Vedant Vikrom Borah

Scopus Publications

Comment on “Nanotechnology in Cardiology: A New Era of Targeted Therapies and Advanced Diagnostics – A Review”
Lima Hazarika, Vedant Vikrom Borah
American Journal of Cardiology, 2026
Proteus mirabilis: Insights into biofilm formation, virulence mechanisms, and novel therapeutic strategies
Meeky Anthony Lyngdoh Kynshi, Emidahun Kharkamni, Vedant Vikrom Borah
Microbe Netherlands, 2025
Proteus mirabilis , a gram-negative bacterium, is a significant cause of catheter-associated urinary tract infections, bacteremia, and other serious health complications. Its pathogenicity is driven by several virulence factors, including swarming motility, urease production, fimbriae, hemolysins, and the ability to form biofilms. These features enable the bacterium to colonize host tissues, evade immune responses, and resist antimicrobial treatments. For instance, urease increases urine alkalinity, promoting the formation of crystalline biofilms and struvite stones, which further complicates infections. Biofilm formation provides a shield against antibiotics, rendering infections persistent and difficult to treat. The increasing resistance of P. mirabilis to antibiotics highlights an urgent need for innovative therapeutic approaches. Ciprofloxacin, a commonly used antibiotic, significantly reduces 33–55 % of the biofilm’s biomass. Complementary strategies, including the use of phytochemicals and nanoparticles (NPs), have emerged as promising alternatives. Phytochemicals, such as allicin and curcumin, target specific virulence factors, whereas nanoparticles reduce biomass up to 53.4 %. Lactobacilli spp., such as L. gasseri produce lactic acid, which inhibits growth and prevents the formation of urinary stones caused by P. mirabilis . Additionally, phage therapy offers targeted solutions that combine phage vB PmiS-TH with ampicillin, causing removal of the biofilm after 24 h and preventing urinary tract infections. Targeted therapies addressing virulence factors, combined with traditional and novel antimicrobial strategies, have the potential to improve patient outcomes, particularly those vulnerable to severe complications, such as the elderly and immunocompromised individuals.
Environmentally Friendly Synthesis of Coumarin–Pyrazolo[1,5-a]pyrimidine Hybrids with Potent Antibacterial and Antibiofilm Activities
T. R. A. Sangma, L. B. Marpna, M. Rymbai, S. Kaping, V. V. Borah, J. N. Vishwakarma
Russian Journal of Bioorganic Chemistry, 2025
Abstract Objective: This study aimed to synthesize a series of coumarin–pyrazolo[1,5-a]pyrimidine hybrid compounds and evaluate their potential antibacterial and antibiofilm activities. Methods: In our synthetic approach, a mixture of 3-acetylcoumarin (I) and N,N-dimethylformamide dimethyl acetal (DMF-DMA) was refluxed in toluene to afford the enaminone intermediate (II). Subsequent condensation with 3-aminopyrazoles in the presence of potassium hydrogen sulfate (KHSO4) yielded a series of 7-(2-oxo-2H-chromen-3-yl)pyrazolo[1,5-a]pyrimidine derivatives. The structures of the synthesized compounds were confirmed using spectroscopic and analytical techniques, including FT-IR, 1H, 13C NMR, and high-resolution mass spectrometry (HRMS). Antibacterial and antibiofilm activities were evaluated against Staphylococcus epidermidis ATCC 35984 and Pseudomonas aeruginosa using MIC, MIC50 assays, and biofilm formation inhibition studies. Results and Discussion: The synthesized coumarin–pyrazolo[1,5-a]pyrimidine (CPP) hybrids (IVa–IVj) were obtained in high yields (74–92%) within short reaction times (9–18 min). These compounds exhibited significant anti-adhesion and antibiofilm activities against both S. epidermidis and P. aeruginosa. All compounds were tested for their ability to inhibit bacterial cell adhesion to polystyrene surfaces. Conclusions: Hybrids (IVd) and (IVe) demonstrated outstanding and consistent antibiofilm activity against strong biofilm-forming strains, S. epidermidis ATCC 35984 and P. aeruginosa, indicating broad-spectrum efficacy at low concentrations.
Assessment of Bioactivity in Four Pteridophyte Species from Assam, Northeast India, Reveals Prominent Antioxidative and Cytotoxic Potential
Shivangi Borkotoky, Supriyo Sen, Vedant Vikrom Borah
Proceedings of the National Academy of Sciences India Section B Biological Sciences, 2024
Bioinformatics and advanced research in gut microflora
Arabinda Ghosh, Muddukrishnaiah Kotakonda, Vedant Vikrom Borah, Nobendu Mukerjee
Prebiotics and Probiotics in Disease Regulation and Management, 2022
Novel ferrocene-pyrazolo[1,5-a]pyrimidine hybrids: A facile environment-friendly regioselective synthesis, structure elucidation, and their antioxidant, antibacterial, and anti-biofilm activities
SUSMA DAS, SHIVANGI BORKOTOKY, MAXMILLANDO RYMBAI, VEDANT V BORAH, JAYANTI D ROY, SHUNAN KAPING, PHILIPPE HELISSEY, JAI N VISHWAKARMA
Journal of Chemical Sciences, 2022
In silico application of data science, genomics, and bioinformatics in screening drug candidates against COVID-19
Rene Barbie Browne, Jai Narain Vishwakarma, Vedant Vikrom Borah, Raj Kumar Pegu, Jayanti Datta Roy
Data Science for Genomics, 2022
Quantitative phytochemical analysis reveals significant antibiofilm activity in pleione maculata, an endangered medicinal orchid
Hakani D. Sympli, Supriyo Sen, Bahunlang Susngi, Vedant Vikrom Borah
Journal of Pure and Applied Microbiology, 2021
Pleione maculata has no scientific reports on quantitative phytochemical and antibiofilm activity till date. The objective of the study was to quantify and determine medicinally important bioactivity in P. maculata and analyse its anti-biofilm activity against clinical isolates Staphyloccocus aureus, Klebsiella pneumoniae and Proteus mirabilis. P. maculata exhibited the highest Total Antioxidant Capacity (TAC) about 193.98±0.1 mg, highest Total Phenolic Content (TPC) at 552±0.0 mg and Total Flavonoid Content (TFC) were observed highest at 879.5±0.2 mg. The acetone and ethyl acetate extracts of P. maculata pseudobulb showed distinct and significant zone of inhibition (ZOI) against drug-resistant S.aureus about 16±0.00 mm (MIC 0.875 mg/mL), ZOI of acetonitrile pseudobulb extract against P. mirabilis was 15.33±0.4 mm (MIC 1 mg/mL), ZOI of acetonitrile extracts of leaves and stem, ethyl acetate extract of pseudobulb was 12±0.0 mm, 12±01.4 mm, 12±2.8 mm against K. pneumoniae (MIC 1.8 mg/mL, 0.68 mg/mL and 3 mg/mL). Acetonitrile extract of pseudobulbs exhibited the highest Minimum Biofilm Inhibition concentration (MBIC) at 0.25 mg/mL against S. aureus, water root extract inhibited attachment of K. pneumoniae with lowest MBIC value 0.093 mg/mL, water and acetone extract of leaves inhibited cell attachment of P. mirabilis at lowest MBIC 0.117 and 0.171 mg/mL. The UV-VIS absorption band of P. maculata extracts ranges from 204-665 nm indicating the presence of phenolic and flavonoid compounds. The study indicates the potentiality of P. maculata as a rich source of medicinal active compounds as an antibiofilm agent against antibiotic-resistant clinical isolates.
In Silico Approach for Phytocompound-Based Drug Designing to Fight Efflux Pump-Mediated Multidrug-Resistant Mycobacterium tuberculosis
Santasree Sarma Biswas, Rene Barbie Browne, Vedant Vikrom Borah, Jayanti Datta Roy
Applied Biochemistry and Biotechnology, 2021
Polymorph of trans-dichlorotetrakis(pyridine-N)ruthenium(II) influenced by a dihydrazone: crystal structure, spectral, Hirshfeld surfaces, antimicrobial, toxicity and in silico docking studies
DEBAJANI BASUMATARY, MADAN KUMAR SHANKAR, KULLAIAH BYRAPPA, KANDARPA KUMAR SAIKIA, AJAZ AHMAD DAR, VEDANT VIKROM BORAH, PRANJIT SARMA, PRANAMI MAHANTA, MRITUNJAYA ASTHANA, NAMRATHA KEERTHIRAJ
Journal of Chemical Sciences, 2020
Screening of Enhydra fluctuans for Phytochemical Composition and Broad-Spectrum Antibacterial Activity against Clinical Bacterial Isolates
Upasana Sarma, Vedant V. Borah, Kandarpa Kr. Saikia, N. K. Hazarika
Journal of Herbs Spices and Medicinal Plants, 2016
First report on the detection of OXA-48 β-lactamase gene in Escherichia coli and Pseudomonas aeruginosa co-infection isolated from a patient in a Tertiary Care Hospital in Assam
Vedant Vikrom Borah, Kandarpa Kumar Saikia, Naba Kumar Hazarika
Indian Journal of Medical Microbiology, 2016
New Delhi metallo-β-lactamase and extended spectrum β-lactamases co-producing isolates are high in community-acquired urinary infections in Assam as detected by a novel multiplex polymerase chain reaction assay
VV Borah, KK Saikia, P Chandra, NK Hazarika, R Chakravarty
Indian Journal of Medical Microbiology, 2016
Enhydra fluctuans: A review on its pharmacological importance as a medicinal plant and prevalence and use in north-east India
International Journal of Pharmacy and Pharmaceutical Sciences, 2014
Comparative screening of antibacterial and antifungal activity of six ethno-medicinally important plants of Assam
International Journal of Pharma and Bio Sciences, 2013

RECENT SCHOLAR PUBLICATIONS

In vitro antibiofilm activity of Aquilaria malaccensis leaf extracts and literature-derived docking studies on LasR and RhIR of Pseudomonas aeruginosa
S Sen, M Nath, VV Borah
Available at https://doi.org/10.21203/rs.3.rs-7082118/v1 , 2026
2026
Phytochemical profiling and biofilm inhibitory potential of Sphaerostephanos unitus (L.) Holttum
S Borkotoky, S Sen, VV Borah
https://doi.org/10.21203/rs.3.rs-8502915/v1 , 2026
2026
Comment on "Nanotechnology in Cardiology: A New Era of Targeted Therapies and Advanced Diagnostics - A Review"
L Hazarika, VV Borah
The American Journal of Cardiology , 2026
2026
Preliminary evaluation of the anti-Candida antibiofilm and phytochemical potential of Graphis ceylanica Zahlbr
B Dey, D Das, VV Borah
2026
Proteus mirabilis: Insights into biofilm formation, virulence mechanisms, and novel therapeutic strategies
MAL Kynshi, E Kharkamni, VV Borah
The Microbe 8, 100450 , 2025
2025
Citations: 8
Analysis on Genetic diversity of Threatened Medicinal epiphyte Pleione maculata from different Geographical habitats using RAPD and ISSR marker
HD Sympli, VV Borah
Indian Forester 151 (8), 779‐790 , 2025
2025
Documentation of Lichen Diversity on a University Campus
IH Ahmed, S Yadav, VV Borah
Horizons of Understanding: Dimensions of Research in Science and Arts 1, 116-125 , 2025
2025
Unveiling the Antibiofilm Properties of Lichen-Derived Compounds
B Dey, VV Borah
Horizons of Understanding: Dimensions of Research in Science and Arts 1, 108-115 , 2025
2025
Exploring the Flavor and Health Promoting Compounds in Traditional Ginger-Based Beverage Using Gc-Ms Led Approach
S Sen, B Lynkhoi, M Terongpi, VV Borah
Available at SSRN 5358192 , 2025
2025
Environmentally Friendly Synthesis of Coumarin–Pyrazolo[1,5-a]pyrimidine Hybrids with Potent Antibacterial and Antibiofilm Activities
TRA Sangma, LB Marpna, M Rymbai, S Kaping, VV Borah, ...
Russian Journal of Bioorganic Chemistry 51 (3), 1306–1319 , 2025
2025
Citations: 3
Assessment of Bioactivity in Four Pteridophyte Species from Assam, Northeast India, Reveals Prominent Antioxidative and Cytotoxic Potential
S Borkotoky, S Sen, VV Borah
Proceedings of the National Academy of Sciences, India Section B: Biological … , 2024
2024
Citations: 7
Antimicrobial potential of crude extracts and fatty acid fractions of Four pteridophyte species from Assam, northeast India, and their Identification by GC-MS
S Borkotoky, VV Borah
International Journal of Pharmaceutical Sciences and Research 14 (9), 4489-4508 , 2023
2023
Citations: 5
Genetic Variability, Heritability and Genetic Advance of Aromatic Rice for Yield and its Components
N Borah, PP Behera, VV Borah, RN Sarma
Biological Forum – An International Journal 15 (5), 1516-1522 , 2023
2023
Citations: 3
Status of Genomic Research in Non-basmati Aromatic Joha Rice of Assam
N Borah, RN Sarma, VV Borah, PP Behera
International Journal of Environment and Climate Change 12 (10), 338-347 , 2022
2022
Citations: 2
Bioinformatics and Advanced Research in Gut Microflora
A Ghose, M Kotakonda, VV Borah, N Mukerjee
Prebiotics and Probiotics in Disease Regulation and Management , 2022
2022
Citations: 2
Novel ferrocene-pyrazolo[1,5-a]pyrimidine hybrids: A facile environment-friendly regioselective synthesis, structure elucidation, and their antioxidant, antibacterial, and anti …
S Das, S Borkotoky, M Rymbai, VV Borah, JD Roy, S Kaping, P Helissey, ...
Journal of Chemical Sciences 134 (3) , 2022
2022
Citations: 9
Medicinal Uses of Ginger and its Cultivation in North-East India
BL Nongbri, M Teronpi, VV Borah
Indigenous Traditional Knowledge, 39-46 , 2022
2022
In silico application of data science, genomics, and bioinformatics in screening drug candidates against COVID-19
RB Browne, JN Vishwakarma, VV Borah, RK Pegu, JD Roy
Data Science for Genomics 1, 107-128 , 2022
2022
Citations: 1
Quantitative Phytochemical Analysis Reveals Significant Antibiofilm Activity in Pleione maculata, an Endangered Medicinal Orchid
H Sympli, S Sen, B Susngi, VV Borah
Journal of Pure and Applied Microbiology 15 (3), 1573-1590 , 2021
2021
Citations: 3
In Silico Approach for Phytocompound-Based Drug Designing to Fight Efflux Pump-Mediated Multidrug-Resistant Mycobacterium tuberculosis
JDR Santasree Sarma Biswas, Rene Barbie Browne, Vedant Vikrom Borah
Applied Biochemistry and Biotechnology , 2021
2021
Citations: 21

MOST CITED SCHOLAR PUBLICATIONS

New Delhi metallo-β-lactamase and extended spectrum β-lactamases co-producing isolates are high in community-acquired urinary infections in Assam as detected by a novel …
VV Borah, KK Saikia, P Chandra, NK Hazarika, R Chakravarty
Indian journal of medical microbiology 34 (2), 173-182 , 2016
2016
Citations: 35
Enhydra fluctuans: A review on its pharmacological importance as a medicinal plant and prevalence and use in North-East India
U Sarma, VV Borah, KK Saikia, NK Hazarika
Int. J. Pharmcy Pharm. Sci 6 (Supplement 2), 48-50 , 2014
2014
Citations: 35
First report on the detection of OXA-48 β-lactamase gene in Escherichia coli and Pseudomonas aeruginosa co-infection isolated from a patient in a Tertiary Care Hospital in Assam
VV Borah, KK Saikia, NK Hazarika
Indian J Med Microbiol 34 (2), 252-3 , 2016
2016
Citations: 25
In Silico Approach for Phytocompound-Based Drug Designing to Fight Efflux Pump-Mediated Multidrug-Resistant Mycobacterium tuberculosis
JDR Santasree Sarma Biswas, Rene Barbie Browne, Vedant Vikrom Borah
Applied Biochemistry and Biotechnology , 2021
2021
Citations: 21
High prevalence of antibiotic resistance in Escherichia coli isolated from fecal sample of cows and assessment of antibacterial efficacy of indigenous medicinal plants from …
V Borah, P Bora, M Roy, KK Saikia
Austin J Biotechnol Bioeng 1 (1), 6 , 2014
2014
Citations: 16
Novel ferrocene-pyrazolo[1,5-a]pyrimidine hybrids: A facile environment-friendly regioselective synthesis, structure elucidation, and their antioxidant, antibacterial, and anti …
S Das, S Borkotoky, M Rymbai, VV Borah, JD Roy, S Kaping, P Helissey, ...
Journal of Chemical Sciences 134 (3) , 2022
2022
Citations: 9
A review of the unexplored medicinal orchids of the genus Pleione
HD Sympli, MG Choudhury, VV Borah
The MIOS Journal 19 (8), 3-12 , 2018
2018
Citations: 9
Proteus mirabilis: Insights into biofilm formation, virulence mechanisms, and novel therapeutic strategies
MAL Kynshi, E Kharkamni, VV Borah
The Microbe 8, 100450 , 2025
2025
Citations: 8
Assessment of Bioactivity in Four Pteridophyte Species from Assam, Northeast India, Reveals Prominent Antioxidative and Cytotoxic Potential
S Borkotoky, S Sen, VV Borah
Proceedings of the National Academy of Sciences, India Section B: Biological … , 2024
2024
Citations: 7
Antimicrobial potential of crude extracts and fatty acid fractions of Four pteridophyte species from Assam, northeast India, and their Identification by GC-MS
S Borkotoky, VV Borah
International Journal of Pharmaceutical Sciences and Research 14 (9), 4489-4508 , 2023
2023
Citations: 5
Preparation and health benefits of rice beverages from ethnomedicinal plants: case study in north-east of India
VV Borah, MG Choudhury, P Phanjom
Plant-Based Functional Foods and Phytochemicals, 163-198 , 2021
2021
Citations: 5
Comparative screening of antibacterial and antifungal activity of six ethno-medicinally important plants of Assam
KK Saikia, VV Borah, MC Kalita, M Lahkar
Int J Pharm Bio Sci 4 (1), 890 - 898 , 2013
2013
Citations: 5
Use of tools of NLD in analysis and calibration of Cu-doped ZnO nanoparticles (NPs) for biological applications
R K Saha, M K Debanath, E Saikia, V V Borah, K K Saikia
Advanced Materials Proceedings 2 (1), 26-31 , 2017
2017
Citations: 4
Screening of Enhydra fluctuans for Phytochemical Composition and Broad-Spectrum Antibacterial Activity against Clinical Bacterial Isolates
U Sarma, VV Borah, KK Saikia, NK Hazarika
Journal of Herbs, Spices & Medicinal Plants 22 (4), 300-308 , 2016
2016
Citations: 4
Environmentally Friendly Synthesis of Coumarin–Pyrazolo[1,5-a]pyrimidine Hybrids with Potent Antibacterial and Antibiofilm Activities
TRA Sangma, LB Marpna, M Rymbai, S Kaping, VV Borah, ...
Russian Journal of Bioorganic Chemistry 51 (3), 1306–1319 , 2025
2025
Citations: 3
Genetic Variability, Heritability and Genetic Advance of Aromatic Rice for Yield and its Components
N Borah, PP Behera, VV Borah, RN Sarma
Biological Forum – An International Journal 15 (5), 1516-1522 , 2023
2023
Citations: 3
Quantitative Phytochemical Analysis Reveals Significant Antibiofilm Activity in Pleione maculata, an Endangered Medicinal Orchid
H Sympli, S Sen, B Susngi, VV Borah
Journal of Pure and Applied Microbiology 15 (3), 1573-1590 , 2021
2021
Citations: 3
Phytochemical And Anti-Bacterial Activity Of An Endangered Orchid, Pleione Maculata (Orchidaceae) Of Meghalaya
MGC Hakani D. Sympli, Samrat Paul, Vedant Vikrom Borah
International Journal of Research and Analytical Reviews 6 (2), 221-232 , 2019
2019
Citations: 3
Status of Genomic Research in Non-basmati Aromatic Joha Rice of Assam
N Borah, RN Sarma, VV Borah, PP Behera
International Journal of Environment and Climate Change 12 (10), 338-347 , 2022
2022
Citations: 2
Bioinformatics and Advanced Research in Gut Microflora
A Ghose, M Kotakonda, VV Borah, N Mukerjee
Prebiotics and Probiotics in Disease Regulation and Management , 2022
2022
Citations: 2

Vedant Vikrom Borah

RESEARCH INTERESTS

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS