandemic coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With a high pervasiveness of diabetes mellitus, there is an urgency to understand the special aspects of COVID-19 in hyperglycemic patients. Diabetic patients are at higher risk than the general population of viral or bacterial infections, thus require special attention since diabetes is linked with severe, critical, and lethal modes of COVID-19. Objective: The objective of this study was to focus on epidemiology, pathophysiology, mechanism, and management of DM with COVID-19. Method: The search was carried out on databases portals such as Pubmed, EMBASE, Google Scholar, and CINAHL with the keywords, i.e., COVID-19, coronavirus, SARS-CoV-2, diabetes, covid-19, etc. Result: DM and COVID-19 disease conditions can impact each other in terms of clinical progression and outcome. Available laboratory/clinical observations suggest that hyperglycemia-induced immune dysfunction, inflated lactate grades, and cytokines storm may play critical roles in the seriousness of COVID-19 in patients with diabetes; however, the exact mechanisms linking diabetes and COVID-19 remain to be further clarified. Conclusion: Standards to constrain the disease spread at the individual and community level are the key to extenuate the speedily rising pandemic, while definitive treatment, like plasma therapy, chemoprophylaxis, or vaccine for COVID-19, has yet to be discovered.
Manoj Kumar, Mrunal D. Barbhai, Muzaffar Hasan, Sneh Punia, Sangram Dhumal, Radha, Nadeem Rais, Deepak Chandran, R. Pandiselvam, Anjineyulu Kothakota,et al.
Elsevier BV
Manoj Kumar, Maharishi Tomar, Sneh Punia, Jyoti Dhakane-Lad, Sangram Dhumal, Sushil Changan, Marisennayya Senapathy, Mukesh K. Berwal, Vellaikumar Sampathrajan, Ali A.S. Sayed,et al.
Elsevier BV
Nadeem Rais, Kehkashan Parveen, Rizwan Ahmad, Waseem Ahmad Siddiqui, Ayasha Nadeem, and Akash Ved
FapUNIFESP (SciELO)
Anshu Sharma, Ruchi Sharma, Munisha Sharma, Manoj Kumar, Mrunal Deepak Barbhai, José M. Lorenzo, Somesh Sharma, Mahesh Kumar Samota, Maria Atanassova, Gianluca Caruso,et al.
Hindawi Limited
The prevalence of viral infections, cancer, and diabetes is increasing at an alarming rate around the world, and these diseases are now considered to be the most serious risks to human well-being in the modern period. There is a widespread practice in Asian countries of using papaya leaves (C. papaya L.) as herbal medicine, either alone or in combination with prescribed medications, to treat a variety of ailments. The importance of conducting the necessary descriptive studies in order to determine the safety of papaya leaf consumption is also emphasized in the context of their application in the healthcare sector. Electronic databases such as Google Scholar, Scopus, and PubMed were used to gather information on papaya leaves, their therapeutic potential, and clinical evidence-based studies. The literature was gathered from publications on papaya leaves, their therapeutic potential, and clinical evidence-based studies. The antidengue, anticancer, antidiabetic, neuroprotective, and anti-inflammatory effects of papaya leaves discussed in this article are supported by evidence from preclinical, in vivo, in vitro, and clinical trial studies, as well as from other sources. Leaves have been investigated for their mechanism of action as well as their potential to be used in the development of novel herbal products for the health business. According to the reports gathered, only a small number of research demonstrated that leaf extract at high concentrations was hazardous to certain organs. The collective literature reviewed in this review provides insights into the use of papaya leaves as a cure for epidemic diseases, highlighting the phytochemical composition and pharmacological attributes of papaya leaves, as well as the results of various preclinical and clinical studies that have been conducted so far on the subject. The review clearly demonstrates the successful medical evidence for the use of papaya leaf extracts in the healthcare system as a supplemental herbal medication in a variety of clinical settings.
Ashok K. Das, Sanjay Kalra, Shashank Joshi, Ambrish Mithal, Prasanna Kumar K. M., Ambika G. Unnikrishnan, Hemant Thacker, Bipin Sethi, Subhankar Chowdhury, Romik Ghosh,et al.
Wiley
Longitudinal data on management and progression of type 2 diabetes mellitus (T2DM) in India are scarce. LANDMARC (CTRI/2017/05/008452), first‐of‐its‐kind, pan‐India, prospective, observational study aimed to evaluate real‐world patterns and management of T2DM over 3 years.
Pramod Prakash, Radha, Manoj Kumar, Neeraj Kumari, Suraj Prakash, Sonia Rathour, Mamta Thakur, Radhika Jamwal, Salena Janjua, Mansoor Ali,et al.
MDPI AG
The main aim of this study is to document important ethnomedicinal plants from the Maraog region, located in the district of Shimla in Himachal Pradesh, India. A total of 110 medicinal plant species belonging to 102 genera and 57 families were reported from the study site. All of the species were collected from wild habitats. The rural people of the Maraog region were surveyed through interview methods, group discussions, and participatory observations. In the current study, data were collected from 88 informants through the snowball method. A total of 110 plant species were collected from the study area, including 64 herbs, 24 shrubs, 9 trees, 5 climbers, 3 grasses, and 5 ferns. Most of the plant species, reported from the study area, belong to the Rosaceae and Asteraceae families, each contributing 12 plant species, followed by the Lamiaceae family with 6 plant species. The most used part of the plant in the preparation of herbal medications is the leaves, which have been reported in 62 plants, followed by roots in 14 plants, and flowers and other aerial parts in 9 plants. The ethnomedicinal data were analyzed using “Use Value,” a statistical quantitative method, with Artemisia vestita having the highest use value (1.00), followed by Cannabis sativa (0.79), Rhododendron arboreum (0.79), and Datura stramonium (0.71). Older people were found to have a vast knowledge of wild medicinal plants, while the younger generation’s knowledge was lacking. As a result, traditional knowledge about the use of plants as a source of medicine has decreased day-by-day. Therefore, there is a need to document traditional ethnobotanical knowledge. The data could serve as a basis for research by pharmacological and nutraceutical industries for the development of novel drugs.
Ashok K. Das, Ambrish Mithal, Shashank Joshi, K. M. Prasanna Kumar, Sanjay Kalra, A. G. Unnikrishnan, Hemant Thacker, Bipin Sethi, Romik Ghosh, Vaishali Kanade,et al.
Wiley
Longitudinal data on progression, complications, and management of type 2 diabetes mellitus (T2DM) across India are scarce. LANDMARC (CTRI/2017/05/008452), the first pan‐India, longitudinal, prospective, observational study, aims to understand the management and real‐world outcomes of T2DM over 3 years.