Tatiane Nassar Britos

@unifesp.br

Instituto de Ciências Ambientais, Químicas e Farmacêuticas
Universidade Federal de São Paulo

Tatiane Nassar Britos


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https://researchid.co/tatianebritos
10

Scopus Publications

107

Scholar Citations

6

Scholar h-index

4

Scholar i10-index

Scopus Publications

  • Synthesis, Characterization, and Toxicity Assessment of Superparamagnetic Iron Oxide Nanoparticles Coated with Antitumor Molecules
    Camila Chagas, Emerson B. da Silva, Beatriz da C. A. Alves, Glaucia L. da Veiga, Edimar C. Pereira, et al.
    ACS Omega, 2025
  • Superparamagnetic nanoparticles as potential drug delivery systems for the treatment of Duchenne muscular dystrophy
    Maria L. Schumacher, Tatiane N. Britos, Fernando L. A. Fonseca, Fabio F. Ferreira, David Feder, et al.
    Nanoscale, 2024
    This study aims to use superparamagnetic iron oxide nanoparticles (SPIONs), specifically magnetite (Fe3O4), to deliver deflazacort (DFZ) and ibuprofen (IBU) to Duchenne muscular dystrophy-affected (DMD).
  • A review of superparamagnetic nanoparticles applications and regulatory aspects in medicine and environmental areas
    Danilo W. Losito, Nicole I. N. Souza, Tereza S. Martins, Tatiane N. Britos, Maria L. Schumacher, et al.
    Journal of Materials Science, 2024
  • In vitro results with minimal blood toxicity of a combretastatin A4 analogue
    Camila Chagas, Jaqueline Vital Mansano, Emerson Barbosa da Silva, Giuliana Petri, Beatriz da Costa Aguiar Alves Reis, et al.
    Investigational New Drugs, 2024
  • Antioxidant action of L-cysteine anchored on the surface of magnetite nanoparticles
    Tatiane Britos, Nicole Santana, Maria Lucia Schumacher, Emerson Barbosa, Ariane de Espindola, et al.
    Next Nanotechnology, 2024
  • Potential Use of DMSA-Containing Iron Oxide Nanoparticles as Magnetic Vehicles against the COVID-19 Disease
    Elisama S. Martins, Ariane Espindola, Tatiane N. Britos, Camila Chagas, Emerson Barbosa, et al.
    Chemistryselect, 2021
    Iron oxide magnetic nanoparticles have been employed as potential vehicles for a large number of biomedical applications, such as drug delivery. This article describes the synthesis, characterization and in vitro cytotoxic in COVID‐19 cells evaluation of DMSA superparamagnetic iron oxide magnetic nanoparticles. Magnetite (Fe3O4) nanoparticles were synthesized by co‐precipitation of iron salts and coated with meso‐2,3‐dimercaptosuccinic acid (DMSA) molecule. Structural and morphological characterizations were performed by X‐ray diffraction (XRD), Fourier transformed infrared (FT‐IR), magnetic measurements (SQUID), transmission electron microscopy (TEM), and dynamic light scattering (DLS). Our results demonstrate that the nanoparticles have a mean diameter of 12 nm in the solid‐state and are superparamagnetic at room temperature. There is no toxicity of SPIONS‐DMSA under the cells of patients with COVID‐19. Taken together the results show that DMSA‐ Fe3O4 are good candidates as nanocarriers in the alternative treatment of studied cells.
  • In vivo evaluation of thiol-functionalized superparamagnetic iron oxide nanoparticles
    Tatiane N. Britos, Carlos E. Castro, Bruno M. Bertassoli, Giuliana Petri, Fernando L.A. Fonseca, et al.
    Materials Science and Engineering C, 2019
  • Preparation, Characterization and Tests of Incorporation in Stem Cells of Superparamagnetic Iron Oxide
    P S Haddad, T N Britos, L M Li, L D S Li
    Journal of Physics Conference Series, 2015
    Superparamagnetic iron oxide nanoparticles (SPIONs) have been produced and used as contrast-enhancing agents in magnetic resonance imaging (MRI) for diagnostic use in a wide range of maladies including cardiovascular, neurological disorders, and cancer. The reasons why these SPIONs are attractive for medical purposes are based on their important and unique features. The large surface area of the nanoparticles and their manipulation through an external magnetic field are features that allow their use for carrying a large number of molecules such as biomolecules or drugs. In this scenario, the present work reports on the synthesis and characterization of SPIONs and in vitro MRI experiments to increase their capacity as probes for MRI applications on stem cells therapy. Initially, the SPIONs were prepared through the co-precipitation method using ferrous and ferric chlorides in acidic solution. The SPIONs were coated with two thiolmolecules such as mercaptosuccinic acid (MSA) and cysteine (Cys) (molar ratio SPIONs:ligand = 1:20), leading to the formation of a stable aqueous dispersion of thiolated nanoparticles (SH-SPIONs). The SH-SPIONs were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM), and vibrating sample magnetometry (VSM). The results showed that the SH-SPIONs have a mean diameter of 14 nm and display superparamagnetic behavior at room temperature. Preliminary tests of incorporation of SH-SPIONs were evaluated stem cells. The results showed that the thiolated nanoparticles have no toxic effects for stem cells and successfully internalized and enhance the contrast in MRI.
  • Synthesis, Characterization and Cytotoxicity Evaluation of Nitric Oxide-Iron Oxide magnetic Nanoparticles
    P S Haddad, T N Britos, M C Santos, A B Seabra, M V Palladino, et al.
    Journal of Physics Conference Series, 2015
    The present work is focused on the synthesis, characterization and cytotoxic evaluation of superparamagnetic iron oxide nanoparticles (SPIONs). SPIONs have been proposed for an increasing number of biomedical applications, such as drug-delivery. To this end, toxicological studies of their potential effects in biological systems must be better evaluated. The aim of this study was to examine the in vitro cytotoxicity of thiolated (SH) and S-nitrosated (S-NO) SPIONs in cancer cell lines. SPIONs were prepared by the coprecipitation method using ferrous and ferric chlorides in aqueous solution. The nanoparticles (Fe3O4) were coated with thiol containing molecule cysteine (Cys) (molar ratio SPIONs:ligand = 1:20), leading to the formation of an aqueous dispersion of thiolated nanoparticles (SH- SPIONs). These particles were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM). The results obtained showed that Cys-SPIONs have a mean diameter of 14 nm at solid state and present super paramagnetic behavior at room temperature. Thiol groups on the surface of the nanoparticles were nitrosated through the addition of sodium nitrite leading to the formation of S-NOCys-SPIONs (S-nitrosated-Cys-SPIONs), which act as spontaneous nitric oxide (NO) donor). The cytotoxicity of thiolated and S-nitrosated nanoparticles was evaluated in acute T cell leukemia (Jurkat cell line) and Lewis lung carcinoma (3LL) cells. The results showed that at low concentrations thiolated (Cys) and S- nitrosated (S-NOCyst) SPIONs display low cytotoxicity in both cell types. However, at higher concentrations, Cys-SPIONs exhibited cytotoxic effects, whereas S-NOCys-SPIONs protected them, and also promoted cell proliferation.
  • Spectroscopy of high lying resonances in 9Be produced with radioactive 8Li beams
    A. Lépine-Szily, E. Leistenschneider, D. R. Mendes, P. Descouvemont, R. Lichtenthäler, et al.
    EPJ Web of Conferences, 2014
    We present the results of the 8Li(p,α)5He and 8Li(p,p)8Li reactions measured at the RIBRAS (Radioactive Ion Beams in Brazil) system. The experiment was realized in inverse kinematics using a thick [CH2]n polyethylene target and an incident 8Li beam, produced by RIBRAS. Using the thick target method, the complete excitation function could be measured between Ecm = 0.2 - 2.1 MeV, which includes the Gamow peak energy region. The excitation function of the 8Li(p,α)5He reaction, populating resonances between 16.888 and 19.0 MeV in 9Be, was obtained[1] and the resonances were fitted using R-matrix calculations. This study shed light on spins, parities, partial widths and isospin values of high lying resonances in 9Be. The measurement of the resonant elastic scattering 8Li(p,p)8Li populating resonances in the same energy region can constrain the resonance parameters. Preliminary results of the elastic scattering are also presented. © Owned by the authors, published by EDP Sciences, 2014.

RECENT SCHOLAR PUBLICATIONS

  • Synthesis, Characterization, and Toxicity Assessment of Superparamagnetic Iron Oxide Nanoparticles Coated with Antitumor Molecules
    C Chagas, EB da Silva, BCA Alves, GL da Veiga, EC Pereira, P Haddad, ...
    ACS omega 10 (17), 17237-17248 , 2025
    2025
    Citations: 1
  • Superparamagnetic nanoparticles as potential drug delivery systems for the treatment of Duchenne muscular dystrophy
    ML Schumacher, TN Britos, FLA Fonseca, FF Ferreira, D Feder, P Fratini, ...
    Nanoscale 17 (7), 3752-3767 , 2025
    2025
    Citations: 8
  • A review of superparamagnetic nanoparticles applications and regulatory aspects in medicine and environmental areas
    DW Losito, NIN Souza, TS Martins, TN Britos, ML Schumacher, ...
    Journal of Materials Science 59 (34), 16038-16068 , 2024
    2024
    Citations: 15
  • In vitro results with minimal blood toxicity of a combretastatin A4 analogue
    C Chagas, JV Mansano, EB da Silva, G Petri, ...
    Investigational New Drugs 42 (3), 318-325 , 2024
    2024
  • Antioxidant action of L-cysteine anchored on the surface of magnetite nanoparticles
    T Britos, N Santana, ML Schumacher, E Barbosa, A de Espindola, ...
    Next Nanotechnology 6, 100076 , 2024
    2024
    Citations: 5
  • Synthesis and characterization of SPIONs functionalized with Cysteine and Glutathione for biomedical applications
    TN Britos, CS Chagas, EB Silva, FLA Fonseca, PSH Ferreira
    Proceedings of the 21. Brazil MRS Meeting, 603-603 , 2023
    2023
  • Potential use of DMSA‐containing iron oxide nanoparticles as magnetic vehicles against the COVID‐19 disease
    ES Martins, A Espindola, TN Britos, C Chagas, E Barbosa, CE Castro, ...
    ChemistrySelect 6 (31), 7931-7935 , 2021
    2021
    Citations: 21
  • Thiolated superparamagnetic nanoparticles as potential biological vehicles
    T Britos, CS Chagas, FF Ferreira, FLA Fonseca, PSH Ferreira
    Proceedings of the 44. annual meeting of the Brazilian society on chemistry … , 2021
    2021
  • Tuning the local structure of SPIONs by PDF
    FF Ferreira, VDN Bezzon, TN Britos, PS Haddad
    Proceedings of the 2021: Brazil MRS Meeting; International Union of … , 2021
    2021
  • In vivo evaluation of thiol-functionalized superparamagnetic iron oxide nanoparticles
    TN Britos, CE Castro, BM Bertassoli, G Petri, FLA Fonseca, FF Ferreira, ...
    Materials Science and Engineering: C 99, 171-179 , 2019
    2019
    Citations: 34
  • Synthesis and characterization of superparamagnetic iron oxide nanoparticles functionalized with cysteine, glutathione and gold for potential biomedical applications
    TN Britos, PS Haddad
    2018
  • Human risk assessment and its application to nanotechnology: A challenge for assessors
    C Emond, TN Britos
    Journal of Physics: Conference Series 617 (1), 012039 , 2015
    2015
    Citations: 3
  • Synthesis, characterization and cytotoxicity evaluation of nitric oxide-iron oxide magnetic nanoparticles
    PS Haddad, TN Britos, MC Santos, AB Seabra, MV Palladino, GZ Justo
    Journal of Physics: Conference Series 617 (1), 012022 , 2015
    2015
    Citations: 9
  • Preparation, characterization and tests of incorporation in stem cells of superparamagnetic iron oxide
    PS Haddad, TN Britos, LM Li, LDS Li
    Journal of Physics: Conference Series 617 (1), 012002 , 2015
    2015
    Citations: 11
  • Spectroscopy of high lying resonances in 9Be produced with radioactive 8Li beams
    A Lépine-Szily, E Leistenschneider, DR Mendes, P Descouvemont, ...
    EPJ Web of Conferences 69, 00006 , 2014
    2014
  • MS48. P05
    T Britos, L Min, LDS Li, P Haddad
    Acta Cryst 70, C743 , 2014
    2014
  • Experimental study of the resonant elastic scattering'ANTPOT. 8'LI'(p, p)'ANTPOT. 8'LI'
    E Leistenschneider, DR Mendes Jr, PN de Faria, V Morcelle, KCC Pires, ...
    Resumos , 2013
    2013
  • Coulomb excitation of {sup 8} Li
    M Assuncao, TN Britos, P Descouvemont, A Lepine-Szily, ...
    2012
  • Elastic and Inelastic scattering measurement of 8Li on 197Au
    TN Britos, V Morcelle, M Assunção, P Descouvemont, A Lépine-Szily, ...
    Resumo , 2012
    2012
  • Coulomb excitation of 8Li
    M Assuncao, TN Britos, P Descouvemont, A Lepine-Szily, ...
    2012

MOST CITED SCHOLAR PUBLICATIONS

  • In vivo evaluation of thiol-functionalized superparamagnetic iron oxide nanoparticles
    TN Britos, CE Castro, BM Bertassoli, G Petri, FLA Fonseca, FF Ferreira, ...
    Materials Science and Engineering: C 99, 171-179 , 2019
    2019
    Citations: 34
  • Potential use of DMSA‐containing iron oxide nanoparticles as magnetic vehicles against the COVID‐19 disease
    ES Martins, A Espindola, TN Britos, C Chagas, E Barbosa, CE Castro, ...
    ChemistrySelect 6 (31), 7931-7935 , 2021
    2021
    Citations: 21
  • A review of superparamagnetic nanoparticles applications and regulatory aspects in medicine and environmental areas
    DW Losito, NIN Souza, TS Martins, TN Britos, ML Schumacher, ...
    Journal of Materials Science 59 (34), 16038-16068 , 2024
    2024
    Citations: 15
  • Preparation, characterization and tests of incorporation in stem cells of superparamagnetic iron oxide
    PS Haddad, TN Britos, LM Li, LDS Li
    Journal of Physics: Conference Series 617 (1), 012002 , 2015
    2015
    Citations: 11
  • Synthesis, characterization and cytotoxicity evaluation of nitric oxide-iron oxide magnetic nanoparticles
    PS Haddad, TN Britos, MC Santos, AB Seabra, MV Palladino, GZ Justo
    Journal of Physics: Conference Series 617 (1), 012022 , 2015
    2015
    Citations: 9
  • Superparamagnetic nanoparticles as potential drug delivery systems for the treatment of Duchenne muscular dystrophy
    ML Schumacher, TN Britos, FLA Fonseca, FF Ferreira, D Feder, P Fratini, ...
    Nanoscale 17 (7), 3752-3767 , 2025
    2025
    Citations: 8
  • Antioxidant action of L-cysteine anchored on the surface of magnetite nanoparticles
    T Britos, N Santana, ML Schumacher, E Barbosa, A de Espindola, ...
    Next Nanotechnology 6, 100076 , 2024
    2024
    Citations: 5
  • Human risk assessment and its application to nanotechnology: A challenge for assessors
    C Emond, TN Britos
    Journal of Physics: Conference Series 617 (1), 012039 , 2015
    2015
    Citations: 3
  • Synthesis, Characterization, and Toxicity Assessment of Superparamagnetic Iron Oxide Nanoparticles Coated with Antitumor Molecules
    C Chagas, EB da Silva, BCA Alves, GL da Veiga, EC Pereira, P Haddad, ...
    ACS omega 10 (17), 17237-17248 , 2025
    2025
    Citations: 1
  • In vitro results with minimal blood toxicity of a combretastatin A4 analogue
    C Chagas, JV Mansano, EB da Silva, G Petri, ...
    Investigational New Drugs 42 (3), 318-325 , 2024
    2024
  • Synthesis and characterization of SPIONs functionalized with Cysteine and Glutathione for biomedical applications
    TN Britos, CS Chagas, EB Silva, FLA Fonseca, PSH Ferreira
    Proceedings of the 21. Brazil MRS Meeting, 603-603 , 2023
    2023
  • Thiolated superparamagnetic nanoparticles as potential biological vehicles
    T Britos, CS Chagas, FF Ferreira, FLA Fonseca, PSH Ferreira
    Proceedings of the 44. annual meeting of the Brazilian society on chemistry … , 2021
    2021
  • Tuning the local structure of SPIONs by PDF
    FF Ferreira, VDN Bezzon, TN Britos, PS Haddad
    Proceedings of the 2021: Brazil MRS Meeting; International Union of … , 2021
    2021
  • Synthesis and characterization of superparamagnetic iron oxide nanoparticles functionalized with cysteine, glutathione and gold for potential biomedical applications
    TN Britos, PS Haddad
    2018
  • Spectroscopy of high lying resonances in 9Be produced with radioactive 8Li beams
    A Lépine-Szily, E Leistenschneider, DR Mendes, P Descouvemont, ...
    EPJ Web of Conferences 69, 00006 , 2014
    2014
  • MS48. P05
    T Britos, L Min, LDS Li, P Haddad
    Acta Cryst 70, C743 , 2014
    2014
  • Experimental study of the resonant elastic scattering'ANTPOT. 8'LI'(p, p)'ANTPOT. 8'LI'
    E Leistenschneider, DR Mendes Jr, PN de Faria, V Morcelle, KCC Pires, ...
    Resumos , 2013
    2013
  • Coulomb excitation of {sup 8} Li
    M Assuncao, TN Britos, P Descouvemont, A Lepine-Szily, ...
    2012
  • Elastic and Inelastic scattering measurement of 8Li on 197Au
    TN Britos, V Morcelle, M Assunção, P Descouvemont, A Lépine-Szily, ...
    Resumo , 2012
    2012
  • Coulomb excitation of 8Li
    M Assuncao, TN Britos, P Descouvemont, A Lepine-Szily, ...
    2012