Koustav sarkar

@srmist.edu.in

Research Assistant Professor, Department of Biotechnology/ Engineering and Technology
SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603203, India

PROFESSIONAL CAREER:
August, 2002 – Present
Research Assistant Professor (SRM Research Institute, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu – 603203, India) [April 01, 2016 – Present]
Post-Doctoral Research Scholar (University of Iowa Children’s Hospital, Iowa City, IA 52246, USA) [June 30, 2013 – March 25, 2016]
Post-Doctoral Associate (Children’s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA) [Sept 15, 2011 – June29, 2013]
Post-Doctoral Research Fellow (Massachusetts General Hospital, Harvard University, Boston, MA 02114, USA) [Feb 02, 2009 - Sept 14, 2011]
Senior Research Fellow (Indian Council of Medical Research) [Dec 1, 2005 - Jan 30, 2009]
Junior Research Fellow (Department of Science and Technology, Govt. of India) [Mar 01, 2003 - Jul 24, 2005]
Project Fellow (University Grants Commission, India) [Aug 14, 2002 - Feb 28, 2003]
Major Field of research: Immunology
Field of specialization: Cancer Immunology & Immunotherapy and Epigenetics

EDUCATION

PhD from Jadavpur University/Chittaranjan National Cancer Institute, Kolkata, West Bengal, India
M,Sc. from Banaras Hindu University, Varanasi, Uttar Pradesh, India
B.Sc. from University of Calcutta, Kolkata, West Bengal, India

RESEARCH INTERESTS

My research focuses on explicating the molecular underpinnings of immune dysregulation and cancer immunotherapy. The broad components of my research interests are:
1. Immune dysregulation
2. Cancer immunotherapy
94

Scopus Publications

2193

Scholar Citations

26

Scholar h-index

55

Scholar i10-index

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

  • STAT4 mediated modulation of T–B cell interactions profiling: enhances antitumor immunity in non-small cell lung cancer (NSCLC)
    R Bibi, M George, K Sarkar
    Molecular Biology Reports 53 (1), 389 , 2026
    2026
  • Interferon-alpha 2b (IFNα2b) enhances monocyte-derived dendritic cell maturation and Th1-skewed anti-tumor immunity in non-small cell lung cancer
    S Bindu, O Mukherjee, R Bibi, M George, K Sarkar
    Molecular Biology Reports 53 (1), 165 , 2026
    2026
  • Epigenetic and epitranscriptomic modulation by STAT1: unraveling T helper cell differentiation in NSCLC
    R Bibi, M George, K Sarkar
    Journal of Immunotherapy 49 (4), 152-163 , 2026
    2026
    Citations: 1
  • Facilitation of STK19 in transcription coupled nuclear excision repair (TC-NER): Mechanisms, interactions, and genome stability
    S Naskar, N Mahajan, N Sriraman, A Sarkar, K Sarkar
    Human Gene, 201537 , 2026
    2026
  • RNA-guided STAT3 modification fine tunes the epigenetic and epitranscriptomic regulation of CD4+ T helper cell differentiation during non-small cell lung cancer (NSCLC)
    R Bibi, M George, K Sarkar
    Medical Oncology 43 (2), 102 , 2026
    2026
    Citations: 2
  • Therapeutic potential of exosomes in malignancies: from drug delivery to clinical application
    R Bibi, A Koley, K Sarkar
    Pathology-Research and Practice, 156381 , 2026
    2026
    Citations: 1
  • Power quality investigation with multilevel inverter by photovoltaic-fed dynamic voltage restorer
    K Sarker, K Sarkar, J Sarker, P Bhowmik, D Chatterjee, SK Goswami
    International Journal of Modelling and Simulation 46 (1), 196-222 , 2026
    2026
    Citations: 14
  • STAT2 Mediated Epigenetic and Epitranscriptomic Regulation of CD4 + T Helper Cell Differentiation in Non‐Small Cell Lung Cancer (NSCLC)
    R Bibi, M George, K Sarkar
    Immunology , 2026
    2026
  • Brahmi (Bacopa monnieri) plant preparation facilitates to enhance the activities of dendritic cells to control non-small cell lung cancer (NSCLC)
    RI Kumar, K Jain, P Arora, H Gururajan, KR Rai, O Mukherjee, M George, ...
    Journal of Cancer Research and Clinical Oncology 152 (1), 18 , 2026
    2026
  • Involvement of CCCTC-binding factor (CTCF) in immunomodulation and epigenetic regulation of T helper cell differentiation during Non-Small Cell Lung Cancer (NSCLC)
    O Mukherjee, S Bose, S Rakshit, G Shanmugam, A Baranwal, S Saha, ...
    Clinical Immunology, 110662 , 2025
    2025
  • Targeting epigenetic modifications as an emerging immunotherapeutic strategy for cancers
    RI Kumar, K Jain, KR Rai, H Gururajan, K Sarkar
    Immunologic Research 73 (1), 121 , 2025
    2025
    Citations: 6
  • Beyond DNA binding: CTCF at the crossroads of chromatin architecture and epitranscriptomic regulation
    O Mukherjee, K Sarkar
    Epigenomics, 1-14 , 2025
    2025
  • Power Quality Enhancement in Smart Grids Using DFIG-PV-IG Integrated UPQC with Unequal Step Multilevel Inverter for Sensitive Electric Vehicle and Medical Loads
    K Sarker, J Sarker, K Sarkar, D Chatterjee, P Bhowmik
    Arabian Journal for Science and Engineering, 1-32 , 2025
    2025
  • Epidrugs in cancer: mechanisms, applications, and future direction
    R Bibi, L Varshetha, RK Lahary, J Namburi, FA Laskar, K Sarkar
    Clinical and Translational Oncology, 1-16 , 2025
    2025
    Citations: 6
  • Corrigendum to “Participation of Brahmi (Bacopa monnieri L.) plant in regulation of cancer”[South African Journal of Botany Volume 168 (Year 2024) Pages 236–245].
    S Roy, S Rakshit, G Shanmugam, K Sarkar
    South African Journal of Botany , 2025
    2025
  • Mechanistic understanding of Wiskott–Aldrich syndrome protein (WASp)-mediated epigenetic regulation of T helper cell differentiation in acute leukemia
    R Pradeep, S Rakshit, G Shanmugam, A Choudhary, R Ramesh, ...
    3 Biotech 15 (9), 302 , 2025
    2025
  • Effect of N-quaternization on crystal and electronic structures of E-pyridylvinyl benzothiazoles–Photophysical and electrochemical properties, and cytotoxicity studies
    S Baskar, R Yadav, G Shanmugam, K Sarkar, A Samanta, GK Kole
    Journal of Photochemistry and Photobiology A: Chemistry 466, 116392 , 2025
    2025
    Citations: 4
  • A single-phase grid-tied transformer-less multilevel solar inverter with voltage boost
    S Chakraborty, K Sarkar, D Maiti, A Chakrabarti, S Dasgupta, SK Biswas
    IEEE Transactions on Industrial Electronics , 2025
    2025
    Citations: 5
  • Interferon alpha-2b (IFNα2b) in precision oncology: Innovations in delivery and combinatorial immunotherapy
    S Bindu, A Ash, K Sarkar
    Pathology-Research and Practice, 156113 , 2025
    2025
    Citations: 3
  • Epigenetic control of T helper cells differentiation: a mechanistic insight into the association between acute leukemia and coronary artery disease
    S Roy, G Shanmugam, R Pradeep, M George, K Sarkar
    Medical Oncology 42 (7), 272 , 2025
    2025
    Citations: 1

MOST CITED SCHOLAR PUBLICATIONS

  • HDAC inhibitors: Targets for tumor therapy, immune modulation and lung diseases
    G Shanmugam, S Rakshit, K Sarkar
    Translational Oncology 16, 101312 , 2022
    2022
    Citations: 195
  • Nuclear role of WASp in the pathogenesis of dysregulated TH1 immunity in human Wiskott-Aldrich syndrome
    MD Taylor, S Sadhukhan, P Kottangada, A Ramgopal, K Sarkar, S D’Silva, ...
    Science translational medicine 2 (37), 37ra44-37ra44 , 2010
    2010
    Citations: 149
  • Nuclear role of WASp in gene transcription is uncoupled from its ARP2/3-dependent cytoplasmic role in actin polymerization
    S Sadhukhan, K Sarkar, M Taylor, F Candotti, YM Vyas
    The Journal of Immunology 193 (1), 150-160 , 2014
    2014
    Citations: 78
  • Neuropeptide Y in the forebrain of the adult male cichlid fish Oreochromis mossambicus: distribution, effects of castration and testosterone replacement.
    SNK Sakharkar AJ, Singru PS, Sarkar K
    J Comp Neurol. 489 (2), 148-165 , 2005
    2005
    Citations: 78
  • Neem leaf glycoprotein restores the impaired chemotactic activity of peripheral blood mononuclear cells from head and neck squamous cell carcinoma patients by maintaining CXCR3 …
    K Chakraborty, A Bose, S Pal, K Sarkar, S Goswami, D Ghosh, S Laskar, ...
    International immunopharmacology 8 (2), 330-340 , 2008
    2008
    Citations: 77
  • DNA methylation and cancer: transcriptional regulation, prognostic, and therapeutic perspective
    S Bhootra, N Jill, G Shanmugam, S Rakshit, K Sarkar
    Medical oncology 40 (2), 71 , 2023
    2023
    Citations: 72
  • R-loops cause genomic instability in T helper lymphocytes from patients with Wiskott-Aldrich syndrome
    K Sarkar, SS Han, KK Wen, HD Ochs, L Dupré, MM Seidman, YM Vyas
    Journal of Allergy and Clinical Immunology 142 (1), 219-234 , 2018
    2018
    Citations: 66
  • Neem leaf glycoprotein matures myeloid derived dendritic cells and optimizes anti-tumor T cell functions
    S Goswami, A Bose, K Sarkar, S Roy, T Chakraborty, U Sanyal, R Baral
    Vaccine 28 (5), 1241-1252 , 2010
    2010
    Citations: 61
  • Neem leaf glycoprotein induces perforin-mediated tumor cell killing by T and NK cells through differential regulation of IFNγ signaling
    A Bose, K Chakraborty, K Sarkar, S Goswami, T Chakraborty, S Pal, ...
    Journal of Immunotherapy 32 (1), 42-53 , 2009
    2009
    Citations: 57
  • Neem leaf glycoprotein activates CD8+ T cells to promote therapeutic anti-tumor immunity inhibiting the growth of mouse sarcoma
    A Mallick, S Barik, KK Goswami, S Banerjee, S Ghosh, K Sarkar, A Bose, ...
    PLoS One 8 (1), e47434 , 2013
    2013
    Citations: 49
  • Neem leaf glycoprotein directs T-bet–associated type 1 immune commitment
    A Bose, K Chakraborty, K Sarkar, S Goswami, E Haque, T Chakraborty, ...
    Human immunology 70 (1), 6-15 , 2009
    2009
    Citations: 48
  • Neem leaf glycoprotein helps to generate carcinoembryonic antigen specific anti-tumor immune responses utilizing macrophage-mediated antigen presentation
    K Sarkar, A Bose, K Chakraborty, E Haque, D Ghosh, S Goswami, ...
    Vaccine 26 (34), 4352-4362 , 2008
    2008
    Citations: 47
  • Role of chemotherapeutic drugs in immunomodulation of cancer
    O Mukherjee, S Rakshit, G Shanmugam, K Sarkar
    Current research in immunology 4, 100068 , 2023
    2023
    Citations: 45
  • Tumor-associated mesenchymal stem cells inhibit naïve T cell expansion by blocking cysteine export from dendritic cells.
    BA Ghosh T, Barik S, Bhuniya A, Dhar J, Ghosh S, Sarkar M, Guha I, Sarkar K ...
    International Journal of Cancer 139 (9), 2068-2081 , 2016
    2016
    Citations: 45
  • Disruption of hSWI/SNF complexes in T cells by WAS mutations distinguishes X-linked thrombocytopenia from Wiskott-Aldrich syndrome
    K Sarkar, S Sadhukhan, SS Han, YM Vyas
    Blood, The Journal of the American Society of Hematology 124 (23), 3409-3419 , 2014
    2014
    Citations: 43
  • Neem leaf glycoprotein enhances carcinoembryonic antigen presentation of dendritic cells to T and B cells for induction of anti-tumor immunity by allowing generation of immune …
    K Sarkar, S Goswami, S Roy, A Mallick, K Chakraborty, A Bose, R Baral
    International immunopharmacology 10 (8), 865-874 , 2010
    2010
    Citations: 42
  • Antibody response against neem leaf preparation recognizes carcinoembryonic antigen
    K Sarkar, A Bose, S Laskar, SK Choudhuri, S Dey, PK Roychowdhury, ...
    International immunopharmacology 7 (3), 306-312 , 2007
    2007
    Citations: 42
  • Restoration of dysregulated CC chemokine signaling for monocyte/macrophage chemotaxis in head and neck squamous cell carcinoma patients by neem leaf glycoprotein maximizes …
    K Chakraborty, A Bose, T Chakraborty, K Sarkar, S Goswami, S Pal, ...
    Cellular & molecular immunology 7 (5), 396-408 , 2010
    2010
    Citations: 38
  • SUMOylation-disrupting WAS mutation converts WASp from a transcriptional activator to a repressor of NF-κB response genes in T cells
    K Sarkar, S Sanjoy, HS Su, V Yatin M
    Blood , 2015
    2015
    Citations: 37
  • Neem leaf glycoprotein is nontoxic to physiological functions of Swiss mice and Sprague Dawley rats: histological, biochemical and immunological perspectives
    A Mallick, S Ghosh, S Banerjee, S Majumder, A Das, B Mondal, S Barik, ...
    International immunopharmacology 15 (1), 73-83 , 2013
    2013
    Citations: 36

GRANT DETAILS

Independent Research Grant(s):
1. As Principal Investigator (PI):
Title of the project: “Wiskott Aldrich Syndrome protein (WASp) mediated epigenetic regulation of T helper (Th) cell differentiation linked to malignancies through R-loop modulation”.
Funding Agency: SERB, DST, Govt. of India
Date of Start: March 03, 2017; Duration: 36 months; Sanctioned amount: Rs. 44,45,210/-
2. As Co-PI:
Title of the project: “Therapeutic potential of Nrf2 activators on endoplasmic reticulum stress-induced endothelial dysfunction in diabetes”.
Funding Agency: SERB, DST Govt. of India
Date of Start: October 09, 2017, Duration: 36 months; Sanctioned amount: Rs. 50,54,200/-

Grant(s) received for conducting international Conference:
As convener:
Title of the conference: “International Conference on Immunology (Theme: Major breakthroughs and advances in immunology for human diseases)”
i. Funding Agency: SERB, DST, Govt. of India
Duration: 3 days (September 26-28, 2018). Sanctioned amount: Rs. 2,00,000/-
ii. Funding Agency: Department of Biotechnology (DBT), Govt. of India
Duration: 3 days (September 26-28, 2018). Sanctioned amount: Rs. 1,00,000/-

RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)

Patent:
Process for isolating glycoprotein from neem leaf and its characterization to define the immunomodulatory and cancer preventive functions of this glycoprotein. Patent Number: 259434; Indian Patent Application Number: 429/KOL/2007; Publication Date: 14-Mar-2014; Grant Date: 12-Mar-2014.