Prof. (Dr.) Biswajit Basu
@adamasuniversity.ac.in
Professor, Department of Pharmaceutical Technology
School of Health and Medical Sciences, Adamas University
Teaching experience – 15+ years
Total publication – 35, Book Chapters – 11.
M. Pharm. Students guided till now – 22 (Completed), On-going – 02
Ph.D student guided – 02 (ongoing)
Best Researcher Award 2014. Atmiya University, Rajkot, Gujarat.
Travel grants from the DST
He has been awarded “Young Achiever Award 2021” from Institute of Scholar (InSc.), InSc Award 2021.
He has been awarded “Award for excellence in research” from National Education Brilliance Award 2021, in recognition of and appreciation for outstanding contribution to education.
He has been awarded “Young Researcher Award 2022” from Institute of Scholar (InSc.), InSc Award 2022.
EDUCATION
M. Pharm., Ph.D.
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmaceutical Science, Pharmacology, Toxicology and Pharmaceutics, Pharmacy, Multidisciplinary
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Biswajit Basu, Kevinkumar Garala, and Bhupendra G. Prajapati
Wiley
B. G. Prajapati, Chandresh P. Patel, and Biswajit Basu
A and V Publications
Particle engineering techniques have gained a unique place in the present pharma industry to improve physicochemical properties of the drugs. The aim of this research work was to formulate and evaluate directly compressible agglomerates of Levofloxacin HCl with a view to improve their micromeritic properties and thereby to reduce the cost of production. Fluoroquinolone anti-infective, is used to treat bacterial conjunctivitis, sinusitis, chronic bronchitis, community- acquired pneumonia and pneumonia caused by penicillin resistant strains of Streptococcus pneumonia. Some of the fluoroquinolone high dose’s exhibit poor compressibility and flow properties, hence may not be suitable candidate for direct compression process, but by applying the crystallo-co-agglomeration (CCA) technique, the attempt may be made to change the properties of these molecules to make them suitable candidates for direct compression. This investigation was aimed to utilize CCA process to develop spherical agglomerates of levofloxacin HCl in selected polymers in different ratio. The developed spherical agglomerates of levofloxacin HCl may exhibit improved micrometric and dissolution properties hence may be suitable for direct compression process. Results indicated that micromeritic, mechanical and compressional properties of the agglomerates were greatly influenced by nature and type of polymer incorporated. The mean release time, mean dissolution time, dissolution efficiency, Q30 and Q90 of the tablets prepared from agglomerates showed remarkable increase in CCA compared to tablets prepared by wet granulation. Observations also revealed that by varying the type and concentration of polymer, desired release rate can be obtained.
Ghallab Alotaibi, Sitah Alharthi, Biswajit Basu, Dipanjana Ash, Swarnali Dutta, Sudarshan Singh, Bhupendra G. Prajapati, Sankha Bhattacharya, Vijay R. Chidrawar, and Havagiray Chitme
MDPI AG
In the 21st century, melanoma and non-melanoma skin cancers have become an epidemic outbreak worldwide. Therefore, the exploration of all potential preventative and therapeutic measures based on either physical or bio-chemical mechanisms is essential via understanding precise pathophysiological pathways (Mitogen-activated protein kinase, Phosphatidylinositol 3-kinase Pathway, and Notch signaling pathway) and other aspects of such skin malignancies. Nano-gel, a three-dimensional polymeric cross-linked porous hydrogel having a diameter of 20–200 nm, possesses dual properties of both hydrogel and nanoparticle. The capacity of high drug entrapment efficiency with greater thermodynamic stability, remarkable solubilization potential, and swelling behavior of nano-gel becomes a promising candidate as a targeted drug delivery system in the treatment of skin cancer. Nano-gel can be either synthetically or architectonically modified for responding to either internal or external stimuli, including radiation, ultrasound, enzyme, magnetic, pH, temperature, and oxidation-reduction to achieve controlled release of pharmaceuticals and several bio-active molecules such as proteins, peptides, genes via amplifying drug aggregation in the active targeted tissue and reducing adverse pharmacological effects. Several drugs, such as anti-neoplastic biomolecules having short biological half-lives and prompt enzyme degradability capacity, must be appropriate for administration employing either chemically bridged or physically constructed nano-gel frameworks. The comprehensive review summarizes the advancement in the preparation and characterization methods of targeted nano-gel with enhanced pharmacological potential and preserved intracellular safety limits for the mitigation of skin malignancies with a special emphasize on skin cancer inducing pathophysiological pathways and prospective research opportunities for skin malignancy targeted nano-gels.
D. Karati, Swarupananda Mukherjee, Sudarshan Singh, Bhupendra G. Prajapati and Biswajit Basu
Kevinkumar Garala, Biswajit Basu, and Bhupendra Prajapatic
Jenny Stanford Publishing
Kevinkumar Garala, Rachana Joshi, Biswajit Basu, and Bhupendra Prajapatic
Jenny Stanford Publishing
Biswajit Basu, Ayon Dutta, Akshay Parihar, Bhupendra Prajapati, and Raja Majumdere
Jenny Stanford Publishing
Biswajit Basu, Ayon Dutta, Dipanjana Ash, Bhupendra Prajapati, and Kevinkumar Garalae
Jenny Stanford Publishing
Himanshu Paliwal, Bhupendra G. Prajapati, Akshay Parihar, Geeta K. Patel, Prakash Kendre, Biswajit Basu, and Jayvadan K. Patel
Springer International Publishing
Biswajit Basu, Bhupendra Prajapati, Ayon Datta, and Jigna B. Prajapati
CRC Press
Bhupendra G. Prajapati, Vipul D. Prajapati, Biswajit Basu, Prakash N. Kendre, Swarupananda Mukherjee, Tiyas Pal, Moumita Kundu, Sudarshan Singh, Sankha Bhattacharya, Jidnesh B. Dharmameher,et al.
Elsevier
Biswajit BASU, Ankur MANKAD, and Ayon DUTTA
Galenos Yayinevi
Objectives
The focus of this study was to design and optimize methylphenidate hydrochloride mouth dissolving film (MDF) that can be beneficial in an acute condition of attention deficit hyperactivity disorder (ADHD) and narcolepsy.
Materials and Methods
Solvent casting method was used for the preparation of this film. Optimization of the effect of independent variables such as the number of polymers and active pharmaceutical ingredients [hydroxypropyl methyl cellulose (HPMC) E5, HPMC E15, and maltodextrin], % of drug release, disintegration time, and tensile strength of the film done using simplex centroid design. Complex formation of the film was tested using fourier-transform infrared spectroscopy and differential scanning calorimetry study. The multiple regression analysis was obtained from equations of the results that adequately describe influence of the independent variables on the selected responses. Polynomial regression analysis, contour plots, and 3-D surface plots were used to relate dependent and independent variables.
Results
Experimental results indicated that different polymer amounts had complex effects on % drug release from the film, disintegration time as well as the tensile strength of the film. The observed responses were in near alignment with expected values calculated from the developed regression equations as shown by percentage relative error. Final formulation showed more than 95% drug release within 2 min and was shown to disintegrate within a minute that had good tensile strength.
Conclusion
These findings suggest that MDF containing methylphenidate hydrochloride is likely to become a choice of methylphenidate hydrochloride preparations for treatment in ADHD and narcolepsy conditions.
Biswajit Basu, Bhupendra G. Prajapati, Swarupananda Mukherjee, Tapas Kumar Roy, Arnab Roy, Chowdhury Mobaswar Hossain, Jigna B. Prajapati, and Jayvadan Patel
Springer International Publishing
Biswajit Basu, Ketan R. Aviya, and Amitava Bhattacharya
Springer Science and Business Media LLC
Biswajit Basu, Abhishek Bagadiya, Sagar Makwana, Vora Vipul, Devraj Batt, and Abhay Dharamsi
Medknow
The aim of this investigation was to develop fast dissolving tablet of cinnarizine. A combination of super disintegrants, i.e., sodium starch glycolate (SSG) and crosscarmellose sodium (CCS) were used along with camphor as a subliming material. An optimized concentration of camphor was added to aid the porosity of the tablet. A 32 full factorial design was applied to investigate the combined effect of two formulation variables: Amount of SSG and CCS. Infrared (IR) spectroscopy was performed to identify the physicochemical interaction between drug and polymer. IR spectroscopy showed that there is no interaction of drug with polymer. In the present study, direct compression was used to prepare the tablets. The powder mixtures were compressed into tablet using flat face multi punch tablet machine. Camphor was sublimed from the tablet by exposing the tablet to vacuum drier at 60°C for 12 hours. All the formulations were evaluated for their characteristics such as average weight, hardness, wetting time, friability, content uniformity, dispersion time (DT), and dissolution rate. An optimized tablet formulation (F 9) was found to have good hardness of 3.30 ± 0.10 kg/cm2, wetting time of 42.33 ± 4.04 seconds, DT of 34.67 ± 1.53 seconds, and cumulative drug release of not less than 99% in 16 minutes.