Effect of stretch on conduction in myelinated nerve due to wrist movement: An experimental and analytical study Sabrina Sharmin, Mohammad Abu Sayem Karal, Zaid Bin Mahbub, Khondkar Siddique-e Rabbani Plos One, 2025 Based on related measurements by others, an earlier publication suggested increased nerve conduction velocity (NCV) with stretch in myelinated fibers, an anomaly based on existing knowledge, and hypothesized that widening of narrow zigzag gaps between structures of interdigitated Schwann cell processes at the node affected saltatory conduction to produce this increased NCV. A new nodal resistance Rne between the axonal membrane and extracellular fluid was introduced into the century old cable theory. Later, a direct and careful measurement of ulnar NCV across a 10 cm segment around the elbow by another publication appeared to support the suggestion of increased NCV with stretch. However, in order to eliminate the possibility of slacks of ulnar nerve in the upper arm affecting the measurements, the present work was taken up on a shorter 5 cm segment which again supported the suggestion, increasing confidence in the Rne hypothesis. Furthermore, wrist flexion or extension was also observed to affect the ulnar NCV at the elbow to some extent, revealing a new phenomenon. While attempting to formulate an analytical treatment of Rne, the earlier work found it very challenging as the physical structure was extremely complex. Proposing an alternative physical model to simulate the variation in Rne suggested earlier, the current study presents an analytical treatment that relates Rne and a corresponding effective resistivity value to increases in stretch, and relates these quantitatively to stretch values based on the measured values of NCV. This then provided the basis of a quantitative analysis which could be useful for future research. While appreciating that other microstructures in the node at or near the axonal membrane may also contribute to the observed anomaly, but lack of direct experimental evidence related to nerve stretch tends to weigh more on the Rne hypothesis in explaining the anomaly.
Signer-Independent Arabic Sign Language Recognition System Using Deep Learning Model Kanchon Kanti Podder, Maymouna Ezeddin, Muhammad E. H. Chowdhury, Md. Shaheenur Islam Sumon, Anas M. Tahir, et al. Sensors, 2023 Every one of us has a unique manner of communicating to explore the world, and such communication helps to interpret life. Sign language is the popular language of communication for hearing and speech-disabled people. When a sign language user interacts with a non-sign language user, it becomes difficult for a signer to express themselves to another person. A sign language recognition system can help a signer to interpret the sign of a non-sign language user. This study presents a sign language recognition system that is capable of recognizing Arabic Sign Language from recorded RGB videos. To achieve this, two datasets were considered, such as (1) the raw dataset and (2) the face–hand region-based segmented dataset produced from the raw dataset. Moreover, operational layer-based multi-layer perceptron “SelfMLP” is proposed in this study to build CNN-LSTM-SelfMLP models for Arabic Sign Language recognition. MobileNetV2 and ResNet18-based CNN backbones and three SelfMLPs were used to construct six different models of CNN-LSTM-SelfMLP architecture for performance comparison of Arabic Sign Language recognition. This study examined the signer-independent mode to deal with real-time application circumstances. As a result, MobileNetV2-LSTM-SelfMLP on the segmented dataset achieved the best accuracy of 87.69% with 88.57% precision, 87.69% recall, 87.72% F1 score, and 99.75% specificity. Overall, face–hand region-based segmentation and SelfMLP-infused MobileNetV2-LSTM-SelfMLP surpassed the previous findings on Arabic Sign Language recognition by 10.970% accuracy.
BIO-CXRNET: a robust multimodal stacking machine learning technique for mortality risk prediction of COVID-19 patients using chest X-ray images and clinical data Tawsifur Rahman, Muhammad E. H. Chowdhury, Amith Khandakar, Zaid Bin Mahbub, Md Sakib Abrar Hossain, et al. Neural Computing and Applications, 2023 Nowadays, quick, and accurate diagnosis of COVID-19 is a pressing need. This study presents a multimodal system to meet this need. The presented system employs a machine learning module that learns the required knowledge from the datasets collected from 930 COVID-19 patients hospitalized in Italy during the first wave of COVID-19 (March–June 2020). The dataset consists of twenty-five biomarkers from electronic health record and Chest X-ray (CXR) images. It is found that the system can diagnose low- or high-risk patients with an accuracy, sensitivity, and F1-score of 89.03%, 90.44%, and 89.03%, respectively. The system exhibits 6% higher accuracy than the systems that employ either CXR images or biomarker data. In addition, the system can calculate the mortality risk of high-risk patients using multivariate logistic regression-based nomogram scoring technique. Interested physicians can use the presented system to predict the early mortality risks of COVID-19 patients using the web-link: Covid-severity-grading-AI. In this case, a physician needs to input the following information: CXR image file, Lactate Dehydrogenase (LDH), Oxygen Saturation (O2%), White Blood Cells Count, C-reactive protein, and Age. This way, this study contributes to the management of COVID-19 patients by predicting early mortality risk.
MultiResUNet3+: A Full-Scale Connected Multi-Residual UNet Model to Denoise Electrooculogram and Electromyogram Artifacts from Corrupted Electroencephalogram Signals Md Shafayet Hossain, Sakib Mahmud, Amith Khandakar, Nasser Al-Emadi, Farhana Ahmed Chowdhury, et al. Bioengineering, 2023 Electroencephalogram (EEG) signals immensely suffer from several physiological artifacts, including electrooculogram (EOG), electromyogram (EMG), and electrocardiogram (ECG) artifacts, which must be removed to ensure EEG’s usability. This paper proposes a novel one-dimensional convolutional neural network (1D-CNN), i.e., MultiResUNet3+, to denoise physiological artifacts from corrupted EEG. A publicly available dataset containing clean EEG, EOG, and EMG segments is used to generate semi-synthetic noisy EEG to train, validate and test the proposed MultiResUNet3+, along with four other 1D-CNN models (FPN, UNet, MCGUNet, LinkNet). Adopting a five-fold cross-validation technique, all five models’ performance is measured by estimating temporal and spectral percentage reduction in artifacts, temporal and spectral relative root mean squared error, and average power ratio of each of the five EEG bands to whole spectra. The proposed MultiResUNet3+ achieved the highest temporal and spectral percentage reduction of 94.82% and 92.84%, respectively, in EOG artifacts removal from EOG-contaminated EEG. Moreover, compared to the other four 1D-segmentation models, the proposed MultiResUNet3+ eliminated 83.21% of the spectral artifacts from the EMG-corrupted EEG, which is also the highest. In most situations, our proposed model performed better than the other four 1D-CNN models, evident by the computed performance evaluation metrics.
Increase in conduction velocity in myelinated nerves due to stretch – An experimental verification Sabrina Sharmin, Mohammad Abu Sayem Karal, Zaid Bin Mahbub, Khondkar Siddique-e Rabbani Frontiers in Neuroscience, 2023 BackgroundBased on published experimental evidence, a recent publication revealed an anomalous phenomenon in nerve conduction: for myelinated nerves the nerve conduction velocity (NCV) increases with stretch, which should have been the opposite according to existing concepts and theories since the diameter decreases on stretching. To resolve the anomaly, a new conduction mechanism for myelinated nerves was proposed based on physiological changes in the nodal region, introducing a new electrical resistance at the node. The earlier experimental measurements of NCV were performed on the ulnar nerve at different angles of flexion, focusing at the elbow region, but left some uncertainty for not reporting the lengths of nerve segments involved so that the magnitudes of stretch could not be estimated.AimsThe aim of the present study was to relate NCV of myelinated nerves with different magnitudes of stretch through careful measurements.MethodEssentially, we duplicated the earlier published NCV measurements on ulnar nerves at different angles of flexion but recording appropriate distances between nerve stimulation points on the skin carefully and assuming that the lengths of the underlying nerve segment undergoes the same percentages of changes as that on the skin outside.ResultsWe found that the percentage of nerve stretch across the elbow is directly proportional to the angle of flexion and that the percentage increase in NCV is directly proportional to the percentage increase in nerve stretch. Page’s L Trend test also supported the above trends of changes through obtained p values.DiscussionOur experimental findings on myelinated nerves agree with those of some recent publications which measured changes in CV of single fibres, both myelinated and unmyelinated, on stretch. Analyzing all the observed results, we may infer that the new conduction mechanism based on the nodal resistance and proposed by the recent publication mentioned above is the most plausible one to explain the increase in CV with nerve stretch. Furthermore, interpreting the experimental results in the light of the new mechanism, we may suggest that the ulnar nerve at the forearm is always under a mild stretch, with slightly increased NCV of the myelinated nerves.
FootSegONN: an ensemble of Self-ONN-based models for diabetic foot ulcer segmentation RHMEHC Md. Shaheenur Islam Sumon, Saadia Binte Alam, Rashedur Rahman, Rusab ... Neural Computing and Applications 38 (121) , 2026 2026
Effect of stretch on conduction in myelinated nerve due to wrist movement: An experimental and analytical study S Sharmin, MAS Karal, ZB Mahbub, KS Rabbani Plos one 20 (10), e0333925 , 2025 2025
Restoration of magnetohydrodynamic-corrupted 12-lead electrocardiogram to enhance cardiac monitoring during magnetic resonance imaging S Mahmud, MEH Chowdhury, MH Chowdhury, A Alqahtani, ZB Mahbub, ... Engineering Applications of Artificial Intelligence 133, 108483 , 2024 2024 Citations: 2
NDDNet: a deep learning model for predicting neurodegenerative diseases from gait pattern: NDDNet: a deep learning model for predicting neurodegenerative diseases from gait pattern MAA Faisal, MEH Chowdhury, ZB Mahbub, S Pedersen, MU Ahmed, ... Applied Intelligence 53 (17), 20034-20046 , 2023 2023 Citations: 41
Signer-independent arabic sign language recognition system using deep learning model KK Podder, M Ezeddin, MEH Chowdhury, MSI Sumon, AM Tahir, ... Sensors 23 (16), 7156 , 2023 2023 Citations: 68
Fetal ECG extraction from maternal ECG using deeply supervised LinkNet++ model A Rahman, S Mahmud, MEH Chowdhury, HC Yalcin, A Khandakar, ... Engineering Applications of Artificial Intelligence 123, 106414 , 2023 2023 Citations: 34
BIO-CXRNET: a robust multimodal stacking machine learning technique for mortality risk prediction of COVID-19 patients using chest X-ray images and clinical data T Rahman, MEH Chowdhury, A Khandakar, ZB Mahbub, MSA Hossain, ... Neural Computing and Applications 35 (24), 17461-17483 , 2023 2023 Citations: 38
MultiResUNet3+: a full-scale connected multi-residual UNet model to denoise electrooculogram and electromyogram artifacts from corrupted electroencephalogram signals MS Hossain, S Mahmud, A Khandakar, N Al-Emadi, FA Chowdhury, ... Bioengineering 10 (5), 579 , 2023 2023 Citations: 32
Increase in conduction velocity in myelinated nerves due to stretch–An experimental verification S Sharmin, MAS Karal, ZB Mahbub, KS Rabbani Frontiers in Neuroscience 17, 1084004 , 2023 2023 Citations: 5
Machine learning-based classification of healthy and impaired gaits using 3D-GRF signals MNI Shuzan, MEH Chowdhury, MBI Reaz, A Khandakar, FF Abir, ... Biomedical Signal Processing and Control 81, 104448 , 2023 2023 Citations: 36
Fiber Bragg Gratings based smart insole to measure plantar pressure and temperature S Mahmud, A Khandakar, MEH Chowdhury, M AbdulMoniem, MBI Reaz, ... Sensors and Actuators A: Physical 350, 114092 , 2023 2023 Citations: 27
Design and implementation of a smart insole system to measure plantar pressure and temperature A Khandakar, S Mahmud, MEH Chowdhury, MBI Reaz, S Kiranyaz, ... Sensors 22 (19), 7599 , 2022 2022 Citations: 73
Design, Implementation, and Performance Evaluation of a Fiber Bragg Gratings (FBG) based Smart Insole to Measure Plantar Pressure and Temperature S Mahmud, A Khandakar, MEH Chowdhury, M AbdulMoniem, MBI Reaz, ... arXiv preprint arXiv:2208.12201 , 2022 2022 Citations: 4
Design and implementation of a complete wearable smart insole solution to measure plantar pressure and temperature A Khandakar, S Mahmud, MEH Chowdhury, MBI Reaz, S Kiranyaz, ... arXiv preprint arXiv:2206.07779 , 2022 2022 Citations: 12
Thermal change index-based diabetic foot thermogram image classification using machine learning techniques A Khandakar, MEH Chowdhury, MBI Reaz, SHM Ali, TO Abbas, T Alam, ... Sensors 22 (5), 1793 , 2022 2022 Citations: 62
Bangla sign language (bdsl) alphabets and numerals classification using a deep learning model KK Podder, MEH Chowdhury, AM Tahir, ZB Mahbub, A Khandakar, ... Sensors 22 (2), 574 , 2022 2022 Citations: 91
Recent developments in the kinetics of ruptures of giant vesicles under constant tension ZBM Mohammad Abu Sayem Karal, Md. Kabir Ahamed, Marzuk Ahmed RSC Advances , 2021 2021 Citations: 16
A new purification technique to obtain specific size distribution of giant lipid vesicles using dual filtration ZBM Mohammad Abu Sayem Karal, Tawfika Nasrin, Marzuk Ahmed, Md. Kabir Ahamed ... PLOS ONE , 2021 2021 Citations: 10
A novel non-invasive estimation of respiration rate from motion corrupted photoplethysmograph signal using machine learning model MNI Shuzan, MH Chowdhury, MS Hossain, MEH Chowdhury, MBI Reaz, ... IEEE Access 9, 96775-96790 , 2021 2021 Citations: 67
A novel non-invasive estimation of respiration rate from photoplethysmograph signal using machine learning model MNI Shuzan, MH Chowdhury, MEH Chowdhury, MM Uddin, A Khandakar, ... arXiv preprint arXiv:2102.09483 , 2021 2021 Citations: 6
MOST CITED SCHOLAR PUBLICATIONS
Can AI help in screening viral and COVID-19 pneumonia? MEH Chowdhury, T Rahman, A Khandakar, R Mazhar, MA Kadir, ... Ieee Access 8, 132665-132676 , 2020 2020 Citations: 2369
Transfer learning with deep convolutional neural network (CNN) for pneumonia detection using chest X-ray T Rahman, MEH Chowdhury, A Khandakar, KR Islam, KF Islam, ... Applied Sciences 10 (9), 3233 , 2020 2020 Citations: 794
Reliable tuberculosis detection using chest X-ray with deep learning, segmentation and visualization T Rahman, A Khandakar, MA Kadir, KR Islam, KF Islam, R Mazhar, ... Ieee Access 8, 191586-191601 , 2020 2020 Citations: 771
Estimating blood pressure from the photoplethysmogram signal and demographic features using machine learning techniques MH Chowdhury, MNI Shuzan, MEH Chowdhury, ZB Mahbub, MM Uddin, ... Sensors 20 (11), 3127 , 2020 2020 Citations: 308
Bangla sign language (bdsl) alphabets and numerals classification using a deep learning model KK Podder, MEH Chowdhury, AM Tahir, ZB Mahbub, A Khandakar, ... Sensors 22 (2), 574 , 2022 2022 Citations: 91
Design and implementation of a smart insole system to measure plantar pressure and temperature A Khandakar, S Mahmud, MEH Chowdhury, MBI Reaz, S Kiranyaz, ... Sensors 22 (19), 7599 , 2022 2022 Citations: 73
Signer-independent arabic sign language recognition system using deep learning model KK Podder, M Ezeddin, MEH Chowdhury, MSI Sumon, AM Tahir, ... Sensors 23 (16), 7156 , 2023 2023 Citations: 68
A novel non-invasive estimation of respiration rate from motion corrupted photoplethysmograph signal using machine learning model MNI Shuzan, MH Chowdhury, MS Hossain, MEH Chowdhury, MBI Reaz, ... IEEE Access 9, 96775-96790 , 2021 2021 Citations: 67
Thermal change index-based diabetic foot thermogram image classification using machine learning techniques A Khandakar, MEH Chowdhury, MBI Reaz, SHM Ali, TO Abbas, T Alam, ... Sensors 22 (5), 1793 , 2022 2022 Citations: 62
Nanosensors in biomedical and environmental applications: Perspectives and prospects M Rabbani, ME Hoque, ZB Mahbub Nanofabrication for smart nanosensor applications, 163-186 , 2020 2020 Citations: 47
NDDNet: a deep learning model for predicting neurodegenerative diseases from gait pattern: NDDNet: a deep learning model for predicting neurodegenerative diseases from gait pattern MAA Faisal, MEH Chowdhury, ZB Mahbub, S Pedersen, MU Ahmed, ... Applied Intelligence 53 (17), 20034-20046 , 2023 2023 Citations: 41
BIO-CXRNET: a robust multimodal stacking machine learning technique for mortality risk prediction of COVID-19 patients using chest X-ray images and clinical data T Rahman, MEH Chowdhury, A Khandakar, ZB Mahbub, MSA Hossain, ... Neural Computing and Applications 35 (24), 17461-17483 , 2023 2023 Citations: 38
Machine learning-based classification of healthy and impaired gaits using 3D-GRF signals MNI Shuzan, MEH Chowdhury, MBI Reaz, A Khandakar, FF Abir, ... Biomedical Signal Processing and Control 81, 104448 , 2023 2023 Citations: 36
Study of molecular transport through a single nanopore in the membrane of a giant unilamellar vesicle using COMSOL simulation MAS Karal, MK Islam, ZB Mahbub European Biophysics Journal 49 (1), 59-69 , 2020 2020 Citations: 35
Fetal ECG extraction from maternal ECG using deeply supervised LinkNet++ model A Rahman, S Mahmud, MEH Chowdhury, HC Yalcin, A Khandakar, ... Engineering Applications of Artificial Intelligence 123, 106414 , 2023 2023 Citations: 34
MultiResUNet3+: a full-scale connected multi-residual UNet model to denoise electrooculogram and electromyogram artifacts from corrupted electroencephalogram signals MS Hossain, S Mahmud, A Khandakar, N Al-Emadi, FA Chowdhury, ... Bioengineering 10 (5), 579 , 2023 2023 Citations: 32
Fiber Bragg Gratings based smart insole to measure plantar pressure and temperature S Mahmud, A Khandakar, MEH Chowdhury, M AbdulMoniem, MBI Reaz, ... Sensors and Actuators A: Physical 350, 114092 , 2023 2023 Citations: 27
Bangla sign language alphabet recognition using transfer learning based convolutional neural network KK Podder, M Chowdhury, ZB Mahbub, M Kadir Bangladesh J. Sci. Res 31 (1), 20-26 , 2020 2020 Citations: 25
Can AI help in screening viral and COVID-19 pneumonia? arXiv 2020 ME Chowdhury, T Rahman, A Khandakar, R Mazhar, MA Kadir, ... arXiv preprint arXiv:2003.13145 , 2020 2020 Citations: 24
Deformation and poration of giant unilamellar vesicles induced by anionic nanoparticles MAS Karal, S Ahammed, V Levadny, M Belaya, MK Ahamed, M Ahmed, ... Chemistry and Physics of Lipids 230, 104916 , 2020 2020 Citations: 23