Prof. Jaya Dwivedi
Verified @yahoo.co.in
Professor and Department of Chemistry
Banasthali Vidyapith
RESEARCH INTERESTS
Organic synthesis, Material development
Scopus Publications
Scopus Publications
Shivangi Jaiswal, Kanika Verma, Jaya Dwivedi, and Swapnil Sharma
Elsevier BV
Nirmala Kumari Jangid, Swati Kaliraman, Agrima Singh, Anamika Srivastava, Manish Srivastava, Sapana Jadoun, Jaya Dwivedi, and Navjeet Kaur
Elsevier BV
Saraswati Patel, Sonika Jain, Ritika Gururani, Swapnil Sharma, and Jaya Dwivedi
Springer Science and Business Media LLC
Neetu Yaduvanshi, Sanjana Tewari, Shivangi Jaiswal, Meenu Devi, Shruti Shukla, Jaya Dwivedi, and Swapnil Sharma
Elsevier BV
Priyanka Joshi, Saraswati Patel, Ajita Paliwal, Smita Jain, Kanika Verma, Jaya Dwivedi, and Swapnil Sharma
Elsevier BV
Diksha Bareth, Sonika Jain, Jyoti Kumawat, Dharma Kishore, Jaya Dwivedi, and Sonia Zeba Hashmi
Elsevier BV
Jyoti Kaushik, Sonika Jain, Prerna Malik, Jyoti Kumawat, Pankaj Jain, Dharma Kishore, and Jaya Dwivedi
Wiley
AbstractBeckmann rearrangement has been quite successful in the preparation of many medicinally potent scaffolds. In synthetic organic chemistry, the Beckmann rearrangement is quite popular, caprolactam is synthesized from cyclohexanone oxime on a large scale for Nylon‐6 production. The function of numerous catalysts and media in the Beckmann rearrangement has been discussed in depth in this review. In the last 20 years, Beckmann rearrangement catalysis has evolved from a potentially hazardous to a more environmentally friendly catalyst, as a result of greater usage. Catalytic performance and synthetic performance of various catalytic systems have been re‐evaluated in the present review article.
Sanjana Tewari, Neha Singh, Jaya Dwivedi, and Nalini Sankararamakrishnan
Springer Science and Business Media LLC
Vijayendra Kumar Tripathi, Jaya Dwivedi, Manish Srivastava, Lokesh Kumar Jangir, and Kumud Malika Tripathi
Elsevier
Jyoti Kaushik, Sonika Jain, Dharma Kishore, and Jaya Dwivedi
Wiley
AbstractN‐Heterocyclic compounds have been appealing pharmacophores in their use as drug production substrates. In this review paper, the cyclization of N‐heterocycles, using iron as a catalyst, and their mechanistic pathways have been highlighted and presented comprehensively. This paper will provide researchers with in‐depth knowledge of their approach to synthesis by employing a greener way rather than a conventional one. The present review firmly establishes that iron catalysts by their innate ability and inherent potential to acquire the four oxidation states coupled with their easy accessibility, inexpensive, and environment‐friendly nature have remained the mainstay in chemistry as the evergreen catalyst in the domain of organic synthesis. This review paper extensively explores iron‐catalyzed cyclization of N‐heterocycles, elucidating mechanistic pathways and emphasizing greener synthesis methods. Iron's versatility, accessibility, and eco‐friendliness solidify its position as a cornerstone in organic synthesis.
Vijayendra Kumar Tripathi, Manish Shrivastava, Jaya Dwivedi, Raju Kumar Gupta, Lokesh Kumar Jangir, and Kumud Malika Tripathi
Royal Society of Chemistry (RSC)
This review article provides a detailed overview of the synthesis techniques of biomass-based graphene aerogels and highlights the influence of fabrication parameters on the performance of the resulting aerogels for wastewater treatment applications.
Shivangi Jaiswal, Jaya Dwivedi, Dharma Kishore, and Swapnil Sharma
Bentham Science Publishers Ltd.
Abstract: Tetrazole is a most versatile pharmacophore of which more than twenty FDAapproved drugs have been marketed globally for the management of various diseases. In spite of many remarkable and consistent efforts having been made by the chemists towards the development of greener and sustainable strategies for the synthesis of tetrazole derivatives, this approach still needs more attention. The present review focuses on the green synthetic approach for the preparation of tetrazole derivatives from different starting materials such as nitrile, isonitrile, carbonyl, amine, amide, oxime and terminal alkyne functions. The mechanism of tetrazole synthesis from different substrates is discussed. In addition to this, a four component Ugi-azide reaction to the tetrazole synthesis is also described. Of note, the present articles exploited several water-mediated and solvent-free methodologies for tetrazole synthesis. The important key features of tetrazole synthesis were pinpointing in each synthetic scheme which provides excellent guide to those searching for selective procedure to achieve the desired transformation. This review seeks to present a timely account (2011-2023) on the splendid array of ecofriendly procedures of synthesis known today for the preparation of tetrazole derivatives from different starting materials. The rational of this review is to enlighten recent advancements in the synthesis of tetrazole derivatives from different substrates.
Smita Jain, Swapnil Sharma, Ajita Paliwal, Jaya Dwivedi, Shailendra Paliwal, Vartika Paliwal, Sarvesh Paliwal, and Jaiprakash Sharma
Springer Science and Business Media LLC
Shivangi Jaiswal, Nikhilesh Arya, Neetu Yaduvanshi, Meenu Devi, Sonika Jain, Smita Jain, Jaya Dwivedi, and Swapnil Sharma
Elsevier BV
Neetu Yaduvanshi, Meenu Devi, Sanjana Tewari, Shivangi Jaiswal, Sonia Zeba Hashmi, Shruti Shukla, Jaya Dwivedi, and Swapnil Sharma
Elsevier BV
Gouri Sankar Das, Vijayendra Kumar Tripathi, Jaya Dwivedi, Lokesh Kumar Jangir, and Kumud Malika Tripathi
Royal Society of Chemistry (RSC)
Smart biocomposites with integrated nano-carbons based sensors for structural health monitoring advances the real-world applications.
Priyanka Joshi, Kanika Verma, Deepak Kumar Semwal, Jaya Dwivedi, and Swapnil Sharma
Wiley
AbstractCancer is the world's second leading cause of mortality and one of the major public health problems. Cancer incidence and mortality rates remain high despite the great advancements in existing therapeutic, diagnostic, and preventive approaches. Therefore, a quest for less toxic and more efficient anti‐cancer strategies is still at the forefront of the current research. Traditionally important, curcumin commonly known as a wonder molecule has received considerable attention as an anti‐cancer, anti‐inflammatory, and antioxidant candidate. However, limited water solubility and low bioavailability restrict its extensive utility in different pathological states. The investigators are making consistent efforts to develop newer strategies to overcome its limitations by designing different analogues with better pharmacokinetic and pharmacodynamic properties. The present review highlights the recent updates on curcumin and its analogues with special emphasis on various mechanistic pathways involved in anti‐cancer activity. In addition, the structure–activity relationship of curcumin analogues has also been precisely discussed. This article will also provide key information for the design and development of newer curcumin analogues with desired pharmacokinetic and pharmacodynamic profiles and will provide in depth understanding of molecular pathways involved in the anti‐cancer activities.
Ritika Gururani, Saraswati Patel, Akansha Bisht, Smita Jain, Sarvesh Paliwal, Jaya Dwivedi, and Swapnil Sharma
Wiley
BACKGROUND
Tylophora indica (Burm. f.) Merr is a climbing perennial plant reported in Indian traditional system of medicine for its use in allergy and asthma. However, only few scientific studies have been performed in the past to validate its antiasthmatic potential.
OBJECTIVES
The present study deals with investigation of airway smooth muscle relaxant and antiasthmatic potential of extract and subsequent fractions prepared from T. indica.
METHODS
The most active fraction of T. indica leaves selected through bio-guided activity was subjected to liquid chromatography-mass spectrometry (LC-MS) analysis for chemical profiling. The binding affinity of identified compounds in fraction towards M3 and H1 receptors was determined by molecular docking study. F-2 (chloroform fraction prepared from methanolic extract of T. indica leaves) was examined for its smooth muscle relaxant properties using isolated trachea of guinea-pig. Further, F-2 was evaluated through in vivo studies employing ovalbumin-induced asthma model in guinea-pigs.
RESULTS
F-2 was found most effective in bioassay-guided fractionation. Characterization by LC-MS analysis revealed presence of five major bioactive compounds in F-2 that showed good docking interactions with M3 and H1 receptors. The ex vivo study demonstrated that F-2 could significantly relax tracheal rings via targeting multiple signalling pathways videlicet, namely, noncompetitive antagonism of the histamine and muscarinic receptors, β2-adrenergic stimulation and activation of soluble guanylyl cyclase. In in vivo studies, F-2 ameliorated airway hyperresponsiveness and decreased broncho alveolar lavage fluid (BALF) levels of inflammatory cytokines and immunoglobulin E (IgE).
CONCLUSION
These results confirm the traditional use of T. indica as an antiasthmatic agent which are evidenced through ex vivo, in silico and in vivo studies.
Jigar Panchal, Shivangi Jaiswal, Sonika Jain, Jyoti Kumawat, Ashima Sharma, Pankaj Jain, Smita Jain, Kanika Verma, Jaya Dwivedi, and Swapnil Sharma
Elsevier BV
Anjali Yadav, Sapna Raghav, Nirmala Kumari Jangid, Anamika Srivastava, Sapana Jadoun, Manish Srivastava, and Jaya Dwivedi
MDPI AG
Heavy metal contamination in water resources is a major issue worldwide. Metals released into the environment endanger human health, owing to their persistence and absorption into the food chain. Cadmium is a highly toxic heavy metal, which causes severe health hazards in human beings as well as in animals. To overcome the issue, current research focused on cadmium ion removal from the polluted water by using porous magnetic chitosan composite produced from Kaphal (Myrica esculenta) leaves. The synthesized composite was characterized by BET, XRD, FT-IR, FE-SEM with EDX, and VSM to understand the structural, textural, surface functional, morphological-compositional, and magnetic properties, respectively, that contributed to the adsorption of Cd. The maximum Cd adsorption capacities observed for the Fe3O4 nanoparticles (MNPs) and porous magnetic chitosan (MCS) composite were 290 mg/g and 426 mg/g, respectively. Both the adsorption processes followed second-order kinetics. Batch adsorption studies were carried out to understand the optimum conditions for the fast adsorption process. Both the adsorbents could be regenerated for up to seven cycles without appreciable loss in adsorption capacity. The porous magnetic chitosan composite showed improved adsorption compared to MNPs. The mechanism for cadmium ion adsorption by MNPs and MCS has been postulated. Magnetic-modified chitosan-based composites that exhibit high adsorption efficiency, regeneration, and easy separation from a solution have broad development prospects in various industrial sewage and wastewater treatment fields.
Priyanka Joshi, Akansha Bisht, Ajita Paliwal, Jaya Dwivedi, and Swapnil Sharma
Wiley
AbstractCurcumin, a natural polyphenol, derived from Curcuma longa L. is extensively studied by various researchers across the globe and has established its immense potential in the management of several disorders at clinical level. The underlying mechanism of curcumin involves regulation of various molecular targets, namely, inflammatory cytokines, transcription factor, apoptotic genes, growth factors, oxidative stress biomarkers, and protein kinases. In clinical trials, curcumin as an adjuvant has significantly boost‐up the efficacy of many proven drugs in the management of arthritis, neurodegenerative disorder, oral infection, and gastrointestinal disorders. Moreover, clinical studies have suggested curcumin as an appropriate candidate for the prevention and/or management of various cancers via regulation of signaling molecules including NF‐kB, cytokines, C‐reactive protein, prostaglandin E2, Nrf2, HO‐1, ALT, AST, kinases, and blood profiles. This article highlights plethora of clinical trials that have been conducted on curcumin and its derivatives in the management of several ailments. Besides, it provides recent updates to the investigators for conducting future research to fulfill the current gaps to expedite the curcumin utility in clinical subjects bearing different pathological states.
Akansha Bisht, Shruti Richa, Shivangi Jaiswal, Jaya Dwivedi, and Swapnil Sharma
CRC Press
Meenu Devi, Shivangi Jaiswal, Neetu Yaduvanshi, Sonika Jain, Smita Jain, Kanika Verma, Rahul Verma, Dharma Kishore, Jaya Dwivedi, and Swapnil Sharma
Elsevier BV
Gitanjali Arora, Nirmala Kumari Jangid, Anamika Srivastava, Jaya Dwivedi, Manish Srivastava, and Shruti Shukla
American Chemical Society (ACS)
Kanika Verma, Ritika Jaiswal, Sarvesh Paliwal, Jaya Dwivedi, and Swapnil Sharma
Wiley
Akt, a known serine/threonine‐protein kinase B has been revealed to be an imperative protein of the PI3K/Akt pathway. Akt is available in three isoforms, Akt1, Akt2, and Akt3. Ubiquitously expressed Akt1 & Akt2 are essential for cell survival and are believed to be involved in regulating glucose homeostasis. PI3K/Akt pathway has been evidenced to be associated with metabolic diseases viz. hypertension, dyslipidemia, and diabetes. Akt interacting proteins have been revealed to be scaffold proteins of the PI3K/Akt pathway. Notably, some protein–protein interactions are imperative for the inhibition or uncontrolled activation of these signaling pathways. For instance, Akt interacting protein binds with other protein namely, FOXO1 and mTOR, and play a key role in the onset and progression of metabolic syndrome (MS). The purpose of this review is to highlight the role of the PI3K/Akt pathway and associated protein–protein interactions which might serve as a valuable tool for investigators to develop some new promising therapeutic agents in the management of MS.