Guy Baudouin Henri DECANTE

@3Bs.uminho.pt

3B's Research Group on Biomaterials, Biodegradables and Biomimetics
University of Minho

Guy Baudouin Henri DECANTE


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https://researchid.co/guydecante

EDUCATION

2019: Engineering Double Diploma between the ECAM Lyon and the University of Limerick.
- 2018 – 2019: Master in Biomedical Device Materials at the University of Limerick, Ireland. First Class Honours.
- 2015 – 2018: Combined Bachelor’s and Master’s Degrees in General Engineering at the ECAM Lyon, Graduate School Of Engineering, France

RESEARCH INTERESTS

3D bioprinting of naturally-derived biomaterials for tissue engineering applications.
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Scopus Publications

Scopus Publications

  • Sustainable highly stretchable and tough gelatin-alkali lignin hydrogels for scaffolding and 3D printing applications
    Guy Decante, Ibrahim Fatih Cengiz, João B. Costa, Maurice N. Collins, Rui L. Reis, Joana Silva-Correia, J. Miguel Oliveira
    Materials Today Communications, 2024
    Hydrogels and bioinks obtained from gelatin (Gel) generally present poor mechanical properties and require a series of time-consuming and stepwise chemical processes to exhibit improved elasticity and resistance to fatigue. Alkali lignin (AL) is an underutilized by-product of the paper and pulp industry. It is a widely available and inexpensive biomaterial that presents enormous potential for high-value applications owing to its ease of chemical modification and unique naturally occurring polyaromatic structure. This work aims to develop different GelAL hydrogel formulations with a single-step method that are innovative and sustainable. The results obtained from the mechanical, rheological, and degradation studies of the developed GelAL hydrogels demonstrated that their properties can be easily modified and tuned using straightforward processing techniques, allowing these stretchable and tough hydrogels to be used as bioinks in 3D printing. The modulation of mechanical properties through hydrogel formulations is a result of interactions between the Gel and AL which can be associated with the interplay of anionic sulfonates in AL and the arginine and lysine residues from Gel. The tensile stress at the break for the Gel20AL10 formulation was 32% higher than the value for Gel20AL5 and 157% higher than that of Gel10AL10. The elongation at break also decreased as it averaged 659 ± 149% for the Gel20AL10 formulation, which is 20% more than that of Gel20AL5 and 55% more than the average elongation at break of Gel10AL10. Further zeta potential measurements and quartz crystal microbalance with energy dissipation studies demonstrated that Gel and AL seem to form neutral complexes when mixed. These assays support the idea that AL and Gel are readily bound through weak interactions, and chemical crosslinking strategies need to be considered when degradability and mechanical properties tuning are envisioned. Altogether, these high-performance GelAL hydrogels display mechanical properties similar to soft tissues with high elasticity beyond that of natural hydrogels and fulfill the requirements of a broad range of biomedical and tissue engineering scaffolding applications.
  • Enzymatic crosslinked hydrogels
    Guy Decante, Rui L. Reis, Joana Silva-Correia, J. Miguel Oliveira
    Hydrogels for Tissue Engineering and Regenerative Medicine from Fundamentals to Applications, 2023
    Crosslinking is a fundamental aspect of hydrogel formation and plays an essential role in the subsequent hydrogel properties in terms of mechanical and chemical stability. Enzyme-catalysed crosslinking has been developed rather recently compared to the physical and chemical methodologies. This technique allows for easy and efficient in situ forming of covalently bonded bioactive hydrogels under mild conditions. Enzymes can be used during the primary hydrogel formation, or during secondary processing to enhance the crosslinking rate of a hydrogel. Enzymes can be used by their own or coupled with other crosslinking chemistries for improved performance. This chapter reviews the fundamental aspects of synthesising and processing enzymatically crosslinked hydrogels for applications in catalysis, tissue engineering, microfluidics, artificial extracellular matrices, and drugs & cells delivery.
  • Injectable Polymeric System Based on Polysaccharides for Therapy
    Guy Decante, Joaquim Miguel Oliveira, Rui L. Reis, Joana Silva-Correia
    Polysaccharides of Microbial Origin Biomedical Applications with 257 Figures and 85 Tables, 2022
  • Engineering bioinks for 3D bioprinting
    Guy Decante, João B Costa, Joana Silva-Correia, Maurice N Collins, Rui L Reis, J Miguel Oliveira
    Biofabrication, 2021
    In recent years, three-dimensional (3D) bioprinting has attracted wide research interest in biomedical engineering and clinical applications. This technology allows for unparalleled architecture control, adaptability and repeatability that can overcome the limits of conventional biofabrication techniques. Along with the emergence of a variety of 3D bioprinting methods, bioinks have also come a long way. From their first developments to support bioprinting requirements, they are now engineered to specific injury sites requirements to mimic native tissue characteristics and to support biofunctionality. Current strategies involve the use of bioinks loaded with cells and biomolecules of interest, without altering their functions, to deliver in situ the elements required to enhance healing/regeneration. The current research and trends in bioink development for 3D bioprinting purposes is overviewed herein.