@pu.edu.pk
PhD & Post Doctorate (Biochemistry & Molecular Biology)
School of Biological Sciences, University of The Punjab, Lahore, Pakistan
The proposed project aims to harness advanced protein engineering strategies for the design, production, and application of recombinant peptides and enzymes with high industrial and therapeutic potential. Building upon previous research in keratin-associated peptides for cosmetic biotechnology and thermostable α-amylases for industrial biocatalysis, this project will focus on developing novel bioactive peptides with applications in hair and skin health, alongside engineered enzymes with enhanced thermostability, catalytic efficiency, and substrate specificity for the textile, detergent, starch, and food industries. A combination of computational biology (in silico modeling, molecular docking, and dynamics simulations) and experimental approaches (site-directed mutagenesis, X-ray crystallography, ITC, and SUMO-fusion technology) will be employed to achieve targeted modifications. Furthermore, potential therapeutic peptide leads will be explored for antimicrobial and immunomodulatory.
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