MSc in Advanced Clinical Anaesthesia (2012) and BSc in Anaesthesia (2008), University of Gondar, Ethiopia
RESEARCH INTERESTS
Mechanisms and management of perioperative pain, chemotherapy-induced neuropathic pain management, nerve block, perioperative anaesthetic patient care, resuscitation, perioperative patient care, perioperative patient safety and outcome, critical care, cancer, global health, global surgery
Incidence and factors associated with failed spinal anaesthesia among patients undergoing surgery: a multi- center prospective observational study Atalay Eshetie Demilie, Zewditu Abdissa Denu, Yosef Belay Bizuneh, Endale Gebreegziabher Gebremedhn BMC Anesthesiology, 2024 Background Failed spinal anaesthesia causes prolonging of operation time, insufficient analgesia for surgery and needs repeating spinal anaesthesia which in turn causes local anaesthesia toxicity, high spinal and total spinal, and conversion to general anaesthesia. However, the problem remains unexplored in Amhara regional state comprehensive specialized hospitals. Objective To determine incidence and factors associated with failed spinal anaesthesia among patients undergoing surgery in selected Amhara National Regional State comprehensive specialized hospitals, Northwest Ethiopia, 2023. Methods Multi-center prospective observational study was conducted. Data was collected using questionnaire and checklist. All consecutive scheduled emergency and elective patients were included in the study. Data was transformed from Epi data to SPSS and logistic regression analysis was done. Both crude and adjusted odds ratio were used to assess the strength of association. Variables with a p-value of less than 0.05 were considered as statistically significant. Results A total of 532 patients were included in this study with a response rate of 98%. Incidence of failed spinal anaesthesia was 22.4% (CI = 19-25.9). Emergency surgery (AOR = 7.01, CI = 4.5–12.7), dose of bupivacaine of ≤ 10 mg (AOR = 3.02, CI = 1.3–10.2), work experience of anaesthetist < 2 years (AOR = 3.1, CI = 1.7–5.72), bloody CSF (AOR = 8.5, CI = 2.53–18.5), hyperbaric local anaesthetic drug (AOR = 3.3, 95% CI = 3.2–8.2) and local anaesthetist without adjuvants (AOR = 5.25, CI = 2.62–14.2) were associated failed spinal anaesthesia. Conclusion and recommendation The incidence of failed spinal anaesthesia was high in Amhara Region comprehensive specialized hospitals. We suggest that anaesthesia providers should minimize failure by using adjuvants and appropriate dose of local anaesthetic. Additionally, simulation training should be given for anaesthesia trainees to improve their skills and to produce competent professionals.
Health-care providers’ knowledge, attitudes, and practices regarding adult cardiopulmonary resuscitation at Debre Markos Referral Hospital, Gojjam, Northwest Ethiopia Temesgen Agegnehu Abebe, Liknaw Bewket Zeleke, Mulunesh Alemayehu Assega, Worku Mekonnen Sefefe, Endale Gebreegziabher Gebremedhn Advances in Medical Education and Practice, 2021 Background Cardiac arrest is one of the leading causes of death worldwide. Good knowledge, attitudes, and practices of health-care providers regarding cardiopulmonary resuscitation are vital to improve patient outcomes after cardiac arrest. This study aimed to assess knowledge, attitudes, and practices with regard to management of adult patients with cardiac arrest among health-care providers at Debre Markos Referral Hospital, Debre Markos, northwest Ethiopia in 2019. Methods A hospital-based cross-sectional study was conducted from January to February, 2019 at Debre Markos Referral Hospital. All health-care providers who fulfilled the inclusion criteria were enrolled in the study. A pretested structured questionnaire was used for data collection. Data were entered into EpiData 3.1 and transferred to SPSS 20 for analysis. Results Of the 352 health-care providers, 324 participated in the study for a response rate of 92%. Amajority (63%) were male. The age of male (80%) was 26–35 years old, with a mean of 29.28±4.8 years. A majority (77.8%) had inadequate knowledge about cardiopulmonary resuscitation. Almost all (97.8%) had no knowledge about cardiocerebral resuscitation. More than half (64.2%) had unfavorable attitudes toward CPR. Moreover, 288 (88.9%) had unsafe practices regarding cardiopulmonary resuscitation. The site and depth of chest compression was answered correctly by only 33 (10.2%) and 59 (18.2%) of participants, respectively. Conclusion Health-care providers’ knowledge, attitudes, and practices were inadequate, unfavorable, and unsafe regarding the management of cardiac arrest. Training on the assessment of critically ill patients, cardiopulmonary resuscitation, and cardiocerebral resuscitation should be provided for health-care providers. Additionally, resuscitation equipment like defibrillators and emergency drugs should be available in all wards and emergency rooms.
Variability of Oxaliplatin-Induced Neuropathic Pain Symptoms in Each Cycle and Its Implications on the Management of Colorectal Cancer Patients: A Retrospective Study in South Western Sydney Local Health District Hospitals, Sydney, Australia Endale G. Gebremedhn, Peter J. Shortland, David A. Mahns Journal of Oncology, 2019 Oxaliplatin-induced neuropathic pain limits treatment compliance. However, the variability of neuropathic pain symptoms in each cycle for individual patients and the impacts on treatment compliance remain untested. Data from 322 adult patients who received oxaliplatin-based chemotherapy were extracted based on pattern of chemotherapy, adverse events, and patient survival. Cox regression and survival analyses were employed. Seventy-eight percent of patients developed neuropathic pain that oscillated between a complete absence and presence on a cycle-by-cycle basis. Consequently, the presence of neuropathy in one cycle did not predict the incidence of neuropathy in subsequent cycles. This implies that neuropathic pain need not be a sufficient criterion to reduce, delay, or cease chemotherapy. In the case of multiple system adverse events during combined drug treatment, the responsible cause for dose reduction was not identified. Cox regression analysis revealed that middle age (61–78 years old,P=0.003) and oxaliplatin cumulative dose <850 mg/m2(P=0.002) were associated with patient mortality. Completion of chemotherapy (8 cycles) and cumulative dose >850 mg/m2of oxaliplatin prolonged the median survival time by 8 and 5 months, respectively. As oxaliplatin-induced neuropathic pain fluctuates across cycles in a manner that varies from patient-to-patient, current assumptions on the predictive nature of the emergence of neuropathy (and its impact on treatment compliance) need to be reconsidered. Detailed patient-by-patient analysis of adverse events should be applied to future studies in order to determine the efficacy of current treatments (and future interventions) and whether neuropathic pain should be retained as a criterion to vary the treatment. Additionally, when two or more system toxicities occurred in cases of combined drug treatment, the causes for drug reduction should be separately recorded.
Efficacy of intravenous tramadol and low-dose ketamine in the prevention of post-spinal anesthesia shivering following cesarean section: A double-blinded, randomized control trial Girmay Fitiwi Lema, Endale Gebreegziabher Gebremedhn, Amare Hailekiros Gebregzi, Yilkal Tadesse Desta, Adugna Aregawi Kassa International Journal of Women S Health, 2017 Background Shivering is a frequent and undesirable complication of spinal anesthesia. It is a physiologic response to increase the body core temperature in an attempt to raise metabolic heat production. However, shivering may trigger myocardial ischemia; increase intraocular and intracranial pressures, increase wound pain, delay wound healing and interfere with pulse rate, blood pressure and electrocardiogram monitoring. We aimed to compare the efficacy of intravenous (IV) ketamine with IV tramadol for the prevention of shivering in patients who underwent cesarean delivery under spinal anesthesia. Patients and methods A prospective, randomized, double-blind study was conducted. One hundred and twenty-three American Society of Anesthesiologist I and II patients, aged between 18 and 39 years, who underwent cesarean section were included in the study. Patients were randomly allocated to one of three groups: group S (n=41; control group) received saline, group K (n=41) received ketamine 0.2 mg/kg and group T (n=41) received tramadol 0.5 mg/kg. Incidence and grade of shivering and side effects between the treatment groups were recorded. Results The incidence of shivering was significantly reduced in the ketamine and tramadol groups (41.5% and 53.7%, respectively) compared to the saline group (70.7%; p=0.028). Grade 3 shivering occurred in 16 (39%) patients in the saline group, compared to 9 (22%) in the tramadol group and 8 (19.5%) in the ketamine group (p=0.011). Only two cases in the saline group developed grade 4 shivering (p<0.01). Neonatal outcome and perioperative complications were comparable among the three groups. Conclusion The prophylactic administration of low-dose IV ketamine or IV tramadol is effective for reducing the incidence and intensity of shivering. We recommend low-dose IV ketamine or tramadol prophylaxis for parturients undergoing cesarean section under spinal anesthesia.
Efficacy of single-injection unilateral thoracic paravertebral block for post open cholecystectomy pain relief: A prospective randomized study at gondar university hospital Demeke Yilkal Fentie, Endale Gebreegziabher Gebremedhn, Zewditu Abdissa Denu, Amare Gebreegzi Local and Regional Anesthesia, 2017 Background Cholecystectomy can be associated with considerable postoperative pain. While the benefits of paravertebral block (PVB) on pain after thoracotomy and mastectomy have been demonstrated, not enough investigations on the effects of PVB on pain after open cholecystectomy have been conducted. We tested the hypothesis that a single-injection thoracic PVB reduces pain scores, decreases opioid consumption, and prolongs analgesic request time after cholecystectomy. Methods Of 52 patients recruited, 50 completed the study. They were randomly allocated into two groups: the paravertebral group and the control group. The outcome measures were the severity of pain measured on numeric pain rating scale, total opioid consumption, and first analgesic request time during the first postoperative 24 hours. Result The main outcomes recorded during 24 hours after surgery were Numerical Rating Scale (NRS) pain scores (NRS, 0–10), cumulative opioid consumption, and the first analgesic request time. Twenty four hours after surgery, NRS at rest was 4 (3–6) vs 5 (5–7) and at movement 4 (4–7) vs 6 (5–7.5) for the PVB and control groups, respectively. The difference between the groups over the whole observation period was statistically significant (P<0.05). Twenty-four hours after surgery, median (25th–75th percentile) cumulative morphine consumption was 0 (0–2) vs 2.5 (2–4) mg (P<0.0001) and cumulative tramadol consumption was 200 (150–250) mg vs 300 (200–350) mg in the paravertebral and in the control group, respectively (P=0.003). After surgery, the median (25th–75th percentile) first analgesic requirement time was prolonged in the PVB group in statistically significant fashion (P<0.0001). Conclusion and recommendations Single-shot thoracic PVB as a component of multi-modal analgesic regimen provided superior analgesia when compared with the control group up to 24 postoperative hours after cholecystectomy, and we recommend this block for post cholecystectomy pain relief.
Assessment of sleep quality and associated factors in adult patients admitted in intensive care unit at Bahir Dar city comprehensive specialized hospitals, Northwest Ethiopia … AE Demilie, HT Bayu, ET Dejen, EG Gebremedhn Sleep Science and Practice 10 (1), 9 , 2026 2026
Prevalence and factors associated with acute pain among emergency trauma patients EA Worku, HA Aytolign, ZA Mekonnen, EG Gebremedhn World Journal of Emergency Medicine 17 (1), 36 , 2026 2026
Prevalence and factors associated with chemotherapy-induced adverse events in cancer treatment centers in Amhara national regional state comprehensive referral hospitals, 2024 … AE Demilie, HT Bayu, MM Taye, FT Diress, EG Gebremedhn BMC cancer , 2025 2025 Citations: 1
Prevalence and severity of preoperative anemia, and associated factors among orthopedic patients at public comprehensive referral hospitals, Northwest Ethiopia 2024: multi … AE Demile, HT Bayu, EG Gebremedhn Perioperative Medicine 14 (1), 125 , 2025 2025
A prospective audit on the current practice of patient care in adult surgical intensive care unit AE Demilie, ZA Denu, YB Bizuneh, EG Gebremedhn IJS Global Health 8 (5), e00589 , 2025 2025
Audit on the assessment of the practice of storage, labeling, and usage of anesthetic medications in the operation theaters at a comprehensive specialized hospital, 2024 … EA Worku, HA Aytolign, ZA Mekonnen, EG Gebremedhn IJS Global Health 8 (4), e00573 , 2025 2025
Priorities for African Postoperative Pain Research: An International Delphi Study G Tegu, T Melkie, A Shiferaw, T Mwiti, N Gaston, R Francois, A Mikailu, ... ANESTHESIA AND ANALGESIA 140 (5), 438-442 , 2025 2025
Audit on physicians’ adherence with the WHO analgesic ladder to treat postoperative pain BE Asrat, MM Temesgen, HY Tawuye, EG Gebremedhn IJS Global Health 8 (1), e00539 , 2025 2025 Citations: 1
Incidence and factors associated with failed spinal anaesthesia among patients undergoing surgery: a multi-center prospective observational study AE Demilie, ZA Denu, YB Bizuneh, EG Gebremedhn BMC anesthesiology 24 (1), 129 , 2024 2024 Citations: 20
Setting priorities for African postoperative pain research through an international Delphi process G Asfaw, TB Melkie, AA Shiferaw, TM Mwiti, G Nyirigira, F Retief, ... Anesthesia & Analgesia, 10.1213 , 2022 2022 Citations: 4
Pre-emptive analgesia for the prevention of chronic postsurgical pain: a systematic review and meta-analysis with trial sequential analysis EG Gebremedhn, WM Sefefe J Anesth Clin Res 13 (11), 1-11 , 2022 2022 Citations: 3
Health-care providers’ knowledge, attitudes, and practices regarding adult cardiopulmonary resuscitation at Debre Markos Referral Hospital, Gojjam, Northwest Ethiopia TA Abebe, LB Zeleke, MA Assega, WM Sefefe, EG Gebremedhn Advances in Medical Education and Practice, 647-654 , 2021 2021 Citations: 41
Exploring the Incidence and Variability of Oxaliplatin-induced Neuropathic Pain Symptoms in Colorectal Cancer Patients, Comparative in vivo/in vitro Modelling of Oxaliplatin … EG Gebremedhn Sydney University , 2021 2021
Research Article Variability of Oxaliplatin-Induced Neuropathic Pain Symptoms in Each Cycle and Its Implications on the Management of Colorectal Cancer Patients: A … EG Gebremedhn, PJ Shortland, DA Mahns 2019
Variability of oxaliplatin‐induced neuropathic pain symptoms in each cycle and its implications on the management of colorectal cancer patients: A retrospective study in South … EG Gebremedhn, PJ Shortland, DA Mahns Journal of oncology 2019 (1), 4828563 , 2019 2019 Citations: 11
Outcome assessment of emergency laparotomies and associated factors in low resource setting. A case series EG Gebremedhn, AF Agegnehu, BB Anderson Annals of medicine and surgery 36, 178-184 , 2018 2018 Citations: 22
The incidence of acute oxaliplatin-induced neuropathy and its impact on treatment in the first cycle: a systematic review EG Gebremedhn, PJ Shortland, DA Mahns BMC cancer 18 (1), 410 , 2018 2018 Citations: 135
Effectiveness of intravenous metoclopramide prophylaxis on the reduction of intraoperative and early postoperative nausea and vomiting after emergency caesarean section under … ENS Endalew, E Gebremedhn, A Gebreegzi, H Kassahun, A Kassa J Anesth Clin Res 9 (809), 2 , 2018 2018 Citations: 10
Magnitude of Airway Problems at a University Teaching and Referral Hospital Recovery Room of Low Resource Setting-A Cross Sectional Study EG Gebremedhn, HY Tawuye J Anesth Clin Res 9 (825), 2 , 2018 2018
Efficacy of intravenous tramadol and low-dose ketamine in the prevention of post-spinal anesthesia shivering following cesarean section: a double-blinded, randomized control trial GF Lema, EG Gebremedhn, AH Gebregzi, YT Desta, AA Kassa International journal of women's health, 681-688 , 2017 2017 Citations: 80
MOST CITED SCHOLAR PUBLICATIONS
The incidence of acute oxaliplatin-induced neuropathy and its impact on treatment in the first cycle: a systematic review EG Gebremedhn, PJ Shortland, DA Mahns BMC cancer 18 (1), 410 , 2018 2018 Citations: 135
Audit on preoperative fasting of elective surgical patients in an African academic medical center EG Gebremedhn, VB Nagaratnam World journal of surgery 38 (9), 2200-2204 , 2014 2014 Citations: 91
Efficacy of intravenous tramadol and low-dose ketamine in the prevention of post-spinal anesthesia shivering following cesarean section: a double-blinded, randomized control trial GF Lema, EG Gebremedhn, AH Gebregzi, YT Desta, AA Kassa International journal of women's health, 681-688 , 2017 2017 Citations: 80
Risk factors for postoperative throat pain after general anaesthesia with endotracheal intubation at the University of Gondar Teaching Hospital, Northwest Ethiopia, 2014 BM Gemechu, EG Gebremedhn, TB Melkie The Pan African Medical Journal 27, 127 , 2017 2017 Citations: 77
Patient satisfaction with anaesthesia services and associated factors at the University of Gondar Hospital, 2013: a cross-sectional study EG Gebremedhn, WB Chekol, WD Amberbir, TD Flatie BMC research notes 8 (1), 377 , 2015 2015 Citations: 74
Patient satisfaction with the perioperative surgical services and associated factors at a University Referral and Teaching Hospital, 2014: a cross-sectional study EG Gebremedhn, GF Lemma Pan African Medical Journal 27 (1) , 2017 2017 Citations: 70
Knowledge and skills of neonatal resuscitation of health professionals at a university teaching hospital of Northwest Ethiopia E Gebreegziabher, A Aregawi, H Getinet World journal of emergency medicine 5 (3), 196 , 2014 2014 Citations: 62
Assessment of patient satisfaction with the preoperative anesthetic evaluation EG Gebremedhn, V Nagaratnam Patient related outcome measures, 105-110 , 2014 2014 Citations: 50
The incidence of oxygen desaturation during rapid sequence induction and intubation EG Gebremedhn, D Mesele, D Aemero, E Alemu World journal of emergency medicine 5 (4), 279 , 2014 2014 Citations: 45
Attitude and skill levels of graduate health professionals in performing cardiopulmonary resuscitation E Gebreegziabher Gebremedhn, G Berhe Gebregergs, BB Anderson, ... Advances in medical education and practice, 43-50 , 2017 2017 Citations: 42
Health-care providers’ knowledge, attitudes, and practices regarding adult cardiopulmonary resuscitation at Debre Markos Referral Hospital, Gojjam, Northwest Ethiopia TA Abebe, LB Zeleke, MA Assega, WM Sefefe, EG Gebremedhn Advances in Medical Education and Practice, 647-654 , 2021 2021 Citations: 41
Efficacy of fascia iliaca compartment nerve block as part of multimodal analgesia after surgery for femoral bone fracture FT Kumie, EG Gebremedhn, HY Tawuye World journal of emergency medicine 6 (2), 142 , 2015 2015 Citations: 40
The knowledge level of final year undergraduate health science students and medical interns about cardiopulmonary resuscitation at a university teaching hospital of Northwest … EG Gebremedhn, GB Gebregergs, BB Anderson World journal of emergency medicine 5 (1), 29 , 2014 2014 Citations: 30
Outcome assessment of emergency laparotomies and associated factors in low resource setting. A case series EG Gebremedhn, AF Agegnehu, BB Anderson Annals of medicine and surgery 36, 178-184 , 2018 2018 Citations: 22
Incidence and factors associated with failed spinal anaesthesia among patients undergoing surgery: a multi-center prospective observational study AE Demilie, ZA Denu, YB Bizuneh, EG Gebremedhn BMC anesthesiology 24 (1), 129 , 2024 2024 Citations: 20
Analgesic effect of intrathecal fentanyl as an adjuvant to spinal anaesthesia in comparison with spinal anaesthesia with bupivacaine only for mothers delivered by emergency … KA Yesuf, EG Gebremedhn, TB Melkie J Anesth Crit Care Open Access 7 (5), 00278 , 2017 2017 Citations: 16
Analgesic efficacy of bilateral ilioinguinal and iliohypogastric nerve block for post caesarean delivery under spinal anaesthesia, 2016. Double blind randomized study YA Nigatu, EG Gebremedhn, HY Tawuye, AH Gebreegzi J Anesth Clin Res 8 (751), 2 , 2017 2017 Citations: 14
Efficacy of single-injection unilateral thoracic paravertebral block for post open cholecystectomy pain relief: a prospective randomized study at Gondar University Hospital DY Fentie, EG Gebremedhn, ZA Denu, AH Gebreegzi Local and Regional Anesthesia, 67-74 , 2017 2017 Citations: 13
Audit on anesthetic record completeness at a university teaching hospital operation theater of low-resource setting, 2013 EG Gebremedhn, V Nagaratnam J Anesth Crit Care (Open Access) 8 (2), 00298 , 2013 2013 Citations: 13
Variability of oxaliplatin‐induced neuropathic pain symptoms in each cycle and its implications on the management of colorectal cancer patients: A retrospective study in South … EG Gebremedhn, PJ Shortland, DA Mahns Journal of oncology 2019 (1), 4828563 , 2019 2019 Citations: 11
GRANT DETAILS
1. Research Grant (funded by the University of Gondar, Gondar, Ethiopia): Project on postoperative patient outcome after emergency laparotomy and associated factors at the University of Gondar teaching and referral hospital, Northwest Ethiopia, 2014/2016. $10,000 (ETB).
2. Research Grant (funded by the University of Gondar, Gondar, Ethiopia): Project on Knowledge and skills of neonatal resuscitation of health professionals at the University of Gondar teaching and referral hospital, Northwest Ethiopia, 2013. $5,000(ETB).