The interplay between the renin angiotensin system and pacing postconditioning induced cardiac protection Fawzi Babiker, Aishah Al-Jarallah, Shaji Joseph Plos One, 2016 Background Accumulating evidence suggests a cardioprotective role of pacing postconditioning (PPC) maneuvers in animal models and more recently in humans. The procedure however remains to be optimized and its interaction with physiological systems remains to be further explored. The renin angiotensin system (RAS) plays a dual role in ischemia/reperfusion (I/R) injury. The interaction between RAS and PPC induced cardiac protection is however not clearly understood. We have recently demonstrated that angiotensin (1–7) via Mas receptor played a significant role in PPC mediated cardiac protection against I/R injury. Objective The objective of this study was to investigate the role of angiotensin converting enzyme (ACE)—chymase—angiotensin II (Ang II)—angiotensin receptor 1 (AT1) axes of RAS in PPC mediated cardiac protection. Methods Isolated rat hearts were subjected to I/R (control) or PPC in the presence or absence of Ang II, chymostatin (inhibitor of locally produced Ang II), ACE blocker (captopril) or AT1 antagonist (irbesartan). Hemodynamics data was computed digitally and infarct size was determined histologically using TTC staining and biochemically by measuring creatine kinase (CK) and lactate dehydrogenase levels. Results Cardiac hemodynamics were significantly (P<0.001) improved and infarct size and cardiac enzymes were significantly (P<0.001) reduced in hearts subjected to PPC relative to hearts subjected to I/R injury. Exogenous administration of Ang II did not affect I/R injury or PPC mediated protection. Nonetheless inhibition of endogenously synthesized Ang II protected against I/R induced cardiac damage yet did not block or augment the protective effects of PPC. The administration of AT1 antagonist did not alleviate I/R induced damage. Interestingly it abrogated PPC induced cardiac protection in isolated rat hearts. Finally, PPC induced protection and blockade of locally produced Ang II involved enhanced activation of ERK1/2 and Akt components of the reperfusion injury salvage kinase (RISK) pathway. Conclusions This study demonstrate a novel role of endogenously produced Ang II in mediating I/R injury and highlights the significance of AT1 signaling in PPC mediated cardiac protection in isolated rodents hearts ex vivo. The interaction between Ang II-AT1 and PPC appears to involve alterations in the activation state of ERK1/2 and Akt components of the RISK pathway.
The role of 17-beta estradiol in ischemic preconditioning protection of the heart Experimental and Clinical Cardiology, 2012
What's new in salvage of the ischemic myocardium: Estrogen postconditioning Fawzi A. Babiker, Shaji Joseph, Jasbir S. Juggi Medical Principles and Practice, 2011 Murry et al. [1] , devised the promising technique of preconditioning to salvage the myocardium from perfusion’s subsequent ischemic insult. This technique is used for repetitive brief episodes of ischemia before the occurrence of prolonged major ischemia that becomes lethal. While the technique is very promising as a new method of treatment for ischemic heart disease, its application in clinical practice has been arduous and highly risky. The difficulty is caused by a lack of the means to determine the time of occurrence of ischemia. Nevertheless, the technique can be applied in open heart surgery. At this level, repetitive inflating and deflating of the angioplasty balloon is easy to apply with almost no damage to the occluded blood vessel and can offer salvage from subsequent prolonged ischemia. Sometime later, Vinten-Johansen and his coworkers [2] introduced a technique similar to preconditioning with a greater probability of application to actual clinical practice. Postconditioning, the newly introduced technique, is the application of brief, repetitive ischemia and reperfusion. However, the innovation is that the procedure is performed after the ischemic insult and immediately at the beginning of reperfusion. This technique was found to be very efficient in providing protection to the ischemic myocardium and easily applied in clinical practice. An Early Intervention in the Treatment of Ischemic Heart Disease
Protective role of normothermic, hyperthermic and estrogen preconditioning and pretreatment on tumour necrosis factor-alpha-induced damage Experimental and Clinical Cardiology, 2011
Bridging Divides: Technology as a Catalyst for Empowering Underrepresented Communities in India A Venkateswaran, S Joseph Inclusive Futures, 457-480 , 2026 2026
The Neuroscience of Digital Influence and the Emotional and Cognitive Drivers in Social Media Marketing Through Subconscious Persuasion Theory B Kesar, S Joseph Consumer Behavior and Digital Influence in Global Markets, 93-122 , 2026 2026
From Social Capital to Economic Agency Through a Self-Efficacy Perspective on Women's Entrepreneurship B Kesar, S Joseph, D Kesar Global Perspectives on Social Empowerment Using Current Technology, 59-84 , 2026 2026
Social Media as a Field of Power, Habitus, Capital, and Intergenerational Digital Practices B Kesar, S Joseph, D Kesar Sociological Dimensions of Platformization: Power, Culture, and Identity in … , 2026 2026
AI-Enhanced Network Learning Theory Transforming Education Through Personalized, Inclusive, and Ethical Artificial Intelligence B Kesar, S Joseph, D Kesar Reshaping Blended Learning Environments With AI, 53-84 , 2026 2026
Exploring the influence of ethical leadership and culture on employee job satisfaction: the moderating effects of age, gender, tenure, and organizational age S Joseph, A Jadhav, S Gochhait, AO Salau Humanities and Social Sciences Communications 12 (1), 1933 , 2025 2025 Citations: 2
A study of the impact of learning organization on performance of IT organizations: an investigation using second-order SEM R Sandhane, K Patil, S Joseph The Learning Organization 32 (5), 712-732 , 2025 2025 Citations: 2
Exploring the Educational Frontiers of Metaverse S Joseph, AV Kulkarni, P Shah, R Sekhar 2025 International Conference on Information, Implementation, and Innovation … , 2025 2025
MBA Students Perception of Organizational Strategies Driving Sustainability Goals MS Bhor, S Joseph Journal of Asia Entrepreneurship and Sustainability 21 (1), 32-82 , 2025 2025
Harnessing Geospatial Technology for Sustainable Agricultural Development D Kumar, S Joseph Journal of Asia Entrepreneurship and Sustainability 21 (1), 6-31 , 2025 2025
Improving foundational numeracy skills of primary school children: A Case Study L Daniel, A Joshi, N Singh, S Joseph, PJ Dange, M Vesvikar International Review of Economics & Finance, 1059-0560 , 2025 2025
Sustainability education in India: a discourse in education development S Joseph, KP Patil, AV Kulkarni, M John Routledge Handbook of Global Sustainability Education and Thinking for the … , 2025 2025 Citations: 2
Navigating the Digital Wave Equipping Public Officials for Technology- Driven Governance B Kesar, J Shaji Digital Competency Development for Public Officials: Adapting New … , 2025 2025 Citations: 6
Impact of E-Waste Processing on Health and Environment B Kesar, S Joseph Integrated Approaches for Sustainable E-Waste Management, 283-308 , 2025 2025 Citations: 4
Training and Development of Community Resource Person as a Tool for Empowerment of Women—A Qualitative Enquiry L Daniel, S Joseph, SV Thomas, N Singh Securing the Future through Sustainability, Health, Education, and … , 2025 2025
Artificial intelligence technology readiness for social sustainability and business ethics: Evidence from MSMEs in developing nations AV Kulkarni, S Joseph, KP Patil International Journal of Information Management Data Insights 4 (2), 100250 , 2024 2024 Citations: 113
Leaders as Active Creators of Ethical Organizational Culture: A Study of MSME Leaders from India S Joseph Responsible Corporate Leadership Towards Attainment of Sustainable … , 2024 2024 Citations: 2
Influence of Community-Based and Service-Learning Initiatives on Learners’ Engagement in Promoting Sustainable Development D Kumar, S Joseph, N Mukherjee International Conference on Intelligent and Fuzzy Systems, 438-447 , 2024 2024 Citations: 2
Strategic integration of social media in IT sector communication: designing effective practices B Kesar, S Joseph Available at SSRN 5643370 , 2024 2024
Green blockchain technology for organization performance without risky activities: natural-resource-based view KP Patil, D Pramod, S Joseph 2024 Sixth International Conference on Computational Intelligence and … , 2024 2024 Citations: 5
MOST CITED SCHOLAR PUBLICATIONS
Artificial intelligence technology readiness for social sustainability and business ethics: Evidence from MSMEs in developing nations AV Kulkarni, S Joseph, KP Patil International Journal of Information Management Data Insights 4 (2), 100250 , 2024 2024 Citations: 113
An empirical study on the impact of employee voice and silence on destructive leadership and organizational culture S Joseph, N Shetty Asian Journal of Business Ethics 11 (Suppl 1), 85 , 2022 2022 Citations: 55
SYNERGIES BETWEEN SOCIAL MEDIA FEATURES AND USER ENGAGEMENT TO ENHANCE ONLINE BRAND VISIBILITY - A CONCEPTUAL MODEL K A.Goswami, Bharathi, Kelkar, R.Raman, S. Joseph IJET- International Journal of Engineering and Technology 5 (3), 2705-2718 , 2013 2013 Citations: 29
Role of artificial intelligence in sustainability reporting by leveraging ESG theory into action A Kulkarni, S Joseph, K Patil 2023 international Conference on Advancement in Computation & computer … , 2023 2023 Citations: 28
Creating sustainable contribution to the environment: case studies from MSMEs in Pune S Joseph, AV Kulkarni International Journal of Social Ecology and Sustainable Development (IJSESD … , 2020 2020 Citations: 23
Use of structural equation modeling to empirically study the turnover intentions of information technology professionals in Pune city R Raman, V Bharathi, S Allen, S Joseph Indian Journal of Science and Technology 6 (12), 5612-5624 , 2013 2013 Citations: 21
Empowering women of rural India for renewable energy adoption–an exploratory factor analysis S Krishnamurthy, S Joseph, V Pradhan, P Rao Indian Journal of Science and Technology 10 (37), 1-10 , 2017 2017 Citations: 17
Power of the people: political mobilisation and guaranteed employment S Joseph Economic and Political Weekly, 5149-5156 , 2006 2006 Citations: 16
An empirical study on the factors contributing to work family conflict among young employees in the IT companies S Joseph, B Gautam, V Bharathi Indian Journal of Science and Technology 8, S6 , 2015 2015 Citations: 13
Blog Content and User Engagement - An Insight Using Statistical Analysis. Kulkarni, Joseph, Raman, Bharathi, Kelkar, Goswami IJET- International Journal of Engineering and Technology 5 (3), 2719-2733 , 2013 2013 Citations: 11
Role of ethical organisational culture on employee job satisfaction: an empirical study S Joseph, A Jadhav, B Vispute International Journal of Business Governance and Ethics 16 (3), 337-354 , 2022 2022 Citations: 10
Creating environment friendly projects in rural India–A synergy framework for sustainable renewable energy S Krishnamurthy, S Joseph, V Bharathi International Journal of Applied Engineering Research, ISSN, 0973-4562 , 2014 2014 Citations: 10
An approach to solve the identification and authentication challenges in metaverse CN Chetan, DH Ashit, S Joseph 2023 Somaiya International Conference on Technology and Information … , 2023 2023 Citations: 8
Giving Voice to Values A Study of the Leadership Role in Creating a Value Culture in the MSME Sector in India AVKAN Joseph. S. The International Journal of Social Sustainability in Economic, Social and … , 2020 2020 Citations: 7
Navigating the Digital Wave Equipping Public Officials for Technology- Driven Governance B Kesar, J Shaji Digital Competency Development for Public Officials: Adapting New … , 2025 2025 Citations: 6
Green blockchain technology for organization performance without risky activities: natural-resource-based view KP Patil, D Pramod, S Joseph 2024 Sixth International Conference on Computational Intelligence and … , 2024 2024 Citations: 5
Emotional intelligence in the IT industry: a study on emotional intelligence among IT professionals S Kapadwala, S Joseph Cardiometry, 756-763 , 2022 2022 Citations: 5
An empirical study of the impact of ethical leadership on employee job satisfaction (study of MSMEs in India) S Joseph, A Jadhav, A Nagendra Indian Journal of Ecology 47 (spl), 1-7 , 2020 2020 Citations: 5
Inclusion of sustainability education in business schools–An Indian B-school case study of MBA-ITBM curriculum S Krishnamurthy, S Joseph, V Bharathi, V Pradhan International Journal of Applied Engineering Research 9 (23), 22703-22725 , 2014 2014 Citations: 5
Impact of E-Waste Processing on Health and Environment B Kesar, S Joseph Integrated Approaches for Sustainable E-Waste Management, 283-308 , 2025 2025 Citations: 4
