Dr. Nabakumar Pramanik
@nitap.ac.in
Associate Professor in Chemistry, Department of Basic and Applied Science, National Institute of Technology (NIT), Arunachal Pradesh
Jote-791113, Itanagar, Dist- Papum Pare, Arunachal Pradesh, India
Dr. Nabakumar Pramanik received his PhD from the Indian Institute of Technology (IIT) Kharagpur, India, in Chemistry in 2009. After that, he worked as Research Associate (RA) in Materials Science Centre, IIT Kharagpur for the duration 2009 to 2010. Afterward, he served as a Postdoctoral Research Associate (PDF) at the National Taiwan University of Science and Technology (NTUST), Taipei, Taiwan, for the duration 2010 to 2011. He has published many scientific papers in various international journals of repute. His research work has also been presented at various national and international conferences. He is the receiver of different prestigious Academic Accreditations, Recognitions, Fellowships, Awards, etc. from various organizations/professional bodies. He is a life member of different professional scientific bodies. Presently he is serving as an Associate Professor in the discipline of Chemistry under the Department of Basic and Applied Science, NIT, Arunachal Pradesh, India.
EDUCATION
1. Postdoc (PDF) in Applied Science and Technology, National Taiwan University of Science and Technology (NTUST), Taiwan, 2011.
2. Doctorate (PhD) in Chemistry, Indian Institute of Technology (IIT), Kharagpur, India, 2009.
3. Master (M. Sc) in Applied Chemistry, Indian Institute of Engineering Science and Technology (IIEST), Shibpur, India, 2003.
RESEARCH INTERESTS
Nanomaterials, Biomaterials, Biopolymers, Ceramic-polymer composites, Nanocomposites, and Calcium Phosphate based composites for biomedical applications
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Abinash Das, Togam Ringu, Sampad Ghosh, and Nabakumar Pramanik
Wiley
AbstractOsteomyelitis (OM), a debilitating disease caused by a microbial infection of the bones, continues to pose a formidable obstacle for orthopedic surgeons. The conventional methods for the prevention and treatment of OM are insufficient. In this research work, we developed a strategic green nanostructure using the antifungal drug Fluconazole (FCZ)‐assimilated zinc oxide nanoparticles (ZnO‐NPs) and hydroxyapatite (HAp) nanostructures as filler and hydrophobic polycaprolactone (PCL) as matrix by a solution‐based chemical method. The ceramic carrier‐like nanostructures ZnO and HAp were synthesized by the in situ precipitation method. The physicochemical characterization of the prepared polymer‐coated drug ceramic nanocomposite (FCZ‐ZnO‐HAp‐PCL) was achieved using Fourier transform infrared spectroscopy (FTIR), Field Emission Scanning Electron Microscopy (FESEM), particle size distribution (PSD), X‐ray diffraction (XRD), and Energy‐dispersive X‐ray (EDX) analysis. Furthermore, the biocompatibility and anticancer activity of the nanocomposite were explored by an MTT assay study. Successfully synthesized FCZ‐ZnO‐HAp‐PCL nanocomposite exhibited profound antimicrobial activity against targeted microbe species and potential cytotoxicity towards MCF‐7 human breast adenocarcinoma cell lines, which may be potentially used for the treatment of OM and prospective infections.
Abinash Das, Togam Ringu, Sampad Ghosh, and Nabakumar Pramanik
Wiley
AbstractNanotechnology, a versatile field, holds promise in diverse applications, such as advanced pharmaceutical techniques and innovative chemical compound fabrication. Recently, the World Health Organization (WHO) has identified sepsis as a global health priority, attributing most sepsis‐related deaths to the underlying infection. Sepsis is a complex disease that manifests in various ways, depending on factors, such as pathogen involved, mode of transmission, and the patient's immune competence. This study focuses on synthesizing zinc oxide (ZnO) through an in‐situ precipitation method and employing a solution‐based technique to coat the inorganic ZnO nanomaterial with the antimicrobial drug fluconazole (FLZ), resulting in a FLZ‐ZnO composite. Further enhancement is achieved by modifying the composite with poly(vinyl alcohol) (PVA) to improve mechanical strength, physicochemical characteristics, and the interfacial network between ZnO and FLZ. Characterization through X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), particle size distribution (PSD), and thermo gravimetric analysis (TGA) confirms the synthesized compounds are stoichiometric in nature. The FLZ‐ZnO‐PVA nanocomposite demonstrates significant antifungal activity against C. albicans and A. niger, as well as enhanced antibacterial activity against E. coli and S. aureus evaluated through well diffusion technique. In vitro cellular compatibility assessment using the MTT assay with NIH‐3T3 cells reveals exceptional viability (above 75%) and negligible cytotoxicity at a concentration of 1.56 μg/mL, indicating high biosafety. The FLZ‐ZnO‐PVA nanocomposite exhibits outstanding biological performance, making it a promising candidate for clinical applications in preventing sepsis and prospective infections.Highlights Developments and preparation of FLZ‐ZnO‐PVA nanocomposite. FLZ‐ZnO‐PVA nanocomposite shows optimum antimicrobial activity. FLZ‐ZnO‐PVA shows cytotoxicity against the mouse embryonic fibroblast cell line. FLZ‐ZnO‐PVA could be used as a suitable material for treatment of sepsis.
Abinash Das, Togam Ringu, Sampad Ghosh, and Nabakumar Pramanik
Elsevier BV
Abinash Das, Togam Ringu, Sampad Ghosh, and Nabakumar Pramanik
Springer Science and Business Media LLC
Abinash Das, Sampad Ghosh, Togam Ringu, and Nabakumar Pramanik
Springer Science and Business Media LLC
Nabakumar Pramanik, Rajeev Kumar, Anirban Ray, Vinay Kumar Chaudhary, and Sampad Ghosh
Springer Science and Business Media LLC
Togam Ringu, Sampad Ghosh, Abinash Das, and Nabakumar Pramanik
Springer Science and Business Media LLC
Mini Loya, Nabakumar Pramanik, Pallab Pahari, and Ananta Kumar Atta
Elsevier BV
Sampad Ghosh, Anirban Ray, and Nabakumar Pramanik
Elsevier BV
Saikat Ghosh, Sampad Ghosh, and Nabakumar Pramanik
Springer Science and Business Media LLC
Samiul Islam Hazarika, Goutam Mahata, Pallab Pahari, Nabakumar Pramanik, and Ananta Kumar Atta
Elsevier BV
Saikat Ghosh, Rathnakaram Siva Kumar Raju, Nilanjana Ghosh, Koel Chaudhury, Sampad Ghosh, Indranil Banerjee, and Nabakumar Pramanik
Elsevier BV
Bholanath Dolai, Atanu Bhaumik, Nabakumar Pramanik, Kalyan Sundar Ghosh, and Ananta Kumar Atta
Elsevier BV
Saikat Ghosh, Sampad Ghosh, Ananta Kumar Atta, and Nabakumar Pramanik
American Scientific Publishers
Sampad Ghosh, Anirban Ray, Nabakumar Pramanik, and Balram Ambade
Elsevier BV
Nabakumar Pramanik and Toyoko Imae
American Chemical Society (ACS)
A successful synthesis of mesostructured hydroxyapatite (HAp) using cetyltrimethylammonium bromide and poly(amido amine) dendrimer porogens has been reported. A comparative study of physicochemical properties has also been performed. The formation of a single-phase hydroxyapatite crystal in synthesized HAp particles with an aspect ratio of 2.3 was revealed. The formation of the mesostructural nature of HAp was proven with a specific surface area (56-63 m(2)/g) and a certain pore size (4.7-5.5 nm), although there were significant differences between particles from surfactant micelle and dendrimer porogens. In addition, the surface modification of mesoporous HAp particles was carried out using poly(amido amine) dendrimer. The content and thickness of the dendrimer coating on particle surfaces were highly dependent on the pH. At pH 9 or greater, the coating thickness corresponded to at least a double layer of dendrimer, but it decreased sharply with decreasing pH from 9 to 6, in agreement with the protonation of amine groups in the dendrimer, indicating the strong interaction of nonionic dendrimer with HAp. The developed dendrimer-functionalized mesoporous hydroxyapatite materials may be applicable in biocomposite material and/or bone tissue engineering.
S. Bose, N. Pramanik, C.K. Das, A. Ranjan, and A.K. Saxena
Elsevier BV
Nabakumar Pramanik, Sasmita Mohapatra, Parag Bhargava, and Panchanan Pramanik
Elsevier BV
Soumya K. Biswas, A. Pathak, N.K. Pramanik, D. Dhak, and P. Pramanik
Elsevier BV
Nabakumar Pramanik, Sasmita Mohapatra, Sarfaraz Alam, and Panchanan Pramanik
Wiley
Hydroxyapatite (HAp)/poly(vinyl alcohol phosphate) (PVAP) nanocomposite has been prepared using a solution-based method varying HAp from 10 to 60% (w/w). X-ray diffraction, Fourier transform infrared absorption spectra (FTIR), and thermal analysis have indicated the presence of bonding between HAp particles and PVAP matrix. Transmission electron microscope analysis shows the needle-like crystals of HAp powder having a diameter of 6–10 nm and a length of 26–38 nm. The surface roughness and the homogeneous dispersion of HAp particles in the polymer matrix have been observed by scanning electron microscopy. Particle size distribution analysis shows the narrow distribution of hydrodynamic particles in the polymer matrix. The tensile stress–strain curves show the improvement in mechanical properties of the composites with increase in amount of HAp particles loading. The composites along with polymer are highly hemocompatible. The use of PVAP promotes the homogeneous distribution of particles on the polymer matrix along with strong particle–polymer interfacial bonding, which has supported the improvement in mechanical properties of the composites. The prepared HAp/PVAP composite with uniform microstructure would be effective to act as a potential biomaterial. POLYM. COMPOS., 2008. © 2008 Society of Plastics Engineers
Nabakumar Pramanik, Soumya Kanti Biswas, and Panchanan Pramanik
Wiley
A hydroxyapatite (HAp)/poly(vinyl alcohol phosphate) (PVAP) nanocomposite has been prepared by a chemical method by varying the HAp content by 10-60% (w/w). The bonding between HAp and PVAP has been investigated through Fourier transform infrared absorption spectra, X-ray diffraction, and thermogravimetric analyses. Transmission electron microscopy study shows a homogeneous dispersion of nanoparticles in the polymer matrix. Scanning electron microscopy study shows enhancement of the surface roughness of the composite with an increase in the nanoparticle content. The mechanical properties of the composites improve significantly with an increase in the HAp content. The HAp/PVAP nanocomposite prepared may have bone-implant applications.
Sasmita Mohapatra, Nabakumar Pramanik, Samrat Mukherjee, Sudip K. Ghosh, and Panchanan Pramanik
Springer Science and Business Media LLC
Nabakumar Pramanik, Abhijit Tarafdar, and Panchanan Pramanik
Elsevier BV
Nabakumar Pramanik, Sasmita Mohapatra, Panchanan Pramanik, and Parag Bhargava
Wiley
A hydroxyapatite/poly(ethylene-co-acrylic acid) (HAp/EAA) nanocomposite has been synthesized by a solution-based method. p-Aminophenyl phosphonic acid has been used as a coupling agent in order to enhance the bonding between HAp and EAA, and hence to improve the mechanical properties of the composite. XRD study has indicated the development of compressive and tensile stresses in a nanocomposite due to thermal expansion mismatch between nano-hydroxyapatite (n-HAp) and EAA. Fourier-transform infrared spectrometry (FTIR) and thermal analysis have shown the presence of strong interfacial bonding between n-HAp and EAA. The surface roughness and the homogeneous dispersion of nanoparticles have been observed by field emission scanning electron microscopy (FESEM). A comparison of mechanical properties between phosphonic acid treated (cn-HAp/EAA) and untreated (un-HAp/EAA) nanocomposites has been made. The use of a phosphonic acid coupling agent promotes the uniform dispersion of n-HAp in the polymer matrix with a strong nanoparticle-polymer interfacial bonding, which provides a means of preparing a HAp/polymer nanocomposite for implant applications.
Nabakumar Pramanik, Parag Bhargava, S. Alam, and Panchanan Pramanik
Wiley
Hydroxyapatite (HAp)/poly(ethylene-co-acrylic acid) composites have been synthesized by a solution-based method, using nanosized (n-HAp) and coarse hydroxyapatite (c-HAp) particles, respectively. X-ray diffraction study has indicated the development of compressive and tensile stresses in composites because of the thermal expansion mismatch between the particles and polymer matrix. Fourier transform infrared absorption spectra and thermal analysis have showed the presence of strong interfacial bonding between the particles and polymer. The surface roughness and the homogeneous dispersion of HAp particles in the polymer matrix have been observed by scanning electron microscopy. A comparison in mechanical properties between composites prepared with n-HAp and c-HAp particles, respectively, has been studied. Nanosized particles contribute excellent improvement of mechanical properties of the composites rather than the coarse particles. The uniform dispersion of HAp particles, followed by the improvement in mechanical properties of the composite, provides a means of preparing HAp/polymer composites for low load-bearing implant applications. POLYM. COMPOS., 27:633–641, 2006. © 2006 Society of Plastics Engineers