Hindustan Abdul Ahad
@abdulhindustan@gmail.com
Professor and Head, Department of Pharmaceutics
RR College of Pharmacy
Dr. Hindustan Abdul Ahad received his B. Pharm degree in 1997 from Bangalore University, Karnataka, and his M. Pharm degree in 2001 from Annamalai University in Chidambaram, Tamil Nadu, and his Ph.D. in Pharmaceutical Sciences in 2011 from Jawaharlal Technological University in Hyderabad, Telangana. He received the best researcher award for the years 2019, 2020, and 2021. He has published more than 400 publications in national and international journals, published 11 books and a book chapter and received several awards, including the Best Educationist Award (2015), Best Researcher Award (2019), and many more in his 23 years of experience in academic/research/administrative. He has guided 4 Ph.D. and is currently guiding 7 Ph.D.
EDUCATION
M. Pharm., PhD., FAGE
RESEARCH, TEACHING, or OTHER INTERESTS
General Pharmacology, Toxicology and Pharmaceutics, Pharmaceutical Science, Pharmacology, Toxicology and Pharmaceutics, Pharmaceutical Science
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Hindustan Abdul Ahad, Mazin Aboobaida Abdalla Abdelaziz, Hossamaldeen Bakrey, Abdulkadir Abdu, Yassin Babkir Elshiekh Mohamed, and Amal. A. Noureldeen
A and V Publications
The drive of the currentexamination is to decide the consequence of temperature and duration on Opuntia elatior cladodes extraction. The literature claims that little attempt was made to extract from cladodes and other plant parts. The effect of dependent factors on the independent response was not attempted to be screened for. The effect of the dependent variable on the answer was controlled during the experiment's design by the Design Expert. The effect of independent variables (temperature and exposure duration) on the response (% yield) could also be evaluated by positioning, authenticating, and hauling out samples in the water. The extraction and exposure times are directly proportional, and the research found that 40°C is the best temperature for removing the substance from cladodes.
Pynskhemlin Syiemlieh, K.S. Srilatha, Hindustan Abdul Ahad, Chrishmitha Sequeira, Becare Dkhar, and John Mithi
Diva Enterprises Private Limited
Haranath Chinthaginjala, Hindustan Abdul Ahad, Sainath Kethandapatti Srinivasa, Srihith Roy Yaparla, Snehitha Buddadasari, Junaid Abul Hassan, and Sai Sree Pullaganti
EManuscript Technologies
Objectives: The existing study is concerned with the formulation and optimization of dextromethorphan hydrobromide floating tablets via central composite design. Materials and Methods: Direct compression method was employed to prepare the tablets. Drug -excipient studies were executed through FT-IR and DSC analysis. The independent variables selected were the concentrations of Carbopol 934 (X 1 ) and HPMC K15M (X 2 ). The dependent variables designated were Floating Lag Time (FLT) and Drug Release (DR) at 12 hr. The model was found to be nonlinear and the curvature effect was significant. Hence, the system suggested to central composite design. Results: FT-IR studies demonstrated that there is no considerable interaction amid the drug and the excipients. DSC studies revealed that drug and excipient were compatible as there is no significant alteration in melting point of drug when blended with excipients. The precompression parameters of the formulations showed good flow properties. The evaluation of post compression parameters indicated that all the prepared formulations were within the specified limits. Floating lag time of formulations were marked to be less than 1 min and total floating time exceeding 12 hr. Percentage drug release of all formulations were in the range of 89.7% to 99.4%. The obtained design space/contour plots were used for selecting batches in desirable ranges. Conclusion: The results revealed that experimental design was successfully used to optimize polymer concentrations. It was determined that the central composite design would be used to formulate dextromethorphan gastroretentive floating tablets with fewer trials and higher quality features.
Lakavath Sunil Kumar and Hindustan Abdul Ahad
EManuscript Technologies
Sowjanya Hatthi Belgal Mundarinti and Hindustan Abdul Ahad
EManuscript Technologies
Gorantla Naresh Babu, Menaka M, Hindustan Abdul Ahad, and Sreedhar Veerabomma
A and V Publications
The study's main goal is to test gastro retentive mucoadhesive Acyclovir (ACR) microspheres for various in vivo characteristics as a follow-up to the work done by Naresh et al (2022). The optimized ACR Azadirachta indica mucoadhesive microspheres (AAMM) were evaluated in vitro using a variety of parameters. Based on previous research findings, the authors used formula-8 (AAMM-8) for in vivo testing. The availability of plasma drugs was tested on six healthy rabbits of both sexes (weighing 2.-2.5kg). By using a parallel design, they were haphazardly parted into two groups of similar size. Later, the study involved HPLC analysis of the drug in the plasma, which required the fabrication of a spiked plasma sample and the development of an analytical procedure (a simple and cost-effective method for ACR).Pharmacokinetic parameters were measured in plasma samples. The study revealed that in vivo animal studies in rabbits showed good levels of ACR. After a single dose of formulation AAMM-8 (8.85mg/kg), the symmetrical mean Cmax values of formulation AAMM-8 (24.36±0.84µg/mL of ACR), were higher than those of ACR. The tmax values of the AAMM-8 were found to be 6 h. The AUC (0-10h) values were observed to be 176.0µg.h/mL, whereas (AUC)0-∞ was observed to be 248.5µg. h/mL. The AUMC readings were observed to be 724.62µg.h/mL. According to the findings, ACR reached systemic circulation faster than pure medication and had acceptable kinetic values.
HindustanA Ahad, Haranath Chinthaginjala, Ksheerasagare Tarun, GummadisaniG Reddy, AdamA.O Adam, AbdelrahamanI Ali, and JyothiV Krishna
Medknow
Background Dragon fruits (Hylocereus undatus) are popular edible fruits of desert and dry-land origin. They are rich in constituents. An attempt was made to find the optimum temperature and duration of exposure for the effective extraction of content from the fruits using Design-Export software. Aim This study aims to see what effect temperature and duration have on dragon fruit (H. undatus) extraction. According to the literature, numerous attempts have been made to extract components from fruits and other plant parts. Materials and methods The authors made an attempt to check if independent variables had an effect on the dependent response. The Design-Expert software was used to control the impact of the independent variable on the response during the experiment’s design. Alternatively, samples were positioned, authenticated, and hauled out into the water, with independent factors (temperature and exposure time) affecting the response (percent yield). Results and conclusions According to the study, 40°C is the ideal temperature to extract the substance from the fruits, and the extraction and exposure times are directly proportional.
Debaraj Roy
Kare Publishing
The work aimed to explore the clinical hypothesis on the possible alternative to Opiorphin and its stable analogues for treating fibromyalgia pain. Fibromyalgia is a condition characterized by chronic pain triggered by an interplay of biological and psychosocial variables, although the exact pathogenesis is still controversial. Standard therapy for low threshold tender point pain includes NSAIDs and opioid analgesics, both of which have serious adverse profiles after long-term exposure, highlighting the need for an intermediate compound capable of bridging the gap between NSAIDs and opioid analgesics. Opiorphin is an anti-nociceptive modulator which inhibits the enzyme responsible for the degradation of natural endogenous opioid neuropeptides. This paper hypothesizes and concludes that Opiorphin and its stable analogues (Sialorphine, STR-324) can be an alternative for the treatment of chronic long-standing low-threshold tender point pain associated with fibromyalgia.
Gorantla Naresh Babu, Menaka Muthukaruppan, and Hindustan Abdul Ahad
College of Science for Women
The drive of this exploration is to investigate the mucoadhesive assets of A. indica (Azadirachta indica) fruit mucilage by incorporating it into mucoadhesive microspheres with Acyclovir (AVR) as a model drug. The study was performed to check the impact of the mucilage proportion on particle size and swelling index. Nine batches of AVR mucoadhesive microspheres were made with varying proportions of Polyacrylic acid 934P and A. indica fruit mucilage (AIFM). A central composite design with design expert software to check the impact of dependent variables (A. indica mucilage and Polyacrylic acid 934 P levels) on particle size and swelling index as a response. As part of congeniality studies, the batches were examined for their physical constraints, AVR contents, and liberation. The particle size was found to be 35.2±0.3-48.1±0.6μm. In batch B-1, the particle was least sized compared to the larger size in B-5. The investigation found that the particle size and the swelling index depended on AIFM and Polyacrylic acid proportions. The research discovered that AVR was systematically released in a controlled manner and that the entrapment efficacy, mucoadhesion, drug content, and other constraints were found to be good. Acyclovir is capable of good stomach-specific drug delivery by Polyacrylic acid 934P and enhanced by A. indica fruit mucilage when prepared as mucoadhesive microspheres. Scanning electron microscopy reveals that the microspheres were spherical with a fairly smooth surface.
Gorantla Naresh Babu, Menaka Muthukarupan, Hindustan Abdul Ahad, and Veerabomma Sreedhar
Oriental Scientific Publishing Company
In this study, we investigated the mucoadhesive properties of neem fruit mucilage by incorporating it into mucoadhesive microcapsules with Acyclovir (ACR). Methpol-934P and Neem fruit mucilage (NFM) was used to construct 12 different mucoadhesive microcapsules. We assessed FTIR and DSC capabilities for compatibility with ACR and NFM. ACR mucoadhesive microcapsules (ANMM) were characterized for mucoadhesion and ACR release Physico-chemical characteristics. CR was found to be compatible with NFM in the research. The entrapment increased as the levels of NFM in the formulations increased, and mucoadhesion time was longer in formulations with higher levels of NFM. As levels of NFM increase in formulations, the release of drugs is slightly reduced. NFM may be responsible for this due to its release retarding properties. An additive of neem fruit mucilage allowed for the retention of ACR after ingestion when a mucoadhesive polymer (methpol 934P) was used.
Chinthaginjala Haranath
Medic Scientific
Lipid based nanovesicles are the formulations which are used for the delivery of hydrophilic, hydrophobic and amphiphilic drugs or compounds. They are very helpful for the drugs which are hydrophilic and irritant drugs that can be encapsulated and delivered to the target site. They are very advantageous over conventional formulations. Lipid based nanovesicular systems will efficaciously help the drugs addressing the issues of solubility and penetration thereby promotes bioavailability. Now a days lipid based nanovesicles for transdermal delivery of drug has become very useful especially for hydrophilic drugs. The use of the nanovesicles for transdermal drug delivery will overcome the drawbacks associated with the route of drug delivery, such as oral and parenteral. Lipid based nanocarriers includes liposomes, transferosomes, ethosomes, niosomes, ufasomes, spinghosomes, pharmacosomes etc., This review article describes the types, formulation methods, evaluation and the research works done on lipid based nanovesicles for transdermal delivery of the drug.
Chinthaginjala Haranath
Medic Scientific
In recent years, nanoscience has drug development and has taken a new slant, that have proven difficult with traditional dosage forms in drug delivery.Nanoparticles, liposomes, niosomes, quantum dots and Aquasomes are the examples of nanomaterials are just a few examples of nanobiotechnologically created carrier systems. The nano-particulate self-assembled carrier system is anew approachas well as ideal choice for the administration of drugs. Aquasomes proved to be important drug delivery system of ceramic nanoparticles.These are three-tiered framework composed of a core made of solid crystals and adsorbed biologically active drug molecules are coated with carbohydrates.Aquasomes formulations are typically administered via the intravenous route.Aquasomes have the ability to maintain conformational consistency and have a high level of exposure to the surface, making them ideal for the transportation of molecules made up of peptides as well as vaccine and gene delivery to specific sites.
Hindustan Abdul Ahad, Haranath Chinthaginjala, Govardhan Reddy, Aravind Kumar Ganthala, and Tharun Teja Siddhartha
Walter de Gruyter GmbH
Abstract The work is aimed at producing fast disintegrating diclofenac potassium tablets to relieve pain and tenderness by applying a quality-by-design approach. Diclofenac potassium (DP) is of BCS class II and has issues of minimal oral bioavailability. This can be overcome by complexing DP with β-cyclodextrin (β-CD) and sodium starch glycolate (SSG). The attempt was to optimize DP tablets by applying central composite design (CCD). Nine different DP tablet formulations were created and assessed for physicochemical constraints, disintegration time and drug dissolution at the end of 30 min. The separate and mutual consequences of β-CD and SSG on the disintegration time of DP tablets are highly significant (P<0.01). The DP tablets made with β-CD in 150 mg disintegrated rapidly within 39±2 sec, and gave very rapid drug dissolution (96.35±2.36%) at the end of 30 min. These DP tablets (F-8) contain β-CD (150 mg) and SSG at 32.07 mg. The intermittent levels of β-CD and higher levels of SSG gave good dissolution of DP tablets. The polynomial equation linking the response, i.e. disintegration time in sec (Y1) and the levels of β-CD (A) and SSG (B) based on the pragmatic results, is Y1=45-3.14277A- 2.46599B-1.25AB+1.75A2-0.5B2. In contrast, the DP release at the end of 30 min was expressed as Y2 = 88.57 + 4.09333A + 3.27837B + 1.2525AB - 2A2 + 0.8875B2. The study concludes that SSG decreases the disintegration time with its concentration and β-CD concentration ingresses the drug release from the formulation.
Lakavath Sunil Kumar and Hindusthan Abdhul Ahad
A and V Publications
This review aimed to deliver the progressive trends and need for research activities in the area of liquid bi-phasic systems i.e., Nano emulsion (NE). These categories of drug delivery system (DDS) are progressive modes for providing and increasing the bioavailability of non-aqueous drugs and the drug which have increased the first-pass metabolism. The NE's can be framed by either high or low energy techniques. High-pressure homogenization, micro fluidization, and ultra-sonication are involved in High energy techniques whereas the phase inversion emulsion forming method and the self-NE method are involved in low energy techniques. High energy techniques are having lower usage when compared to low energy techniques due to their high consumption of energy, hence low energy techniques are more operative and do not need any sophisticated devices. Even though high energy techniques are more suitable for food-grade emulsion as they need a reduced amount of surfactant than low energy techniques. Methods for formulation of NE DDS are overlying in nature, exclusively in the process of low energy techniques. This review gives the eminence of NE'S by comparing previous research carried over it.
Hindustan Abdul Ahad, Rahul Raghav Dasari, Chinthaginjala Haranath, Madana Gowthami, Naga Jyothi Varam, and Pandyala Sravanthi
A and V Publications
The point of present writing is gathering past work done on mucoadhesive bilayered tablets. Numerous specialists are getting pulled towards these systems to plan of examinations in the streamlining of medication conveyance frameworks as very few studies were advanced till date. Mucoadhesive system is simple to create, utilize, and easily accessible to evaluate the results. The authors made an adequate attempt to bring a platform on various polymers utilized in the advancement mucoadhesive bilayered tablets.
Hindustan Abdul Ahad, Chinthaginjala Haranath, Naga Jyothi Varam, Tarun Ksheerasagare, Jyothi Vinay Krishna, and Siddartha Tharun Teja
A and V Publications
The main aim of the present investigation was to explore the Liver shielding of Ficus benghalensis fruit extracts alongside perchloromethane persuaded toxic hepatitis in New Zealand albino rats. The ethanolic extract of the fruits of F. benghalensis (Family: Moraceae) was evaluated for Liver shielding in New Zealand Albino rats with liver mutilation persuaded by perchloromethane. F. benghalensis fruit extract unveiled a momentous Liver shielding consequence by dropping the serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total serum bilirubin (TSB) and malondialdehyde equivalent 500 mg/kg (oral). These biochemical explanations were accompanied by a histopathological assessment of liver segments. The liver shielding of F. benghalensis fruit extracts was comparable to that of a known Liver shielding Liv-52.
Hindustan Abdul Ahad, Haranath Chinthaginjala, Manchikanti Sai Priyanka, Dasari Rahul Raghav, Madana Gowthami, and Varam Naga Jyothi
EManuscript Technologies
Aim and Objectives: The main motto of this work was to search the additive effect of Datura stramonium leaves mucilage in the making of buccoadhesive film by taking Aceclofenac as a model drug. Materials and Methods: Nine formulations of buccal films were made using Carbopol 934 P and varying proportions of Ethyl Cellulose and D. stramonium leaves mucilage. The films were judged for compatibility studies and physical constraints including Aceclofenac content and discharge. Results: Among the films F-9 containing 1:1 of Aceclofenac and ethyl cellulose; and 1:0.5 ratios of Aceclofenac: D. stramonium leaves mucilage was found to have good Mucoadhesion time (10.5±0.1h) and Bioadhesive strength (5.5±0.2g). The formulation F2 showed the highest % release i.e., 92.85% up to 8 h. Conclusion: The study resolved that buccoadhesive drug delivery system for Aceclofenac with ethyl cellulose aided with D. stramonium leaves mucilage meets the ideal requirement for buccal devices is an efficient approach to surpass the hepatic first-pass metabolism and increase bioavailability.
Haranath Chinthaginjala, Hindustan Abdul Ahad, Bhupalam Pradeepkumar, K. Sainath Gandhi, K. Kalpana, G. Pushpalatha, and K. Sumala
A and V Publications
Hindustan Abdul Ahad, Chinthaginjala Haranath, Srikantham Sai Vikas, Naga Jyothi Varam, Tarun Ksheerasagare, and Surya Prakash Reddy Gorantla
A and V Publications
Shaik Gundikota Javeed Ahammed, Pradeepkumar Bhupalam, Hindustan Abdul Ahad, Haranath Chinthaginjala, Syed Rahamathulla, and Srividya Yadav
Oriental Scientific Publishing Company
The authors aimed to give a quick reference guide for humanity about the new threat even after the COVID-19 health battle i.e., the Black fungus also baptized as Mucormycosis infection. After recovering from COVID-19, patients with diabetes mellitus and patients who have undergone steroidal treatment are more prone to black fungus infection. This review gives quick information about various types of Mucormycosis infections, risk factors, symptoms, treatment, and prevention of black fungus. The things that can be and cannot be done to eradicate the black fungus. Any sign of black nasal mucosa/sputum, fever, headache, hazy/blurred/double vision with eye pain, loss of one side sensation on face and loss in the sensation while chewing, etc., then it should not be neglected and immediately intimated to the health professionals and get treated. If black fungus is unidentified early stages and untreated in time, the patients may lose their facial/neck parts as a part of cleaning surgery. The study concludes that by maintaining hygienic conditions, health checkups, and doctors’ advice one can fight and eradicate the black fungus.
Haranath Chinthaginjala, Hindustan Abdul Ahad, Eranti Bhargav, and Bhupalam Pradeepkumar
EManuscript Technologies
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