Pranab Kishor Mohapatra
@cgu-odisha.ac.in
Assistant Professor, Department of Chemistry
C. V. Raman Global University
EDUCATION
PhD (Sambalpur University, India)
RESEARCH INTERESTS
Medicinal Chemistry
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Abeer S. Aloufi, Amr Ahmed El-Arabey, Wafa Ali Eltayb, Rasha Elsayim, Hanin S. Marenga, Yosra Modafer, Maaweya E. Awadalla, Pranab K. Mohapatra, Ranjan K. Mohapatra, and Mohnad Abdalla
Informa UK Limited
The transmembrane glycoprotein angiotensin-converting enzyme 2 (ACE2) is a key component of the renin-angiotensin system (RAS). It was shown to be the receptor of severe acute respiratory syndrome coronavirus 2 in the COVID-19 outbreak (SARS-COV-2). Furthermore, ACE2 aids in the transport of amino acids across the membrane. ACE2 is lost from the membrane, resulting in soluble ACE2 (sACE2). We aim to examine the structural conformation alterations between SARS-CoV-1 or 2 variants at various periods with ACE2 from various sources, particularly in the area where it interacts with the viral protein and the receptor. It is important to study the molecular dynamics of ACE2/SARS-COV RBD when the structure is available on the database. Here we analyzed the crystal structure of ACE2 from Human, Dog, Mus, Cat, and Bat ACE2 in complex with RBD from SARS-COV-1 and SARS-COV-2. The result shows, there is a variation in the type of residues, number of contact atoms and hydrogen bonds in ACE2 and RBD during the interaction interfaces. By using molecular dynamics simulation, we can measure RMSD, RMSF, SASA, Rg and the difference in the percentage of α helix and β strand. As bat ACE2 & SARS-CoV-2 RBD found to have a high amount of β strand compared to another structure complex, while hACE2 & SARS-CoV-1 RBD has fewer amounts of β strand. Our study provides a deep view of the structure which is available and a summary of many works around ACE2/SARS-CoV RBD interaction.Communicated by Ramaswamy H. Sarma.
Mohammad Azam, Soumya R. Barik, Pranab K. Mohapatra, Manjeet Kumar, Azaj Ansari, Ranjan K. Mohapatra, Agata Trzesowska-Kruszynska, and Saud I. Al-Resayes
Pleiades Publishing Ltd
Rehab Kadhim Al-Shemary, Ranjan K. Mohapatra, Manjeet Kumar, Ashish K. Sarangi, Mohammad Azam, Hardeep Singh Tuli, Azaj Ansari, Pranab K. Mohapatra, and Kuldeep Dhama
Elsevier BV
Pranab Kishor Mohapatra, Kumar Sambhav Chopdar, Ganesh Chandra Dash, Abhay Kumar Mohanty, and Mukesh Kumar Raval
Informa UK Limited
Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has compelled the scientific community to search for an effective drug that can cure or a vaccine that can prevent the disease. Alternatively, symptomatic treatment and traditional immunity boosters are prescribed. Holy Tulsi (Ocimum sanctum) has been known as an ancient remedy for cure of common cold and respiratory ailment. Several reports have come on virtual screening of phytochemicals including those of Tulsi against various enzymes of the virus. We undertook in silico analysis of the ethanol extracted phytochemicals of Tulsi as inhibitors of SARS-CoV-2 (2019-nCoV) main protease with an approach to look into the possibility of covalent ligand binding with the catalytic residue Cys145, which makes the report unique. The results suggest that the flavonoids and polyphenolic compounds of Tulsi, have potential to covalently bind to the catalytic residue Cys145 of main protease and irreversibly inhibit the viral enzyme. Luteolin-7-O-glucuronide is specially considered for its optimum properties, namely, low toxicity (LD50 5000 mg/kg body weight), high drug-likeness score (0.71), the active site binding free energy (ΔGbind) -19.19 kcal/mol by GBSA method and covalent binding energy -24.23 kcal/mol. Further experimental validations are required to establish the theoretical findings.Communicated by Ramaswamy H. Sarma.
Showkat Ahmad Mir, Ganesh Chandra Dash, Rajesh Kumar Meher, Prajna Parimita Mohanta, Kumar Sambhav Chopdar, Pranab Kishor Mohapatra, Iswar Baitharu, Ajaya Kumar Behera, Mukesh Kumar Raval, and Binata Nayak
Springer Science and Business Media LLC
Ranjan K. Mohapatra, Venkataramana Kandi, Snehasish Mishra, Ashish K. Sarangi, Manoj Kumar Pradhan, Pranab K. Mohapatra, Ajit Behera, and Kuldeep Dhama
Elsevier BV
Ranjan K. Mohapatra, Mohammad Azam, Pranab K. Mohapatra, Ashish K. Sarangi, Mohnad Abdalla, Lina Perekhoda, Oval Yadav, Saud I. Al-Resayes, Kim Jong-Doo, Kuldeep Dhama,et al.
Elsevier BV
Soumya R. Barik, Ranjan K. Mohapatra, Pranab K. Mohapatra, Ahmed Mahal, and Marei M. El-Ajaily
Bentham Science Publishers Ltd.
: Nanotechnology has gained momentum in recent years in the field of drug delivery, including nanomedicine and nano-delivery systems. Several applications such as biological agents, chemotherapeutic agents and immunotherapeutic agents are used for the treatment of a number of diseases. This review compiles an updated summary on recent developments in this emerging field of nanomedicines and nanotechnology-based drug delivery systems. The study of nanostructured drug delivery systems helps to understand the efficient transport and controlled release of drugs to the diseased tissues of living organisms. This has stimulated the authors to highlight recent advances in smart nanocarriers composed of biopolymeric nanoparticles such as liposomes, dendrimers, and hydrogels. This review also highlights some critical issues in the design of nanocarrier systems for biomedical applications.
Kumar Sambhav Chopdar, Ganesh Chandra Dash, Pranab Kishor Mohapatra, Binata Nayak, and Mukesh Kumar Raval
Informa UK Limited
Abstract Urease inhibitors are known to play a vital role in the field of medicine as well as agriculture. Special attention is attributed to the development of novel urease inhibitors with a view to treat the Helicobacter pylori infection. Amongst a number of urease inhibitors, a large number of molecules fail in vivo and in clinical trials due to their hydrolytic instability and toxicity profile. The search for potential inhibitors may require screening of large and diverse databases of small molecules and to design novel molecules. We developed a Monte-Carlo method-based QSAR model to predict urease inhibiting potency of molecules using SMILES and GRAPH descriptors on an existing diverse database of urease inhibitors. The QSAR model satisfies all the statistical parameters required for acceptance as a good model. The model is applied to identify urease inhibitors among the wide range of compounds in the phytochemical database, NPACT, as a test case. We combine the ligand-based and structure-based drug discovery methods to improve the accuracy of the prediction. The method predicts pIC50 and estimates docking score of compounds in the database. The method may be applied to any other database or compounds designed in silico to discover novel drugs targeting urease. Communicated by Ramaswamy H. Sarma
Mohnad Abdalla, Ranjan K. Mohapatra, Ashish K. Sarangi, Pranab K. Mohapatra, Wafa Ali Eltayb, Mahboob Alam, Amr Ahmed El-Arabey, Mohammad Azam, Saud I. Al-Resayes, Veronique Seidel,et al.
Elsevier BV
Siddhartha Pati, Tanmay Sarkar, Hassan I. Sheikh, Kaushik Kumar Bharadwaj, Pranab Kishor Mohapatra, Anil Chatterji, Bisnu Prasad Dash, Hisham Atan Edinur, and Bryan Raveen Nelson
Frontiers Media SA
The γ-irradiated horseshoe crab chitosan was used as food coating to extend the shelf life of marine shrimp and fish. Fourier-transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FE-SEM), and X-ray diffraction (XRD) were used to characterize the γ-irradiated chitosan. After employing control (untreated seafood samples/no preservatives), chemical preservation (treated with 2% glacial acetic acid) and 2% chitosan (0, 10, and 20 kGy γ-irradiation) for the assessment assay, the shrimp (Penaeus merguiensis), pomfret (Pampus argenteus), and hilsa fish (Tenualosa ilisha) samples were examined for pH, thiobarbituric acid reactive substance (TBARS), total viable counts (TVC), and sensory evaluation changes while under 15-day refrigeration at 4°C. The results of FT-IR, XRD, and FE-SEM analysis revealed that irradiated chitosan possessed a crystalline structure with smooth texture on its surface. Analysis of pH, TBARS, TVC, and sensory evaluation demarcated irradiated chitosan with the ability to delay microbial growth and this prolonged the shelf life of refrigerated shrimp and fish. With novelty on γ-irradiated horseshoe crab chitosan use as natural preserving agent, fisheries industries and food packaging practitioners would benefit from its microbial-inert abilities particularly for long distant cold storage transport of packaged marine meats.
Taghreed H. Al-Noor, Ranjan K. Mohapatra, Mohammad Azam, Lekaa K. Abdul Karim, Pranab K. Mohapatra, Abeer A. Ibrahim, Pankaj K. Parhi, Ganesh C. Dash, Marei M. El-ajaily, Saud I. Al-Resayes,et al.
Journal of Molecular Structure Elsevier BV
Ranjan K Mohapatra, Pradeep K Das, Khan Sharun, Ruchi Tiwari, Saumya Ranjan Mohapatara, Pranab K. Mohapatra, Ajit Behera, Tamoghna Acharyya, Venkataramana Kandi, Kudrat-E Zahan,et al.
Informa UK Limited
ABSTRACT The ongoing coronavirus disease 2019 (COVID-19) pandemic driven by severe acute respiratory syndrome coronavirus – 2 (SARS-CoV-2) has become the most critical universal health disaster of this century. Millions of people are staying at home obeying lockdown to halt the spread of this novel virus. The spread of the virus has forced people to use the mask, gloves, hand sanitizer, etc. daily, and healthcare workers to use personal protection equipment following the WHO guidelines, resulting in huge amounts of medical waste. This pandemic has led to a slowdown of economic activities significantly, and consequently, stock markets have nosedived beyond speculation. Although the deadly coronavirus has taken away millions of precious lives and the livelihood of many sections of people worldwide, it has brought several positive changes in the world. Furthermore, it has led to a massive restoration of the environment and improved air and water quality. Pandemic showed the resilient nature of the environment, including air and water, when human activities are paused. In addition, we also discussed how this pandemic affects human lifestyle behavior.
Pramod Kumar Sahu, Pranab Kishor Mohapatra, Dhanji Popatbhai Rajani, and Mukesh Kumar Raval
Bentham Science Publishers Ltd.
Background: Shikimate pathway is essential for tubercular bacillus but it is absent in mammals. Therefore, Shikimate kinase and other enzymes in the pathway are potential targets for the development of novel anti-tuberculosis drugs. Objective: In the present study, Shikimate kinase is selected as the target for in silico screening of phytochemicals with an aim to discover a novel herbal drug against Mycobacterium tuberculosis (Mtb). Methods: A structure-based drug discovery approach is undertaken for the execution of the objective. Virtual screening of phytochemical database NPACT against the target, Shikimate kinase (PDB ID 3BAF), is carried out followed by toxicity and drug-likeness filtration. Finally, a lead, narirutin was selected for in vitro anti-tubercular study. Results: Narirutin, present in citrus fruits, emerges as the lead. It is considered to be non-toxic with predicted high LD50 value, 12000 mg/kg body weight. The phytochemical is tested for its antitubercular activity in vitro. It has MIC99 62.5 μg/mL against the MtbH37Rv strain. Conclusions: This is the first-ever report to show anti-tuberculosis potency of narirutin.
Nibedita Mishra, Pranab K. Mohapatra, and Mukesh K. Raval
Bentham Science Publishers Ltd.
Background: Research on harvesting solar energy through an artificial photosynthetic device is gaining momentum in the present era. The device is a promising solution to the energy crisis by overcoming the crunch in fossil fuel and low efficiency of heat engine. Reports are available on design of isolated parts of the photosynthetic device, for example, only sensitizer or only redox unit containing metallo-peptides. Objective: An attempt has been made to design an in silico photoreaction center in a single chain protein matrix containing all the three basic units: sensitizer, electron donor, and acceptor mimicking the photosynthetic reaction center II. Methods: A single chain of a protein containing a closely packed transmembrane four-helix bundle (PDB ID 2bl2 A) is selected for the purpose. The protein is suitably mutated in silico to accommodate the basic elements of a reaction center: Mn-Ca binding site as water oxidizing moiety, Fe-binding site as quinine reducing moiety, and MgDPP as photosensitizer to achieve the desired function of photoredox reaction. Results: A photoelectron transport protein has been designed, which may incorporate into the bilayer membrane system. It has the potential to photo-oxidize water to oxygen on one side and reduce quinone on the other side of the membrane. The stability and transmembrane orientation of the molecular device in an artificial membrane system has been validated theoretically by molecular dynamics study. Conclusion: An attempt to incorporate in silico all the elements essential for a photoelectron transport device into a single chain transmembrane protein model is the first of its kind. Donor and acceptor moieties are separated on the inner and outer side of a membrane bilayer. These features make the model unique and novel. The design of the model is the first step towards the study of experimental viability of the model, which remains to be validated in future.
Marei M. El‐ajaily, Ashish K. Sarangi, Ranjan K. Mohapatra, Saffa S. Hassan, Rehab N. Eldaghare, Pranab K. Mohapatra, Mukesh K. Raval, Debadutta Das, Ahmed Mahal, Amira Cipurkovic,et al.
Wiley
The anticancer studies of a Schiff base; (E)-2((2-hydroxybenzylidene)amino-3-mercaptopropanoic acid (H2L) (obtained from 2hydroxybenzaldehyde and L-cysteine) and its transition metal complexes have been reported. The evaluation of the growth inhibitory action was studied for the compounds against human colon carcinoma (HCT-116), human hepatocellular liver carcinoma (HEPG-2), normal melanocytes (HFB-4) and human breast carcinoma (MCF-7) cell lines. The obtained results revealed that the Schiff base and its chelates are active against human hepatocellular liver carcinoma (HEPG-2) cell lines. The powder X-ray diffraction analysis for the compounds was carried out through Phillips X’Pert High score software. The density functional theory computation for ligand and Co(II), Ni (II) and Cu(II) metal complexes were made to understand the mode of bonding by GAUSSIAN 03 rev. A.01 programme. The quantitative structure-activity relationship investigation was performed by using HyperChem Professional 8.0.3 software to understand the biological potency of the ligands. Moreover, a docking analysis using iGEMDOCKv2.1 software was carried out against the kinase enzyme PDB ID:1fvv.
Lichita Patro, Pranab Kishor Mohapatra, Udaya Chand Biswal, and Basanti Biswal
Elsevier BV
Pranab Kishor Mohapatra, Padmanava Joshi, Nemmara Krishnan Ramaswamy, Mukesh Kumar Raval, Udaya Chand Biswal, and Basanti Biswal
Elsevier BV
Jayakishan K. Meher, Nibedita Mishra, Pranab Kishor Mohapatra, Mukesh Kumar Raval, Pramod Kumar Meher, and Gananath Dash
Springer Berlin Heidelberg
Pranab Kishor Mohapatra, Lichita Patro, Mukesh Kumar Raval, Nemmara Krishnan Ramaswamy, Udaya Chand Biswal, and Basanti Biswal
Wiley
A link between senescence-induced decline in photosynthesis and activity of beta-glucosidase is examined in the leaves of Arabidopsis. The enzyme is purified and characterized. The molecular weight of the enzyme is 58 kDa. It shows maximum activity at pH 5.5 and at temperature of 50 degrees C. Photosynthetic measurements and activity of the enzyme are conducted at different developmental stages including senescence of leaves. Senescence causes a significant loss in total chlorophyll, stomatal conductance, rate of evaporation and in the ability of the leaves for carbon dioxide fixation. The process also brings about a decline in oxygen evolution, quantum yield of photosystem II (PS II) and quantum efficiency of PS II photochemistry of thylakoid membrane. The loss in photosynthesis is accompanied by a significant increase in the activity of the cell wall-bound beta-glucosidase that breaks down polysaccharides to soluble sugars. The loss in photosynthesis as a signal for the enhancement in the activity of the enzyme is confirmed from the observation that incubation of excised mature leaves in continuous dark or in light with a photosynthesis inhibitor 3-(3,4-dichlorophenyl)-1, 1-dimethylurea (DCMU) that leads to sugar starvation enhances the activity of the enzyme. The work suggests that in the background of photosynthetic decline, the polysaccharides bound to cell wall that remains intact even during late phase of senescence may be the last target of senescing leaves for a possible source of sugar for remobilization and completion of the energy-dependent senescence program.
M. K. Pradhan, L. Nayak, P. N. Joshi, P. K. Mohapatra, L. Patro, B. Biswal, and U. C. Biswal
Institute of Experimental Botany
S. K. Mishra, L. Patro, P. K. Mohapatra, and B. Biswal
Institute of Experimental Botany