Ministry of Higher Education and Scientific Research Ministry of Higher Education and Scientific Research, Office Reconstruction and Projects, Baghdad, Iraq
DEVELOPMENT AND CHARACTERIZATION OF POLY(METHYL METHACRYLATE)/HYDROXYAPATITE BIOCOMPOSITE TREATED WITH AN ANTIMICROBIAL AGENT AS A BONE ANALOGUE MATERIAL Ali Al. Allaq, Jenan S. Kashan, Amal Ibrahim Mahmood, Farah M. Abdul-Kareem Materiali in Tehnologije, 2025 In the field of bone tissue engineering, biocomposite materials that stimulate and promote the regeneration of broken bones tissues have become the focus of recent research. This research aims to fabricate a biocomposite material of PMMA and hydroxyapatite (HA) combined with various concentrations of curcumin and EGDMA for bone tissue scaffold engineering. A characterization of the fabricated samples was performed using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), Atomic force microscopy (AFM), as well as mechanical properties to measure the tensile fracture and compressive strength of the samples. In order to develop antibacterial biomaterials for effective treatment and prevention of osteomyelitis, two typical strains of bacteria that cause osteomyelitis, Staphylococcus aureus and Escherichia coli, were tested using an agar diffusion assay. Our results strongly indicate that the combination of HA and curcumin nanoparticles into PMMA polymer matrix with reinforced EGDMA for the production of biocomposite scaffolds offer significant potential for bone tissue applications, potentially improving their performance and effectiveness. In addition to the mechanical and morphological properties of the biocomposite (PMMA/HA/Curcumin), the composite had excellent antibacterial activity for the growth of both Gram-positive and Gram-negative bacteria, which offers the potential for the application of the composite in bone tissue engineering applications.
Optimized in vitro assessment of ZrO2–CaO/PMMA hybrid biocomposite with multi-walled carbon nanotube reinforcement for enhanced bone reconstruction Jenan S. Kashan, Ali A. Al-Allaq, Ahmad Umar, Sotirios Baskoutas, Hassan Fouad International Journal of Polymeric Materials and Polymeric Biomaterials, 2025 In this study, multi-walled carbon nanotubes (MWCNTs) are integrated into a poly (methyl methacrylate) (PMMA) and zirconium oxide (ZrO2) biocomposite, stabilized with calcium oxide (CaO). This research aims to pave the way for further optimization of the biocomposite for targeted applications in bone tissue engineering. The incorporation of MWCNTs is intended to enhance the mechanical properties and bioactivity of the composite, making it a suitable candidate for bone reconstruction. Comprehensive analyses were conducted using field emission scanning electron microscopy (FESEM) and energy dispersive X-ray spectroscopy (EDS) to characterize the structural and chemical changes in the biocomposite during immersion in simulated body fluid (SBF). These analyses revealed a significant formation of a robust apatite layer on the composite surface after three days of immersion. Notably, the rate of apatite formation accelerated with the incorporation of MWCNTs, indicating an enhancement in the bioactivity of the composite. The study findings demonstrate that an MWCNT-reinforced PMMA/ZrO2–CaO composite exhibits excellent biocompatibility, as well as accelerated bioactivity. These properties are crucial for bone tissue engineering applications, where materials must integrate seamlessly with natural bone and support new bone formation. The results confirm the potential of this advanced biocomposite as a promising biomaterial for bone replacement procedures, offering improved performance over traditional materials.
In vivo investigations of polymers in bone tissue engineering: a review study Ali A. Al-allaq, Jenan S. Kashan, Farah M. Abdul-Kareem International Journal of Polymeric Materials and Polymeric Biomaterials, 2024 Bone tissue engineering (BTE) applications and regenerative strategies have been used to improve the clinical practice of repairing large bone defects associated with surgical resections, congenital malformations, and trauma. The scaffolds are designed to stimulate a biological response, including cell interactions, and guide tissue regeneration by functioning as artificial biomimetic extracellular matrixes. Polymeric biomaterials are suitable for bone tissue engineering since they possess both chemical and physical properties, enabling the control of shape, morphology, and biodegradability, which makes them suitable for bone regeneration and tissue engineering applications. In vivo animal models were studied for collagen, chitosan, poly (lactic acid) (PLA) and high density polyethylene (HDPE), the four most common polymers employed in bone tissue engineering. Through analysis of the results of this review, the in vivo studies can provide a large-scale evaluation of the possibility of achieving optimal bone-forming capabilities and regenerative capabilities. Furthermore, the review will serve as an essential reference for bone tissue engineering applications as well as contribute to the development of novel in vivo investigations
Synthesis and characterization of nano-biocomposite (PMMA-hydroxyapatite - CaZrO3) for bone tissue engineering Ali A. Al-allaq, Jenan S. Kashan, Abdalla Abdal-Hay, Hassan Fouad Polymer Plastics Technology and Materials, 2024 In a common scenario, bone fractures have a self-healing function with free-surgical intervention. However, some fractures in bone tissue are complex and leave behind remnant deformation that requires biomaterials for replacement. The aim of this study is to develop a new composite 3D scaffold for bone regeneration and replacement composed of calcium zirconate (CaZrO3), hydroxyapatite (HA) and polymethylmethacrylate (PMMA) polymer. Different 3D scaffolds were fabricated by mixing 90, 80, 70, and 60 wt. % PMMA with HA and CaZrO3 nanoparticles in different concentrations. X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM) and atomic force microscopy (AFM) techniques were applied to characterize the 3D composite scaffold properties. Furthermore, the mechanical properties of the fabricated scaffolds were investigated using Brazilian diametral fracture test. It was found that incorporating a uniform distribution of HA nanoparticles significantly increased the surface roughness of the composite scaffold. Furthermore, the fracture strength of the fabricated 3D scaffolds showed a remarkable improvement of 86% in the sample containing 90% PMMA, 7% HA, and 3% CaZrO3 compared to the sample devoid of CaZrO3. Our findings strongly indicate that integrating hybrid CaZrO3-HA nanoparticles into PMMA polymer for the production of 3D composite scaffolds holds significant promise for bone tissue applications, potentially enhancing their efficacy and performance.
HA/HDPE Reinforced with MWCNTs for Bone Reconstruction and Replacement Application Ali A. Al-Allaq, Jenan S. Kashan, Mohamed T. El-Wakad, Ahmed M. Soliman Materiale Plastice, 2022 The objective of this study is to demonstrate how the effect of adding multi-walled carbon nanotubes (MWCNTs) nanoparticles to the (Hydroxyapatite /High-density polyethylene) bio-composites. In this investigation, the samples with various percentages of (MWCNTs) were fabricated by a hot-press technique. The morphological characteristics, roughness of the surface and thermal properties of the bio-composite samples (HA/HDPE/MWCNTs) were investigated. The excellent homo-geneous distribution of the internal fibrous network and microstructure arrangements were among the most prominent characteristics obtained through FE-SEM and AFM examinations. The degree of crystallinity showed that the (MWCNTs) additives enhance by an increase of approximately (35%), compared with pure sample (without addition MWCNTs). Based on the experimental results obtained, the fabrication of the presented bio-composites sample exhibited the excellent characteristics that make them promising material for biomedical application as a substitute material for hard tissue likes bone reconstruction.
EVALUATION OF A HYBRID BIOCOMPOSITE OF HA/HDPE REINFORCED WITH MULTI-WALLED CARBON NANOTUBES (MWCNTs) AS A BONE-SUBSTITUTE MATERIAL Ali A. Al- Allaq, Jenan S. Kashan, Mohamed T. El-Wakad, Ahmed M. Soliman Materiali in Tehnologije, 2021 In this investigation, multi-wall carbon nanotubes (MWCNT) with various percentages (0.6%, 1%, 1.4%, 2%) were combined into and High-density polyethylene HDPE (60) wt. % and hydroxyapatite (40) wt. % to form biocomposite using hot-press techniques. The surface topography by AFM images illustrates differences in the roughness of the sample's surface with different adding percentages of MWCNT. The DSC technique exhibits the effect of adding MWCNT in different percentages with the degree of crystallinity, which its effect on mechanical properties for samples. The in vitro bioactivity was investigated by immersion the samples in Ringer's solution as simulated body fluid (SBF) at (0, 3, 6, 9, 12) days (after immersing). The FE-SEM and EDx image explained the apatite layers formation on the sample's surface after 3 days immersed in Ringer solution. Based on XRD Technique, after immersion days in the Ringer solution, the crystallographic structure of hydroxyapatite is formed, forming the monetite. The enhancement of bioactivity has been shown during the incorporation of MWCNT into HA/HDPE composite. These results exhibited excellent indications of biocompatibility properties with the possibility of making promising biomaterials for making bone substitute applications.
In Vivo Investigations of Bone Plates: A Review study A Al-allaq International Journal of Engineering and Computer Science 15 (3), 31 , 2026 2026
Advances Toward In Vivo Cartilage Repair: A Comprehensive Review of Current Strategies and Future Directions AA Al-Allaq, AA Abdulhakeem, JK Hammood, H Fouad Recent Progress in Materials 8 (2), 1-22 , 2026 2026
Advances Toward In Vivo Cartilage Repair: A Comprehensive Review of Current Strategies and Future Directions AAA Jwan Kh. Hammood Recent Progress in Materials 8 (2), 32 , 2026 2026
Effective Approaches to Cancer Therapies Based on Biomechanics and Pathology: Review Study AAA allaq Regenerative Engineering and Translational Medicine 11 (3), 22 , 2025 2025 Citations: 1
Toward Smart Bone Healing: A Review of In Vivo Evidence and Translational Perspectives on Bioelectronic Scaffolds and Piezoelectric Biomaterials AAAJSKH Fouad International Journal Of Engineering And Computer Science 14 (11), 27857-27872 , 2025 2025 Citations: 1
Optimized in vitro assessment of ZrO 2 –CaO/PMMA hybrid biocomposite with multi-walled carbon nanotube reinforcement for enhanced bone reconstruction JS Kashan, A A. Al-Allaq, A Umar, S Baskoutas, H Fouad International Journal of Polymeric Materials and Polymeric Biomaterials 74 … , 2025 2025
A Study on the In Vivo Bioactivity of Nano-Biocomposite for Bone Tissue Engineering AM Alani, TS Mohammed Hasan, FN Noori, JS Kashan, AA Al-allaq Regenerative Engineering and Translational Medicine, 1-10 , 2025 2025 Citations: 1
Development and characterization of poly (methyl methacrylate)/hydroxyapatite bio-composites treated with antimicrobial agent as a bone analogue material AA Allaq, JS Kashan, AI Mahmood, FM Abdul-Kareem Materials and Technology 59 (2), 315–323-315–323 , 2025 2025 Citations: 3
Review of in vivo investigations on metal implants for bone tissue engineering AA Al-allaq, JS Kashan, FM Abdul-Kareem, AM Alani Regenerative Engineering and Translational Medicine 11 (1), 132-156 , 2025 2025 Citations: 13
Development and characterization of poly (methyl methacrylate)/hydroxyapatite biocomposite treated with an antimicrobial agent as a bone analogue material AA Al-allaq, JS Kashan, AI Mahmood, FM Abdul-Kareem Materiali in tehnologije 59 (2) , 2025 2025
In vivo investigations of polymers in bone tissue engineering: a review study A A. Al-allaq, JS Kashan, FM Abdul-Kareem International Journal of Polymeric Materials and Polymeric Biomaterials 73 … , 2024 2024 Citations: 15
International journal of polymeric materials and polymeric biomaterials JS Kashan, AA Al-Allaq, A Umar, S Baskoutas, H Fouad International Journal of Polymeric Materials and Polymeric Biomaterials … , 2024 2024 Citations: 1
Optimized in vitro assessment of ZrO2–CaO/PMMA hybrid biocomposite withmulti-walled carbon nanotube reinforcement for enhanced bonereconstruction HFME Ali A. Al-Allaq,Prof. Dr.Jenan S. kasha, Ahmad Umar, Sotirios Baskoutas InternatIonal Journal of PolymerIc materIals and PolymerIc BIomaterIals, 1-11 , 2024 2024
Synthesis and characterization of nano-biocomposite (PMMA-hydroxyapatite - CaZrO3) for bone tissue engineering AAA Hassan Fouad Mohamed Elsayed,Jenan S. Kashan Polymer-Plastics Technology and Materials 63, 1-10 , 2024 2024 Citations: 6
Effect of Multi-Walled Carbon Nanotube on the Microstructure, Physical and Mechanical Properties of ZrO2–CaO/Poly(methyl methacrylate) Biocomposite for Bone Reconstruction … HFME Jenan S. Kashan, Ali A. Al-allaq Science of Advanced Materials 15 (3), 285–318 , 2023 2023
Effect of multi-walled carbon nanotube on the microstructure, physical and mechanical properties of ZrO2–CaO/Poly (methyl methacrylate) biocomposite for bone reconstruction … JS Kashan, AA Al-Allaq, H Fouad, ME Yahia Science of Advanced Materials 15 (3), 405-411 , 2023 2023 Citations: 13
A review: In vivo studies of bioceramics as bone substitute materials AA Al‐allaq, JS Kashan Nano Select 4 (2), 123-144 , 2023 2023 Citations: 31
Preparation and characterization of MWCNTs to Reinforce Nano Bio composite as Bone substitute AA Al-allaqa, J Sattar Department of Biomedical Engineering Faculty of Engineering, Helwan University , 2022 2022 Citations: 3
HA/HDPE Reinforced with MWCNTs for Bone Reconstruction and Replacement Application AMS Ali A. Al-allaq , Jenan S. Kashan , Mohamed T. El-Wakad MATERIALE PLASTICE 59 (1), 109-121 , 2022 2022 Citations: 5
EVALUATION OF A HYBRID BIOCOMPOSITE OF HA/HDPE REINFORCED WITH MULTI-WALLED CARBON NANOTUBES (MWCNTs) AS A BONE-SUBSTITUTE MATERIAL AMS Ali A. Al-allaq , Jenan S. Kashan , Mohamed T. El-Wakad Materials and Technology 55 (5), 673-680 , 2021 2021 Citations: 12
MOST CITED SCHOLAR PUBLICATIONS
A review: In vivo studies of bioceramics as bone substitute materials AA Al‐allaq, JS Kashan Nano Select 4 (2), 123-144 , 2023 2023 Citations: 31
The hydrodynamic squeeze film lubrication of the ankle joint AE Yousif, AA Al-allaq International Journal of Mechanical Engineering and Applications 1 (2), 34-42 , 2013 2013 Citations: 17
In vivo investigations of polymers in bone tissue engineering: a review study A A. Al-allaq, JS Kashan, FM Abdul-Kareem International Journal of Polymeric Materials and Polymeric Biomaterials 73 … , 2024 2024 Citations: 15
Multiwall carbon nanotube reinforced HA/HDPE biocomposite for bone reconstruction AMS Ali A. Al-allaq , Jenan S. Kashan , Mohamed T. El-Wakad Periodicals of Engineering and Natural Sciences 9 (2), 930-939 , 2021 2021 Citations: 14
Review of in vivo investigations on metal implants for bone tissue engineering AA Al-allaq, JS Kashan, FM Abdul-Kareem, AM Alani Regenerative Engineering and Translational Medicine 11 (1), 132-156 , 2025 2025 Citations: 13
Effect of multi-walled carbon nanotube on the microstructure, physical and mechanical properties of ZrO2–CaO/Poly (methyl methacrylate) biocomposite for bone reconstruction … JS Kashan, AA Al-Allaq, H Fouad, ME Yahia Science of Advanced Materials 15 (3), 405-411 , 2023 2023 Citations: 13
EVALUATION OF A HYBRID BIOCOMPOSITE OF HA/HDPE REINFORCED WITH MULTI-WALLED CARBON NANOTUBES (MWCNTs) AS A BONE-SUBSTITUTE MATERIAL AMS Ali A. Al-allaq , Jenan S. Kashan , Mohamed T. El-Wakad Materials and Technology 55 (5), 673-680 , 2021 2021 Citations: 12
The bio-composites (Hydroxyapatite/High-density polyethylene) materials reinforced with Multi-walled carbon nanotubes for bone tissue repair AA Al-allaqa, JS Kashanc, MT El-Wakadd, AM Solimanb Journal of Ceramic Processing Research 22 (4), 446-454 , 2021 2021 Citations: 12
Synthesis and characterization of nano-biocomposite (PMMA-hydroxyapatite - CaZrO3) for bone tissue engineering AAA Hassan Fouad Mohamed Elsayed,Jenan S. Kashan Polymer-Plastics Technology and Materials 63, 1-10 , 2024 2024 Citations: 6
HA/HDPE Reinforced with MWCNTs for Bone Reconstruction and Replacement Application AMS Ali A. Al-allaq , Jenan S. Kashan , Mohamed T. El-Wakad MATERIALE PLASTICE 59 (1), 109-121 , 2022 2022 Citations: 5
Numerical Study of the Effects of Aneurysm and Stenosis in the Left Coronary Artery on the Human Blood Stream AAA Nabeel Sameer Engineering and Technology Journal 35 (1 Part A) , 2017 2017 Citations: 4
Development and characterization of poly (methyl methacrylate)/hydroxyapatite bio-composites treated with antimicrobial agent as a bone analogue material AA Allaq, JS Kashan, AI Mahmood, FM Abdul-Kareem Materials and Technology 59 (2), 315–323-315–323 , 2025 2025 Citations: 3
Preparation and characterization of MWCNTs to Reinforce Nano Bio composite as Bone substitute AA Al-allaqa, J Sattar Department of Biomedical Engineering Faculty of Engineering, Helwan University , 2022 2022 Citations: 3
Effective Approaches to Cancer Therapies Based on Biomechanics and Pathology: Review Study AAA allaq Regenerative Engineering and Translational Medicine 11 (3), 22 , 2025 2025 Citations: 1
Toward Smart Bone Healing: A Review of In Vivo Evidence and Translational Perspectives on Bioelectronic Scaffolds and Piezoelectric Biomaterials AAAJSKH Fouad International Journal Of Engineering And Computer Science 14 (11), 27857-27872 , 2025 2025 Citations: 1
A Study on the In Vivo Bioactivity of Nano-Biocomposite for Bone Tissue Engineering AM Alani, TS Mohammed Hasan, FN Noori, JS Kashan, AA Al-allaq Regenerative Engineering and Translational Medicine, 1-10 , 2025 2025 Citations: 1
International journal of polymeric materials and polymeric biomaterials JS Kashan, AA Al-Allaq, A Umar, S Baskoutas, H Fouad International Journal of Polymeric Materials and Polymeric Biomaterials … , 2024 2024 Citations: 1
The computational fluid dynamic simulations for Gangrene disease in diabetic foot AA Al-allaq Al-Khwarizmi Engineering Journal 13 (4), 111-123 , 2017 2017 Citations: 1
In Vivo Investigations of Bone Plates: A Review study A Al-allaq International Journal of Engineering and Computer Science 15 (3), 31 , 2026 2026
Advances Toward In Vivo Cartilage Repair: A Comprehensive Review of Current Strategies and Future Directions AA Al-Allaq, AA Abdulhakeem, JK Hammood, H Fouad Recent Progress in Materials 8 (2), 1-22 , 2026 2026