VELLIYUR KANNIAPPAN GOPALAKRISHNAN

EDUCATION

Ph.D. Biochemistry
1996 University of Madras, Dr. ALMPGIBMS, Taramani Campus, Chennai.

Doctoral thesis title: Biochemical studies on the effect of cis-diammine dichloro platinum - II (cisplatin) and sodium selenite in experimental fibrosarcoma rats.

M. Phil., Biochemistry
1990 University of Madras, Dr. ALMPGIBMS, Taramani Campus, Chennai.

M.Phil thesis title: Mycotoxicoses, effect of patulin on plasma proteins. A preliminary study in rats.

M.Sc. Biochemistry
1988 University of Madras, Dr. ALMPGIBMS, Taramani Campus, Chennai.

B.Sc., Chemistry
1986 MSSWB College, Madurai Kamaraj University, Madurai.

RESEARCH INTERESTS

• Anticancer effect of Medicinal plants against prostate and ovarian cancer in vitro, in vivo and in silico model.
• Antidiabetic and anti-inflammatory activity of medicinal plants.
• Synthesis and Characterization of Nanoparticles from medicinal plants against cancer cell lines.

Scopus Publications

Physicochemical characterization of starch from Maranta arundinacea L. (arrowroot) rhizomes and its inhibition of COX-2: In vivo validation
Nishaa Surendran, Manikandan Vani Raju, Meenakshi Kaniyur Chandrasekaran, Rathi Muthaiyan Ahalliya, Chella Perumal Palanisamy, Geethadevi Chandrasekaran, and Gopalakrishnan Velliyur Kanniappan
Elsevier BV



Quercetin-functionalized nanomaterials: Innovative therapeutic avenues for Alzheimer's disease management
Jinjin Pei, Ranil Vikraman Kumarasamy, Selvaraj Jayaraman, Gopalakrishnan Velliyur Kanniappan, Qianfa Long, and Chella Perumal Palanisamy
Elsevier BV



Glutamine Synthase Expression Profiling and Selective Inhibitor for Burkholderia psuedomallei K96243: An In-silico Approach
Texila International Marketing Management



A Comparative Study of Intraoperative Awareness Using Modified Brice Questionnaire in Patients Undergoing Emergency and Elective Surgery under General Anaesthesia
Texila International Marketing Management



Anaesthetic Management of Laparoscopic Cholecystectomy and Splenectomy in Hereditary Spherocytosis: A Case Report
Texila International Marketing Management



Comprehensive review on single-cell RNA sequencing: A new frontier in Alzheimer's disease research
Wengang Jin, JinJin Pei, Jeane Rebecca Roy, Selvaraj Jayaraman, Rathi Muthaiyan Ahalliya, Gopalakrishnan Velliyur Kanniappan, Monica Mironescu, and Chella Perumal Palanisamy
Elsevier BV



Proteomics profiling of extracellular vesicle for identification of potential biomarkers in Alzheimer's disease: A comprehensive review
JinJin Pei, Chella Perumal Palanisamy, Selvaraj Jayaraman, Prabhu Manickam Natarajan, Vidhya Rekha Umapathy, Jeane Rebecca Roy, Dwarakesh Thalamati, Rathi Muthaiyan Ahalliya, Gopalakrishnan Velliyur Kanniappan, and Monica Mironescu
Elsevier BV



Deciphering the Therapeutic, Larvicidal, and Chemical Pollutant Degrading Properties of Leaves-mediated Silver Nanoparticles Obtained from Alpinia purpurata
Manikandan Vani Raju, Meenakshi Kaniyur Chandrasekaran, Meenakshi Sundari Rajendran, Gopalakrishnan Velliyur Kanniappan, Rathi Muthaiyan Ahalliya, Guru Kumar Dugganaboyana, Mikhlid H. Almutairi, Bader O. Almutairi, Ameer Khusro, and Ponnuswamy Vijayaraghavan
BioResources
The aim of the study was to synthesize silver nanoparticles (AgNPs) from Alpinia purpurata leaves and evaluate their cytotoxic, antimicrobial, antibiofilm, dye degradation, and larvicidal potentials. The synthesized AgNPs were characterized using ultraviolet-visible spectroscopy, Fourier transform infrared, and high-resolution transmission electron microscopy, which confirmed AgNPs synthesis and revealed nanoparticle size (10 to 30 nm) and the presence of silver. Cytotoxicity tests showed IC50 values of 4.59 ± 0.6 µg/mL in A549 cells and 3.48 ± 0.4 µg/mL in PA1 cells, inducing apoptosis and DNA fragmentation. Flow cytometry revealed cell cycle arrest at G0-G1 phase. AgNPs exhibited significant antimicrobial activity, with maximum inhibition zones against K. pneumoniae (23 ± 2 mm) and F. oxysporum (17 ± 2 mm), and minimum inhibitory concentration (MIC) values ranging from 12.5 ± 0.25 to 75 ± 2.5 µg/mL. They also reduced bacterial and fungal biomass and showed antibiofilm effects. Photocatalytic activity degraded methylene blue dye by 88.4 ± 1.4% in 60 minutes. Larvicidal activity resulted in 100% mortality of A. aegypti larvae after 48 hours exposure to AgNPs (10 mg/L), additionally reducing chemical oxygen demand (55.1 ± 2.1% to 63.8 ± 1.5%) and microbial load in wastewater (2.5 to 10 ppm).


Biochemical and Histoarchitectural evaluation of 4-Vinylcyclohexane induced ovarian cancer against Alpinia purpurata (Vieill). K. Schum
Arul Raj Cinthamony, Anusooriya Palanirajan, Manikandan Vani Raju, Meenakshi Kaniyur Chandrasekaran, Rathi Muthaiyan Ahalliya, Gurukumar Dugganaboyana, and Gopalakrishnan Velliyur Kanniappan
Elsevier BV



Antibacterial and biofilm disruptive nonribosomal lipopeptides from Streptomyces parvulus against multidrug-resistant bacterial infections
Shine Kadaikunnan, P. Vijayaragavan, M.A. Rathi, Balasubramanian Balamuralikrishnan, Naiyf S. Alharbi, V.K. Gopalakrishnan, Sumitha Purushothaman, and Ravikumar Sivanesan
Elsevier BV



Isolation, structural characterization, and molecular docking studies on the bioactive compound from n-Hexane extract of Emilia sonchifolia (L.) DC against the pancreatic cancer target Aurora 2 Kinase
Pratibha Prabhakaran, Chella Perumal Palanisamy, Abirami Shanmugam, Prabhu Damodharan, Harshini Swaminathan, Dhivya Devaraj, Rathi Muthaiyan Ahalliya, and Gopalakrishnan Velliyur Kanniappan
Walter de Gruyter GmbH
Abstract Objectives Natural flora historically has played a substantial part in drug development since they serve as active ingredients in medications and templates for the synthesis of novel pharmaceuticals. Emilia sonchifolia is a conventionally utilised therapeutic flora in Indian pharmacopoeia. Therefore, the current study is intended to separate, structurally describe and analyse the anti-pancreatic cancer potential of isolated natural bio-constituents from E. sonchifolia (L.) DC. Methods n-Hexane extract using chromatographic techniques and structurally characterize them using spectroscopic techniques. Further, in silico molecular docking method was employed to investigate the bioactivity of the isolated compound against Aurora 2 Kinase (pancreatic cancer target protein). Results A mixture of stigmasterol with straight-chain monounsaturated alcohol (C49H86O) was isolated and identified from the aerial parts of E. sonchifolia using chromatographic techniques. The docking results showed that the isolated natural compound of stigmasterol with straight-chain monounsaturated alcohol has good docking results compared with Food and Drug Administration-permitted medicine. Conclusions Based on the outcomes, it can be concluded that the stigmasterol with straight-chain monounsaturated alcohol may act as a novel inhibitor for Aurora 2 Kinase. In the future, it may lead to the development of drugs targeting Aurora 2 Kinase for the effective treatment of pancreatic cancer.


Microorganisms and their enzymes in carbon storage and control of greenhouse gas emission
M. Valan Arasu, V. K. Gopalakrishnan, P. Vijayaragavan, M. A. Rathi, Naif Abdullah Al-Dhabi, Ki Choon Choi, and Gauri Singh
De Gruyter



Enhanced antidiabetic and antioxidant properties of gold nanoparticles green synthesized using blossom extract of Azadirachta indica: In vitro studies
V. Gopalakrishnan and R. Singaravelan
Elsevier BV



Assessment of antimicrobial and anthelmintic activity of silver nanoparticles bio-synthesized from Viscum orientale leaf extract
Dugganaboyana Guru Kumar, Raghu Ram Achar, Jajur Ramanna Kumar, Ganamaedi Amala, Velliyur Kanniappan Gopalakrishnan, Sushma Pradeep, Ali A. Shati, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Ekaterina Silina,et al.
Springer Science and Business Media LLC
Abstract Background Viscum orientale is a largely used parasitic plant with traditional medicinal properties. They are considered to possess the medicinal properties of host tree which they grow on. It’s a least explored plant with ethanopharmacological importance. As a result, the current work aimed to investigate the biological effects of Viscum orientale extract and silver nanoparticles (AgNPs) generated from it. Methods AgNPs synthesized using Viscum orientale plant extract and analysed on time dependent series and was characterized using Ultra Violet UV–visible spectra, Fourier Transform Infrared Spectroscopy FTIR, X-ray diffraction (XRD), Energy Dispersive X-ray Spectroscopy (EDX), Scanning Electron Microscopy (SEM). Further using disc method anti-microbial assay was performed following antioxidation screening using 1,1-diphenyl-2-picryl-hydrazyl (DPPH), reducing power and nitric oxide content and heamgglutination with human blood. Results On green synthesis using silver, the phyto contituents of plant Viscum orientale effectively reduced silver ions at 3-4 h of continuous stirring to form AgNPs. UV–vis spectra showed a typical peak of AgNPs at 480 nm. The FTIR analysis confirmed the covering of silver layers to bio-compounds of the extract. SEM analysis represented AgNPs as spherical morphologies ranging from 119–222 nm. AgNPs exhibited impressive zone of inhibition against Escherichia coli (8.1 ± 0.3 mm), Staphylococcus aureus (10.3 ± 0.3 mm), Bacillus subtilis (7.3 ± 0.3 mm), Bacillus cereus (8.2 ± 0.3 mm), Salmonella typhi (7.1 ± 0.2 mm). AgNps exhibited efficiency against DPPH at EC50 value of 57.60 µg/ml. and reducing power at EC50 of 53.42 µg/ml and nitric oxide scavenging of EC50 of 56.01 µg/ml concentration. Further, anthelmintic activity results showed synthesized nanoparticles significant reduction in the paralysis time to 5.4 ± 0.3 min and death time to 6.5 ± 0.6 min in contrast to the individual factors. On hemagglutination using AgNPs, above 80 µg/ml of concentration showed very significant effect on comparison with water extract. Conclusion Synthesized AgNPs using Viscum orientale water extract displayed versatile biological activity than individual extract. This study has forecasted a new path to explore more on this AgNPs for further research.


Aberrant DNA methylation of CDKN2B gene in the Type 1 diabetes mellitus and analysis of epigenetic markers
P. Vijayaragavan, Sumitha Purushothaman, Selvaraj Arokiyaraj, M.A. Rathi, V.K. Gopalakrishnan, Mansour K. Gatasheh, and Ravikumar Sivanesan
Elsevier BV



Molecular docking of monkeypox (mpox) virus proteinase with FDA approved lead molecules
M.Valan Arasu, P. Vijayaragavan, Sumitha Purushothaman, M.A. Rathi, Naif Abdullah Al-Dhabi, V.K. Gopalakrishnan, Ki Choon Choi, and S. Ilavenil
Elsevier BV



Environmentally benign silver bio-nanomaterials as potent antioxidant, antibacterial, and antidiabetic agents: Green synthesis using Salacia oblonga root extract
Guru Kumar Dugganaboyana, Chethan Kumar Mukunda, Anisha Jain, Raghavendra Mandya Kantharaju, Rani R. Nithya, Divya Ninganna, Rathi Muthaiyan Ahalliya, Ali A. Shati, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi,et al.
Frontiers Media SA
Introduction: The use of plant extracts in the green synthesis of metallic nanoparticles is one of the simplest, most practical, economical, and ecologically friendly methods for avoiding the use of toxic chemicals.Method: Silver nanoparticles (AgNPs) were synthesized, employing a high-efficiency, non- toxic, cost-effective, green, and simple technique that included the use of Salacia oblonga root extract (SOR) as a capping agent compared to synthetic nanoparticles. The use of S. oblonga can be seen in traditional medicines for treating diabetes, obesity, rheumatism, gonorrhea, asthma, and hyperglycemia. The objectives of the current study were to green synthesize S. oblonga root extract silver nanoparticles (SOR-AgNPs), characterize them, and study their antioxidant, antibacterial, and antidiabetic activities.Result: The shape of SOR-AgNPs was spherical, at less than 99.8 nm in size, and exhibited a crystalline peak at XRD. The green synthesized SOR-AgNPs showed significant antioxidant properties like DPPH (80.64 μg/mL), reducing power capacity (81.09 ± SEM μg/mL), nitric oxide (96.58 μg/mL), and hydroxyl (58.38 μg/mL) radical scavenging activities. The MIC of SOR-AgNPs was lower in gram-positive bacteria. The SOR-AgNPs have displayed efficient inhibitory activity against α-amylase, with an EC50 of 58.38 μg/mL. Analysis of capping protein around the SOR-AgNPs showed a molecular weight of 30 kDa.Discussion: These SOR-AgNPs could be used as antibacterial and antidiabetic drugs in the future as it is cheap, non-toxic, and environmentally friendly. Bio-fabricated AgNPs had a significant impact on bacterial strains and could be used as a starting point for future antibacterial drug development.


Signaling Molecules in Medicinal Plants Response to Cold Stress
Guru Kumar Dugganaboyana, Sahana Shivaramakrishna, Jajur Ramanna Kumar, Gopalakrishnan Velliyur Kanniappan, Chethan Kumar Mukunda, and Rathi Muthaiyan Ahalliya
Springer Nature Singapore



An Insight into Traditional and Integrative Medicine
D. Sophia, V. K. Gopalakrishnan, C. Ram Kumar, and B. Vijayalakshmi
Springer International Publishing



Synthesis and characterization of silver nanomaterial from aqueous extract of Commelina forskaolii and its potential antimicrobial activity against Gram negative pathogens
R. Vijay, V.M. Drisya, Daniel Raja Femil Selta, M.A. Rathi, VK. Gopalakrishnan, Dalal Hussien M. Alkhalifah, and Wael N. Hozzein
Elsevier BV



Analysis of tumour markers in esophageal carcinoma with different age groups
Rami Adel Pashameah, Atif Abdulwahab A. Oyouni, Osama M. Al-Amer, Waseem AlZamzami, Hussam A.E. Althagafi, Fahad Alharthi, P. Vijayaraghavan, M.A. Rathi, V.K. Gopalakrishnan, and V. Duraipandiyan
Elsevier BV



CpG methylation analysis of tumour suppressor gene and expression of Cathepsin B in renal cell carcinoma
P. Vijayaragavan, M.A. Rathi, V.K. Gopalakrishnan, Rami Adel Pashameah, Atif Abdulwahab A. Oyouni, Osama M. Al-Amer, Waseem AlZamzami, Hussam Awwadh E. Althagafi, V. Duraipandiyan, and Fahad Alharthi
Elsevier BV



Anticancer activity of Alpinia purpurata (Vieill) K. Schum. against MNU and testosterone induced prostate cancer in male Wistar albino rats
Anusooriya Palanirajan, Poornima Kannappan, and Gopalakrishnan Velliyur Kanniappan
Elsevier BV



Nanomaterials as Drug Carriers in Diagnosis and Treatment of Various Cancers
Muthaiyan Ahalliya Rathi, Elliangal Kunhappa Girisan, Velliyur Kanniappan Gopalakrishnan, Periasamy Meenakshi, and Dugganaboyana Guru Kumar
Springer Nature Singapore



Anti-inflammatory and Cytotoxicity activities of Green Synthesized Silver Nanoparticles from Stem Bark of Terminalia brownii
Haftamu Tesfay Berihu, Tesfay Welderfael, Berihu Tekluu, V. K. Gopalakrishnan, M. Rama Rao, P. P. N. Vijay Kumar, U. Shameem, P. John Dogulas, and K. Krishna Chaithanya
Springer Science and Business Media LLC

RECENT SCHOLAR PUBLICATIONS

Comprehensive review on single-cell RNA sequencing: A new frontier in Alzheimer’s disease research
CPP Wengang J, JinJin P, Jeane Rebecca R, Selvaraj J, Rathi M. A ...
Ageing Research Reviews 100, 102454 2024



Artificial Intelligence Tools to Address Challenges of Antimicrobial Resistance in Pathogenic Biofilm Systems
V Mishra, G Velliyur Kanniappan, G Abhijit
Artificial Intelligence Tools to Address Challenges of Antimicrobial 2024



Antibacterial and biofilm disruptive nonribosomal lipopeptides from Streptomyces parvulus against multidrug-resistant bacterial infections
S Kadaikunnan, P Vijayaragavan, MA Rathi, B Balamuralikrishnan, ...
Journal of Infection and Public Health 17 (3), 450-456 2024



Pluripotent Stem Cells in Ethnomedicinal Plant Drug Discovery
GD Sneha Sridhar, Mohana Krishna G.K, Shivaramakrishna, S, Ramanna Kumar J ...
Ethnomedicinal Plants for Drug Discovery, 411-422 2024



Drug Discovery from Ethnomedicinal Plants in the Genomics Era
GD Shivaramakrishna, S, Mohana Krishna G.K, Sneha Sridhar, Vasanth Patil H.B ...
Ethnomedicinal Plants for Drug Discovery., 265–296 2024



Proteomics profiling of extracellular vesicle for identification of potential biomarkers in Alzheimer’s disease: A comprehensive review.
MM 1. Jin Jin P, Chella Perumal P, Selvaraj J, Prabhu M.N, Vidya Rekha U ...
Ageing Research Reviews 99, 102359 2024



Biochemical and Histoarchitectural evaluation of 4-Vinylcyclohexane induced ovarian cancer against Alpinia purpurata (Vieill). K. Schum
GVK Arul Raj Cinthamony, Anusooriya Palanirajan , Manikandan Vani Raju ...
Phytomedicine Plus 4, 100569 2024



Deciphering the therapeutic, larvicidal, and chemical pollutant degrading properties of leaves-mediated silver nanoparticles obtained from Alpinia purpurata
P Raju, M. V., Chandrasekaran, M. K., Rajendran, M. S., Kanniappan, G. V ...
BioResources 19 (2), 3328-3352 2024



21 Microorganisms and their enzymes in carbon storage and control of greenhouse gas emission
P Vijayaragavan, MA Rathi, NA Al-Dhabi, MV Arasu, VK Gopalakrishnan, ...
Microbial Oxidative Enzymes: Biotechnological Applications, 431 2023



Aberrant DNA methylation of CDKN2B gene in the Type 1 diabetes mellitus and analysis of epigenetic markers
P Vijayaragavan, S Purushothaman, S Arokiyaraj, MA Rathi, ...
Journal of King Saud University-Science 35 (8), 102896 2023



An Insight into Traditional and Integrative Medicine
D Sophia, VK Gopalakrishnan, C Ram Kumar, B Vijayalakshmi
Translating Healthcare Through Intelligent Computational Methods, 37-48 2023



Assessment of antimicrobial and anthelmintic activity of silver nanoparticles bio-synthesized from Viscum orientale leaf extract
DG Kumar, RR Achar, JR Kumar, G Amala, VK Gopalakrishnan, ...
BMC Complementary Medicine and Therapies 23 (1), 167 2023



Molecular docking of monkeypox (mpox) virus proteinase with FDA approved lead molecules
MV Arasu, P Vijayaragavan, S Purushothaman, MA Rathi, NA Al-Dhabi, ...
Journal of Infection and Public Health 16 (5), 784-791 2023



Environmentally benign silver bio-nanomaterials as potent antioxidant, antibacterial, and antidiabetic agents: Green synthesis using Salacia oblonga root extract
GK Dugganaboyana, C Kumar Mukunda, A Jain, RM Kantharaju, ...
Frontiers in Chemistry 11, 1114109 2023



Stress-responsive Factors and Molecular Farming in Medicinal Plants.
RMA Guru Kumar D, Shivaramakrishna S, Ramanna Kumar J, Gopalakrishnan V.K ...
Signaling Molecules in Medicinal Plants Response to Cold Stress, 169-191 2023



Synthesis and characterization of silver nanomaterial from aqueous extract of Commelina forskaolii and its potential antimicrobial activity against Gram negative pathogens
R Vijay, VM Drisya, DRF Selta, MA Rathi, VK Gopalakrishnan, ...
Journal of King Saud University-Science 35 (1), 102373 2023



Nanomaterials as Drug Carriers in Diagnosis and Treatment of Various Cancers
MA Rathi, EK Girisan, VK Gopalakrishnan, P Meenakshi, D Guru Kumar
Nanomaterials for Energy Conversion, Biomedical and Environmental 2022



Analysis of tumour markers in esophageal carcinoma with different age groups
RA Pashameah, AAA Oyouni, OM Al-Amer, W AlZamzami, HAE Althagafi, ...
Journal of King Saud University-Science 34 (8), 102361 2022



CpG methylation analysis of tumour suppressor gene and expression of Cathepsin B in renal cell carcinoma
P Vijayaragavan, MA Rathi, VK Gopalakrishnan, RA Pashameah, ...
Journal of King Saud University-Science 34 (8), 102330 2022



Anti-inflammatory and Cytotoxicity activities of Green Synthesized Silver Nanoparticles from Stem Bark of Terminalia brownii
HT Berihu, T Welderfael, B Tekluu, VK Gopalakrishnan, MR Rao, ...
BioNanoScience 11 (4), 998-1016 2021

MOST CITED SCHOLAR PUBLICATIONS

Antioxidant activity of ethanolic extract of Maranta arundinacea L. tuberous rhizomes
S Nishaa, M Vishnupriya, JM Sasikumar, PC Hephzibah, ...
Asian Journal of Pharmaceutical and Clinical Research 5 (4), 85-88 2012
Citations: 142



Functional group analysis of various extracts of Aerva lanata (L.,) by FTIR spectrum
P Ragavendran, D Sophia, C Arul Raj, VK Gopalakrishnan
Pharmacologyonline 1, 358-364 2011
Citations: 139



Production, purification and characterization of invertase by Aspergillus flavus using fruit peel waste as substrate
C Uma, D Gomathi, C Muthulakshmi, VK Gopalakrishnan
Adv Biol Res 4 (1), 31-36 2010
Citations: 104



Cisplatin induced nephrotoxicity and the modulating effect of glutathione ester
E Babu, VK Gopalakrishnan, INP Sriganth, R Gopalakrishnan, ...
Molecular and cellular biochemistry 144, 7-11 1995
Citations: 98



Radical scavenging and antioxidant activity of ethanolic extract of Mollugo nudicaulis by in vitro assays
S Rajamanikandan, T Sindhu, D Durgapriya, D Sophia, P Ragavendran, ...
Indian Journal of Pharmaceutical Education and Research 45 (4), 310-316 2011
Citations: 94



Absence of annexin I expression in B-cell non-Hodgkin's lymphomas and cell lines
JK Vishwanatha, E Salazar, VK Gopalakrishnan
BMC cancer 4, 1-8 2004
Citations: 85



Antidiabetic Activity of Ethanolic Extract of Zaleya decandra in Alloxan-Induced Diabetic Rats
P Meenakshi, R Bhuvaneshwari, MA Rathi, L Thirumoorthi, DC Guravaiah, ...
Applied biochemistry and biotechnology 162, 1153-1159 2010
Citations: 79



Expression of biomarkers modulating prostate cancer angiogenesis: differential expression of annexin II in prostate carcinomas from India and USA
AG Banerjee, J Liu, Y Yuan, VK Gopalakrishnan, SL Johansson, ...
Molecular cancer 2, 1-13 2003
Citations: 79



Hepatoprotective activity of ethanolic extract of Alysicarpus vaginalis against nitrobenzene-induced hepatic damage in rats
MA Rathi, P Meenakshi, VK Gopalakrishnan
South Indian Journal of Biological Sciences 1 (2), 60-65 2015
Citations: 68



Phytochemical screening, functional groups and element analysis of Tylophora pauciflora wight and arn
T Starlin, RC Arul, P Ragavendran, VK Gopalakrishnan
Int Res J Pharm 3 (6), 180-83 2012
Citations: 63



Effect of aqueous extract of Passiflora edulis on biochemical and hematological parameters of Wistar albino rats
K Devaki, U Beulah, G Akila, VK Gopalakrishnan
Toxicology International 19 (1), 63 2012
Citations: 63



In vitro antioxidant activities and HPTLC analysis of ethanolic extract of Cayratia trifolia (L.)
PC Perumal, D Sophia, CA Raj, P Ragavendran, T Starlin, ...
Asian Pacific Journal of tropical disease 2, S952-S956 2012
Citations: 61



Screening and GC-MS profiling of ethanolic extract of Tylophora pauciflora
T Starlin, PS Prabha, BKA Thayakumar, VK Gopalakrishnan
Bioinformation 15 (6), 425 2019
Citations: 58



Phytochemical screening and GC-MS analysis of ethanolic extract of rhizomes of Maranta arundinacea L.
S Nishaa, M Vishnupriya, JM Sasikumar, VK Gopalakrishnan
2013
Citations: 57



Deregulated cyclooxygenase-2 expression in oral premalignant tissues
AG Banerjee, VK Gopalakrishnan, I Bhattacharya, JK Vishwanatha
Molecular cancer therapeutics 1 (14), 1265-1271 2002
Citations: 56



Antimicrobial activity of Moringa oleifera (Lam.) root extract
AJ Raj, VK Gopalakrishnan, SA Yadav, S Dorairaj
Journal of Pharmacy Research 4 (5), 1426-1427 2011
Citations: 53



Enzymatic and non-enzymatic antioxidant properties of Tylophora pauciflora Wight and Arn.–an in vitro study
T Starlin, VK Gopalakrishnan
Asian J. Pharm. Clin. Res 6 (4), 152-157 2013
Citations: 52



Identification of novel PPARγ agonist from GC-MS analysis of ethanolic extract of Cayratia trifolia (L.): a computational molecular simulation studies
PC PERUMAL, S SOWMYA, P PRATIBHA, B VIDYA, P ANUSOORIYA, ...
Journal of Applied Pharmaceutical Science 4 (9), 006-011 2014
Citations: 51



Element and functional group analysis of Ichnocarpus frutescens R. Br.(Apocynaceae)
T Starlin, P Ragavendran, CA Raj, PC Perumal, VK Gopalakrishnan
Int J Pharm Pharm Sci 4, 343-345 2012
Citations: 50



NF-κB activation and proinflammatory cytokines mediated protective effect of Indigofera caerulea Roxb. on CCl4 induced liver damage in rats
G Ponmari, A Annamalai, VK Gopalakrishnan, PTV Lakshmi, ...
International Immunopharmacology 23 (2), 672-680 2014
Citations: 49

Publications

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Scopus:

GRANT DETAILS

Completed Projects

1. Co-investigator in Department of Science and Technology (DST), New Delhi, India, Funded Major Research Project on “Development of mechanism-based antidiabetic formulation, standardization from Indian Traditional Herbz viz., bioavailability, stability studies” Amount sanctioned for the period of three years. lakhs.

2. Principal Investigator in University Grants Commission (UGC) New Delhi, India, Funded Major Research Project on “Expression of transfected FHIT gene in ovarian cancer cell lines” Amount sanctioned for the period of three years (01.04.2007-31.03.2010) Rs-8,03, 600.00 F.No 32-607/2006(SR) dated 02March 2007

3. Principal Investigator in Indian Council of Medical and Research (ICMR) New Delhi, India, Funded Major Research Project on “Anticancer effect of Medicinal Plants on Prostate Cancer Progression Model in vitro” Amount sanctioned for the period of two years (15.05.2007 – 14.5.2009) dated 07.05.2007