Dr. Yuvarajan Subramaniyan

Scopus Publications

Correction: Lactiplantibacillus plantarum exerts anticancer effects and increase the chemosensitivity of 5-fluorouracil against oral cancer cells in vitro (BioImpacts (2025) 15 (30427) DOI: 10.34172/bi.30427)
Fida Fathima, Yuvarajan Subramaniyan, Kesari Ashwath, P. D. Rekha
Bioimpacts, 2025
CorrectionWe would like to bring to your attention a minor error in Figure 5d of our article titled "Lactiplantibacillus plantarum exerts anticancer effects and increases the chemosensitivity of 5-fluorouracil against oral cancer cells in vitro," published in BioImpacts, 2025;15:30427 (doi: 10.34172/bi
Lactiplantibacillus plantarum exerts anticancer effects and increase the chemosensitivity of 5-fluorouracil against oral cancer cells in vitro
Fathima Fida, Subramaniyan Yuvarajan, Kesari Ashwath, Punchappady Devasya Rekha
Bioimpacts, 2025
Introduction: Probiotics are used to provide health benefits and can improve the immune response. They can also target cancer cells directly with anticancer effects through various mechanisms. In this study, Lactiplantibacillus plantarum (basonym: Lactobacillus plantarum) strain MCC 3016 and its postbiotic metabolites/cell free supernatant (CFS) were used against Cal27 oral cancer cells in vitro. Methods: Standard assays were employed to investigate the effect of Lpb. plantarum on cell viability, proliferation, migration, and clonogenicity of Cal27 cells. The mechanism of action was assessed by measuring the levels of reactive oxygen species (ROS), interleukins (IL)-6 and IL-8, tumor necrosis factor-α (TNF-α), as well as the expression of Ki67, vascular endothelial growth factor (VEGF), p53 and caspase-3. Further, the effect of Lpb. plantarum and its CFS on the cytotoxicity of chemotherapy drug 5-fluorouracil (5-FU) was evaluated using cell viability assays. Results: Cal27 cells treated with Lpb. plantarum and its CFS showed a significant decrease (P < 0.01) in cell viability, proliferation, migration, and clonogenicity, along with increased levels of ROS and induced apoptosis. It significantly reduced IL-6, IL-8, TNF-α, and VEGF levels and upregulated p53 and caspase-3 expression. The postbiotic metabolites also showed similar effects on Cal27 cells. Furthermore, the cytotoxic effect of 5-FU on Cal27 cells was enhanced by Lpb. plantarum and its CFS treatment. Conclusion: Lpb. plantarum MCC 3016 and its postbiotic metabolites exhibited promising anticancer effects on oral cancer cells and improved drug efficacy, demonstrating their potential therapeutic value in oral cancer therapy.
Self-assembled polyelectrolyte complexes of chitosan and fucoidan for sustained growth factor release from PRP enhance proliferation and collagen deposition in diabetic mice
Sneha Subramanya Rao, Jayachandran Venkatesan, Subramaniyan Yuvarajan, Punchappady-Devasya Rekha
Drug Delivery and Translational Research, 2022
Linalool-encapsulated alginate microspheres as anti-virulence target against wound infections using In vitro and In vivo models
Saptami Kanekar, Sneha S. Rao, S. Yuvarajan, Suprith Surya, P.D. Rekha
Journal of Drug Delivery Science and Technology, 2022
Urease-negative uropathogen Kalamiella piersonii YU22 metabolizes urea by urea carboxylase and allophanate hydrolase enzyme system
Subramaniyan Yuvarajan, Asif Hameed, Ananthapadmanabha Bhagwath Arun, Kanekar Saptami, Punchappady Devasya Rekha
Microbiological Research, 2022
Computer numerical control-printed paper electrodes for electrochemical detection of Pseudomonas aeruginosa virulence factor pyocyanin
H. Manisha, J. Sonia, S. Shashikiran, S. Yuvarajan, P.D. Rekha, K. Sudhakara Prasad
Electrochemistry Communications, 2022
Disposable paper electrodes (PPE) have significant advantages in biosensor research considering the cost-effectiveness, simplicity, and easy batch manufacturing opportunity. An increase in communicable and non-communicable diseases demands for custom-made sensor platforms. Herein, we report an alternative method for the fabrication of PPE through simple and rapid computer numerical controlled (CNC) printing technique. The fabricated electrodes were electrochemically characterised, and by detecting antibiotic resistant pathogen, Pseudomonas aeruginosa virulence factor pyocyanin, the sensing application is demonstrated. Finally, the sensor is validated with a gold-standard culture-based assay.

RECENT SCHOLAR PUBLICATIONS

Effect of metabolites on the survival and biofilm formation of Pantoea piersonii (Basionym: Kalamiella piersonii) in synthetic urine media
Y Subramaniyan, KS Megha, K Adithyan, RR Nair, M Mujeeburahiman, ...
BMC microbiology 26 (1), 182 , 2026
2026
Corrigendum: Enterococcus faecalis co-cultured with oral cancer cells exhibits higher virulence and promotes cancer cell survival, proliferation, and migration: an in vitro study
F Fathima, Y Subramaniyan, A Rai, PD Rekha
Journal of Medical Microbiology 75 (3), 002141 , 2026
2026
Concurrent bacterial infections in oral cancer: risk and mitigation strategies
BM Baby, Y Subramaniyan, PD Rekha
Future Microbiology 21 (1), 43-57 , 2026
2026
Enterococcus faecalis co-cultured with oral cancer cells exhibits higher virulence and promotes cancer cell survival, proliferation, and migration: an in vitro study …
F Fathima, Y Subramaniyan, A Rai, PD Rekha
JOURNAL OF MEDICAL MICROBIOLOGY 75 (3) , 2026
2026
Influence of Nutritional Conditions on Coexistence of Pseudomonas aeruginosa and Staphylococcus aureus in the Dual‐Species Biofilm
SK Megha, Y Subramaniyan, BM Baby, S Lobo, M Mujeeburahiman, ...
APMIS 133 (12), e70123 , 2025
2025
Citations: 2
Overexpression of Agr quorum sensing system in uropathogenic Staphylococcus aureus in response to simulated urinary metabolic conditions enhancing growth …
Y Subramaniyan, M Mujeeburahiman, A Khan, PD Rekha
Medical Microbiology and Immunology 214 (1), 35 , 2025
2025
Citations: 3
Pantoea piersonii (basionym kalamiella piersonii ) as an emerging pathogen: clinical manifestations, diagnostic challenges, and resistance threats
BM Baby, Y Subramaniyan, PD Rekha
Folia Microbiologica, 1-7 , 2025
2025
Correction to: Lactiplantibacillus plantarum exerts anticancer effects and increase the chemosensitivity of 5-fluorouracil against oral cancer cells in vitro
F Fida, S Yuvarajan, K Ashwath, PD Rekha
BioImpacts: BI 15, 32504 , 2025
2025
Urological metabolic conditions alter regulation of quorum-sensing system and virulence genes expression in uropathogenic Pseudomonas aeruginosa
Y Subramaniyan, A Khan, M Mujeeburahiman, M Shivani, S Patil, ...
Microbial Pathogenesis 203, 107502 , 2025
2025
Citations: 5
Broad-spectrum antimicrobial properties of linalool: Supporting its pharmacological use in chronic wound infections by pathogens within the ESKAPE group and polymicrobial biofilms
A Rai, Y Subramaniyan, F Fathima, PD Rekha
World Journal of Microbiology and Biotechnology 41 (3), 99 , 2025
2025
Citations: 7
Enterococcus faecalis co-cultured with oral cancer cells exhibits higher virulence and promotes cancer cell survival, proliferation, and migration: an in vitro study
F Fathima, Y Subramaniyan, A Rai, PD Rekha
Journal of Medical Microbiology 73 (11), 001931 , 2024
2024
Citations: 3
Burn Wound Healing Abilities of a Uronic Acid Containing Exopolysaccharide Produced by the Marine Bacterium Halomonas malpeensis YU-PRIM-29 T
A Nagaraj, Y Subramaniyan, S Surya, PD Rekha
Applied Biochemistry and Biotechnology 196 (11), 8190-8213 , 2024
2024
Citations: 9
Lactiplantibacillus plantarum exerts anticancer effects and increase the chemosensitivity of 5-fluorouracil against oral cancer cells in vitro
F Fida, S Yuvarajan, K Ashwath, PD Rekha
BioImpacts: BI 15, 30427 , 2024
2024
Citations: 7
High Incidence of Antibiotic Resistance in the Uropathogenic Bacteria Associated with Different Urological Diseases and Metabolic Complications: A Single Center Cross-Sectional …
Y Subramaniyan, A Khan, M Mujeeburahiman, PD Rekha
Microbial Drug Resistance 30 (6), 231-242 , 2024
2024
Citations: 5
Differential expression of urease genes and ureolytic activity of uropathogenic Escherichia coli and Pseudomonas aeruginosa isolates in different nutritional …
Y Subramaniyan, A Khan, F Fathima, PD Rekha
Archives of Microbiology 205 (12), 383 , 2023
2023
Citations: 22
Linalool-encapsulated alginate microspheres as anti-virulence target against wound infections using In vitro and In vivo models
S Kanekar, SS Rao, S Yuvarajan, S Surya, PD Rekha
Journal of Drug Delivery Science and Technology 77, 103848 , 2022
2022
Citations: 12
Self-assembled polyelectrolyte complexes of chitosan and fucoidan for sustained growth factor release from PRP enhance proliferation and collagen deposition in diabetic mice
SS Rao, J Venkatesan, S Yuvarajan, PD Rekha
Drug Delivery and Translational Research 12 (11), 2838-2855 , 2022
2022
Citations: 22
Urease-negative uropathogen Kalamiella piersonii YU22 metabolizes urea by urea carboxylase and allophanate hydrolase enzyme system
S Yuvarajan, A Hameed, AB Arun, K Saptami, PD Rekha
Microbiological research 263, 127142 , 2022
2022
Citations: 11
Computer numerical control-printed paper electrodes for electrochemical detection of Pseudomonas aeruginosa virulence factor pyocyanin
H Manisha, J Sonia, S Shashikiran, S Yuvarajan, PD Rekha, KS Prasad
Electrochemistry Communications 137, 107259 , 2022
2022
Citations: 22

MOST CITED SCHOLAR PUBLICATIONS

Differential expression of urease genes and ureolytic activity of uropathogenic Escherichia coli and Pseudomonas aeruginosa isolates in different nutritional …
Y Subramaniyan, A Khan, F Fathima, PD Rekha
Archives of Microbiology 205 (12), 383 , 2023
2023
Citations: 22
Self-assembled polyelectrolyte complexes of chitosan and fucoidan for sustained growth factor release from PRP enhance proliferation and collagen deposition in diabetic mice
SS Rao, J Venkatesan, S Yuvarajan, PD Rekha
Drug Delivery and Translational Research 12 (11), 2838-2855 , 2022
2022
Citations: 22
Computer numerical control-printed paper electrodes for electrochemical detection of Pseudomonas aeruginosa virulence factor pyocyanin
H Manisha, J Sonia, S Shashikiran, S Yuvarajan, PD Rekha, KS Prasad
Electrochemistry Communications 137, 107259 , 2022
2022
Citations: 22
Linalool-encapsulated alginate microspheres as anti-virulence target against wound infections using In vitro and In vivo models
S Kanekar, SS Rao, S Yuvarajan, S Surya, PD Rekha
Journal of Drug Delivery Science and Technology 77, 103848 , 2022
2022
Citations: 12
Urease-negative uropathogen Kalamiella piersonii YU22 metabolizes urea by urea carboxylase and allophanate hydrolase enzyme system
S Yuvarajan, A Hameed, AB Arun, K Saptami, PD Rekha
Microbiological research 263, 127142 , 2022
2022
Citations: 11
Burn Wound Healing Abilities of a Uronic Acid Containing Exopolysaccharide Produced by the Marine Bacterium Halomonas malpeensis YU-PRIM-29 T
A Nagaraj, Y Subramaniyan, S Surya, PD Rekha
Applied Biochemistry and Biotechnology 196 (11), 8190-8213 , 2024
2024
Citations: 9
Broad-spectrum antimicrobial properties of linalool: Supporting its pharmacological use in chronic wound infections by pathogens within the ESKAPE group and polymicrobial biofilms
A Rai, Y Subramaniyan, F Fathima, PD Rekha
World Journal of Microbiology and Biotechnology 41 (3), 99 , 2025
2025
Citations: 7
Lactiplantibacillus plantarum exerts anticancer effects and increase the chemosensitivity of 5-fluorouracil against oral cancer cells in vitro
F Fida, S Yuvarajan, K Ashwath, PD Rekha
BioImpacts: BI 15, 30427 , 2024
2024
Citations: 7
Urological metabolic conditions alter regulation of quorum-sensing system and virulence genes expression in uropathogenic Pseudomonas aeruginosa
Y Subramaniyan, A Khan, M Mujeeburahiman, M Shivani, S Patil, ...
Microbial Pathogenesis 203, 107502 , 2025
2025
Citations: 5
High Incidence of Antibiotic Resistance in the Uropathogenic Bacteria Associated with Different Urological Diseases and Metabolic Complications: A Single Center Cross-Sectional …
Y Subramaniyan, A Khan, M Mujeeburahiman, PD Rekha
Microbial Drug Resistance 30 (6), 231-242 , 2024
2024
Citations: 5
Overexpression of Agr quorum sensing system in uropathogenic Staphylococcus aureus in response to simulated urinary metabolic conditions enhancing growth …
Y Subramaniyan, M Mujeeburahiman, A Khan, PD Rekha
Medical Microbiology and Immunology 214 (1), 35 , 2025
2025
Citations: 3
Enterococcus faecalis co-cultured with oral cancer cells exhibits higher virulence and promotes cancer cell survival, proliferation, and migration: an in vitro study
F Fathima, Y Subramaniyan, A Rai, PD Rekha
Journal of Medical Microbiology 73 (11), 001931 , 2024
2024
Citations: 3
Influence of Nutritional Conditions on Coexistence of Pseudomonas aeruginosa and Staphylococcus aureus in the Dual‐Species Biofilm
SK Megha, Y Subramaniyan, BM Baby, S Lobo, M Mujeeburahiman, ...
APMIS 133 (12), e70123 , 2025
2025
Citations: 2
Effect of metabolites on the survival and biofilm formation of Pantoea piersonii (Basionym: Kalamiella piersonii) in synthetic urine media
Y Subramaniyan, KS Megha, K Adithyan, RR Nair, M Mujeeburahiman, ...
BMC microbiology 26 (1), 182 , 2026
2026
Corrigendum: Enterococcus faecalis co-cultured with oral cancer cells exhibits higher virulence and promotes cancer cell survival, proliferation, and migration: an in vitro study
F Fathima, Y Subramaniyan, A Rai, PD Rekha
Journal of Medical Microbiology 75 (3), 002141 , 2026
2026
Concurrent bacterial infections in oral cancer: risk and mitigation strategies
BM Baby, Y Subramaniyan, PD Rekha
Future Microbiology 21 (1), 43-57 , 2026
2026
Enterococcus faecalis co-cultured with oral cancer cells exhibits higher virulence and promotes cancer cell survival, proliferation, and migration: an in vitro study …
F Fathima, Y Subramaniyan, A Rai, PD Rekha
JOURNAL OF MEDICAL MICROBIOLOGY 75 (3) , 2026
2026
Pantoea piersonii (basionym kalamiella piersonii ) as an emerging pathogen: clinical manifestations, diagnostic challenges, and resistance threats
BM Baby, Y Subramaniyan, PD Rekha
Folia Microbiologica, 1-7 , 2025
2025
Correction to: Lactiplantibacillus plantarum exerts anticancer effects and increase the chemosensitivity of 5-fluorouracil against oral cancer cells in vitro
F Fida, S Yuvarajan, K Ashwath, PD Rekha
BioImpacts: BI 15, 32504 , 2025
2025

Dr. Yuvarajan Subramaniyan

EDUCATION

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Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS