Megakaryocytopoiesis
Platelet production
Mechanobiology
7450
Scholar Citations
47
Scholar h-index
62
Scholar i10-index
RECENT SCHOLAR PUBLICATIONS
TRPV2 and TRPV4 are both required for effective platelet formation J Boscher, M Devaux, L Ruch, I Guinard, M Ollinger, J Weber, C Strassel, ... Journal of Thrombosis and Haemostasis , 2026 2026
Piezo1 gain of function induces a platelet preactivation state C Bachelot-Loza, A Marchelli, L Ruch, D El Hamaoui, J Demagny, ... Journal of Thrombosis and Haemostasis 24 (3), 1118-1129 , 2026 2026 Citations: 1
Tube into pearls: A membrane-driven pearling instability shapes platelet biogenesis C Leon, N Brassard-Jollive, D Gonzalez-Rodriguez, D Riveline Molecular Biology of the Cell 36 (11), rt1 , 2025 2025 Citations: 1
Casein kinase 1α essentially regulates thrombopoiesis by driving megakaryocyte maturation and cytoskeleton organization F Kollotzek, K Mott, M Fischer, B Findik, V Göb, MC Manke, CE Borst, ... Blood 146 (16), 1964-1978 , 2025 2025 Citations: 5
Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche C Masson, C Scandola, JY Rinckel, F Proamer, E Janus-Bell, F Batool, ... eLife 14, RP104963 , 2025 2025 Citations: 3
3-Hydroxy-β-ionone Suppresses Breast Cancer Progression by Inducing Apoptosis and Blocking EMT Through the TGF-β/Smad Signaling Pathway P Sutana, T Luetragoon, W Buakaew, K Daotak, N Nilsri, Y Thongsri, ... International Journal of Molecular Sciences 26 (18), 8771 , 2025 2025 Citations: 1
Mechanical confinement prevents ectopic platelet release I Guinard, N Brassard-Jollive, L Ruch, J Weber, A Eckly, J Boscher, ... Proceedings of the National Academy of Sciences 121 (38), e2407829121 , 2024 2024 Citations: 8
Newly identified roles for PIEZO1 mechanosensor in controlling normal megakaryocyte development and in primary myelofibrosis V Abbonante, AI Karkempetzaki, C Leon, A Krishnan, N Huang, ... American journal of hematology 99 (3), 336-349 , 2024 2024 Citations: 30
Newly Identified Roles for PIEZO1 Mechanosensor in Controlling Normal Megakaryocyte Development and in Primary Myelofibrosis I Karkempetzaki, V Abbonante, C Leon, N Huang, C Di Buduo, ... Blood 142, 6355 , 2023 2023
Matrix stiffness controls megakaryocyte adhesion, fibronectin fibrillogenesis, and proplatelet formation through Itgβ3 I Guinard, T Nguyen, N Brassard-Jollive, J Weber, L Ruch, L Reininger, ... Blood Advances 7 (15), 4003-4018 , 2023 2023 Citations: 18
Megakaryocytes form linear podosomes devoid of digestive properties to remodel medullar matrix A Oprescu, D Michel, A Antkowiak, E Vega, J Viaud, SA Courtneidge, ... Scientific Reports 12 (1), 6255 , 2022 2022 Citations: 9
Megakaryocyte culture in 3D methylcellulose-based hydrogel to improve cell maturation and study the impact of stiffness and confinement J Boscher, C Gachet, F Lanza, C Léon Journal of Visualized Experiments (JoVE), e62511 , 2021 2021 Citations: 7
In Vivo Two-photon Imaging of Megakaryocytes and Proplatelets in the Mouse Skull Bone Marrow A Bornert, F Pertuy, F Lanza, C Gachet, C Léon JoVE (Journal of Visualized Experiments), e62515 , 2021 2021 Citations: 5
Proplatelet formation dynamics of mouse fresh bone marrow explants I Guinard, F Lanza, C Gachet, C Léon, A Eckly JoVE (Journal of Visualized Experiments), e62501 , 2021 2021 Citations: 10
Megakaryocytes use in vivo podosome‐like structures working collectively to penetrate the endothelial barrier of bone marrow sinusoids A Eckly, C Scandola, A Oprescu, D Michel, JY Rinckel, F Proamer, ... Journal of Thrombosis and Haemostasis 18 (11), 2987-3001 , 2020 2020 Citations: 73
Blood platelet formation at a glance J Boscher, I Guinard, A Eckly, F Lanza, C Leon Journal of cell science 133 (20), jcs244731 , 2020 2020 Citations: 50
Cytoskeletal-based mechanisms differently regulate in vivo and in vitro proplatelet formation A Bornert, J Boscher, F Pertuy, A Eckly, D Stegner, C Strassel, C Gachet, ... Haematologica 106 (5), 1368 , 2020 2020 Citations: 65
Combined deficiency of RAB32 and RAB38 in the mouse mimics Hermansky-Pudlak syndrome and critically impairs thrombosis A Aguilar, J Weber, J Boscher, M Freund, C Ziessel, A Eckly, S Magnenat, ... Blood Advances 3 (15), 2368-2380 , 2019 2019 Citations: 31
Clot contraction drives the translocation of procoagulant platelets to thrombus surface DY Nechipurenko, N Receveur, AO Yakimenko, TO Shepelyuk, ... Arteriosclerosis, thrombosis, and vascular biology 39 (1), 37-47 , 2019 2019 Citations: 136
ANXA4 is localized in platelet alpha-granules and inhibits the blood coagulation reaction of the intrinsic pathway M Nakayama, H Miyagawa, Y Kuranami, C Leon, J Weber, ... MOLECULAR BIOLOGY OF THE CELL 29 (26) , 2018 2018
MOST CITED SCHOLAR PUBLICATIONS
Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y 1 receptor–null mice C Léon, B Hechler, M Freund, A Eckly, C Vial, P Ohlmann, A Dierich, ... The Journal of clinical investigation 104 (12), 1731-1737 , 1999 1999 Citations: 603
Migrating platelets are mechano-scavengers that collect and bundle bacteria F Gaertner, Z Ahmad, G Rosenberger, S Fan, L Nicolai, B Busch, G Yavuz, ... Cell 171 (6), 1368-1382. e23 , 2017 2017 Citations: 431
The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells C Léon, B Hechler, C Vial, C Leray, JP Cazenave, C Gachet FEBS letters 403 (1), 26-30 , 1997 1997 Citations: 401
The P2Y 1 Receptor Is Necessary for Adenosine 5′-Diphosphate–Induced Platelet Aggregation B Hechler, C Léon, C Vial, P Vigne, C Frelin, JP Cazenave, C Gachet Blood, The Journal of the American Society of Hematology 92 (1), 152-159 , 1998 1998 Citations: 357
Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity T Moriyama, T Iida, K Kobayashi, T Higashi, T Fukuoka, H Tsumura, ... Journal of Neuroscience 23 (14), 6058-6062 , 2003 2003 Citations: 290
Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion C Léon, A Eckly, B Hechler, B Aleil, M Freund, C Ravanat, M Jourdain, ... Blood, The Journal of the American Society of Hematology 110 (9), 3183-3191 , 2007 2007 Citations: 221
RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization L Lordier, D Bluteau, A Jalil, C Legrand, J Pan, P Rameau, D Jouni, ... Nature communications 3 (1), 717 , 2012 2012 Citations: 209
Biogenesis of the demarcation membrane system (DMS) in megakaryocytes A Eckly, H Heijnen, F Pertuy, W Geerts, F Proamer, JY Rinckel, C Léon, ... Blood, The Journal of the American Society of Hematology 123 (6), 921-930 , 2014 2014 Citations: 208
Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist A Baurand, P Raboisson, M Freund, C Léon, JP Cazenave, ... European journal of pharmacology 412 (3), 213-221 , 2001 2001 Citations: 201
Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells JW Shin, A Buxboim, KR Spinler, J Swift, DA Christian, CA Hunter, C Leon, ... Cell stem cell 14 (1), 81-93 , 2014 2014 Citations: 195
The P2Y12 receptor induces platelet aggregation through weak activation of the αIIbβ3 integrin–a phosphoinositide 3-kinase-dependent mechanism G Kauffenstein, W Bergmeier, A Eckly, P Ohlmann, C Leon, JP Cazenave, ... FEBS letters 505 (2), 281-290 , 2001 2001 Citations: 192
Platelet ADP receptors contribute to the initiation of intravascular coagulation C Leon, M Alex, A Klocke, E Morgenstern, C Moosbauer, A Eckly, ... Blood 103 (2), 594-600 , 2004 2004 Citations: 188
ATP derivatives are antagonists of the P2Y1 receptor: similarities to the platelet ADP receptor B Hechler, P Vigne, C Leon, JP Breittmayer, C Gachet, C Frelin Molecular pharmacology 53 (4), 727-733 , 1998 1998 Citations: 188
Differential Involvement of the P2Y 1 and P2Y 12 Receptors in Platelet Procoagulant Activity C Léon, C Ravanat, M Freund, JP Cazenave, C Gachet Arteriosclerosis, thrombosis, and vascular biology 23 (10), 1941-1947 , 2003 2003 Citations: 182
Key Role of the P2Y1 Receptor in Tissue Factor–Induced Thrombin-Dependent Acute Thromboembolism: Studies in P2Y1-Knockout Mice and Mice Treated With a P2Y1 Antagonist C Léon, M Freund, C Ravanat, A Baurand, JP Cazenave, C Gachet Circulation 103 (5), 718-723 , 2001 2001 Citations: 173
Activation of ADP receptors and platelet function C Gachet, B Hechlel, C Léon, C Vial, C Leray, P Ohlmann, JP Cazenave Thrombosis and haemostasis 78 (07), 271-275 , 1997 1997 Citations: 169
Desensitization of the platelet aggregation response to ADP: differential down-regulation of the P2Y1 and P2cyc receptors A Baurand, A Eckly, N Bari, C Léon, B Hechler, JP Cazenave, C Gachet Thrombosis and haemostasis 84 (09), 484-491 , 2000 2000 Citations: 165
Presence of P2X1 purinoceptors in human platelets and megakaryoblastic cell lines C Vial, B Hechier, C Léon, JP Cazenave, C Gachet Thrombosis and haemostasis 78 (12), 1500-1504 , 1997 1997 Citations: 141
Abnormal megakaryocyte morphology and proplatelet formation in mice with megakaryocyte-restricted MYH9 inactivation A Eckly, C Strassel, M Freund, JP Cazenave, F Lanza, C Gachet, C Léon Blood, The Journal of the American Society of Hematology 113 (14), 3182-3189 , 2009 2009 Citations: 138
Clot contraction drives the translocation of procoagulant platelets to thrombus surface DY Nechipurenko, N Receveur, AO Yakimenko, TO Shepelyuk, ... Arteriosclerosis, thrombosis, and vascular biology 39 (1), 37-47 , 2019 2019 Citations: 136
