@indrashiluniversity.edu.in
Assistant Professor in chemistry, Department of Humanity and Science, School of Engineering
INDRASHIL UNIVERISTY
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Jaymin Parikh, Keyur Bhatt, Krunal Modi, Ajay Desai, Nihal Patel, Chirag Patel, and Ravibhai Bhola
Informa UK Limited
The detailed binding insight between the fluorophore and analyte plays a pivotal role in the design of an efficient chemosensor for water pollution. In this study, we designed a picolinic acid-functionalized calix[4]pyrrole ligand (PCACP). When testing out the fluorescence study with selected antibiotics, we observed remarkable enhancement of fluorescence spectra in the presence of ciprofloxacin, singling out the PCACP_Ciprofloxacin complex. The detailed binding mechanism is explored via computational methods including molecular docking and dynamics, DFT (density functional theory) and NBO (Natural Bonding Orbital) analysis. The result of this study provides the comprehensive insight into the involvement of functionalized group of PCACP and ciprofloxacin antibiotic. The results of the computational findings are further explored through NMR complexation study, which corroborate the computational findings. With the limit of detection calculated at 18 µM, we carried out the water sample analysis, which shows promising results. The outcome of this research provides a new, effortless fluorescence approach to monitor the presence of ciprofloxacin in water.In the presence of the ciprofloxacin antibiotic, the fluorescence spectra of PCACP experience remarkable enhancements. This complexation phenomenon is studied through different computational and experimental methods.Communicated by Ramaswamy H. Sarma.
Kinjal Modi, Krunal Modi, Keyur Bhatt, Nihal Patel, Jaymin Parikh, Brij Mohan, Namrata Bajaj, Amish Vyas, and Flory Kothari
Springer Science and Business Media LLC
Nihal Patel, Krunal Modi, Keyur Bhatt, Jaymin Parikh, Ajay Desai, Bhavesh Jain, Nirali Parmar, Chirag N. Patel, Alan Liska, Jiri Ludvik,et al.
American Chemical Society (ACS)
The detection of trace amounts of sulfosulfuron, a pesticide of increasing importance, has become a pressing issue, prompting the development of effective chemosensors. In this study, we functionalized cyclotricatechylene (CTC) with propyl-phthalimide due to the presence of electronegative oxygen and nitrogen binding sites. Our optimized ligand displayed the highest docking score with sulfosulfuron, and experimental studies confirmed a significant fluorescence enhancement upon its interaction with sulfosulfuron. To gain a deeper understanding of the binding mechanism, we introduced density functional theory (DFT) studies. We carried out binding constant, Job’s plot, and limit of detection (LOD) calculations to establish the effectiveness of our chemosensor as a selective detector for sulfosulfuron. These findings demonstrate the potential of our chemosensor for future applications in the field of pesticide detection.
Vishv Desai, Shuvankar Dey, Falak Panjwani, Banabithi Koley Seth, Krunal Modi, Manoj Vora, and Vinod Kumar Jain
Elsevier BV
Aleksei Kuzin, Guoxiang Chen, Fenyang Zhu, Dmitry Gorin, Brij Mohan, Udit Choudhury, Jizhai Cui, Krunal Modi, Gaoshan Huang, Yongfeng Mei,et al.
Royal Society of Chemistry (RSC)
Utilizing the capabilities of "nanomotors," "nanomachines," and "nanorobotics" can revolutionize air purification, transitioning from passive approaches to intelligent, active nanoscale control systems.
Nihal Patel, Krunal Modi, Jaymin Parikh, Keyur Bhatt, Chirag Patel, Alan Liska, and Jiri Ludvik
Springer Science and Business Media LLC
Priyanka Kashyap, Dushyantsingh Rajpurohit, Krunal Modi, Hinaly Bhasin, Patrick Fernandes, and Divya Mishra
Springer Science and Business Media LLC
Vishv Desai, Manoj Vora, Krunal Modi, Banabithi Koley Seth, Falak Panjwani, Ashu Verma, Nihal Patel, Chirag Patel, and Vinod Kumar Jain
Wiley
AbstractA novel pyrene appended supramolecular assembly (PAOC) has been fabricated by reacting intermediate‐pyren‐1‐ylmethyl 2‐chloroacetate (PMCA) with oxacalix[4]arene and characterized by 1H NMR, 13 C NMR and ESI‐Mass. PAOC works as fluorescent chemosensor for the selective detection of nitroaromatic compounds such as 4‐nitrophenol (4NP) and 2,4,6‐trinitrophenol (TNP). The binding mechanism between PAOC and the analytes were investigated through various spectroscopic techniques, and the results indicate a strong interaction between the two. The fluorescence intensity of PAOC is quenched upon interaction with nitroaromatic compounds due to a photoinduced electron transfer process, which was validated by DFT calculations. The sensor exhibits excellent selectivity and sensitivity towards TNP over other nitroaromatic compounds. The detection limits for TNP and 4NP were found to be 1.6 μM and 1.9 μM, respectively. PAOC's detection results in real water samples are remarkable. This study provides a new approach to develop highly selective and sensitive chemosensor for the detection of nitroaromatic compounds, which have significant environmental and health hazards.
Nihal Patel, Krunal Modi, Keyur Bhatt, Brij Mohan, Jaymin Parikh, Alan Liska, Jiri Ludvik, Chirag Patel, V.K. Jain, and Divya Mishra
Elsevier BV
Ashwani Kumar, Virender, Brij Mohan, Jaymin Parikh, and Krunal Modi
Elsevier BV
Harsh C. Patel, Manan S. Patel, Jaydeepkumar N. Parekh, Dipakkumar D. Chudasama, Priyanka Dalwadi, Anju Kunjadiya, Vaibhav Bhatt, Krunal M. Modi, Chirag N. Patel, and Kesur R. Ram
Informa UK Limited
Diversely functionalized pyrazolo-pyridine fused tetrazolo-pyrimidines 10aa-am and 10ba-bn were successfully synthesized via a catalyst-free synthetic protocol with moderate to very good yields. The compounds were evaluated for cytotoxicity against MCF-7 and HEK-293 cells using MTT assay. Among the tested compounds, 10ab (IC50- 23.83 µM) and 10ah (IC50- 23.30 µM) demonstrated the highest potency against MCF-7 cells, while 10bc (IC50- 14.46 µM) and 10bh (IC50- 2.53 µM) exhibited excellent cytotoxicity against HEK-293 cells. Additionally, antibacterial screening was performed against three Gram-negative bacteria (E. coli, P. aeruginosa, and S. enterica) and three Gram-positive bacteria (S. aureus, B. megaterium, and B. subtilis) using broth dilution method, while antifungal activity was assessed against three fungal strains (A. niger, Penicillium, and S. cerevisiae) using agar well diffusion method. In antimicrobial screening, the majority of the compounds demonstrated significant antibacterial efficacy compared to antifungal activity. We also conducted comprehensive computational studies, including DFT calculations, molecular docking and dynamics, and drug-likeness assessments. In the DFT study, compounds 10ac and 10bc displayed stable conformations, indicating their potential for higher therapeutic activity. Molecular docking analyses revealed compelling interactions, with compound 10ah demonstrating docking score -7.42 kcal/mol against catalytical domain PARP1 (PDB ID: 7KK4) and 10bh exhibiting a best docking score -10.77 kcal/mol against human corticotropin-releasing factor receptor 1 (PDB ID: 4Z9G). A 100 ns molecular dynamics (MD) simulation study of compounds 10ah and 10bh revealed the stable conformation and binding energy in a stimulating environment. In drug-likeness assessments, both the compounds 10ah and 10bh adhere all the established guidelines.Communicated by Ramaswamy H. Sarma.
Vishv Desai, Manthan Panchal, Jaymin Parikh, Krunal Modi, Manoj Vora, Falak Panjwani, and Vinod Kumar Jain
Springer Science and Business Media LLC
Himali Upadhyay, Uma Harikrishnan, Devanshi Bhatt, Namrata Dhadnekar, Kapil Kumar, Manthan Panchal, Pooja Trivedi, Gaurang Sindhav, and Krunal Modi
Springer Science and Business Media LLC
Vishv Desai, Krunal Modi, Falak Panjwani, Banabithi Koley Seth, Manoj Vora, Jaymin Parikh, and Vinod Kumar Jain
Springer Science and Business Media LLC
Jaymin Parikh, Keyur Bhatt, Nihal Patel, Krunal Modi, and Nirali Parmar
Informa UK Limited
Functionalized calix[4]pyrroles are at forefront of host-guest aided molecular sensors. They offer unique platform for flexible functionalization to develop receptors suitable for different applications. In this context, calix[4]pyrrole derivative (TACP) was functionalized with an acidic group to investigate its binding behavior with different amino acids. The acid functionalization facilitated host-guest interactions through hydrogen bonding and increase the solubility of ligand in 90% aqueous media. The results indicated that TACP exhibited significant fluorescence enhancement in the presence of tryptophan while no considerable changes were observed with other amino acids. The other complexation properties such as LOD and LOQ were determined to be 25 µM and 22 µM respectively with 1:1 stoichiometry. In addition, the proposed binding phenomena were further confirmed through computational docking studies and NMR complexation study. Overall, this work highlights the potential of acid functionalization in developing molecular sensors for amino acid detection using calix[4]pyrrole derivatives.Communicated by Ramaswamy H. Sarma.
Brij Mohan, Sandeep Kumar, Suresh Kumar, Krunal Modi, Deependra Tyagi, Dimitri Papukashvili, Nino Rcheulishvili, and Armando J. L. Pombeiro
Royal Society of Chemistry (RSC)
MicroRNAs (miRNAs) with nucleotides are a class of endogenous small RNAs and can play crucial functions in diagnosing diseases.
Bhavesh Dhumale, Keyur D. Bhatt, Nihal Patel, and Krunal Modi
Elsevier BV
Jaymin Parikh, Brij Mohan, Keyur Bhatt, Nihal Patel, Siddhant Patel, Amish Vyas, and Krunal Modi
Elsevier BV
Chirag N. Patel, Siddhi P. Jani, Sivakumar Prasanth Kumar, Krunal M. Modi, and Yogesh Kumar
Elsevier BV
Ashwani Kumar, Virender, Brij Mohan, Krunal Modi, Muhammad Aizaz Ud Din, and Satish Kumar
Elsevier BV
Brij Mohan, Sandeep Kumar, Virender, Ashwani Kumar, Krishan Kumar, Krunal Modi, Tianhui Jiao, and Quansheng Chen
Elsevier BV
Ajay L. Desai, Keyur D. Bhatt, Krunal M. Modi, Chirag Patel, and Shibu G. Pillai
Elsevier BV
Falak Panjwani, Shuvankar Dey, Anita Kongor, Anshu Kumar, Manthan Panchal, Krunal Modi, Manoj Vora, Ashu kumar, and Vinod Kumar Jain
Springer Science and Business Media LLC
Mansi Panchal, K. Bhatt, Krunal M. Modi and Manthan Panchal
AMG Transcend Association
In terms of social security and support, quick, ultra-sensitive, and ultra-selective detection of explosives is urgently needed around the world. This review is ardent to calixarene a recent selective and sensitive explosive sensor. The structural binding properties of the Calix system and macromolecules can be modified by various structural mode changes and interactions, and multiple possibilities of functionalization of the calixarene make these versatile molecules in the phenomena of specific recognition. This study reflects on the use of fluorescence-based chemosensors for explosive detection that has been mentioned in the literature. From this review, it is implied that calixarene excellently complexes with high selectivity explosives and attraction associated with other simple ion receptor applications using different ions.
Jaymin Parikh, Keyur Bhatt, Krunal Modi, Nihal Patel, Ajay Desai, Sandeep Kumar, and Brij Mohan
Wiley