Lebedeva Gaia Valerievna
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RESEARCH, TEACHING, or OTHER INTERESTS
Medicine
Scopus Publications
- Features of the psychoemotional state of patients with olfactory dysfunction
G. V. Lebedeva, M. V. Svistushkin, A. B. Maltsev, V. M. Svistushkin, V. A. Kudryavtseva, et al.
Meditsinskiy Sovet, 2025
Introduction. In foreign studies, dysosmia is more often considered as a marker for for diagnostics various pathologies. The question of whether olfactory disorder can act as an etiological factor and influence the occurrence of pathological psychoemotional states (anxiety, depression) remains ambiguous. Aim. Тo assess the correlation between the severity of olfactory dysfunction and changes in the psychoemotional state (depression, anxiety disorder). Materials and methods. 60 patients participated in this study. According to the nosology, the patients were divided into 3 groups: polypous rhinosinusitis (n = 23); post-traumatic (n = 10) and post-infectious olfactory dysfunction (n = 27). Before the study, all patients underwent an assessment of their olfactory identification ability using a Russian olfactory test. The study included patients who, according to the test results: olfactory identification ability < 16 points. The PHQ-9 (Patient Health Questionnaire 9) and the GAD-7 (Generalized Anxiety Disorder 7) were used as a method for diagnosing depression and anxiety. Results. When analyzing the obtained data for the entire sample of patients using Spearman correlation, a correlation was found between the severity of olfactory dysfunction and changes in the psychoemotional state (depression r s = -0.388, p < 0.01; anxiety r s = -0.275, p = 0.034). Statistically significant results were also obtained in groups of patients for each nosology: polypous rhinosinusitis r s = -0.485, p = 0.019; post-infectious olfactory dysfunction r s = -0.501, p < 0.01; post-traumatic olfactory dysfunction r s = -0.945, p < 0.001. Similar results were found in patients with anxiety symptoms: polypous rhinosinusitis r s = -0.46, p = 0.027; post-infectious dysfunction r s = -0.52, p < 0.01 and post-traumatic dysfunction r s = -0.73, p = 0.017. Conclusions. The obtained data substantiate the clinical significance of a comprehensive examination of patients with olfactory disorde rs using validated scales for assessing symptoms of depression and anxiety. - Possibilities of using the domestic olfactory test in the diagnosis of typical olfactory disorders
G.V. Lebedeva, M.V. Svistushkin, L.V. Selezneva, V.A. Kudryavtseva, K.K. Pogosyan, et al.
Russian Medical Inquiry, 2024
Background: the diagnosis of olfactory disorders remains a critical issue in clinical practice. Olfactory testing is the most commonly utilized diagnostic tool. Previously, we developed an olfactory test and validated it on healthy volunteers. Aim: to evaluate the diagnostic efficacy of a domestic olfactory test in detecting various olfactory disorders. Materials and Methods: this study included 100 patients presenting with typical olfactory disorders. Subjects were categorized into three groups: acute rhinosinusitis (AR) (n=50), polypous rhinosinusitis (PR) (n=25), and post-viral olfactory dysfunction (PVDO) (n=25). Olfactory function was assessed using the developed test and a visual analog scale (VAS) for comparative analysis. Olfactory threshold and odor discrimination ability were measured in all groups using the olfactory test. In the PR and PVDO groups, the assessment was conducted once on the examination day. In the AR group, assessments were performed twice: on the day of treatment and 14 days post-treatment. Results: olfactory dysfunction was detected in all groups. In the AR group, both the VAS and the domestic olfactory test indicated a decrease in olfactory threshold without changes in odor discrimination ability. Fourteen days post-treatment, improvements in olfactory threshold and odor discrimination were noted, although VAS scores demonstrated a decline. In the PR and PVDO groups, both VAS and the domestic olfactory test showed reductions in olfactory threshold and odor discrimination abilities. VAS results highly correlated with the olfactory threshold across all groups, and additionally with odor discrimination ability in the PVDO group. Conclusion: the study demonstrated the effectiveness of the domestic olfactory test in diagnosing typical olfactory disorders. KEYWORDS: olfaction, olfactory test, olfactory diagnostics, olfactory threshold, odor discrimination ability, acute rhinosinusitis, polypous rhinosinusitis, post-viral olfactory dysfunction, odor. FOR CITATION: Lebedeva G.V., Svistushkin M.V., Selezneva L.V., Kudryavtseva V.A., Pogosyan K.K., Zinchenko I.A., Svistushkin V.M. Possibilities of using the domestic olfactory test in the diagnosis of typical olfactory disorders. Russian Medical Inquiry. 2024;8(8):470–476 (in Russ.). DOI: 10.32364/2587-6821-2024-8-8-5. - Development and validation of Russian olfactory test
G.V. Lebedeva, M.V. Svistushkin, L.V. Selezneva, Yu.N. Muzychenko, A.Yu. Suvorov, et al.
Vestnik Otorinolaringologii, 2024
Olfactory disorders is one of the first symptoms of diseases from various departments of medicine (otorhinolaryngology, psychology, neurology, etc.). Based on international clinical recommendations, olfactory tests are the gold standard for the diagnosis of olfactory disorders. There are many different psychophysical tests: UPSIT (USA, Pennsylvania), Sniffin’ Sticks test (Germany), BAST-24 (Spain), etc. Currently, there is an acute shortage of olfactory tests available for clinical practice In Russia. This problem is related to the fact that there are no olfactory tests registered as medical devices on the territory of the Russian Federation. Also, a significant limitation is the unrecognizability of odors by the population of our country, which include foreign analogues (licorice, anise, turpentine, etc.). Objective. To develop and validate the national olfactory test on healthy volunteers. Material and methods. The development and validation of the olfactory test included several stages. First, the development of an olfactory test was carried out, the selection of aromas to assess the threshold and identification ability of olfaction. 25 dilutions of n-butanol were used for the assessment of the threshold olfactory ability. For the stage of assessing the identification ability of the sense of smell, in our previous study, an assessment of the recognition of odor names in the territory of the Russian Federation was carried out. A total of 3.000 people from 8 federal districts of the Russian Federation were interviewed. During the development of the test, 20 names of flavors with the highest rating were used. By the 8th, the selection of monocomponent substances was carried out. Commercially available certified food and perfume flavorings have been used for fragrances whose equivalent in the test cannot be a monocomponent substance. A group of 25 healthy volunteers selected a flavor or a monocomponent for each of the 20 positions. To carry out the identification stage of testing, a booklet was developed with answer options for each fragrance, including 80 images associated with the smell. A methodology for conducting diagnostics has been created. Next, the validation of the developed olfactory test was carried out on 150 healthy volunteers. The study included an assessment of the threshold and identification ability of the sense of smell using the developed test and conducting a comparative analysis with a set of flavors and descriptors corresponding to the Sniffin’ Sticks test. Results. The developed test includes: 2 panels — panel 1 to assess the threshold ability of smell, panel 2 to assess the identification ability of smell, a booklet with 80 images and captions to them. The norms of threshold and identification olfactory abilities were also determined in the developed test. The domestic test was validated against the relative foreign Sniffin’ Sticks test. Spearman’s correlation between the accuracy values of the domestic test (17—20; 85.00—100.00%) and the values of the foreign test (11—16; 68.75—100.00%) did not reveal statistically significant differences (rs=0.065, p=0.432), which confirms the equally effective assessment of olfactory ability by the domestic olfactory test in comparison with its foreign counterpart. Conclusion. In this work, a methodology for the use of Russian olfactory test was developed and validated on healthy volunteers. The features of the developed test are an assessment of the threshold and identification ability of smell, an adapted set of odors for the Russian population, the use of paper blotters when applying flavor and visual images of descriptors. Despite the wide variety of psychophysical tests, this problem requires further study and comparative analysis of olfactory tests available In Russia and foreign analogues in order to obtain a universal and effective diagnostic method for the populations of our country. This work was supported by the Russian Foundation for Basic Research (Project No. 24-25-00415). - Modern methods of diagnosis and treatment of patients with COVID and post-COVID anosmia
G. V. Lebedeva, S. V. Morozova, L. V. Selezneva, M. V. Svistushkin
Meditsinskiy Sovet, 2023
Since 2019, the interest in coronavirus infection has increased worldwide due to the emergence of several pandemic outbreaks associated with this group of pathogens. In total, 3 outbreaks of pandemics were registered in the 21st century, caused by new strains of coronaviruses: MERS-CoV, SARS-CoV and SARS-CoV-2. Among them the leader in prevalence, occurrence of severe respiratory complications and mortality is SARS-CoV-2. SARS-CoV-2 is the causative agent of the coronavirus disease of 2019. COVID-19 is a disease characterized by acute respiratory viral syndrome, transmitted by airborne droplets. The clinical course of COVID-19 varies significantly from patient to patient and can range from asymptomatic to severe forms. One of the common symptoms of the manifestation of COVID-19 is a smell disorder. The pathogenesis and clinical course of coronavirus infection caused by SARS-CoV-2 were examined to identify the causes leading to olfactory disorders in the manuscript. The analysis of existing methods for the diagnosis of olfactory disorders and their treatment was also carried out. The content of the article includes current hypotheses of the pathogenesis of viral anosmia in COVID-19 and a new look at the relevance of this problem among the population around the world. The article analyzes scientific data on the problem of anosmia in coronavirus infection caused by SARS-CoV-2, investigates modern diagnostic methods, highlights the principles of treatment of patients with post-COVID anosmia and presents prospects for further research on this problem. - Odors determition among the population of the regions of the Russian Federation: Cross-sectional study
G. V. Lebedeva, M. V. Svistushkin, L. V. Selezneva, E. V. Alekseenko, I. A. Kirsch, et al.
Meditsinskiy Sovet, 2023
Introduction. Currently, the main way to assess olfactory disorders is olfactory tests. A necessary condition for adequate diagnosis is that the odors used in tests correspond to the sociocultural characteristics of the population; the identified flavors must be well recognizable. The use of unadapted tests distorts the results and leads to a false diagnosis of the pathology in a person with a normal sense of smell. The research for identification of the most known odors is an important stage in validation of the existing tests and in the development of new ones.Aim. Determination odors in various regions of the Russian Federation.Materials and methods: 3000 people from 8 federal districts of the Russian Federation took part in the study. This study was conducted using a questionnaire based on a Likert scale. The subject was required to assess his level of familiarity with each odor from the proposed list, assigning it a score from 1 to 5. In total, the questionnaire listed 100 names, including 16 names of odors, the standard set of the 3rd stage (assessment of identification ability) Sniffin’ Sticks Test, 40 names of odorants of the University of Pennsylvania Psychophysical Test (UPSIT) and 44 odors found in the everyday life of the population of our country.Results. In the first 25 positions of the most recognizable smells, in descending order, there are: 1) coffee; 2) orange; 3) garlic; bleach; 5) mint; 6) tobacco smoke; 7) gasoline; 8) tangerine; 9) lemon; 10) smoke from a fire; 11) onion; 12) strawberry; 13) apple; 14) alcohol; 15) fish; 16) mown grass; 17) chocolate; 18) acetone; 19) banana; 20) hot bread; 21) rose; 22) lilac; 23) melon; 24) watermelon; 25) cucumber. Among the 16 odors of the 3rd stage of identification of the standard set “Sniffin’ Sticks Test” – 43.75% are included in the first 16 positions of recognizable odors of the Russian rating, and among the 40 odors of the UPSIT olfactory test – 52.5%.Conclusions: This study showed which odors are well recognized by the Russian population and confirmed that cultural adaptation as a necessary procedure before routine use of olfactory tests.
