Magendira Mani Vinayagam
@apcas.ac.in
ASSIATANAT PROFESSOR OF BIOCHEMISTRY
Adhiparasakthi College of Arts and Science
Scopus Publications
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Scopus Publications
Vinayagam Magendira Mani and Abdul Majeeth Mohamed Sadiq
Elsevier BV
Vinayagam Magendira Mani, Adikesavan Gokulakrishnan, and Abdul Majeet Mohammed Sadiq
Elsevier BV
Arunkumar Jagadeesan, Magendira Mani Vinayagam, and Prakash Dharmalingam
Elsevier BV
Mani Ramadhas, Krishnan Palanisamy, Munisamy Sudhagar, and Vinayagam Magendira Mani
Elsevier BV
Vinayagam Magendira Mani, Sivaji Asha, and Abdul Majeeth Mohamed Sadiq
Elsevier BV
Gokulakrishnan Adikesavan, Magendira Mani Vinayagam, Liyakath Ali Abdulrahman, and Thirunavukkarasu Chinnasamy
Springer Science and Business Media LLC
Vinayagam Magendiramani, Syed Umesalma, Srinivasan Kalayarasan, Ponnuraj Nagendraprabhu, Jagadeesan Arunkumar, and Ganapasam Sudhandiran
Wiley
Cyclosporine A (CsA) is the first choice immunosuppressant used for the prevention of allograft rejection in solid organ transplantation and immune‐mediated diseases. Reactive oxygen species‐induced oxidative stress and lipid peroxidation are implicated in the pathophysiology of CsA‐induced renal injury. In this work, we have studied the effect of a garlic‐derived compound, S‐allylcysteine (SAC) on CsA‐induced nephrotoxicity. CsA‐induced nephrotoxicity was assessed in terms of increased activities of serum marker enzymes and levels of kidney markers. CsA administration induced significant elevation in lipid peroxidation along with abnormal levels of enzymic and non‐enzymic antioxidants in the kidneys of the rats. SAC administration improved renal function by bringing about a significant decrease in peroxidative levels and increase in antioxidant status. Elevated expressions of inducible nitric oxide synthase (iNOS) and nuclear factor kappa B (NF‐κB) due to CsA administration were reduced by SAC treatment. An increase in the expression of matrix metalloproteinase‐2 (MMP‐2) was evident in CsA‐induced groups of rats, which was moderately reduced in SAC treated rats. An increase in the levels of serum constituent's urea, uric acid and creatinine was observed in the CsA‐induced rats, which was reduced upon treatment with SAC. These results indicate that SAC has a protective action against CsA‐induced nephrotoxicity which is also supported by histopathological studies. A comparative study of the antioxidant vitamin C and SAC is more valuable to assess the efficacy of the drug that can be used for the treatment of nephrotoxicity. Copyright © 2009 John Wiley & Sons, Ltd.