ABBS FEN REJI T F
@nmcc.ac.in
ASSOCIATE PROFESSOR OF CHEMISTRY
Nesamony Memorial Christian College, Marthandam
RESEARCH, TEACHING, or OTHER INTERESTS
Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Spectroscopy
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
J. JebaLenet, J. Jenisha, J. Brindha, and T. F. Abbs Fen Reji
Pleiades Publishing Ltd
J. Jebalenet, J. Jenisha, and Reji T.F. Abbs Fen
World Researchers Associations
The compound 2-[2-(4-arylamino)-4-phenylamino thiazol-5-oyl]naphthalene was synthesized and characterized by different physico-chemical techniques such as IR, electronic parameters, antioxidant studies etc. The geometrical and electronic characteristics of 2-[2-(4-arylamino)-4-phenylaminothiazol-5-oyl]napht halene were calculated theoretically using the Gaussian 09W software at the B3LYP/6-31G level of theory. The predicted geometrical characteristics are close to those published for 2-[2-(4-arylamino)-4-phenylaminothiazol-5-oyl]naphthalene with similar structures. Geometrical parameters are dependent on the atom's size, bonding nature and charge transfer according to optimization. The estimated MOs are helpful in determining the optimised compounds' collective electronic characteristics. Energy gap, on the other hand, is a measure of chemical reactivity, kinetic stability and polarizability.
K. Thibi Mol, T.F. Abbs Fen Reji, and H. Marshan Robert
Elsevier BV
S. Subi, S. Viola Rose, and T.F. Abbs Fen Reji
Asian Journal of Chemistry
A novel series of pyridinyl isoxazole derivatives was synthesized and characterized by IR, 1H and 13C NMR and high-resolution mass spectrometry. Geometrical and electronic properties of pyridinyl isoxazole derivative was investigated by using B3LYP/6-31G (d,p) basis sets. The HOMO and LUMO analysis was used to determine the charge transfer within the molecule. The pyridinyl isoxazole derivatives exhibited good docking scores against liver cancer 4MMH. The results revealed clearly compound 2b exhibited better radical scavenging ability. Among the synthesized pyridinyl isoxazole derivatives, compound 2b was highly active on the SKMEL cell line (human skin cancer).
J. Jani Matilda and T.F. Abbs Fen Reji
Asian Journal of Chemistry
A novel series of indolyl isoxazole derivatives were synthesized and the structure of the products is confirmed on the basis of IR, 1H NMR, MS and analytical data. The synthesized compounds were evaluated for their antioxidant and anticancer activities. The results revealed clearly those compounds 4b and 4d exhibited better radical scavenging ability. The optimized structural parameters of all compounds was carried out at the B3LYP/6-311++G (d, p) level of DFT basis set implemented in Gaussian 09 program package. Theoretical calculation of the title compounds were carried out using density functional theory method (DFT).
J. Brindha and T.F. Abbs Fen Reji
Asian Journal of Chemistry
A series of 2-alkylamino-4-(3-coumarinyl)thiazoles were synthesized, characterized and evaluated their anticancer activity through molecular docking studies. Cell division protein kinase 2 (PDB code: 1KE9) is selected as a target and the compounds which obeys Lipinski rule of five is selected as a ligand. Molecular docking study is carried out using AutoDock Vina in PyRx virtual screening tool. This study revealed that all the compounds are active against the molecular target and compounds 5a and 5c have the highest docking score.
A. Yardily, V. Anu Danie, Bojaxa A. Rosy, and T.F. Abbs Fen Reji
Elsevier BV
Y. Ramani Bai and T.F. Abbs Fen Reji
Elsevier BV
T.F. Abbs Fen Reji, A. Jeena Pearl, and Bojaxa A. Rosy
Elsevier BV