nagarjuna sivaraj
@gems.edu.in
Research Associate
Great Eastern Medical School and Hospital
EDUCATION
M.Sc. Biochemistry, Andhra University
M.Phil. MolecularCellbiology and Medical Genetics, SDUAHER
*Ph.D. Biochemistry and Bioinformatics, GITAMS
RESEARCH INTERESTS
Molecular Sciences, Molecular Biology, Cell Biology, Genetics, Microbiology, Biochemistry
Scopus Publications
Scholar Citations
Scholar h-index
Scopus Publications
Nagarjuna Sivaraj, Bunga Papa Kusuma, L V Simhachalam Kutikuppala, K Vijaya Rachel, Vijaya Sirisha Balaga, and Samhitha Gundakaram
Wiley
BACKGROUND
Various cytokines released by white blood cells like lymphocytes are linked to the immune system during pregnancy. The polymorphism of the TNFSF11 (rs2200287 and rs2148072) gene is related to the preeclampsia of pregnancy.
MATERIALS AND METHODS
This study was a prospective study involving 304 pregnant women with preeclampsia (n = 152) and controls (non-preeclamptic pregnant women) (n = 152). To investigate the rs2200287 and rs2148072 SNP's of TNFSF11 gene polymorphism by using the PCR - RFLP techniques.
RESULTS
A significantly different genotype distribution of TNFSF11 (rs2200287 and rs2148072) polymorphisms were observed between the two groups, with the G allele of variant rs2200287 was highly significant in the preeclamptic group (P = 000; 0.5814; OR = 0.5814; 95% CI = 0.4211 - 0.8012). And the C allele of variant rs2148072 was also highly significant in the preeclamptic group (P = 000; OR = 0.5076; 95% CI - 0.362 - 0.71) in this study.
CONCLUSION
The outcomes of the present study indicate that there was an association in TNFSF 11 (rs2200287 and rs2148072) gene polymorphism with preeclampsia compared to non - preeclampsia women. This article is protected by copyright. All rights reserved.
Nagarjuna Sivaraj, Rachel K.V., Tarun Kumar Suvvari, Shilaja Prasad, Sri Harsha Boppana, and Pradeep Kumar Vegi
Elsevier BV
K. Vijaya Rachel and Nagarjuna Sivaraj
Elsevier
Krishnaveni Chengalvala, Pushpa Kotur, Mitesh Shetty, Praveen Kumar, Jagadish T.V., Nagarjuna Sivaraj, and Sharath Balakrishna
Elsevier BV