Tanmoy Ghosh
@msruas.ac.in
Assistant Professor Dept. Of Pharmaceutics Faculty of Pharmacy
MS Ramaiah University Of Applied Sciences Bangalore 560054
RESEARCH INTERESTS
Wound healing, biomaterials, natural compounds, polymorphs, Cocrystals
Scopus Publications
Scopus Publications
Tanmoy Ghosh, Deveswaran Rajamanickam, Damodar Nayak, Bharath Srinivasan, and Basavaraj B.V.
Elsevier BV
Tanmoy Ghosh, Yusuf Mohammed, Manikanta Murahari, Sharon Esther Samual, Rajamanickam Deveswaran, and B.V. Basavaraj
Elsevier BV
Tanmoy Ghosh, Rajamanickam Deveswaran, Manikanta Murahari, and Srinivasan Bharath
Springer Science and Business Media LLC
U.K. Manisha, Tanmoy Ghosh, V.P. Apoorva, B. Divya, S.P. Swathy, Ankita Paul, and B.V. Basavraj
Elsevier BV
Tanmoy Ghosh, Rajamanickam Deveswaran, and Srinivasan Bharath
Elsevier BV
Thimmasetty J, Shashank NN, Abdul Raheem T, Shwetha SKK, and Tanmoy G
A and V Publications
The present investigation was designed to prepare and characterize BCS class II drug modafinil cocrystals for its solubility enhancement and other properties. Hansen solubility parameter (HSP) was used for prediction of cocrystal formation. Coformers/excipients namely boric acid, cinnamic acid, salicylic acid, and tartaric acid were used in the preparation of cocrystals by liquid assisted grinding method with 1:1 molar ratio of drug and coformer. The prepared cocrystals were subjected to characterization by performing melting point determination, solubility analysis at its saturation point, and drug release by in vitro method. Furthermore, characterization was also done by Fourier Transform IR spectroscopy, Differential Scanning Calorimetry, PXRD and Scanning Electron Microscopy. The formation of modafinil cocrystals by using cinnamic acid and salicylic acid and the formation of modafinil complexes with boric acid and tartaric acid were confirmed by collectively assessing the results. Moreover, a drastic improvement in the solubility revealed the importance of preparing pharmaceutically useful cocrystals of marketed active pharmaceutical ingredients (APIs). However, the increased dissolution rates were seen with cocrystals but not with the complexes. Thus solid state manipulation technique can be used to improve the physicochemical properties of an API using HSP as a successful tool for the prediction of cocrystal formation among the partners.
J. Thimmasetty, T. Ghosh, N. Shashank Nayak, and A. Raheem
Springer Science and Business Media LLC
Sathiya Krishnaraj, Komala Mahadevappa, Radhika Muniyappa Narayanaswamy, Devanand Kamnoore, Ramya Lingutla, and Tanmoy Ghosh
Bentham Science Publishers Ltd.
Background: Many topical agents are available in the market, which interfere with the pigmentation process at different levels. They are often known to cause side effects ranging from irritation to tumor over chronic use. Objective: The present study was designed to develop and characterize an anti blemish cream containing herbal oils. Methods: A herbal cream was formulated using dill, nagarmotha and black cumin oil and subjected to evaluation of its anti blemish potential against stress augmented UV-B rays-induced hyperpigmentation. Topical oil in water type of creams containing 2%, 4% and 6% of each oil was formulated using herbal oils. The formulated cream was characterized for solubility, pH, particle size, grittiness, viscosity, stability, phase separation, shelf life and spreadability, and found to be stable. Acute dermal toxicity was carried out individually for dill, nagarmotha and black cumin oil according to the OECD guidelines 402. Hyperpigmentation was induced in all the experimental animals by stress-augmented UV-B irradiation method. The animals were treated for 30 days (twice daily) with standard and test formulations by topical administration, whereas the disease group was left untreated. The skin of the animals was subjected to photographical study as well as grading for pigmentation and irritation before and after treatment. After the treatment period, the serum antioxidant levels were estimated and histopathology, histochemical studies of skin were performed. Results: The animals treated with test formulations containing 2%, 4%, and 6% of herbal oil showed significant improvement in pigmentation compared to disease control as it is evident in photographic biochemical, histopathological and histochemical studies. Conclusion: Thus, it was concluded that the developed anti-blemish cream containing herbal oils possesses significant anti-blemish potential. This study necessitates further evaluations in human subjects as it could have a high positive therapeutic value in the treatment of hyperpigmentation.
T. Ghosh, V. Karki, A. Ghosh, Ashok Kumar and Prabha Hullatti
Objective: The objective of the work was to formulate coated microbeads using core-coat technique for chronotherapeutic delivery of Carvedilol (cd). Methods: Sodium alginate microbeads containing cd was formulated by ionic gelation method using calcium chloride as a gelling agent. Microbeads were then coated with acrylcoat L 100 (acL 100), acrylcoat S 100 (acS 100), ethyl cellulose (EC), and acrylcoat E30 D (acE 30D) in different ratio. Formulated batches were evaluated using FTIR, particle size measurement, percent entrapment efficiency, micrometric properties, swelling studies, loose surface crystal studies, percentage moisture loss. The formulations were then subjected to in vitro dissolution studies. Cumulative release data was then subjected to different dissolution models reported in the literature. Results: Formulated batches of microbeads were within acceptable particle size range with good to fair flow properties. Entrapment efficiency was in the range of 64% to 99.52%. Loose surface crystal study revealed successful drug entrapment within a range of 2.11 to 9.93%. Swelling studies revealed maximum swelling in alkaline phosphate buffer pH 7.4 solution and percentage moisture loss was within 0.24% to 7.55%. SEM showed microbeads to be spherical in nature and FTIR study exhibited compatibility among the drug and polymer. In vitro release study was carried out for first 3 h in 0.1N HCl and subsequently for 7 h in phosphate buffer solution pH 7.4. Formulation code AC3, AC4, LA4 and LA6 were found in line with our objective of chronotherapeutic drug delivery. Conclusion: Sodium alginate beads loaded with cd and coated with different ratios of coating solutions were successfully formulated and evaluated to optimize the best possible combinations of the coat-core ratio for chronotherapeutic delivery.
Amith Kumar B, Kiran Kumar Hullatti, Tanmoy Ghosh, and Prabha Hullatti
SynthesisHub Advance Scientific Research
Standardization is the need of the hour in Ayurvedic system of medicine. The traditional systems of medicine are really effective but the problem with them is they lack in quality assurance. This enables us to recognise the quality of the formulation. The Central Council of Research in Ayurveda and Siddha has prescribed the preliminary guidelines for testing the quality of these formulations. It is essential to derive a protocol or develop methods for evaluation of herbal formulation to maintain uniformity between batches during production. The present work aims to review to standardize a polyherbal churnas available in the market.
A. Ghosh, S. Biswas, and T. Ghosh
EManuscript Technologies
Silymarin is a hepatoprotective agent, having poor water solubility and oral absorption of about 23 - 47%, leading to low bioavailability of the drug. The aim of the present study is to improve the solubility and dissolution rate and in turn the hepatoprotective activity of the drug, by formulating its inclusion complex with beta (β)-cyclodextrin, using different methods. The phase solubility analysis indicates the formation of 1:1 molar inclusion complex of the drug with beta cyclodextrin. Apparent stability constant for Silymarin (K c ) was 722 K−1 with β-cyclodextrin complex. The inclusion complexes were prepared by four different methods, namely, physical mixing, kneading, co-precipitation, and solvent evaporation. The prepared complexes were characterized using differential scanning colorimetry, scanning electron microscopy, and x-ray diffractometry. The inclusion complex prepared by the co-precipitation methods exhibits an overall best result, with respect to the formulation of sustained release formulations.
A Ghosh and T Ghosh
SynthesisHub Advance Scientific Research
Substances taken for nonmedical reasons, usually for their mind-altering effects, are called drugs of abuse. The use of psychoactive plants as drugs of abuse has had a long tradition. Most commonly abused drugs extracted from or based on natural products are illicit substances, such as cannabis products, morphine, or cocaine, but other herbal products used to produce a "high" are becoming increasingly popular drugs of abuse. Unfortunately, these "new herbal drugs" are falsely labelled as safe and legal. Health care professionals must be cognizant of this emerging problem as increased media coverage and marketing have made these products accessible and recognizable to many young adults and teenagers. This article gives a brief view of some herbal drugs of abuse, and their current trends of use.