Nurgali Rakhymbayev

@kaznmu.kz

School of Pharmacy
Asfendiyarov Kazakh National Medical University



           

https://researchid.co/nr_farma

RESEARCH INTERESTS

Ferula asafoetida, GC-MS analysis, CO2 extraction, antimicrobial effect, component composition, plant raw materials

2

Scopus Publications

Scopus Publications

  • COMPONENT COMPOSITION AND ANTIMICROBIALACTIVITY OF SUBCRITICAL CO<inf>2</inf> EXTRACT OF FERULA ASAFOETIDA L., GROWING IN THE TERRITORY OF KAZAKHSTAN
    Nurgali Rakhymbayev, Ubaidilla Datkhayev, Bayan Sagindykova, Diyas Myrzakozha, Kairat Zhakipbekov, and Zhanar Iskakbayeva
    Private Company Technology Center
    Ferula asafoetida L. has been studied for centuries by many scientists as food products and in traditional medicine, which are relevant for Kazakhstan as well. Recent studies have shown that Ferula asafoetida L. has neuroprotective, memory-enhancing, digestive enzymatic, antioxidant, antispasmodic, hypotensive, hepatoprotective, antimicrobial, antitumor, cytotoxic, and anthelmintic effects. The aim of this study is to determine the component composition by GC-MS method and to study the antimicrobial properties of Ferula asafoetida L. extract obtained by CO2 extraction, which grows in Kazakhstan. Materials and methods. To determine the possibility of using Ferula asafoetida L., we carried out the component composition of the extract obtained by CO2 extraction in subcritical conditions of the underground part of Ferula asafoetida L. by a certain GC-MS method and also investigated the antimicrobial effect of this extract. Results. The plant raw materials were collected in accordance with GACP requirements. Conducted subcritical CO2 extraction of plant raw materials showed a 2.5% extraction yield. The study of the component composition by GC-MS revealed 46.3% of sulfate compounds. The determination of antimicrobial activities showed high efficacy against gram-positive (Staphylococcus aureus subsp. Aureus, Bacillus subtilis subsp. Spizizenii), gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae subsp. pneumoniae, Salmonella enterica subsp. enterica) and fungi (Candida albicans, Aspergillus niger). Conclusions. The possibility of using the obtained CO2 extract of Ferula asafoetida L. in the field of pharmaceutical products as a substance and a drug that has a huge antimicrobial effect

  • Study of cold-pressed tobacco seed oil properties by gas chromatography method
    Murat Z. Ashirov, Ubaidilla M. Datkhayev, Diyas A. Myrzakozha, Hidetoshi Sato, Kairat S. Zhakipbekov, Nurgali A. Rakhymbayev, and Bolat N. Sadykov
    Hindawi Limited
    A special place among vegetable oils was occupied by natural tobacco oil. Natural tobacco oil in folk medicine is used as an antiseptic and antibacterial agent. To determine the possible alternative use of tobacco, the seeds representing Kazakhstan tobacco cultivars, extracted from ground Nicotiana tabacum seeds, were investigated by using the cold press. The quality of the oil was assessed in terms of free fatty acid content. The percentage oil yield was 36.75 ± 0.50%. Tobacco seed oil is highly unsaturated, nonacidic, and would require little purification. The oil can be used for the production of soap, antiwrinkle cream for the face, hair shampoo, shoe cream, and as a high-resolution base oil for perfumes and light industry and can be commercialized due to its high oil yield, for use as anti-inflammatory drugs.