Dinal
@ddu.ac.in
Assistant professor, Faculty of Pharmacy, Dharmsinh Desai University
Faculty of Pharmacy, Dharmsinh Desai University
RESEARCH INTERESTS
Pharmacy
8
Scopus Publications
73
Scholar Citations
7
Scholar h-index
3
Scholar i10-index
Scopus Publications
- Development and characterization of bilayer tablet containing leflunomide and co-enzyme Q-10
Abhi Depani, Dinal V. Patel, Tushar Parmar, Komal Parmar, Mansi S. Dholakia, Amit Vitthani, and Tejal G. Soni
Elsevier BV - Development of Chitosan-Maize Starch based Co-processed excipient: As release retardant material
Smit Patel, Dinal Patel, Himani Patel, Dr. Mansi Dholakia, and Dr. Tejal Soni
Elsevier BV - Development of Novel Women's Friendly Antifungal Microemulsion Loaded Gel for Vulvovaginal Infections
Mansi S. Dholakia, Dinal Patel, Kruti A. Patel, Parth R. Joshi, Khushboo J. Bhatt, Mehul N. Patel, Kishor Sorathia, and Tejal Soni
Bentham Science Publishers Ltd.
Aim: The research was carried out to develop the microemulsion-loaded gel of curcu-min, alkylpolyglucoside, and tea tree oil to treat vulvovaginal candidiasis infection. Methods: Screening of oils, surfactants, and co-surfactants was done based on solubility studies and the construction of pseudo-ternary phase diagrams with curcumin. The microemulsion was characterized for globule size, zeta potential, viscosity, and thermodynamic stability. Ex-vivo studies were carried out using Franz diffusion cells. The antifungal activity of microemulsion-loaded hydrogel was evaluated using the cup plate method using Candida albicans ATCC 10231 in glucose yeast agar medium. Results: The selected micro-emulsion consisted of curcumin 35μg/mL, IPM+TTO (1:1) 0.1 mL, Milcoside 100 + Acconon MC 8-2 EP NF 0.6-0.3 mL, phosphate buffer pH 4 160 mL showed maximum thermodynamic stability and exhibited lowest particle size and highest intensity. The viscosity of microemulsion-loaded gel was 11.2 pa.s. The surface tension of the microemulsion was measured by tensiometer and was found to be 26.07 mN/m. Antimicrobial susceptibility test-ing assay was done according to NCCLs assay protocol, and the EC50 value of our formulation was found to be 0.4465 μg/mL. In-vitro drug release and ex-vivo permeation studies showed 67.9% release in 420 minutes and 83.02% release in 360 minutes, respectively. An in-vitro irrita-tion study concluded that there was no redness or irritation on goat mucosa. Conclusion: The texture analysis test showed adhesiveness at -172.46 g s at - 4.60 adhesive force, and the peak load was 13.40 g. The microemulsion-loaded gel formulation can be a promis-ing alternative to the marketed formulations available for vaginal yeast infections. - DoE-based Optimization of Oral In-situ Gel containing Dandelion Leaf Extract
Dinal V. Patel, Mansi Dholakia, Harshida Chauhan, and Bhanubhai N. Suhagia
Bentham Science Publishers Ltd.
Aim: The present study developed an oral in-situ gel containing the leaf extract of Tarax-acum officinale (T.O.) using an experimental design. Background: Peptic ulcer disease was an epidemic in the 19th and early 20th centuries. The applica-tion of herbal drugs for peptic diseases is an attractive area for research and implementation as compared to the allopathic system in the recent era. From the number of plants, the antioxidant effect of an aqueous extract of Taraxacum officinale, which is the dandelion leaf, was proven by an animal study in previous literature. However, most of the marketed preparations consist of root ex-tract primarily used for the detoxification of the liver in comparison to the leaf extract having a non-specific application. Hence, the aqueous extract of dandelion leaf was taken as the active ingredient in the formulation. Over the past 30 years, greater attention has been given to the development of controlled and sustained drug delivery systems. The development of in situ gel systems has received considerable attention over the past few years due to the number of advantages. Objective: By considering the merits of herbal ingredients with drug delivery technology, herbal in-situ gel was developed using statistical analysis. Methods: Herbal in-situ oral gel was developed using a factorial design. The concentration of sodi-um alginate, xanthan gum, and HPMC K15 M was taken as the factors, and viscosity and drug re-lease (total phenol content) in 10 h were selected as the responses. By evaluating the designed batches, the optimized batch was chosen as the promising formulation for curing the peptic ulcer. Results: The batch consisting of 1.711% w/v sodium alginate, 0.727% w/v xanthan gum, and 0.869% w/v HPMC K15M was selected as the optimized batch, as per the software, and the viscosi-ty and % drug release in 10 h were found to be 299.5 cps and 70.2%, respectively. Other evaluation parameters such as gelling capacity, floating parameters, and stability were also found to be good for the designed batches. Conclutions: The improved in-situ gel was found to be effective for extending the floating of the drug incorporated into the formulation as well as the residence time in the stomach for sustained drug release. - Green synthesis and properties of arginine derived complexes for assorted drug delivery systems: A review
Dinal V. Patel, Mehul N. Patel, Mansi S. Dholakia, and B.N. Suhagia
Elsevier BV - Topical arginine solid lipid nanoparticles: Development and characterization by QbD approach
Dinal Patel, Mehul Patel, Tejal Soni, and Bhanubhai Suhagia
Elsevier BV - Development and characterization of pluronic lecithin organogel containing fluocinolone acetonide
Dinal Patel and Viral Patel
Informa UK Limited
Abstract The rabble-rousing skin condition can be conventionally treated, but due to some demerits, there is a need to find a novel approach with an appropriate release profile. The research work narrates the optimization of the topical delivery system of Fluocinolone acetonide loaded in pluronic lecithin organogel. The preliminary studies were carried out and, the ternary phase diagram was established by Chemix school version 3.60. The formulation was optimized by taking a different concentration of polymers as independent and viscosity and drug release (6 h) as dependent variables by applying 32 full factorial design. The optimized batch was further compared with marketed preparation and also kept for the stability study. The release profile of the optimized batch exhibited a sustained release of up to 6 h (77.00%). It gave ex vivo drug release up to 6 h (90.64%) which is more prolonged than marketed preparation and, cutaneous disposition was found to be higher. Besides, the texture analysis was compared to that of the marketed formulation of the drug. However, the proof of the effectiveness of the formulated pluronic lecithin organogel will require further in vivo study for future aspects. In a nutshell, the proposed formulation of fluocinolone acetonide is the simplest and promising dosage form for the treatment of psoriasis. - Preparation and evaluation of Levosalbutamol sulphate chitosan microsphere for the treatment of asthma
DDinal Patel, VNirav Patel, TVaishali Thakkar, and RTejal Gandhi
Medknow
Mucoadhesive drug delivery systems are those that provide intimate contact of the drug with the mucosa for an extended period of time. In present work, mucoadhesive chitosan microspheres of Levosalbutamol sulphate were prepared by Spray drying method. Formulations were characterized for various physicochemical attributes size, encapsulation efficiency, swelling ability, in vitro release study and mucoadhesion study by rat ileum. Through these parameters we conclude that the batch B2 was found to be best mainly by mucoadhesion study and in vitro drug release. Mucoadhesion was found to be increased with incresed concentration of polymer and visa versa in case of drug release. Batch B3 had also similar results with that of Batch B2. That's why here Batch B2 was said to be the best batch with less polymeric content as compare to Batch B3.
RECENT SCHOLAR PUBLICATIONS
- Development and Characterization of Bilayer Tablet Containing Leflunomide and Co-enzyme Q-10
A Depani, DV Patel, T Parmar, K Parmar, MS Dholakia, A Vitthani, ...
Journal of Drug Delivery Science and Technology, 106493 2024 - Development of Novel Women's Friendly Antifungal Microemulsion Loaded Gel for Vulvovaginal Infections
MS Dholakia, D Patel, KA Patel, PR Joshi, KJ Bhatt, MN Patel, K Sorathia, ...
Drug Delivery Letters 14 (4), 308-319 2024 - Development of Chitosan-Maize Starch based Co-processed Excipient: as Release Retardant Material
S Patel, D Patel, H Patel, M Dholakia, T Soni
Carbohydrate Polymer Technologies and Applications, 100580 2024 - The nasal route, advanced drug delivery systems and evaluation: a review
K Rutvik, P Meshva, P Dinal, D Mansi
The Egyptian Journal of Chest Diseases and Tuberculosis 72 (4), 471-477 2023 - DoE Based Optimization of Oral In-Situ Gel Containing Dandelion Leaf Extract
HCBNS Mansi Dholakia, Dinal V Patel*
Drug delivery letters 12 2022 - Green synthesis and properties of arginine derived complexes for assorted drug delivery systems: A Review
DVPMNPMSDBN Suhagia
Sustainable chemistry and Pharmacy 21, 100441 2021 - Development and characterization of pluronic lecithin organogel containing fluocinolone acetonide
D Patel, V Patel
Drug Development and Industrial Pharmacy 47 (3), 377-384 2021 - Topical arginine solid lipid nanoparticles: Development and characterization by QbD approach
D Patel, M Patel, T Soni, B Suhagia
Journal of Drug Delivery Science and Technology 61, 102329 2021 - OPTIMIZATION AND CHARACTERIZATION OF COLON TARGETED DRUG DELIVERY SYSTEM USING COMPRESSION COATING TECHNIQUE
TG Dhaval Suthar*, Dinal Patel*, Vaishali Thakkar
European Journal of Biomedical and Pharmaceutical sciences 3 (4), 190-199 2016 - Formulation and evaluation of spironolactone loaded emulgel for topical application
B Kapadiya, D Gohil, D Patel, S Patel, C Aundhia, N Shah, K Pandya
An International Journal of Pharmaceutical Science and Bioscientific Research 2016 - Formulation and evaluation of floating microsponges of allopurinol
D Patel, D Gohil, D Patel, H Shah, S Patel, K Pandya, C Shah
An International Journal of Pharmaceutical Sciences 2016 - Development and characterization of mucoadhesive microspheres of levosalbutamol sulphate
D Patel, N Patel, V Thakkar, A Modi, T Gandhi
International Journal of Pharmaceutical Sciences and Research 4 (5), 1838 2013 - Preparation and evaluation of Levosalbutamol sulphate chitosan microsphere for the treatment of asthma
DD Patel, VN Patel, TV Thakkar, RT Gandhi
Journal of Pharmacy and Bioallied Sciences 4 (Suppl 1), S46-S47 2012
MOST CITED SCHOLAR PUBLICATIONS
- Topical arginine solid lipid nanoparticles: Development and characterization by QbD approach
D Patel, M Patel, T Soni, B Suhagia
Journal of Drug Delivery Science and Technology 61, 102329 2021
Citations: 14 - Formulation and evaluation of spironolactone loaded emulgel for topical application
B Kapadiya, D Gohil, D Patel, S Patel, C Aundhia, N Shah, K Pandya
An International Journal of Pharmaceutical Science and Bioscientific Research 2016
Citations: 12 - Preparation and evaluation of Levosalbutamol sulphate chitosan microsphere for the treatment of asthma
DD Patel, VN Patel, TV Thakkar, RT Gandhi
Journal of Pharmacy and Bioallied Sciences 4 (Suppl 1), S46-S47 2012
Citations: 11 - Green synthesis and properties of arginine derived complexes for assorted drug delivery systems: A Review
DVPMNPMSDBN Suhagia
Sustainable chemistry and Pharmacy 21, 100441 2021
Citations: 9 - Development and characterization of pluronic lecithin organogel containing fluocinolone acetonide
D Patel, V Patel
Drug Development and Industrial Pharmacy 47 (3), 377-384 2021
Citations: 9 - Formulation and evaluation of floating microsponges of allopurinol
D Patel, D Gohil, D Patel, H Shah, S Patel, K Pandya, C Shah
An International Journal of Pharmaceutical Sciences 2016
Citations: 7 - Development and characterization of mucoadhesive microspheres of levosalbutamol sulphate
D Patel, N Patel, V Thakkar, A Modi, T Gandhi
International Journal of Pharmaceutical Sciences and Research 4 (5), 1838 2013
Citations: 7 - The nasal route, advanced drug delivery systems and evaluation: a review
K Rutvik, P Meshva, P Dinal, D Mansi
The Egyptian Journal of Chest Diseases and Tuberculosis 72 (4), 471-477 2023
Citations: 3 - DoE Based Optimization of Oral In-Situ Gel Containing Dandelion Leaf Extract
HCBNS Mansi Dholakia, Dinal V Patel*
Drug delivery letters 12 2022
Citations: 1