CARMEN ALONSO-MARTIN

@calonsoma@saludcastillayleon.es

HOSPITAL UNIVERSITARIO RIO HORTEGA



           

https://researchid.co/calonsoma
17

Scopus Publications

Scopus Publications

  • Esophageal necrosis secondary to thoracic aortic aneurysm
    Laura Juan Casamayor, Cristina Martínez Cuevas, Esteban Fuentes-Valenzuela, and Carmen Alonso-Martín
    Sociedad Espanola de Patologia Digestiva (SEPD)
    We present the case of a 78-year-old man with dyslipidemia with ongoing treatment with statins. He was admitted for a history of 3-month dysphagia and weight loss. The physical exam was unremarkable. Blood tests revealed anemia (hemoglobin 11,5 g/dL). Gastroscopy showed a partially stenotic bulging ulcer in the middle esophagus, with a fibrinous base and residual clot Histopathology ruled out any malignancy and confirmed the presence of transmural necrosis with infiltration of inflammatory cells. Computed tomography (CT) revealed a 11x11x12 cm thoracic aortic aneurysm, with an intramural 4 cm thrombus in the anterolateral wall. The patient was referred for urgent Vascular Surgery, but unfortunately, he presented massive hematemesis with cardiorespiratory arrest, and despite cardiopulmonary resuscitation, he died.

  • The impact of obesity on postoperative complications and short-term survival after liver transplantation
    Javier Tejedor-Tejada, Felix Garcia-Pajares, Rifaat Safadi, Violeta Mauriz-Barreiro, Esther Molina, Laura Juan-Casamayor, Samuel Fernández-Prada, Abdelaleem Helal, Esteban Fuentes-Valenzuela, Carmen Alonso-Martin,et al.
    Ovid Technologies (Wolters Kluwer Health)
    BACKGROUND AND AIMS Obesity is considered a risk factor for perioperative complications, but its effect on patients undergoing liver transplantation (LT) remains unclear. This study was conducted to analyze the impact of obesity on early morbidity and mortality risk following LT. METHODS A multicenter study of outcomes in patients submitted to LT between 2009 and 2019 was conducted. Recipients were stratified into obese (BMI ≥ 30 kg/m2) and nonobese patients (BMI < 30 kg/m2). Early postoperative complications were compared and 30-day and 1-year patient and graft survival were assessed by Kaplan-Meier method. Primary graft nonfunction (PGNF) was defined as the presence of total bilirubin > 10 mg/dl, INR > 1.6 or ALT > 2000 U/l within the first week after LT. RESULTS A total of 1608 patients were included after applying exclusion criteria, nonobese (1149, 71.46%) and obese patients (459, 28.54%). There were no significant differences in age, sex, Model for End-stage Liver Disease, Charlson comorbidity score, ethnicity, waiting list time and ischemia time. There were significantly higher rates of vascular (17.58% vs 23.53%, P = 0.021) and biliary complications (27.68% vs 35.73%, P = 0.006) and PGNF (11.40% vs 12.20%, P = 0.021) in obese patients. There was a significantly increased risk for long-term graft failure; however, there was no significant difference in patient survival after LT. CONCLUSION Obese patients have significantly increased morbidity in terms of vascular and biliary complications and PGNF after LT. They have a higher risk for worse 1-year graft survival in comparison to controls.

  • Antimigration versus conventional fully covered metal stents in the endoscopic treatment of anastomotic biliary strictures after deceased-donor liver transplantation
    Esteban Fuentes-Valenzuela, Marina de Benito Sanz, Félix García-Pajares, José Estradas, Irene Peñas-Herrero, Miguel Durá-Gil, Ana Yaiza Carbajo, Carlos de la Serna-Higuera, Ramon Sanchez-Ocana, Carmen Alonso-Martín,et al.
    Springer Science and Business Media LLC

  • DRESS syndrome secondary to carbamazepine
    Miryam Moreta Rodríguez, Félix García-Pajares, Carolina Almohalla-Álvarez, Carmen Alonso-Martín, Antonio González López, José Pablo Miramontes-González, Javier Miguel Martín Guerra, and Begoña Morejón Huerta
    Sociedad Espanola de Patologia Digestiva (SEPD)
    DRESS syndrome is a multisystem disorder that appears in the context of an adverse drug reaction, characterized by fever, rash and peripheral eosinophilia with involvement of other organs such as the liver. The typical liver involvement is acute toxic hepatitis (DILI), showing improvement and a tendency to resolution when corticotherapy is started. We must not forget this manifestation in the clinical context of a DRESS syndrome.

  • Postreperfusion Biopsy as a Predictor of Biliary Complication After Deceased Donor Liver Transplantation. A Retrospective Cohort Study
    Esteban Fuentes-Valenzuela, Laura Sánchez-Delgado, Carlos Maroto-Martín, Laura Juan-Casamayor, Samuel Fernández-Prada, Miryam Moreta Rodríguez, Javier Tejedor-Tejada, Beatriz Madrigal Rubiales, Carmen Alonso-Martín, Irene Peñas-Herrero,et al.
    Elsevier BV

  • XI factor deficiency as cause of recurrent gastrointestinal bleeding
    Laura Juan-Casamayor, Esteban Fuentes-Valenzuela, Carmen Alonso-Martín, Elena Fernández-Fontecha, and Félix García-Pajares
    Sociedad Espanola de Patologia Digestiva (SEPD)
    We present the case of a 73-year-old woman with no relevant medical history. She was admitted for a 3-month intermittent melena. The physical exam was unremarkable. Blood tests revealed anemia (hemoglobin 7.4 g/dL), raised urea (69 mg/dL), normal platelets and coagulation. Gastroscopy was performed with active oozing bleeding in the fundus and gastric body. Endoscopic fulguration of the potential lesions with holmium laser was performed. She was discharged with resolution of the symptoms and analytical improvement. However, the patient required hospitalization two weeks later due to recurrence of melena and anemia.

  • Postreperfusion Liver Biopsy as Predictor of Early Graft Dysfunction and Survival After Orthotopic Liver Transplantation
    Esteban Fuentes-Valenzuela, Javier Tejedor-Tejada, Félix García-Pajares, Beatriz M. Rubiales, Rodrigo Nájera-Muñoz, Carlos Maroto-Martín, Laura Sánchez-Delgado, Carmen Alonso-Martín, Carolina A. Álvarez, and Gloria Sánchez-Antolín
    Elsevier BV

  • COVID-19 and Short- and Medium-term Outcomes in Liver Transplant Patients: A Spanish Single-center Case Series
    Javier Tejedor-Tejada, Esteban Fuentes-Valenzuela, Carmen Alonso-Martin, Carolina Almohalla-Alvarez, and Felix Garcia-Pajares
    Elsevier BV

  • Acute liver failure due to anti-tuberculous treatment: when you travel without medical follow-up
    Laura Sánchez-Delgado, Carolina Almohalla-Álvarez, Beatriz Madrigal-Rubiales, Félix García-Pajares, Irene Peñas-Herrero, Carmen Alonso-Martín, Fátima Sánchez-Martín, and Gloria Sánchez-Antolín
    Sociedad Espanola de Patologia Digestiva (SEPD)
    We present an uncommon cause of liver transplant in a patient with a particular personal situation, who suffered loss of follow-up during his antitubercular treatment. He presented a dress syndrome with fulminant liver failure that required a liver transplant. This case demonstrates the importance of close monitoring of liver function during this treatment.

  • De-novo nonalcoholic fatty liver disease at 5 years after liver transplantation: Prevalence and predictive factors
    Javier Tejedor-Tejada, Esteban Fuentes Valenzuela, Rodrigo Nájera Muñoz, Laura Hernandez Gómez, Félix García-Pajares, Carolina Almohalla Álvarez, Fátima Sánchez-Martín, Carmen Alonso-Martín, and Gloria Sánchez-Antolín
    Ovid Technologies (Wolters Kluwer Health)
    BACKGROUND AND AIMS Nonalcoholic fatty liver disease (NAFLD) is a long-term complication after liver transplantation. Our aims were to determine de-novo-NAFLD at 5-year post-liver transplantation and identify predictive risk factors. METHODS This was a retrospective analysis of de-novo-NAFLD at 5-year post-liver transplantation. NAFLD was defined as the radiological evidence of steatosis. Data from transplanted patients between November 2001 and May 2014 were collected. Noninvasive fibrosis scores were calculated. Predictors of de-novo NAFLD and survival were assessed by multivariate analyses and Kaplan-Meier method. RESULTS A total of 252 liver transplantations were evaluated after applying exclusion criteria, (78.6% men) with 54.9 years old (SD ± 9.5). Prevalence of de-novo NAFLD at 5-year post-liver transplantation was 36.1%. Cardiovascular events were presented in 19.88% and 23.08% of non-NAFLD and NAFLD patients, (P = 0.58). On multivariate analysis, male sex (OR, 5.40; P = 0.001), obesity (OR, 3.72; P = 0.017), metabolic syndrome (OR, 4.69; P < 0.001) and de-novo diabetes (OR, 2.79; P = 0.018), were predictive. Significant fibrosis (≥F2) was presented in 58-86%. The mean survival in NAFLD and control group was 166.3 and 173.6 months, respectively (P = 0 0.50). CONCLUSION De-novo NAFLD at fifth-year post-liver transplantation is frequently and associated with cardiovascular comorbidity. Male sex, obesity, de-novo diabetes and metabolic syndrome were factors associated with de-novo NAFLD. A significant proportion of patients had advanced fibrosis. This group trends toward worse patients' survival.

  • Utility of Ethyl-Glucuronide for Evaluation of Abstinence in Patients Presenting for Liver Transplantation
    Carmen Alonso-Martín, Javier Tejedor-Tejada, Esteban Fuentes Valenzuela, Carolina Almohalla-Álvarez, Fátima Sánchez-Martín, Luisa Fernanda Lurueña Sanchez, Félix García-Pajares, and Gloria Sánchez-Antolín
    Elsevier BV

  • Immunosuppressive Treatment With mTOR Inhibitors for Malignancies After Liver Transplantation: Long-Term Survival Retrospective Analysis
    Javier Tejedor-Tejada, Carmen Alonso-Martín, Carolina Almohalla-Álvarez, Esteban Fuentes Valenzuela, Rodrigo Nájera Muñoz, Laura Sánchez Delgado, Carlos Maroto Martín, Fátima Sánchez-Martín, Félix García-Pajares, and Gloria Sánchez-Antolín
    Elsevier BV

  • Adenoma detection rate and cecal intubation rate: Quality indicators for colonoscopy
    María Lourdes Ruiz-Rebollo, Noelia Alcaide-Suárez, Beatriz Burgueño-Gómez, Beatriz Antolin-Melero, M.ª Fe Muñoz-Moreno, Carmen Alonso-Martín, and Javier Santos-Fernández
    Elsevier BV

  • Colovesical fistula: visualization of the bladder during colonoscopy
    Noelia Alcaide, Sara Lorenzo Pelayo, Carmen Alonso Martin, Ana Macho Conesa, and Francisco Blanco-Antona
    Elsevier BV

  • Hepatocolic fistula managed with a novel padlock® device for endoscopic closure
    Benito Velayos Jiménez, Lourdes Del Olmo Martínez, Carmen Alonso Martín, Javier Trueba Arguiñarena, and José Manuel González Hernández
    Sociedad Espanola de Patologia Digestiva (SEPD)

  • Incidence of non-alcoholic fatty liver disease and metabolic dysfunction in first episode schizophrenia and related psychotic disorders: a 3-year prospective randomized interventional study
    María José Morlán-Coarasa, María Teresa Arias-Loste, Víctor Ortiz-García de la Foz, Obdulia Martínez-García, Carmen Alonso-Martín, Javier Crespo, Manuel Romero-Gómez, Emilio Fábrega, and Benedicto Crespo-Facorro
    Springer Science and Business Media LLC

  • Increased expression profile and functionality of TLR6 in peripheral blood mononuclear cells and hepatocytes of morbidly obese patients with non-alcoholic fatty liver disease
    María Arias-Loste, Paula Iruzubieta, Ángela Puente, David Ramos, Carolina Santa Cruz, Ángel Estébanez, Susana Llerena, Carmen Alonso-Martín, David San Segundo, Lorena Álvarez,et al.
    MDPI AG
    Current evidence suggests that gut dysbiosis drives obesity and non-alcoholic fatty liver disease (NAFLD) pathogenesis. Toll-like receptor 2 (TLR2) and TLR6 specifically recognize components of Gram-positive bacteria. Despite the potential implications of TLR2 in NAFLD pathogenesis, the role of TLR6 has not been addressed. Our aim is to study a potential role of TLR6 in obesity-related NAFLD. Forty morbidly obese patients undergoing bariatric surgery were prospectively studied. Cell surface expression of TLR2 and TLR6 was assessed on peripheral blood mononuclear cells (PBMCs) by flow cytometry. Freshly isolated monocytes were cultured with specific TLR2/TLR6 agonists and intracellular production of cytokines was determined by flow-cytometry. In liver biopsies, the expression of TLR2 and TLR6 was analyzed by immunohistochemistry and cytokine gene expression using RT-qPCR. TLR6 expression in PBMCs from non-alcoholic steatohepatitis (NASH) patients was significantly higher when compared to those from simple steatosis. The production of pro-inflammatory cytokines in response to TLR2/TLR6 stimulation was also significantly higher in patients with lobular inflammation. Hepatocyte expression of TLR6 but not that of TLR2 was increased in NAFLD patients compared to normal liver histology. Deregulated expression and activity of peripheral TLR6 in morbidly obese patients can mirror the liver inflammatory events that are well known drivers of obesity-related NASH pathogenesis. Moreover, TLR6 is also significantly overexpressed in the hepatocytes of NAFLD patients compared to their normal counterparts. Thus, deregulated TLR6 expression may potentiate TLR2-mediated liver inflammation in NAFLD pathogenesis, and also serve as a potential peripheral biomarker of obesity-related NASH.